Published in J Am Chem Soc on October 19, 2005
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed Engl (2009) 8.15
Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation. Angew Chem Int Ed Engl (2009) 3.81
Cell-selective metabolic labeling of proteins. Nat Chem Biol (2009) 2.61
Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl (2010) 2.57
Unnatural amino acid incorporation into virus-like particles. Bioconjug Chem (2008) 1.54
Discovery of Escherichia coli methionyl-tRNA synthetase mutants for efficient labeling of proteins with azidonorleucine in vivo. Proc Natl Acad Sci U S A (2009) 1.45
Bringing chemistry to life. Nat Methods (2011) 1.45
Noncanonical amino acids in the interrogation of cellular protein synthesis. Acc Chem Res (2011) 1.44
Genetically encoded copper-free click chemistry. Angew Chem Int Ed Engl (2011) 1.35
A versatile approach to high-throughput microarrays using thiol-ene chemistry. Nat Chem (2009) 1.24
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res (2009) 1.20
Fast, cell-compatible click chemistry with copper-chelating azides for biomolecular labeling. Angew Chem Int Ed Engl (2012) 1.19
Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc Natl Acad Sci U S A (2006) 1.05
In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry. Environ Microbiol (2014) 1.04
Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors. Biophys J (2009) 1.01
Electrochemically protected copper(I)-catalyzed azide-alkyne cycloaddition. Chembiochem (2008) 0.99
CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum. J Am Chem Soc (2015) 0.98
A copper-catalyzed, pH-neutral construction of high-enantiopurity peptidyl ketones from peptidic s-acylthiosalicylamides in air at room temperature. Angew Chem Int Ed Engl (2009) 0.96
Design strategies for bioorthogonal smart probes. Org Biomol Chem (2014) 0.95
Mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells. Proc Natl Acad Sci U S A (2013) 0.94
Attenuation-based dual-fluorescent-protein reporter for screening translation inhibitors. Antimicrob Agents Chemother (2012) 0.92
A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules. ACS Chem Biol (2010) 0.91
Identification and quantitation of newly synthesized proteins in Escherichia coli by enrichment of azidohomoalanine-labeled peptides with diagonal chromatography. Mol Cell Proteomics (2009) 0.88
State-selective metabolic labeling of cellular proteins. ACS Chem Biol (2012) 0.87
Chemical tools for temporally and spatially resolved mass spectrometry-based proteomics. Ann Biomed Eng (2013) 0.85
Non-Standard Genetic Codes Define New Concepts for Protein Engineering. Life (Basel) (2015) 0.84
"Turn-on" protein fluorescence: in situ formation of cyanine dyes. J Am Chem Soc (2015) 0.82
Introduction of an aliphatic ketone into recombinant proteins in a bacterial strain that overexpresses an editing-impaired leucyl-tRNA synthetase. Chembiochem (2009) 0.82
Teaching old NCATs new tricks: using non-canonical amino acid tagging to study neuronal plasticity. Curr Opin Chem Biol (2013) 0.81
Oligonucleotide models of telomeric DNA and RNA form a Hybrid G-quadruplex structure as a potential component of telomeres. J Biol Chem (2012) 0.81
Site-specific bioconjugation of a murine dihydrofolate reductase enzyme by copper(I)-catalyzed azide-alkyne cycloaddition with retained activity. PLoS One (2014) 0.79
Progress and prospects for small-molecule probes of bacterial imaging. Nat Chem Biol (2016) 0.79
Visualizing in situ translational activity for identifying and sorting slow-growing archaeal-bacterial consortia. Proc Natl Acad Sci U S A (2016) 0.78
Size-matched alkyne-conjugated cyanine fluorophores to identify differences in protein glycosylation. Electrophoresis (2014) 0.77
Site-specific fatty acid-conjugation to prolong protein half-life in vivo. J Control Release (2013) 0.77
Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue. Nat Commun (2016) 0.76
In vivo virus-based macrofluorogenic probes target azide-labeled surface glycans in MCF-7 breast cancer cells. Mol Pharm (2012) 0.76
Bioorthogonal Fluorescent Labelling of Biopolymers via Inverse Electron Demand Diels-Alder Reactions. Chembiochem (2017) 0.75
Evaluation of fluorescent phosphatidylserine substrates for the aminophospholipid flippase in mammalian cells. J Fluoresc (2011) 0.75
Fluorescence imaging of chromosomal DNA using click chemistry. Sci Rep (2016) 0.75
Discrimination of colon cancer stem cells using noncanonical amino acid. Chem Commun (Camb) (2012) 0.75
An Artificial Reaction Promoter Modulates Mitochondrial Functions via Chemically Promoting Protein Acetylation. Sci Rep (2016) 0.75
Designing materials for biology and medicine. Nature (2004) 7.73
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. Proc Natl Acad Sci U S A (2001) 4.88
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc Natl Acad Sci U S A (2006) 4.44
Ballistic carbon nanotube field-effect transistors. Nature (2003) 4.35
In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. Nat Neurosci (2010) 3.51
Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloaddition. J Am Chem Soc (2003) 3.25
Fluorescence visualization of newly synthesized proteins in mammalian cells. Angew Chem Int Ed Engl (2006) 2.96
Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging. Nat Protoc (2007) 2.82
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med (2011) 2.80
Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis (2012) 2.77
Polarization-controlled tunable directional coupling of surface plasmon polaritons. Science (2013) 2.73
Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A (2004) 2.62
Cell-selective metabolic labeling of proteins. Nat Chem Biol (2009) 2.61
Improvement of Fat Graft Survival with Autologous Bone Marrow Aspirate and Bone Marrow Concentrate: A One-Step Method. Plast Reconstr Surg (2016) 2.59
A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes. Org Lett (2004) 2.57
Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation (2006) 2.50
Cilium-generated signaling and cilia-related disorders. Lab Invest (2005) 2.42
Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J Neurosci (2004) 2.40
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proc Natl Acad Sci U S A (2006) 2.23
GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data. Bioinformatics (2012) 2.21
High-kappa dielectrics for advanced carbon-nanotube transistors and logic gates. Nat Mater (2002) 2.18
Modeling elastic properties in finite-element analysis: how much precision is needed to produce an accurate model? Anat Rec A Discov Mol Cell Evol Biol (2005) 2.01
An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices. J Am Chem Soc (2004) 1.98
Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. Int J Cardiol (2012) 1.98
Quantifying cellular traction forces in three dimensions. Proc Natl Acad Sci U S A (2009) 1.98
OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY. Retina (2016) 1.93
A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet (2011) 1.92
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell (2007) 1.90
Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res (2010) 1.89
Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci (2005) 1.89
Presentation and detection of azide functionality in bacterial cell surface proteins. J Am Chem Soc (2004) 1.88
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell (2007) 1.88
Electron transport in very clean, as-grown suspended carbon nanotubes. Nat Mater (2005) 1.86
Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. J Clin Oncol (2012) 1.84
Non-canonical amino acids in protein engineering. Curr Opin Biotechnol (2003) 1.78
Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders. Cell (2004) 1.76
ABSORB: Atlas Building by Self-organized Registration and Bundling. Neuroimage (2010) 1.75
An aurora kinase is essential for flagellar disassembly in Chlamydomonas. Dev Cell (2004) 1.75
Thermal conductance of an individual single-wall carbon nanotube above room temperature. Nano Lett (2006) 1.73
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood (2010) 1.72
Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9. Hepatol Res (2009) 1.70
High-field quasiballistic transport in short carbon nanotubes. Phys Rev Lett (2004) 1.68
Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells. Blood (2011) 1.67
The feeding biomechanics and dietary ecology of Australopithecus africanus. Proc Natl Acad Sci U S A (2009) 1.66
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol (2013) 1.65
A comprehensive view of nuclear receptor cancer cistromes. Cancer Res (2011) 1.64
Self-directed self-assembly of nanoparticle/copolymer mixtures. Nature (2005) 1.62
Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications. Curr Opin Chem Biol (2010) 1.61
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest (2002) 1.56
Three-dimensional traction force microscopy: a new tool for quantifying cell-matrix interactions. PLoS One (2011) 1.55
Unnatural amino acid incorporation into virus-like particles. Bioconjug Chem (2008) 1.54
Clinical presentation and management of mTOR inhibitor-associated stomatitis. Oral Oncol (2011) 1.54
Systemic trafficking of plant virus nanoparticles in mice via the oral route. Virology (2005) 1.53
A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions. J Cell Biol (2007) 1.53
Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum. Proc Natl Acad Sci U S A (2012) 1.52
Tuning the erosion rate of artificial protein hydrogels through control of network topology. Nat Mater (2006) 1.51
Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg (2012) 1.50
Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis (2006) 1.49
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem (2010) 1.48
Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev (2011) 1.47
Cleavable biotin probes for labeling of biomolecules via azide-alkyne cycloaddition. J Am Chem Soc (2010) 1.47
An experimental design to study adipocyte stem cells for reconstruction of calvarial defects. J Craniofac Surg (2009) 1.47
Genome-scale transcriptome analysis of the desert poplar, Populus euphratica. Tree Physiol (2011) 1.47
Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways. Bioinformatics (2008) 1.46
Discovery of Escherichia coli methionyl-tRNA synthetase mutants for efficient labeling of proteins with azidonorleucine in vivo. Proc Natl Acad Sci U S A (2009) 1.45
A cone-beam computed tomography study of maxillary first permanent molar root and canal morphology in a Chinese population. J Endod (2010) 1.45
Comparative cell response to artificial extracellular matrix proteins containing the RGD and CS5 cell-binding domains. Biomacromolecules (2004) 1.44
Noncanonical amino acids in the interrogation of cellular protein synthesis. Acc Chem Res (2011) 1.44
Surface modification of tobacco mosaic virus with "click" chemistry. Chembiochem (2008) 1.43
Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated. Hepatol Res (2009) 1.42
Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus. Biomacromolecules (2003) 1.42
Global impairment of brachial, carotid, and aortic vascular function in young smokers: direct quantification by high-resolution magnetic resonance imaging. J Am Coll Cardiol (2004) 1.41
Mechanism for the phase transition of a genetically engineered elastin model peptide (VPGIG)40 in aqueous solution. Biomacromolecules (2003) 1.40
RTE1 is a Golgi-associated and ETR1-dependent negative regulator of ethylene responses. Plant Physiol (2007) 1.39
Carbon nanotube DNA sensor and sensing mechanism. Nano Lett (2006) 1.39
Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis (2011) 1.38
Preparation of superhydrophobic polymeric film on aluminum plates by electrochemical polymerization. Molecules (2009) 1.38
The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Ann Neurol (2008) 1.38
Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease. Ann Neurol (2012) 1.37
SharpMean: groupwise registration guided by sharp mean image and tree-based registration. Neuroimage (2011) 1.37
Endothelial cell adhesion to the fibronectin CS5 domain in artificial extracellular matrix proteins. Biomaterials (2003) 1.37
Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci (2007) 1.37
Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc Natl Acad Sci U S A (2006) 1.35
Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med (2013) 1.35
Characteristics of long non-coding RNA and its relation to hepatocellular carcinoma. Carcinogenesis (2013) 1.33
Electromechanical properties of metallic, quasimetallic, and semiconducting carbon nanotubes under stretching. Phys Rev Lett (2003) 1.32
Two-color labeling of temporally defined protein populations in mammalian cells. Bioorg Med Chem Lett (2008) 1.30
Protein engineering approaches to biomaterials design. Curr Opin Biotechnol (2005) 1.30
Non-canonical amino acid labeling in vivo to visualize and affinity purify newly synthesized proteins in larval zebrafish. ACS Chem Neurosci (2012) 1.30
Genomic insights into salt adaptation in a desert poplar. Nat Commun (2013) 1.30
Engineering cooperativity in biomotor-protein assemblies. Science (2006) 1.30
Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther (2009) 1.29
A sequence-based genetic linkage map as a reference for Brassica rapa pseudochromosome assembly. BMC Genomics (2011) 1.29
miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. J Pathol (2011) 1.28