Published in Nat Cell Biol on August 01, 2002
Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem J (2003) 2.42
Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacol Rev (2010) 2.30
Arrestins: ubiquitous regulators of cellular signaling pathways. Genome Biol (2006) 2.15
RalB mobilizes the exocyst to drive cell migration. Mol Cell Biol (2006) 1.91
RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells. Mol Cell Biol (2004) 1.59
Functional architecture of Weibel-Palade bodies. Blood (2011) 1.55
Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction. Br J Pharmacol (2007) 1.49
Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning. Proc Natl Acad Sci U S A (2012) 1.22
Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by filamin A and beta-arrestins. Mol Cell Biol (2006) 1.19
A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol (2003) 1.09
GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness. PLoS One (2011) 1.04
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The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2. Carcinogenesis (2009) 1.02
Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism. Mol Pharmacol (2015) 1.01
RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells. Mol Biol Cell (2004) 1.00
Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. PLoS One (2011) 0.99
A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors. J Biol Chem (2008) 0.97
β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. PLoS One (2013) 0.95
Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases. PLoS One (2011) 0.92
The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network. J Cell Sci (2007) 0.91
Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 0.90
Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. J Biol Chem (2010) 0.87
Regulation of Rho-GEF Rgf3 by the arrestin Art1 in fission yeast cytokinesis. Mol Biol Cell (2014) 0.81
Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma. Oncogene (2015) 0.81
α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. J Cell Sci (2015) 0.80
G-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanisms. J Smooth Muscle Res (2015) 0.79
The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral. Oncogene (2011) 0.78
RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS. Cell Death Dis (2015) 0.77
Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation. Mol Biol Cell (2011) 0.76
β-Arrestin 1-dependent regulation of Rap2 is required for fMLP-stimulated chemotaxis in neutrophil-like HL-60 cells. J Leukoc Biol (2016) 0.75
The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. Pharmacol Rev (2017) 0.75
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension (2011) 3.26
ORL1 receptor-mediated internalization of N-type calcium channels. Nat Neurosci (2005) 2.24
The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2005) 2.13
The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part II - therapy. Can J Cardiol (2005) 2.03
The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Can J Cardiol (2007) 2.01
Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin. J Biol Chem (2009) 1.98
The 2012 Canadian hypertension education program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol (2012) 1.86
The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. Can J Cardiol (2013) 1.85
Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization. Circ Res (2006) 1.76
Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases. Life Sci (2003) 1.74
The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1. Mol Cell Neurosci (2005) 1.72
The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II - Therapy. Can J Cardiol (2006) 1.67
Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis. Pharmacol Ther (2006) 1.62
KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells. Endocrinology (2013) 1.55
Gonadotropin-releasing hormone-regulated chemokine expression in human placentation. Am J Physiol Cell Physiol (2009) 1.51
The 2001 Canadian recommendations for the management of hypertension: Part two--Therapy. Can J Cardiol (2002) 1.49
miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications. Diabetes (2011) 1.47
The 2004 Canadian recommendations for the management of hypertension: Part II--Therapy. Can J Cardiol (2004) 1.46
The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Can J Cardiol (2010) 1.44
The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy. Can J Cardiol (2009) 1.42
Simplified therapeutic intervention to control hypertension and hypercholesterolemia: a cluster randomized controlled trial (STITCH2). J Hypertens (2013) 1.42
Updated national and international hypertension guidelines: a review of current recommendations. Drugs (2014) 1.41
Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci (2007) 1.41
The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol (2011) 1.38
CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci (2010) 1.38
Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells. Mol Cancer Res (2009) 1.38
Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion. J Biol Chem (2001) 1.32
Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin. J Biol Chem (2005) 1.28
The vesicular acetylcholine transporter is required for neuromuscular development and function. Mol Cell Biol (2009) 1.27
The impact of the Canadian Hypertension Education Programme in its first decade. Eur Heart J (2009) 1.26
Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity (2006) 1.26
The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Can J Cardiol (2008) 1.25
Group I metabotropic glutamate receptor signalling and its implication in neurological disease. CNS Neurol Disord Drug Targets (2010) 1.22
The 2004 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2004) 1.20
Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases. J Neurochem (2006) 1.19
Endocytic intermediates involved with the intracellular trafficking of a fluorescent cellular prion protein. J Biol Chem (2002) 1.16
Regulation of angiotensin II type 1A receptor intracellular retention, degradation, and recycling by Rab5, Rab7, and Rab11 GTPases. J Biol Chem (2004) 1.16
Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2. J Biol Chem (2002) 1.15
NRAGE mediates p38 activation and neural progenitor apoptosis via the bone morphogenetic protein signaling cascade. Mol Cell Biol (2005) 1.14
Inhibition of Notch signaling induces myotube hypertrophy by recruiting a subpopulation of reserve cells. J Cell Physiol (2006) 1.13
Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease. J Neurosci (2010) 1.11
G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling. J Biol Chem (2004) 1.11
Substrate binding and catalytic mechanism of human choline acetyltransferase. Biochemistry (2006) 1.10
Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation. Free Radic Biol Med (2008) 1.07
Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. J Neurochem (2005) 1.07
Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation. Am J Physiol Cell Physiol (2013) 1.06
GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness. PLoS One (2011) 1.04
Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain. FASEB J (2010) 1.04
Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation (2003) 1.03
Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Dev Biol (2002) 1.03
The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification. Can J Cardiol (2002) 1.02
Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol (2007) 1.02
Two novel human NUMB isoforms provide a potential link between development and cancer. Neural Dev (2010) 1.00
Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood (2008) 0.99
Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. J Neurosci (2004) 0.99
A switch in numb isoforms is a critical step in cortical development. Dev Dyn (2007) 0.99
Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons. J Biol Chem (2009) 0.98
Regulation of GPR54 signaling by GRK2 and {beta}-arrestin. Mol Endocrinol (2009) 0.97
A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding. J Biol Chem (2003) 0.97
Amyloid-beta oligomers increase the localization of prion protein at the cell surface. J Neurochem (2011) 0.97
The "ins" and "outs" of the high-affinity choline transporter CHT1. J Neurochem (2006) 0.97
Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. Am J Physiol Cell Physiol (2009) 0.96
The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin. Biochem Biophys Res Commun (2010) 0.96
Protein kinase C isoform-specific differences in the spatial-temporal regulation and decoding of metabotropic glutamate receptor1a-stimulated second messenger responses. J Biol Chem (2002) 0.95
β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. PLoS One (2013) 0.95
Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1. J Biol Chem (2010) 0.95
Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.95
Raf kinase activation of adenylyl cyclases: isoform-selective regulation. Mol Pharmacol (2004) 0.94
Somatic mutations in GRM1 in cancer alter metabotropic glutamate receptor 1 intracellular localization and signaling. Mol Pharmacol (2013) 0.94
GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner. PLoS One (2010) 0.93
Barriers to blood pressure control: a STITCH substudy. J Clin Hypertens (Greenwich) (2010) 0.93
Mechanisms of metabotropic glutamate receptor desensitization: role in the patterning of effector enzyme activation. Neurochem Int (2002) 0.93
Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop. J Biol Chem (2005) 0.92
Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway. Mol Brain (2010) 0.92
Surface-entropy reduction used in the crystallization of human choline acetyltransferase. Acta Crystallogr D Biol Crystallogr (2005) 0.92