Published in Nat Genet on September 27, 2009
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RNAi screens identify CHD4 as an essential gene in breast cancer growth. Oncotarget (2016) 0.75
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Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia. J Leukoc Biol (2016) 0.75
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Tumor suppressor miR-1 inhibits tumor growth and metastasis by simultaneously targeting multiple genes. Oncotarget (2017) 0.75
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A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
A loss-of-function RNA interference screen for molecular targets in cancer. Nature (2006) 8.11
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A (2008) 7.45
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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature (2005) 6.40
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature (2008) 6.24
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An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci (2006) 5.18
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev (2004) 3.16
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med (2005) 2.63
Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A (2008) 2.53
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Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility. EMBO J (2006) 1.31
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A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science (2007) 12.42
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell (2002) 6.80
Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron (2003) 5.19
Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol (2003) 4.22
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron (2004) 3.65
Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell (2004) 3.48
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell (2004) 3.27
Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature (2010) 3.03
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96
DNA damage-mediated induction of a chemoresistant niche. Cell (2010) 2.94
Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem (2005) 2.88
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell (2008) 2.65
Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Cancer Discov (2013) 2.59
The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell (2009) 2.54
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Filopodia are required for cortical neurite initiation. Nat Cell Biol (2007) 2.49
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The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol (2011) 2.22
Arp2/3 is a negative regulator of growth cone translocation. Neuron (2004) 2.19
Ena/VASP proteins have an anti-capping independent function in filopodia formation. Mol Biol Cell (2007) 2.12
Ena/VASP: towards resolving a pointed controversy at the barbed end. J Cell Sci (2009) 2.05
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci (2011) 2.00
Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy. Proc Natl Acad Sci U S A (2010) 1.95
Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Mol Biol Cell (2005) 1.93
The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Sci Signal (2013) 1.92
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol (2003) 1.86
Error-prone translesion synthesis mediates acquired chemoresistance. Proc Natl Acad Sci U S A (2010) 1.85
A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A (2003) 1.84
Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell (2002) 1.81
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol (2009) 1.78
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Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. J Biol Chem (2003) 1.72
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Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis (2008) 1.64
MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol (2006) 1.61
Haploinsufficiency of mTR results in defects in telomere elongation. Proc Natl Acad Sci U S A (2002) 1.56
Function and regulation of Ena/VASP proteins. Trends Cell Biol (2003) 1.56
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization. Mol Biol Cell (2002) 1.47
Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol (2004) 1.46
Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle (2009) 1.44
Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clin Cancer Res (2008) 1.44
Ena/VASP: proteins at the tip of the nervous system. Curr Opin Neurobiol (2008) 1.37
Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell (2010) 1.35
Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton (2004) 1.34
A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip (2010) 1.33
The Ena/VASP enigma. J Cell Sci (2002) 1.28
Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol Cell (2008) 1.27
A mammalian functional-genetic approach to characterizing cancer therapeutics. Nat Chem Biol (2010) 1.26
Tuba stimulates intracellular N-WASP-dependent actin assembly. J Cell Sci (2006) 1.26
Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell (2012) 1.26
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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet (2002) 1.25
Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol (2010) 1.24
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res (2010) 1.24
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis (2011) 1.23
Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system. J Neurosci (2004) 1.22
Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol (2002) 1.20
Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. Mol Microbiol (2003) 1.20
Defining principles of combination drug mechanisms of action. Proc Natl Acad Sci U S A (2012) 1.19
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VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J Cell Sci (2009) 1.13
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WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. J Cell Sci (2005) 1.05
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Chemotherapeutic resistance: surviving stressful situations. Cancer Res (2011) 0.99
Mena binds α5 integrin directly and modulates α5β1 function. J Cell Biol (2012) 0.98
Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer. Breast Cancer Res (2012) 0.96
Mammalian enabled (Mena) is a critical regulator of cardiac function. Am J Physiol Heart Circ Physiol (2011) 0.94
Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Physiol (2009) 0.93
Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts. Mol Cell Proteomics (2011) 0.92
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Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death. Mol Cancer Ther (2009) 0.84
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Nervous Rac: DOCK7 regulation of axon formation. Neuron (2006) 0.82
A breast cancer stem cell-selective, mammospheres-potent osmium(VI) nitrido complex. J Am Chem Soc (2014) 0.81
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