Published in Hepatology on April 01, 2009
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle (2010) 2.80
The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin Cancer Biol (2010) 2.07
Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis. Hepatology (2011) 1.73
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. J Hepatol (2013) 1.55
Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol (2010) 1.24
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease. J Biol Chem (2011) 1.07
Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation. PLoS One (2010) 0.98
Etiopathogenesis of nonalcoholic steatohepatitis: role of obesity, insulin resistance and mechanisms of hepatotoxicity. Int J Hepatol (2012) 0.95
Molecular imaging of Cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe. Mol Biosyst (2011) 0.89
Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc Res (2013) 0.87
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J Hepatol (2014) 0.86
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Sci Rep (2016) 0.85
Regulation of TGF-β1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. J Biol Chem (2014) 0.85
Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. Lab Invest (2014) 0.82
A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis. PLoS One (2012) 0.80
Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress. Redox Biol (2014) 0.80
Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer. Sci Rep (2015) 0.79
Mechanisms of fibrosis in acute liver failure. Liver Int (2015) 0.79
A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma. Theranostics (2016) 0.78
Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model. Sci Rep (2015) 0.78
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells. Dis Model Mech (2014) 0.78
New role and molecular mechanism of Gadd45a in hepatic fibrosis. World J Gastroenterol (2016) 0.77
A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique. J Dent (Shiraz) (2016) 0.77
Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation. Cell Death Dis (2016) 0.75
Cathepsin L and B as Potential Markers for Liver Fibrosis: Insights From Patients and Experimental Models. Clin Transl Gastroenterol (2017) 0.75
Liver fibrosis. J Clin Invest (2005) 17.27
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut (2005) 5.39
Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06
Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest (2007) 4.41
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell (2004) 4.38
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (1998) 3.98
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest (2000) 3.58
History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis (2001) 3.13
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J (1995) 2.38
Unraveling the role of proteases in cancer. Clin Chim Acta (2000) 2.27
Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates. Biochem J (1980) 2.20
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis. Cancer Lett (2005) 2.10
Mechanisms of liver fibrosis. Clin Chim Acta (2005) 2.09
Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. Gastroenterology (2004) 1.94
The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology (2008) 1.88
Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol (2006) 1.77
Lysosomes as targets for cancer therapy. Cancer Res (2005) 1.76
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest (2003) 1.73
Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med (2005) 1.69
Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. J Clin Invest (1992) 1.62
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ (2004) 1.59
Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J (1999) 1.56
Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol (1999) 1.43
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med (2008) 1.38
Proteome analysis of rat hepatic stellate cells. Hepatology (2000) 1.34
Cysteine cathepsins (proteases)--on the main stage of cancer? Cancer Cell (2004) 1.27
Extracellular proteases as targets for treatment of cancer metastases. Chem Soc Rev (2004) 1.26
Cathepsin D in cancer metastasis: a protease and a ligand. APMIS (1999) 1.24
Catalytically inactive human cathepsin D triggers fibroblast invasive growth. J Cell Biol (2005) 1.22
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci (2003) 1.21
Identification of latent procathepsins B and L in microsomal lumen: characterization of enzymatic activation and proteolytic processing in vitro. Arch Biochem Biophys (1988) 1.10
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J Neurosci (2001) 1.10
Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta. J Biol Chem (2001) 1.09
Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer. Adv Enzyme Regul (2002) 1.08
Histone h3 modifications in rat hepatic stellate cells by ethanol. Alcohol Alcohol (2005) 1.02
Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B. J Biochem (2006) 1.00
Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation. Cancer Res (2007) 0.94
Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and/or liver cirrhosis: potential clinical implications. Oncology (1997) 0.92
Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line. Cancer Res (1999) 0.91
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis. Eur J Clin Chem Clin Biochem (1996) 0.87
Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B. Int J Cancer (2006) 0.85
Pepstatin A attenuates the inhibitory effect of N-acetyl-L-cysteine on proliferation of hepatic myofibroblasts (stellate cells). Eur J Pharmacol (2002) 0.81
Collagenolytic cathepsin B and L activity in experimental fibrotic liver and human liver. Res Commun Chem Pathol Pharmacol (1992) 0.79
Kinetics of in vivo inhibition of tissue cathepsin D by pepstatin A. Int J Biochem (1988) 0.77
Increased activities of liver cathepsins T and D in carbon tetrachloride-treated rats. Biochim Biophys Acta (1984) 0.77
Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28
Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis. Hepatology (2011) 1.73
Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans. Hepatology (2010) 1.61
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol (2013) 1.61
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest (2003) 1.58
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. J Hepatol (2010) 1.51
Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol (2011) 1.31
Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J Neurosci (2009) 1.27
Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha. J Biol Chem (2002) 1.24
Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol (2010) 1.24
Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem (2010) 1.22
Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. Cancer Res (2008) 1.21
Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology (2006) 1.19
Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion. Am J Pathol (2009) 1.15
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology (2003) 1.14
Sphingolipid signalling and liver diseases. Liver Int (2007) 1.13
Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12
Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta (2012) 1.11
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease. J Biol Chem (2011) 1.07
Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. J Biol Chem (2003) 1.07
Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury. Hepatology (2010) 1.05
Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation. Gastroenterology (2008) 1.04
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. J Clin Invest (2004) 0.98
Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy. J Biol Chem (2002) 0.93
Redox regulation of hepatocyte apoptosis. J Gastroenterol Hepatol (2007) 0.90
Alcohol, signaling, and ECM turnover. Alcohol Clin Exp Res (2009) 0.89
Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology (2007) 0.89
Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes. J Lipid Res (2007) 0.87
Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease. Traffic (2011) 0.87
Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics. Alcohol Clin Exp Res (2009) 0.86
Systemic effects of cigarette smoke exposure in the guinea pig. Respir Med (2005) 0.85
Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease. J Bioenerg Biomembr (2009) 0.85
Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity. FEBS Lett (2004) 0.84
Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids. J Hepatol (2013) 0.82
Divergent role of ceramide generated by exogenous sphingomyelinases on NF-kappa B activation and apoptosis in human colon HT-29 cells. FEBS Lett (2002) 0.81
Metabolic therapy: lessons from liver diseases. Curr Pharm Des (2011) 0.78
Glycosphingolipids and cell death: one aim, many ways. Apoptosis (2015) 0.78
Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit. Hepatology (2003) 0.77
Glucose dependence of glycogen synthase activity regulation by GSK3 and MEK/ERK inhibitors and angiotensin-(1-7) action on these pathways in cultured human myotubes. Cell Signal (2013) 0.76
Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde. Liver Int (2005) 0.75