Published in Mol Biol Cell on July 01, 2002
The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity. J Cell Biol (2002) 3.01
Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem (2005) 2.88
Emergence of large-scale cell morphology and movement from local actin filament growth dynamics. PLoS Biol (2007) 2.30
Ena/VASP proteins have an anti-capping independent function in filopodia formation. Mol Biol Cell (2007) 2.12
How VASP enhances actin-based motility. J Cell Biol (2003) 1.97
Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. EMBO J (2007) 1.93
Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation. EMBO J (2008) 1.90
Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia. Cell Host Microbe (2010) 1.75
The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc Natl Acad Sci U S A (2006) 1.72
Metastasis: tumor cells becoming MENAcing. Trends Cell Biol (2010) 1.44
Arp2/3-mediated actin-based motility: a tail of pathogen abuse. Cell Host Microbe (2013) 1.40
A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity. EMBO J (2003) 1.39
Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. J Cell Physiol (2009) 1.30
Molecular mechanism of Ena/VASP-mediated actin-filament elongation. EMBO J (2011) 1.30
Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway. J Cell Biol (2007) 1.23
Differential VASP phosphorylation controls remodeling of the actin cytoskeleton. J Cell Sci (2009) 1.19
Motility determinants in WASP family proteins. Mol Biol Cell (2002) 1.08
The effect of diffusion, depolymerization and nucleation promoting factors on actin gel growth. Eur Biophys J (2003) 1.08
Molecular insights on context-specific role of profilin-1 in cell migration. Cell Adh Migr (2012) 1.07
A crucial role for profilin-actin in the intracellular motility of Listeria monocytogenes. EMBO Rep (2003) 0.99
Listeria monocytogenes actin-based motility varies depending on subcellular location: a kinematic probe for cytoarchitecture. Mol Biol Cell (2004) 0.99
Mena binds α5 integrin directly and modulates α5β1 function. J Cell Biol (2012) 0.98
Bacterial shape and ActA distribution affect initiation of Listeria monocytogenes actin-based motility. Biophys J (2005) 0.94
Characterization of EVL-I as a protein kinase D substrate. Cell Signal (2008) 0.92
Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeleton. Mol Endocrinol (2009) 0.89
Endogenous cGMP-dependent protein kinase reverses EGF-induced MAPK/ERK signal transduction through phosphorylation of VASP at Ser239. Oncol Lett (2012) 0.85
Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis. Cell Res (2012) 0.81
Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion. Infect Immun (2007) 0.81
Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages. PLoS Pathog (2016) 0.79
S137 phosphorylation of profilin 1 is an important signaling event in breast cancer progression. PLoS One (2014) 0.79
Crucial role for the LSP1-myosin1e bimolecular complex in the regulation of Fcγ receptor-driven phagocytosis. Mol Biol Cell (2015) 0.78
Miniature protein ligands for EVH1 domains: interplay between affinity, specificity, and cell motility. Biochemistry (2007) 0.78
WAVE binds Ena/VASP for enhanced Arp2/3 complex-based actin assembly. Mol Biol Cell (2014) 0.78
Threonine 89 Is an Important Residue of Profilin-1 That Is Phosphorylatable by Protein Kinase A. PLoS One (2016) 0.75
Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature (1999) 8.61
Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13
L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein. Cell (1992) 7.15
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell (2002) 6.80
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A (1999) 5.62
A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin. EMBO J (1992) 4.84
Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell (1996) 4.43
Negative regulation of fibroblast motility by Ena/VASP proteins. Cell (2000) 3.89
The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. EMBO J (1995) 3.69
Mena is required for neurulation and commissure formation. Neuron (1999) 2.94
VASP dynamics during lamellipodia protrusion. Nat Cell Biol (1999) 2.70
A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells. EMBO J (1995) 2.68
Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes. J Cell Biol (1999) 2.62
The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. EMBO J (1992) 2.58
Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells. EMBO Rep (2001) 2.48
The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. J Biol Chem (1999) 2.31
Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and Listeria monocytogenes motility. J Cell Biol (2000) 2.03
Steps and fluctuations of Listeria monocytogenes during actin-based motility. Nature (2000) 1.93
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol (2000) 1.93
The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem (1997) 1.92
The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin. Biochem J (1996) 1.89
Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP. EMBO J (1995) 1.88
Identification of two regions in the N-terminal domain of ActA involved in the actin comet tail formation by Listeria monocytogenes. EMBO J (1997) 1.84
The bacterial actin nucleator protein ActA of Listeria monocytogenes contains multiple binding sites for host microfilament proteins. Curr Biol (1995) 1.83
Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell (2002) 1.81
cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. J Biol Chem (2000) 1.81
Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators. J Biol Chem (1990) 1.81
The amino-terminal part of ActA is critical for the actin-based motility of Listeria monocytogenes; the central proline-rich region acts as a stimulator. Mol Microbiol (1995) 1.77
Surfing pathogens and the lessons learned for actin polymerization. Trends Cell Biol (2001) 1.74
Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog. Science (1990) 1.71
The isolated comet tail pseudopodium of Listeria monocytogenes: a tail of two actin filament populations, long and axial and short and random. J Cell Biol (1997) 1.69
Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility. J Cell Biol (2001) 1.68
Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. J Biol Chem (2000) 1.67
Characterization of human palladin, a microfilament-associated protein. Mol Biol Cell (2001) 1.56
Activation of the Arp2/3 complex by the Listeria acta protein. Acta binds two actin monomers and three subunits of the Arp2/3 complex. J Biol Chem (2000) 1.55
The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes. Curr Biol (1999) 1.53
Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. J Biol Chem (2000) 1.51
Characterization of the actin binding properties of the vasodilator-stimulated phosphoprotein VASP. FEBS Lett (1999) 1.51
The actin binding site of thymosin beta 4 mapped by mutational analysis. EMBO J (1996) 1.50
Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis. J Cell Sci (2001) 1.48
Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): implications for actin-based Listeria motility. Biochemistry (1997) 1.45
Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. Mol Biol Cell (1998) 1.38
Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility. J Cell Biol (1996) 1.35
Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands. Curr Biol (1999) 1.29
Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed. J Cell Sci (2000) 1.23
A WASp-VASP complex regulates actin polymerization at the plasma membrane. EMBO J (2001) 1.20
Mutations of arginine residues within the 146-KKRRK-150 motif of the ActA protein of Listeria monocytogenes abolish intracellular motility by interfering with the recruitment of the Arp2/3 complex. J Cell Sci (2000) 1.14
The use of host cell machinery in the pathogenesis of Listeria monocytogenes. Curr Opin Immunol (2001) 1.08
VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations. Cell Motil Cytoskeleton (2000) 1.02
ActA from Listeria monocytogenes can interact with up to four Ena/VASP homology 1 domains simultaneously. J Biol Chem (2001) 1.00
Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells. Infect Immun (1998) 0.97
The vasodilator-stimulated phosphoprotein is regulated by cyclic GMP-dependent protein kinase during neutrophil spreading. J Immunol (2001) 0.91
Dimerization of profilin II upon binding the (GP5)3 peptide from VASP overcomes the inhibition of actin nucleation by profilin II and thymosin beta4. FEBS Lett (1999) 0.91
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell (2002) 6.80
Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron (2003) 5.19
Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol (2003) 4.22
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron (2004) 3.65
Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell (2004) 3.48
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J (2004) 3.31
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell (2004) 3.27
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell (2012) 2.98
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96
Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem (2005) 2.88
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell (2008) 2.65
Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles. Proc Natl Acad Sci U S A (2011) 2.63
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell (2007) 2.59
Filopodia are required for cortical neurite initiation. Nat Cell Biol (2007) 2.49
Filopodia: the fingers that do the walking. Sci STKE (2007) 2.43
Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res (2009) 2.41
Emergence of large-scale cell morphology and movement from local actin filament growth dynamics. PLoS Biol (2007) 2.30
Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog (2009) 2.29
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29
Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cell (2008) 2.28
New insights into the regulation and cellular functions of the ARP2/3 complex. Nat Rev Mol Cell Biol (2012) 2.25
Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin. Cell (2002) 2.23
Characterization of the Drosophila lipid droplet subproteome. Mol Cell Proteomics (2006) 2.23
The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol (2011) 2.22
Arp2/3 is a negative regulator of growth cone translocation. Neuron (2004) 2.19
Ena/VASP proteins have an anti-capping independent function in filopodia formation. Mol Biol Cell (2007) 2.12
Ena/VASP: towards resolving a pointed controversy at the barbed end. J Cell Sci (2009) 2.05
Coronins: the return of the crown. Trends Cell Biol (2006) 2.02
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci (2011) 2.00
In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat Genet (2009) 1.99
c-Met is essential for wound healing in the skin. J Cell Biol (2007) 1.98
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol (2008) 1.97
Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Mol Biol Cell (2005) 1.93
The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Sci Signal (2013) 1.92
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol (2003) 1.86
A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A (2003) 1.84
Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell (2002) 1.81
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol (2009) 1.78
PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. Nano Lett (2012) 1.77
Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila. Development (2007) 1.76
Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. J Biol Chem (2003) 1.72
The MprF protein is required for lysinylation of phospholipids in listerial membranes and confers resistance to cationic antimicrobial peptides (CAMPs) on Listeria monocytogenes. Mol Microbiol (2006) 1.68
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis (2008) 1.64
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Res (2007) 1.62
MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol (2006) 1.61
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. J Biol Chem (2005) 1.58
Function and regulation of Ena/VASP proteins. Trends Cell Biol (2003) 1.56
F-actin binding is essential for coronin 1B function in vivo. J Cell Sci (2007) 1.55
The cell wall subproteome of Listeria monocytogenes. Proteomics (2004) 1.55
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell (2012) 1.49
Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes. J Bacteriol (2006) 1.48
CD200 is induced by ERK and is a potential therapeutic target in melanoma. J Clin Invest (2007) 1.45
Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clin Cancer Res (2008) 1.44
PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. FEBS Lett (2006) 1.41
IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena. J Cell Sci (2003) 1.40
Pathogenomics of Listeria spp. Int J Med Microbiol (2007) 1.39
Ena/VASP: proteins at the tip of the nervous system. Curr Opin Neurobiol (2008) 1.37
Nanoparticle clearance is governed by Th1/Th2 immunity and strain background. J Clin Invest (2013) 1.36
Enhanced EGFP-chromophore-assisted laser inactivation using deficient cells rescued with functional EGFP-fusion proteins. Proc Natl Acad Sci U S A (2007) 1.35
Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell (2010) 1.35
Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton (2004) 1.34
Comparative proteome analysis of secretory proteins from pathogenic and nonpathogenic Listeria species. Proteomics (2005) 1.34
A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip (2010) 1.33
Actin-based motility of Burkholderia pseudomallei involves the Arp 2/3 complex, but not N-WASP and Ena/VASP proteins. Cell Microbiol (2003) 1.31
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics (2006) 1.29
Listeria monocytogenes exploits ERM protein functions to efficiently spread from cell to cell. EMBO J (2005) 1.28
The Ena/VASP enigma. J Cell Sci (2002) 1.28
Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol Cell (2008) 1.27
Tuba stimulates intracellular N-WASP-dependent actin assembly. J Cell Sci (2006) 1.26
Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends Cell Biol (2011) 1.26
Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell (2012) 1.26
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. J Cell Biol (2012) 1.26
A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet (2002) 1.25
Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons. Environ Microbiol (2010) 1.24
Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol (2010) 1.24
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res (2010) 1.24
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis (2011) 1.23
Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system. J Neurosci (2004) 1.22
The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals. Mol Biol Cell (2008) 1.21
Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol (2002) 1.20
Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. Mol Microbiol (2003) 1.20
Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693. BMC Genomics (2010) 1.14