Published in Adv Enzyme Regul on January 01, 2002
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev (2006) 2.74
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal (2010) 1.64
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential. Hepatology (2009) 1.23
Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma. Cancer Immunol Immunother (2008) 1.12
The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta. Breast Cancer Res (2005) 1.10
Cystatin C, kidney function and cardiovascular disease. Pediatr Nephrol (2006) 0.98
Heterogeneity of proteinase inhibitors in the water-soluble organic matrix from the oyster nacre. Mar Biotechnol (NY) (2007) 0.98
Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols. Biochem J (2006) 0.96
Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes. BMC Evol Biol (2009) 0.93
IGFBP-4 anti-angiogenic and anti-tumorigenic effects are associated with anti-cathepsin B activity. Neoplasia (2013) 0.85
Giardia lamblia cysteine proteases. Parasitol Res (2006) 0.83
Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis. Br J Cancer (2003) 0.81
Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis. Curr HIV Res (2014) 0.80
The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet (2012) 0.79
The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. Molecules (2012) 0.78
Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats. Neural Regen Res (2014) 0.78
Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway. Arterioscler Thromb Vasc Biol (2016) 0.77
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS One (2015) 0.77
Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness. Biochim Biophys Acta (2016) 0.77
Effects of open versus laparoscopic nephrectomy techniques on oxidative stress markers in patients with renal cell carcinoma. Oxid Med Cell Longev (2013) 0.77
The Function of V-ATPases in Cancer. Physiol Rev (2016) 0.76
Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation. Cell Death Dis (2017) 0.75
Expression Analysis of Cathepsin F during Embryogenesis and Early Developmental Stage in Olive Flounder (Paralichthys olivaceus). Balsaenggwa Saengsig (2013) 0.75
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus. World J Gastroenterol (2005) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Averaged kick maps: less noise, more signal... and probably less bias. Acta Crystallogr D Biol Crystallogr (2009) 3.62
Interpretation of ensembles created by multiple iterative rebuilding of macromolecular models. Acta Crystallogr D Biol Crystallogr (2007) 3.07
Cysteine cathepsins: from structure, function and regulation to new frontiers. Biochim Biophys Acta (2011) 2.50
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem (2003) 2.30
Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des (2007) 2.26
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem (2008) 1.85
Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody. J Control Release (2007) 1.73
Lysosomes and lysosomal cathepsins in cell death. Biochim Biophys Acta (2011) 1.61
Cystatins: biochemical and structural properties, and medical relevance. Front Biosci (2008) 1.52
Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity. Plant Cell (2007) 1.41
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol (2011) 1.41
Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi. J Biol Chem (2007) 1.31
Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol Chem (2007) 1.29
Autophagy in protists. Autophagy (2011) 1.29
Cysteine cathepsins (proteases)--on the main stage of cancer? Cancer Cell (2004) 1.27
Crystal structure of Stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases. J Mol Biol (2003) 1.24
Essential role of proline isomerization in stefin B tetramer formation. J Mol Biol (2006) 1.23
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. Curr Pharm Des (2002) 1.23
Cystatins in immune system. J Cancer (2012) 1.22
Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochem (2009) 1.21
Two-step membrane binding by Equinatoxin II, a pore-forming toxin from the sea anemone, involves an exposed aromatic cluster and a flexible helix. J Biol Chem (2002) 1.20
Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proc Natl Acad Sci U S A (2007) 1.20
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro. Exp Cell Res (2003) 1.20
Production and activation of recombinant papain-like cysteine proteases. Methods (2004) 1.18
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. Am J Pathol (2012) 1.16
Lysosomal cysteine proteases (cathepsins): promising drug targets. Acta Crystallogr D Biol Crystallogr (2003) 1.16
Lysosomal pathways to cell death and their therapeutic applications. Exp Cell Res (2012) 1.15
Lysosomes in apoptosis. Methods Enzymol (2008) 1.13
Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis. Biol Chem (2010) 1.13
Improved success of sparse matrix protein crystallization screening with heterogeneous nucleating agents. PLoS One (2007) 1.12
Lysosomal-mitochondrial cross-talk during cell death. Mitochondrion (2010) 1.11
Metacaspases of Trypanosoma cruzi: possible candidates for programmed cell death mediators. Mol Biochem Parasitol (2005) 1.10
Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells. Exp Cell Res (2006) 1.05
Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. Biochimie (2007) 1.05
Role of cysteine cathepsins in matrix degradation and cell signalling. Connect Tissue Res (2008) 1.05
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis. Cancer Gene Ther (2003) 1.05
Stefin B interacts with histones and cathepsin L in the nucleus. J Biol Chem (2010) 1.04
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions. J Biol Chem (2007) 1.04
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro. J Cell Biochem (2006) 1.04
Crystallography and protein-protein interactions: biological interfaces and crystal contacts. Biochem Soc Trans (2008) 1.03
Pore formation by equinatoxin, a eukaryotic pore-forming toxin, requires a flexible N-terminal region and a stable beta-sandwich. J Biol Chem (2004) 1.03
Autocatalytic processing of procathepsin B is triggered by proenzyme activity. FEBS J (2009) 1.02
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. Exp Cell Res (2005) 1.02
The role of cathepsin X in the migration and invasiveness of T lymphocytes. J Cell Sci (2008) 1.01
Lysosomal cysteine proteases: structural features and their role in apoptosis. IUBMB Life (2005) 1.01
Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans. FEBS Lett (2005) 1.00
Molecular basis of Colorado potato beetle adaptation to potato plant defence at the level of digestive cysteine proteinases. Insect Biochem Mol Biol (2004) 0.99
High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas. Acta Neuropathol (2009) 0.99
Cathepsin X binds to cell surface heparan sulfate proteoglycans. Arch Biochem Biophys (2005) 0.99
Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins. Immunology (2008) 0.98
Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds. ChemMedChem (2011) 0.97
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. Bioorg Med Chem (2010) 0.97
Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation. J Biol Chem (2008) 0.96
Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics. J Mol Biol (2008) 0.95
Cystatin C as a potential marker for relapse in patients with non-Hodgkin B-cell lymphoma. Cancer Lett (2006) 0.95
γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways. Biochem J (2012) 0.95
PURY: a database of geometric restraints of hetero compounds for refinement in complexes with macromolecular structures. Acta Crystallogr D Biol Crystallogr (2008) 0.94
Selective activity-based probes for cysteine cathepsins. Angew Chem Int Ed Engl (2008) 0.94
Inhibitory properties of cystatin F and its localization in U937 promonocyte cells. FEBS J (2005) 0.93
DNA accelerates the inhibition of human cathepsin V by serpins. J Biol Chem (2007) 0.92
Comprehensive search for cysteine cathepsins in the human genome. Biol Chem (2004) 0.92
Two decades of thyroglobulin type-1 domain research. Biol Chem (2007) 0.91
Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors. J Cancer Res Clin Oncol (2009) 0.91
Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells. Int J Biochem Cell Biol (2009) 0.91
Cysteine cathepsins and their potential in clinical therapy and biomarker discovery. Proteomics Clin Appl (2014) 0.90
Nanoscale polymer carriers to deliver chemotherapeutic agents to tumours. Expert Opin Biol Ther (2005) 0.90
Bivalent carbohydrate binding is required for biological activity of Clitocybe nebularis lectin (CNL), the N,N'-diacetyllactosediamine (GalNAcβ1-4GlcNAc, LacdiNAc)-specific lectin from basidiomycete C. nebularis. J Biol Chem (2012) 0.90
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer. Anticancer Res (2003) 0.90
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis. Hum Mutat (2004) 0.90
Cysteine proteases: destruction ability versus immunomodulation capacity in immune cells. Biol Chem (2007) 0.90
Proteins of higher fungi--from forest to application. Trends Biotechnol (2012) 0.89
Recombinant human cathepsin H lacking the mini chain is an endopeptidase. Biochemistry (2003) 0.89
Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells. Biochim Biophys Acta (2008) 0.89
Cystatins in non-small cell lung cancer: tissue levels, localization and relation to prognosis. Oncol Rep (2006) 0.89
The balance between extracellular cathepsins and cystatin C is of importance for ovarian cancer. Eur J Clin Invest (2010) 0.89
Lysosomal enzymes, cathepsins in brain tumour invasion. J Neurooncol (2002) 0.89
Natural killer cells as effectors of selection and differentiation of stem cells: role in resolution of inflammation. J Immunotoxicol (2014) 0.88
Nuclear cysteine cathepsin variants in thyroid carcinoma cells. Biol Chem (2010) 0.88
Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients. Cancer Detect Prev (2002) 0.87
Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L. Biol Chem (2005) 0.87
The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates. Proteins (2009) 0.87
Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells. Eur J Cell Biol (2012) 0.87
Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X. J Leukoc Biol (2008) 0.87
Cystatin incorporated in poly(lactide-co-glycolide) nanoparticles: development and fundamental studies on preservation of its activity. Eur J Pharm Sci (2004) 0.87
Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness. Mol Cancer (2009) 0.87
Stefin a and stefin B: markers for prognosis in operable squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys (2007) 0.87
Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target. Front Pharmacol (2012) 0.86