Published in J Neurosci on January 06, 2010
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Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease. Neuropsychiatr Dis Treat (2010) 1.06
Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes. J Neuroinflammation (2012) 1.02
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Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation. Mol Brain (2010) 0.91
Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. Hum Mol Genet (2011) 0.90
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. PLoS One (2013) 0.89
Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates. J Immunol (2013) 0.89
Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium. Future Neurol (2010) 0.89
A new drug design targeting the adenosinergic system for Huntington's disease. PLoS One (2011) 0.85
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Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease. Proc Natl Acad Sci U S A (2016) 0.85
Therapeutic potential of metabotropic glutamate receptor modulators. Curr Neuropharmacol (2012) 0.85
Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis. Mol Brain (2013) 0.85
Orchestrated activation of mGluR5 and CB1 promotes neuroprotection. Mol Brain (2016) 0.84
Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease. Mol Brain (2014) 0.84
Protection by glia-conditioned medium in a cell model of Huntington disease. PLoS Curr (2012) 0.83
Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Front Mol Neurosci (2013) 0.83
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PET brain kinetics studies of (11)C-ITMM and (11)C-ITDM,radioprobes for metabotropic glutamate receptor type 1, in a nonhuman primate. Am J Nucl Med Mol Imaging (2014) 0.82
A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology. Bioessays (2012) 0.81
Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes. Mol Brain (2015) 0.80
Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiat Res (2013) 0.80
Regulation of G protein-coupled receptor trafficking and signaling by Rab GTPases. Small GTPases (2013) 0.78
GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling. J Biol Chem (2015) 0.76
Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. J Huntingtons Dis (2012) 0.76
Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington's Disease. Front Cell Neurosci (2016) 0.76
Group I Metabotropic Glutamate Receptor Interacting Proteins: Fine-Tuning Receptor Functions in Health and Disease. Curr Neuropharmacol (2016) 0.75
An Overview of Potential Targets for Treating Amyotrophic Lateral Sclerosis and Huntington's Disease. Biomed Res Int (2015) 0.75
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Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem (2007) 2.27
ORL1 receptor-mediated internalization of N-type calcium channels. Nat Neurosci (2005) 2.24
Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases. Life Sci (2003) 1.74
Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci (2010) 1.69
Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis. Pharmacol Ther (2006) 1.62
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci (2005) 1.58
P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proc Natl Acad Sci U S A (2005) 1.48
GLAST stability and activity are enhanced by interaction with the PDZ scaffold NHERF-2. Neurosci Lett (2010) 1.43
Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci (2007) 1.41
CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci (2010) 1.38
Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion. J Biol Chem (2001) 1.32
The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1. J Biol Chem (2004) 1.30
Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin. J Biol Chem (2005) 1.28
Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity (2006) 1.26
Group I metabotropic glutamate receptor signalling and its implication in neurological disease. CNS Neurol Disord Drug Targets (2010) 1.22
Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases. J Neurochem (2006) 1.19
Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization. Nat Cell Biol (2002) 1.19
Endocytic intermediates involved with the intracellular trafficking of a fluorescent cellular prion protein. J Biol Chem (2002) 1.16
Regulation of angiotensin II type 1A receptor intracellular retention, degradation, and recycling by Rab5, Rab7, and Rab11 GTPases. J Biol Chem (2004) 1.16
Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2. J Biol Chem (2002) 1.15
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage. J Neurosci (2004) 1.15
Neuro-transmitters in the central nervous system & their implication in learning and memory processes. Curr Med Chem (2009) 1.14
G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling. J Biol Chem (2004) 1.11
Interventions for actinic keratoses. Cochrane Database Syst Rev (2012) 1.10
Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. J Neurochem (2005) 1.07
Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain. FASEB J (2010) 1.04
Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis. Mol Cell (2013) 1.00
Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood (2008) 0.99
Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. J Neurosci (2004) 0.99
Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons. J Biol Chem (2009) 0.98
A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding. J Biol Chem (2003) 0.97
The "ins" and "outs" of the high-affinity choline transporter CHT1. J Neurochem (2006) 0.97
The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin. Biochem Biophys Res Commun (2010) 0.96
Protein kinase C isoform-specific differences in the spatial-temporal regulation and decoding of metabotropic glutamate receptor1a-stimulated second messenger responses. J Biol Chem (2002) 0.95
Raf kinase activation of adenylyl cyclases: isoform-selective regulation. Mol Pharmacol (2004) 0.94
Somatic mutations in GRM1 in cancer alter metabotropic glutamate receptor 1 intracellular localization and signaling. Mol Pharmacol (2013) 0.94
The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. PLoS One (2012) 0.93
Mechanisms of metabotropic glutamate receptor desensitization: role in the patterning of effector enzyme activation. Neurochem Int (2002) 0.93
Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop. J Biol Chem (2005) 0.92
Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway. Mol Brain (2010) 0.92
Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation. Mol Brain (2010) 0.91
Rab GTPases bind at a common site within the angiotensin II type I receptor carboxyl-terminal tail: evidence that Rab4 regulates receptor phosphorylation, desensitization, and resensitization. Mol Pharmacol (2010) 0.91
Regulated recycling and plasma membrane recruitment of the high-affinity choline transporter. Eur J Neurosci (2007) 0.90
Huntington's disease and Group I metabotropic glutamate receptors. Mol Neurobiol (2010) 0.90
The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase. Mol Pharmacol (2010) 0.89
Glucocorticoids regulate innate immunity in a model of multiple sclerosis: reciprocal interactions between the A1 adenosine receptor and beta-arrestin-1 in monocytoid cells. FASEB J (2007) 0.89
Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins. Methods Enzymol (2004) 0.88
Ingenol mebutate: a promising treatment for actinic keratoses and nonmelanoma skin cancers. J Cutan Med Surg (2013) 0.87
Kindling alters neurosteroid-induced modulation of phasic and tonic GABAA receptor-mediated currents: role of phosphorylation. J Neurochem (2011) 0.87
Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet. Epilepsy Res (2007) 0.86
Rab8 modulates metabotropic glutamate receptor subtype 1 intracellular trafficking and signaling in a protein kinase C-dependent manner. J Neurosci (2012) 0.86
Surface patterning using plasma-deposited fluorocarbon thin films for single-cell positioning and neural circuit arrangement. Biomaterials (2010) 0.86
Arrestins: role in the desensitization, sequestration, and vesicular trafficking of G protein-coupled receptors. Prog Mol Biol Transl Sci (2013) 0.85
Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking. J Neurosci (2012) 0.85
Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis. Mol Brain (2013) 0.85
Sertad1 plays an essential role in developmental and pathological neuron death. J Neurosci (2010) 0.84
Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease. Mol Brain (2014) 0.84
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage. J Neurochem (2009) 0.83
Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex. J Neurochem (2002) 0.83
Cell-type-specific pathways of neurotensin endocytosis. Cell Tissue Res (2005) 0.83
Efinaconazole 10% nail solution: a new topical treatment with broad antifungal activity for onychomycosis monotherapy. J Cutan Med Surg (2014) 0.82
Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling. J Biol Chem (2013) 0.82
Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling. J Biol Chem (2009) 0.82
Identification of a novel nuclear localization signal common to 69- and 82-kDa human choline acetyltransferase. J Biol Chem (2003) 0.80
Evidence-based optimal fluconazole dosing regimen for onychomycosis treatment. J Dermatolog Treat (2012) 0.80
Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite. Mol Pharmacol (2007) 0.80
Directing GPCR-transfected cells and neuronal projections with nano-scale resolution. Biomaterials (2013) 0.79
Isoform-specific regulation of adenylyl cyclase function by disruption of membrane trafficking. Mol Pharmacol (2004) 0.79
Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Hum Mol Genet (2013) 0.79
Therapies for onychomycosis a systematic review and network meta-analysis of mycological cure. J Am Podiatr Med Assoc (2014) 0.79
Therapies for the treatment of onychomycosis. Clin Dermatol (2013) 0.78
The small GTPase Ral couples the angiotensin II type 1 receptor to the activation of phospholipase C-delta 1. Mol Pharmacol (2009) 0.78
Regulation of G protein-coupled receptor trafficking and signaling by Rab GTPases. Small GTPases (2013) 0.78
SEC14-like protein 1 interacts with cholinergic transporters. Neurochem Int (2006) 0.77
Simultaneous real-time imaging of signal oscillations using multiple fluorescence-based reporters. Methods Mol Biol (2011) 0.77
Improved efficacy in onychomycosis therapy. Clin Dermatol (2013) 0.77
Role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responses. J Biol Chem (2006) 0.77
Recurrences of dermatophyte toenail onychomycosis during long-term follow-up after successful treatments with mono- and combined therapy of terbinafine and itraconazole. J Cutan Med Surg (2013) 0.77
Systemic antifungals to treat onychomycosis in children: a systematic review. Pediatr Dermatol (2012) 0.76
GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling. J Biol Chem (2016) 0.75
Placebo cure rates in the treatment of onychomycosis. J Am Podiatr Med Assoc (2014) 0.75