Published in J Clin Invest on July 01, 2002
Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci U S A (2003) 2.90
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev (2010) 2.68
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest (2006) 2.33
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation (2008) 2.21
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest (2003) 2.20
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest (2003) 2.19
Mitogen-activated protein kinases in heart development and diseases. Circulation (2007) 1.84
Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res (2011) 1.79
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res (2009) 1.74
The CRM1 nuclear export receptor controls pathological cardiac gene expression. Mol Cell Biol (2004) 1.46
Novel methods for measuring cardiac autophagy in vivo. Methods Enzymol (2009) 1.43
c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. EMBO J (2003) 1.42
Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci U S A (2003) 1.37
Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy. Circ Res (2006) 1.34
Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J Clin Invest (2010) 1.29
Adenylyl cyclase type 5 protein expression during cardiac development and stress. Am J Physiol Heart Circ Physiol (2009) 1.16
Elucidation of thioredoxin target protein networks in mouse. Mol Cell Proteomics (2009) 1.11
Cdc42 is an antihypertrophic molecular switch in the mouse heart. J Clin Invest (2009) 1.08
Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway. J Cell Mol Med (2008) 1.00
Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo. J Am Heart Assoc (2012) 0.99
Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem (2008) 0.96
Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility. Cardiovasc Res (2010) 0.94
Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases. J Mol Cell Cardiol (2008) 0.92
c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction. J Biol Chem (2011) 0.90
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives. Pharmacol Ther (2014) 0.88
Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection. J Biol Chem (2011) 0.87
Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. J Cardiovasc Transl Res (2010) 0.87
Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol (2009) 0.81
A RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1. Cell Death Differ (2015) 0.80
The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart. PLoS One (2013) 0.80
MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells. Dis Model Mech (2015) 0.79
Pacing-induced cardiomyopathy: pathophysiological insights through matrix metalloproteinases. Heart Fail Rev (2014) 0.76
Steroidal Saponin Diosgenin from Dioscorea bulbifera Protects Cardiac Cells from Hypoxia-reoxygenation Injury Through Modulation of Pro-survival and Pro-death Molecules. Pharmacogn Mag (2016) 0.76
H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT. Circ Heart Fail (2017) 0.75
The role of MEKK1 in hypertrophic cardiomyopathy. Int Heart J (2010) 0.75
Signal transduction by the JNK group of MAP kinases. Cell (2000) 18.24
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev (1999) 9.02
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell (1995) 8.80
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science (1993) 7.00
Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol (2001) 4.17
The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol (1997) 3.70
Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation (2001) 3.15
Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem (1992) 2.55
Apoptosis and heart failure: A critical review of the literature. Circ Res (2000) 2.48
"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res (1998) 2.30
Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci U S A (2000) 2.25
Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice. Circulation (2001) 2.23
Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. J Clin Invest (1996) 2.21
A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression. J Cell Biol (1997) 2.19
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science (1998) 2.10
Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem (1998) 2.05
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci U S A (2000) 2.04
Mekk3 is essential for early embryonic cardiovascular development. Nat Genet (2000) 1.95
Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br Heart J (1994) 1.85
The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy. J Biol Chem (1997) 1.80
MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells. EMBO J (1997) 1.66
Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy. J Clin Invest (1998) 1.64
Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol Cell Biol (1998) 1.63
Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circ Res (1999) 1.58
Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases. J Clin Invest (1999) 1.50
Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation (2001) 1.46
Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse. J Clin Invest (1999) 1.39
Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes. J Clin Invest (1994) 1.36
MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. Proc Natl Acad Sci U S A (1999) 1.32
Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J (2000) 1.31
MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton. J Biol Chem (1999) 1.30
Apoptosis of cardiac myocytes in Gsalpha transgenic mice. Circ Res (1999) 1.28
Hemodynamic regulation of tumor necrosis factor-alpha gene and protein expression in adult feline myocardium. Circ Res (1997) 1.27
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci U S A (2002) 1.11
Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circ Res (1999) 1.11
Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol Pharmacol (2001) 1.11
Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis. J Mol Cell Cardiol (2001) 1.10
Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis. Circ Res (2001) 1.08
Proinflammatory consequences of transgenic fas ligand expression in the heart. J Clin Invest (2000) 1.03
Overexpression of tumor necrosis factor- alpha activates both anti- and pro-apoptotic pathways in the myocardium. J Mol Cell Cardiol (2001) 0.99
Collaborative roles for c-Jun N-terminal kinase, c-Jun, serum response factor, and Sp1 in calcium-regulated myocardial gene expression. J Biol Chem (1997) 0.94
Hypoxia-reoxygenation-induced apoptosis in cultured adult rat myocytes and the protective effect of platelets and transforming growth factor-beta(1). J Pharmacol Exp Ther (1999) 0.91
Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load. Hypertension (2001) 0.89
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54
MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res (2007) 5.65
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res (2007) 5.23
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science (2011) 4.36
Ballistic carbon nanotube field-effect transistors. Nature (2003) 4.35
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. Proc Natl Acad Sci U S A (2005) 3.84
Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell (2012) 3.77
Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A (2005) 3.55
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res (2009) 3.53
Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol (2002) 3.46
Quantitative susceptibility map reconstruction from MR phase data using bayesian regularization: validation and application to brain imaging. Magn Reson Med (2010) 3.43
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol (2003) 3.26
Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proc Natl Acad Sci U S A (2009) 3.00
Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell (2007) 2.96
Fluorescence visualization of newly synthesized proteins in mammalian cells. Angew Chem Int Ed Engl (2006) 2.96
Smoking during pregnancy and newborn neurobehavior. Pediatrics (2003) 2.93
The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage (2005) 2.86
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell (2012) 2.83
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res (2004) 2.82
Explaining the increase in coronary heart disease mortality in Beijing between 1984 and 1999. Circulation (2004) 2.81
Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry (2005) 2.79
Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis (2012) 2.77
Polarization-controlled tunable directional coupling of surface plasmon polaritons. Science (2013) 2.73
Characterization of the "deqi" response in acupuncture. BMC Complement Altern Med (2007) 2.70
Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china. Circ Cardiovasc Qual Outcomes (2010) 2.63
Improvement of Fat Graft Survival with Autologous Bone Marrow Aspirate and Bone Marrow Concentrate: A One-Step Method. Plast Reconstr Surg (2016) 2.59
A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes. Org Lett (2004) 2.57
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet (2005) 2.52
Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation (2006) 2.50
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet (2012) 2.47
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47
Cilium-generated signaling and cilia-related disorders. Lab Invest (2005) 2.42
Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J Neurosci (2004) 2.40
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol (2005) 2.39
A cross-sectional study of the microeconomic impact of cardiovascular disease hospitalization in four low- and middle-income countries. PLoS One (2011) 2.23
Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res (2007) 2.22
Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. Nat Genet (2002) 2.21
GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data. Bioinformatics (2012) 2.21
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest (2003) 2.20
Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J Mol Biol (2005) 2.19
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest (2003) 2.19
Comparative genomic analysis of 18 Pseudomonas aeruginosa bacteriophages. J Bacteriol (2006) 2.18
High-kappa dielectrics for advanced carbon-nanotube transistors and logic gates. Nat Mater (2002) 2.18
Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Hum Brain Mapp (2005) 2.15
The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer (2013) 2.11
Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation (2008) 2.09
Morphology enabled dipole inversion (MEDI) from a single-angle acquisition: comparison with COSMOS in human brain imaging. Magn Reson Med (2011) 2.05
Modeling elastic properties in finite-element analysis: how much precision is needed to produce an accurate model? Anat Rec A Discov Mol Cell Evol Biol (2005) 2.01
Efficacy and safety of intracameral triamcinolone acetonide to control postoperative inflammation after phacotrabeculectomy. J Cataract Refract Surg (2013) 2.00
An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices. J Am Chem Soc (2004) 1.98
Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. Int J Cardiol (2012) 1.98
The infant development, environment, and lifestyle study: effects of prenatal methamphetamine exposure, polydrug exposure, and poverty on intrauterine growth. Pediatrics (2006) 1.98
LGN regulates mitotic spindle orientation during epithelial morphogenesis. J Cell Biol (2010) 1.95
MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem (2010) 1.94
Child mortality estimation: appropriate time periods for child mortality estimates from full birth histories. PLoS Med (2012) 1.93
OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY. Retina (2016) 1.93
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell (2007) 1.90
Prenatal methamphetamine use and neonatal neurobehavioral outcome. Neurotoxicol Teratol (2007) 1.90
Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci (2005) 1.89
Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res (2010) 1.89
Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol (2009) 1.89
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell (2007) 1.88
A novel background field removal method for MRI using projection onto dipole fields (PDF). NMR Biomed (2011) 1.88
Electron transport in very clean, as-grown suspended carbon nanotubes. Nat Mater (2005) 1.86
Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell (2013) 1.86
Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. J Clin Oncol (2012) 1.84
Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology (2011) 1.83
Proteomic identification of the cerebral cavernous malformation signaling complex. J Proteome Res (2007) 1.83
Methamphetamine and other substance use during pregnancy: preliminary estimates from the Infant Development, Environment, and Lifestyle (IDEAL) study. Matern Child Health J (2006) 1.81
Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res (2011) 1.79
Selective dye-labeling of newly synthesized proteins in bacterial cells. J Am Chem Soc (2005) 1.77
Impairment of T-regulatory cells in cord blood of atopic mothers. J Allergy Clin Immunol (2008) 1.76
Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders. Cell (2004) 1.76
Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res (2006) 1.75
ABSORB: Atlas Building by Self-organized Registration and Bundling. Neuroimage (2010) 1.75
An aurora kinase is essential for flagellar disassembly in Chlamydomonas. Dev Cell (2004) 1.75
Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models. Clin Cancer Res (2012) 1.74
Thermal conductance of an individual single-wall carbon nanotube above room temperature. Nano Lett (2006) 1.73
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell (2004) 1.73
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood (2010) 1.72