Published in Infect Immun on August 01, 2002
Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization. J Bacteriol (2006) 2.54
Group A Streptococcus transcriptome dynamics during growth in human blood reveals bacterial adaptive and survival strategies. Am J Pathol (2005) 2.05
MtsABC is important for manganese and iron transport, oxidative stress resistance, and virulence of Streptococcus pyogenes. Infect Immun (2003) 1.82
Direct hemin transfer from IsdA to IsdC in the iron-regulated surface determinant (Isd) heme acquisition system of Staphylococcus aureus. J Biol Chem (2008) 1.72
Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes. Infect Immun (2003) 1.68
Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus aureus. J Biol Chem (2008) 1.59
Bacillus anthracis IsdG, a heme-degrading monooxygenase. J Bacteriol (2006) 1.51
The mechanism of direct heme transfer from the streptococcal cell surface protein Shp to HtsA of the HtsABC transporter. J Biol Chem (2006) 1.43
Heme transfer from streptococcal cell surface protein Shp to HtsA of transporter HtsABC. Infect Immun (2005) 1.40
Bacterial heme-transport proteins and their heme-coordination modes. Arch Biochem Biophys (2008) 1.36
Characterization of MtsR, a new metal regulator in group A streptococcus, involved in iron acquisition and virulence. Infect Immun (2005) 1.31
ABC transporter FtsABCD of Streptococcus pyogenes mediates uptake of ferric ferrichrome. BMC Microbiol (2005) 1.28
The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp. BMC Microbiol (2008) 1.22
Bis-methionyl coordination in the crystal structure of the heme-binding domain of the streptococcal cell surface protein Shp. J Mol Biol (2007) 1.20
Bis-methionine ligation to heme iron in the streptococcal cell surface protein Shp facilitates rapid hemin transfer to HtsA of the HtsABC transporter. J Biol Chem (2007) 1.16
PerR confers phagocytic killing resistance and allows pharyngeal colonization by group A Streptococcus. PLoS Pathog (2008) 1.10
HtaA is an iron-regulated hemin binding protein involved in the utilization of heme iron in Corynebacterium diphtheriae. J Bacteriol (2009) 1.10
Shr is a broad-spectrum surface receptor that contributes to adherence and virulence in group A streptococcus. Infect Immun (2008) 1.10
Differential regulation of iron- and manganese-specific MtsABC and heme-specific HtsABC transporters by the metalloregulator MtsR of group A Streptococcus. Infect Immun (2006) 1.10
Active and passive immunizations with the streptococcal esterase Sse protect mice against subcutaneous infection with group A streptococci. Infect Immun (2007) 1.06
Identification and characterization of the heme-binding proteins SeShp and SeHtsA of Streptococcus equi subspecies equi. BMC Microbiol (2006) 1.06
Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans. Front Cell Infect Microbiol (2013) 1.03
A novel streptococcal integrative conjugative element involved in iron acquisition. Mol Microbiol (2008) 0.99
IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus. J Infect Dis (2013) 0.99
Sortase independent and dependent systems for acquisition of haem and haemoglobin in Listeria monocytogenes. Mol Microbiol (2011) 0.97
Spectroscopic identification of heme axial ligands in HtsA that are involved in heme acquisition by Streptococcus pyogenes. Biochemistry (2010) 0.94
Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks. Infect Immun (2002) 0.94
Peroxide stimulon and role of PerR in group A Streptococcus. J Bacteriol (2011) 0.94
Structural, NMR spectroscopic, and computational investigation of hemin loading in the hemophore HasAp from Pseudomonas aeruginosa. J Am Chem Soc (2010) 0.93
Mechanisms of group A Streptococcus resistance to reactive oxygen species. FEMS Microbiol Rev (2015) 0.89
MtsR is a dual regulator that controls virulence genes and metabolic functions in addition to metal homeostasis in the group A streptococcus. Mol Microbiol (2010) 0.86
Novel hemin binding domains in the Corynebacterium diphtheriae HtaA protein interact with hemoglobin and are critical for heme iron utilization by HtaA. J Bacteriol (2011) 0.85
Study of streptococcal hemoprotein receptor (Shr) in iron acquisition and virulence of M1T1 group A streptococcus. Virulence (2012) 0.84
Control of heme homeostasis in Corynebacterium glutamicum by the two-component system HrrSA. J Bacteriol (2011) 0.84
Axial ligand replacement mechanism in heme transfer from streptococcal heme-binding protein Shp to HtsA of the HtsABC transporter. Biochemistry (2013) 0.83
Direct heme transfer reactions in the Group A Streptococcus heme acquisition pathway. PLoS One (2012) 0.81
Benfang Lei's research on heme acquisition in Gram-positive pathogens and bacterial pathogenesis. World J Biol Chem (2010) 0.80
Non-heme-binding domains and segments of the Staphylococcus aureus IsdB protein critically contribute to the kinetics and equilibrium of heme acquisition from methemoglobin. PLoS One (2014) 0.77
A solute-binding protein for iron transport in Streptococcus iniae. BMC Microbiol (2010) 0.77
The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme. PLoS One (2016) 0.75
Characterization of the second conserved domain in the heme uptake protein HtaA from Corynebacterium diphtheriae. J Inorg Biochem (2016) 0.75
Heme-bound SiaA from Streptococcus pyogenes: Effects of mutations and oxidation state on protein stability. J Inorg Biochem (2015) 0.75
SpyB, a Small Heme-Binding Protein, Affects the Composition of the Cell Wall in Streptococcus pyogenes. Front Cell Infect Microbiol (2016) 0.75
Characterization of Spbhp-37, a Hemoglobin-Binding Protein of Streptococcus pneumoniae. Front Cell Infect Microbiol (2016) 0.75
Lipid oxidation in trout muscle is strongly inhibited by a protein that specifically binds hemin released from hemoglobin. J Agric Food Chem (2013) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Pathogenesis of group A streptococcal infections. Clin Microbiol Rev (2000) 15.35
Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc Natl Acad Sci U S A (2001) 9.40
Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression. Proc Natl Acad Sci U S A (1991) 5.46
Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci U S A (2002) 4.85
Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis. Nat Med (2001) 4.09
Lipoproteins of gram-positive bacteria. J Bacteriol (1995) 3.83
Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains. J Clin Invest (1997) 2.94
Global differential gene expression in response to growth temperature alteration in group A Streptococcus. Proc Natl Acad Sci U S A (2001) 2.90
Bacterial heme sources: the role of heme, hemoprotein receptors and hemophores. Curr Opin Microbiol (2000) 2.77
Identification of Rgg-regulated exoproteins of Streptococcus pyogenes. Infect Immun (2001) 2.32
Identification and immunogenicity of group A Streptococcus culture supernatant proteins. Infect Immun (2000) 2.21
Nonpolar inactivation of the hypervariable streptococcal inhibitor of complement gene (sic) in serotype M1 Streptococcus pyogenes significantly decreases mouse mucosal colonization. Infect Immun (2000) 2.19
Emerging strategies in microbial haem capture. Mol Microbiol (2001) 2.19
Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli. J Bacteriol (1989) 2.17
Expression and characterization of a heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Iron acquisition requires oxidative cleavage of the heme macrocycle. J Biol Chem (1998) 2.06
Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice. Infect Immun (1999) 2.04
Corynebacterium diphtheriae genes required for acquisition of iron from haemin and haemoglobin are homologous to ABC haemin transporters. Mol Microbiol (2000) 1.91
Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infect Immun (2001) 1.81
Regulation of virulence by environmental signals in group A streptococci: influence of osmolarity, temperature, gas exchange, and iron limitation on emm transcription. Infect Immun (1995) 1.78
Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of inha inhibitor. J Biol Chem (2000) 1.60
Evaluation of transferrin-binding protein 2 within the transferrin-binding protein complex as a potential antigen for future meningococcal vaccines. Infect Immun (1995) 1.60
Acquisition of iron from host proteins by the group A streptococcus. Infect Immun (1996) 1.54
Recombinant Neisseria meningitidis transferrin binding protein A protects against experimental meningococcal infection. Infect Immun (2001) 1.51
The transferrin binding protein B of Moraxella catarrhalis elicits bactericidal antibodies and is a potential vaccine antigen. Infect Immun (1998) 1.46
Identification and characterization of a Streptococcus pyogenes ABC transporter with multiple specificity for metal cations. Mol Microbiol (1999) 1.43
New protective antigen of group A streptococci. J Clin Invest (1999) 1.39
Iron starvation causes release from the group A streptococcus of the ADP-ribosylating protein called plasmin receptor or surface glyceraldehyde-3-phosphate-dehydrogenase. Infect Immun (1996) 1.15
Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection. Infect Immun (2001) 1.10
Protective capacity of the Pasteurella haemolytica transferrin-binding proteins TbpA and TbpB in cattle. Microb Pathog (1999) 1.09
The role of iron in the growth and hemolysin (Streptolysin S) production in Streptococcus pyogenes. J Basic Microbiol (1988) 1.03
Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol (2009) 10.42
STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99
Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med (2007) 5.95
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol (2005) 5.18
Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc Natl Acad Sci U S A (2002) 5.07
Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci U S A (2002) 4.85
spa typing method for discriminating among Staphylococcus aureus isolates: implications for use of a single marker to detect genetic micro- and macrovariation. J Clin Microbiol (2004) 4.80
Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification. Proc Natl Acad Sci U S A (2008) 4.38
Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome. Am J Respir Crit Care Med (2008) 4.33
Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events. J Infect Dis (2005) 3.89
Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling. Proc Natl Acad Sci U S A (2002) 3.83
Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity. PLoS Pathog (2006) 3.68
Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus. Proc Natl Acad Sci U S A (2006) 3.33
Single-nucleotide polymorphism-based population genetic analysis of Mycobacterium tuberculosis strains from 4 geographic sites. J Infect Dis (2005) 3.32
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell Microbiol (2004) 3.26
A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem (2004) 3.05
Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response. Proc Natl Acad Sci U S A (2005) 2.84
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63
Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs. Arch Pathol Lab Med (2012) 2.62
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proc Natl Acad Sci U S A (2014) 2.56
Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils. Proc Natl Acad Sci U S A (2003) 2.54
Longitudinal analysis of the group A Streptococcus transcriptome in experimental pharyngitis in cynomolgus macaques. Proc Natl Acad Sci U S A (2005) 2.45
Genome sequence of a serotype M28 strain of group a streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity. J Infect Dis (2005) 2.45
Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics. Proc Natl Acad Sci U S A (2010) 2.43
Molecular correlates of host specialization in Staphylococcus aureus. PLoS One (2007) 2.41
Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections. Proc Natl Acad Sci U S A (2004) 2.32
Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain. J Infect Dis (2004) 2.29
The fundamental contribution of phages to GAS evolution, genome diversification and strain emergence. Trends Microbiol (2002) 2.27
Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS One (2007) 2.22
Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis (2011) 2.19
In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence. J Bacteriol (2002) 2.19
Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains. J Infect Dis (2010) 2.13
Macrolide-resistant Streptococcus pyogenes in the United States, 2002-2003. Clin Infect Dis (2005) 2.13
Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival. Infect Immun (2002) 2.10
Group A Streptococcus transcriptome dynamics during growth in human blood reveals bacterial adaptive and survival strategies. Am J Pathol (2005) 2.05
A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. Proc Natl Acad Sci U S A (2008) 2.02
Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation. Mol Microbiol (2007) 2.01
Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (2003) 1.99
Characterization of the Manila family of Mycobacterium tuberculosis. J Clin Microbiol (2003) 1.89
Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS One (2007) 1.89
Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog (2009) 1.89
Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression. Proc Natl Acad Sci U S A (2002) 1.85
Rapidly progressive, fatal, inhalation anthrax-like infection in a human: case report, pathogen genome sequencing, pathology, and coordinated response. Arch Pathol Lab Med (2011) 1.83
Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J Biol Chem (2003) 1.81
Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes. Infect Immun (2002) 1.78
SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis (2010) 1.76
Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection. Cell Microbiol (2007) 1.72
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Mol Microbiol (2010) 1.71
Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One (2011) 1.71
Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus. Proc Natl Acad Sci U S A (2011) 1.70
rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China. J Clin Microbiol (2006) 1.68
Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes. Infect Immun (2003) 1.68
Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease. J Infect Dis (2003) 1.68
Differential distribution and expression of Panton-Valentine leucocidin among community-acquired methicillin-resistant Staphylococcus aureus strains. J Clin Microbiol (2005) 1.67
An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation. J Leukoc Biol (2003) 1.66
Correlation of acetate catabolism and growth yield in Staphylococcus aureus: implications for host-pathogen interactions. Infect Immun (2003) 1.66
Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis. J Clin Invest (2005) 1.64
Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease. J Immunol (2004) 1.63
Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus. J Innate Immun (2010) 1.62
CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes. Infect Immun (2009) 1.62
Molecular mechanisms underlying group A streptococcal pathogenesis. Cell Microbiol (2008) 1.62
Synthesis and deformylation of Staphylococcus aureus delta-toxin are linked to tricarboxylic acid cycle activity. J Bacteriol (2003) 1.59
Prophage induction and expression of prophage-encoded virulence factors in group A Streptococcus serotype M3 strain MGAS315. Infect Immun (2003) 1.57
Molecular pathogenesis of necrotizing fasciitis. Annu Rev Pathol (2010) 1.56
The agr radiation: an early event in the evolution of staphylococci. J Bacteriol (2005) 1.55
A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response. Infect Immun (2008) 1.54
Analysis of the transcriptome of group A Streptococcus in mouse soft tissue infection. Am J Pathol (2006) 1.53
Group A Streptococcus gene expression in humans and cynomolgus macaques with acute pharyngitis. Infect Immun (2003) 1.53
Genome diversification in Staphylococcus aureus: Molecular evolution of a highly variable chromosomal region encoding the Staphylococcal exotoxin-like family of proteins. Infect Immun (2003) 1.53
Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils. J Immunol (2005) 1.53
M types of group a streptococcal isolates submitted to the National Centre for Streptococcus (Canada) from 1993 to 1999. J Clin Microbiol (2002) 1.51
Rgg coordinates virulence factor synthesis and metabolism in Streptococcus pyogenes. J Bacteriol (2003) 1.50
Genome sequence of a Lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease. PLoS One (2008) 1.49
Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A Streptococcus. J Infect Dis (2003) 1.49
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis. Proc Natl Acad Sci U S A (2010) 1.47
Discrimination of shifts in a soil microbial community associated with TNT-contamination using a functional ANOVA of 16S rRNA hybridized to oligonucleotide microarrays. Environ Sci Technol (2006) 1.44
Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx. Infect Immun (2006) 1.42
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells. Proc Natl Acad Sci U S A (2002) 1.42
Neutrophils in the innate immune response. Arch Immunol Ther Exp (Warsz) (2006) 1.42
New understanding of the group A Streptococcus pathogenesis cycle. Trends Microbiol (2007) 1.41
Identification of new candidate vaccine antigens made by Streptococcus pyogenes: purification and characterization of 16 putative extracellular lipoproteins. J Infect Dis (2003) 1.39
Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A (2011) 1.39
The role of complex carbohydrate catabolism in the pathogenesis of invasive streptococci. Trends Microbiol (2008) 1.38
Growth characteristics of and virulence factor production by group A Streptococcus during cultivation in human saliva. Infect Immun (2005) 1.37