Published in Mol Cell Biol on January 01, 2006
PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol (2010) 2.41
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron (2007) 2.13
The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras. Mol Cell (2012) 2.01
Velocity fields in a collectively migrating epithelium. Biophys J (2010) 1.90
An exocyst complex functions in plant cell growth in Arabidopsis and tobacco. Plant Cell (2008) 1.81
Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells. Mol Biol Cell (2007) 1.77
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration. J Cell Sci (2008) 1.68
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J (2008) 1.48
Orientation and function of the nuclear-centrosomal axis during cell migration. Curr Opin Cell Biol (2011) 1.32
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol Cell Biol (2007) 1.32
The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation. Mol Biol Cell (2009) 1.27
Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J Cell Biol (2007) 1.21
Activation and involvement of Ral GTPases in colorectal cancer. Cancer Res (2011) 1.18
Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. Am J Physiol Renal Physiol (2010) 1.16
Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation. Mol Biol Cell (2006) 1.15
Membrane organization and dynamics in cell polarity. Cold Spring Harb Perspect Biol (2009) 1.15
Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation. Oncogene (2010) 1.13
The exocyst complex in exocytosis and cell migration. Protoplasma (2011) 1.12
Ral activation promotes melanomagenesis. Oncogene (2010) 1.07
Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res (2010) 1.05
RalGDS couples growth factor signaling to Akt activation. Mol Cell Biol (2008) 1.05
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J (2007) 1.04
Exocyst is involved in polarized cell migration and cerebral cortical development. Proc Natl Acad Sci U S A (2009) 1.03
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol (2006) 1.01
Exo70 generates membrane curvature for morphogenesis and cell migration. Dev Cell (2013) 0.98
The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Mol Cell Proteomics (2009) 0.98
Live-cell imaging of exocyst links its spatiotemporal dynamics to various stages of vesicle fusion. J Cell Biol (2013) 0.97
Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells. Mol Biol Cell (2009) 0.97
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. J Biol Chem (2010) 0.96
Drosophila RalA is essential for the maintenance of Jak/Stat signalling in ovarian follicles. EMBO Rep (2008) 0.94
Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. Mol Cancer Res (2010) 0.92
Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion. Dev Cell (2013) 0.91
RalA and RalB differentially regulate development of epithelial tight junctions. Mol Biol Cell (2011) 0.91
The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target. Urol Oncol (2008) 0.87
RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development. J Cell Sci (2013) 0.86
Polarity sets the stage for cytokinesis. Mol Biol Cell (2012) 0.86
RalA suppresses early stages of Ras-induced squamous cell carcinoma progression. Oncogene (2009) 0.86
The Exocyst at a Glance. J Cell Sci (2015) 0.85
Binding of bacterial secondary messenger molecule c di-GMP is a STING operation. Protein Cell (2012) 0.84
Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells. Dev Biol (2008) 0.83
Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation. Int J Radiat Oncol Biol Phys (2010) 0.83
Overexpression of RalBP1 in colorectal cancer is an independent predictor of poor survival and early tumor relapse. Cancer Biol Ther (2012) 0.83
RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane. J Biol Chem (2012) 0.83
A central role of RLIP76 in regulation of glycemic control. Diabetes (2009) 0.83
Ras family of small GTPases in immunity and inflammation. Curr Opin Pharmacol (2012) 0.82
RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1. Sci Rep (2015) 0.80
The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral. Oncogene (2011) 0.78
Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization. PLoS One (2012) 0.78
Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem (2013) 0.77
RhoGDI3 and RhoG: Vesicular trafficking and interactions with the Sec3 Exocyst subunit. Small GTPases (2010) 0.76
Dual effects of Ral-activated pathways on p27 localization and TGF-β signaling. Mol Biol Cell (2013) 0.75
Probing Functional Changes in Exocyst Configuration with Monoclonal Antibodies. Front Cell Dev Biol (2016) 0.75
Cell motility: The necessity of Rac1 GDP/GTP flux. Commun Integr Biol (2011) 0.75
Sec-ure nanotubes with RalA and exocyst. Nat Cell Biol (2009) 0.75
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
The exocyst is a Ral effector complex. Nat Cell Biol (2002) 3.33
Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell (2005) 3.17
RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell (2005) 3.09
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol (2003) 3.09
The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A (1999) 2.87
Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J Cell Biol (2004) 2.78
Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Dev Cell (2005) 2.75
Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. J Cell Biol (2001) 2.69
The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat Cell Biol (2002) 2.40
Ral-GTPases: approaching their 15 minutes of fame. Trends Cell Biol (2003) 2.36
Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol (2003) 2.02
RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival. EMBO Rep (2003) 2.02
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J (1999) 1.94
RalA and RalB: antagonistic relatives in cancer cell migration. Cancer Res (2005) 1.89
The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J Neurosci (1999) 1.78
Membrane traffic during cell locomotion. Curr Opin Cell Biol (1998) 1.76
Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration. Proc Natl Acad Sci U S A (1994) 1.68
RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. J Cell Sci (2000) 1.64
The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. J Biol Chem (2001) 1.59
Activation of the small GTPase Ral in platelets. Mol Cell Biol (1998) 1.58
Ral GTPases: corrupting the exocyst in cancer cells. Trends Cell Biol (2005) 1.58
Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways. Mol Cell Biol (2001) 1.38
The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization. J Biol Chem (2004) 1.35
The role of Ral A in epidermal growth factor receptor-regulated cell motility. Cancer Res (2002) 1.31
Two distinct roles for Ras in a developmentally regulated cell migration. Development (1996) 1.26
The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway. J Cell Biol (1999) 1.25
Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. Mol Cell Biol (2002) 1.20
Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization. Nat Cell Biol (2002) 1.19
Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays. Clin Cancer Res (2004) 1.17
Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts. Mol Cell Biol (2000) 1.05
The small G-protein RalA stimulates metastasis of transformed cells. Oncogene (2005) 1.03
Reduced mobility of fibroblast growth factor (FGF)-deficient myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple-mutant mice. Mol Cell Biol (2003) 1.03
Identification of the molecular mechanisms contributing to polarized trafficking in osteoblasts. Exp Cell Res (2003) 0.90
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol (2006) 7.75
Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev (2005) 6.14
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell (2006) 5.08
Force mapping in epithelial cell migration. Proc Natl Acad Sci U S A (2005) 5.08
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature (2007) 4.70
Protein interaction mapping: a Drosophila case study. Genome Res (2005) 4.15
The exocyst is a Ral effector complex. Nat Cell Biol (2002) 3.33
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. J Cell Sci (2009) 2.94
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr Biol (2009) 2.82
Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Dev Cell (2005) 2.75
RNA interference in mammalian cells by chemically-modified RNA. Biochemistry (2003) 2.62
Laparoendoscopic single-site surgery in urology: worldwide multi-institutional analysis of 1076 cases. Eur Urol (2011) 2.46
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
Ral GTPases and cancer: linchpin support of the tumorigenic platform. Nat Rev Cancer (2008) 2.39
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23
The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol Cell Biol (2002) 2.19
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell (2011) 2.13
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol (2003) 2.02
RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival. EMBO Rep (2003) 2.02
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc Natl Acad Sci U S A (2011) 1.98
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature (2004) 1.87
A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A (2003) 1.86
Novel robotic da Vinci instruments for laparoendoscopic single-site surgery. Urology (2010) 1.83
Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene (2002) 1.82
Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med (2010) 1.81
Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis. J Cell Biol (2005) 1.81
Endocytic traffic in animal cell cytokinesis. Curr Opin Cell Biol (2008) 1.80
Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol (2005) 1.79
Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem (2004) 1.76
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages. EMBO J (2004) 1.71
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J Biol Chem (2003) 1.69
Compact scanning laser ophthalmoscope with high-speed retinal tracker. Appl Opt (2003) 1.69
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. Nat Cell Biol (2005) 1.67
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther (2009) 1.66
The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity (2002) 1.66
p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. FEBS Lett (2002) 1.66
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. PLoS Genet (2008) 1.64
Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res (2009) 1.63
Towards patient-based cancer therapeutics. Nat Biotechnol (2010) 1.63
Robotic versus laparoscopic partial nephrectomy: single-surgeon matched cohort study of 150 patients. Urology (2010) 1.61
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell (2013) 1.60
Broad spectrum identification of cellular small ubiquitin-related modifier (SUMO) substrate proteins. J Biol Chem (2004) 1.59
Ral GTPases: corrupting the exocyst in cancer cells. Trends Cell Biol (2005) 1.58
Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes. Development (2007) 1.57
MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7. Curr Biol (2008) 1.55
Variations in atmospheric CO2 growth rates coupled with tropical temperature. Proc Natl Acad Sci U S A (2013) 1.54
ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis. Curr Biol (2009) 1.52
ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. J Cell Biol (2003) 1.51
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J (2008) 1.48
Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data. PLoS Comput Biol (2010) 1.47
Testicular compartment syndrome: a new approach to conceptualizing and managing testicular torsion. Urology (2008) 1.46
A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin Cancer Res (2013) 1.46
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Mol Cell Biol (2004) 1.45
The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J (2004) 1.41
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Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J Biol Chem (2002) 1.39
Cdc42 localization and cell polarity depend on membrane traffic. J Cell Biol (2010) 1.38
A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. J Cell Sci (2002) 1.35
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J Exp Med (2012) 1.35
Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res (2003) 1.32
The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton. FASEB J (2002) 1.30
Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells. Cancer Res (2010) 1.30
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol (2013) 1.28
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J (2007) 1.24
Signaling and membrane dynamics during phagocytosis: many roads lead to the phagos(R)ome. Curr Opin Cell Biol (2004) 1.24
ARF6 GTPase controls bacterial invasion by actin remodelling. J Cell Sci (2005) 1.22
The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity. Sci Signal (2011) 1.21
A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages. Curr Biol (2005) 1.21
Image guided percutaneous probe ablation for renal tumors in 65 solitary kidneys: functional and oncological outcomes. J Urol (2011) 1.20
Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci (2003) 1.16
RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Curr Biol (2009) 1.16
Critical contribution of linker proteins to Raf kinase activation. J Biol Chem (2001) 1.15
Comprehensive mapping of the human kinome to epidermal growth factor receptor signaling. J Biol Chem (2010) 1.14
Automated velocity mapping of migrating cell populations (AVeMap). Nat Methods (2012) 1.13
Laparoendoscopic single site reconstructive procedures in urology: medium term results. J Urol (2012) 1.12
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. Biochemistry (2009) 1.12
Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environments. Biophys J (2011) 1.10
Bayesian optimal discovery procedure for simultaneous significance testing. BMC Bioinformatics (2009) 1.10
Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation. Cancer Res (2010) 1.09
Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps. Genome Res (2010) 1.09
A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol (2003) 1.09
Affinity enrichment of plasma membrane for proteomics analysis. Electrophoresis (2003) 1.08
ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion. Eur J Cell Biol (2012) 1.08
CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation. Curr Biol (2004) 1.08
The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4. EMBO J (2009) 1.07
HDAC6 is required for invadopodia activity and invasion by breast tumor cells. Eur J Cell Biol (2010) 1.07
Decoupling of activation and effector binding underlies ARF6 priming of fast endocytic recycling. Curr Biol (2011) 1.07
Caspase-8 sumoylation is associated with nuclear localization. Oncogene (2005) 1.06
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol (2011) 1.04
Randomized clinical trials presented at the World Congress of Endourology: how is the quality of reporting? J Endourol (2010) 1.04