Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 137071)

Published in Nucleic Acids Res on August 01, 2002

Authors

Paul Bundock1, Haico van Attikum, Paul Hooykaas

Author Affiliations

1: Institute of Molecular Plant Sciences, Sectie 2A, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands. bundock@rulbim.leidenuniv.nl

Articles citing this

Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. EMBO J (2004) 1.72

Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. J Bacteriol (2007) 1.42

Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis. Proc Natl Acad Sci U S A (2003) 1.42

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol (2006) 1.39

Enhanced gene targeting frequency in ku70 and ku80 disruption mutants of Aspergillus sojae and Aspergillus oryzae. Mol Genet Genomics (2006) 1.30

Involvement of the Arabidopsis SWI2/SNF2 chromatin remodeling gene family in DNA damage response and recombination. Genetics (2006) 1.24

Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutants. Plant Cell (2002) 1.24

Comparative biology of telomeres: where plants stand. FEBS Lett (2010) 1.23

The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA. Nucleic Acids Res (2003) 1.14

Telomerase dependence of telomere lengthening in Ku80 mutant Arabidopsis. Plant Cell (2003) 1.11

Telomere structure, function and maintenance in Arabidopsis. Chromosome Res (2003) 1.07

Plant telomere biology. Plant Cell (2004) 1.06

A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plants. EMBO J (2006) 1.05

Suppression of RICE TELOMERE BINDING PROTEIN 1 results in severe and gradual developmental defects accompanied by genome instability in rice. Plant Cell (2007) 1.03

Telomere rapid deletion regulates telomere length in Arabidopsis thaliana. Mol Cell Biol (2006) 1.03

The Ku protein complex is involved in length regulation of Drosophila telomeres. Genetics (2005) 1.02

DNA repair and recombination in higher plants: insights from comparative genomics of Arabidopsis and rice. BMC Genomics (2010) 1.00

Parameters affecting telomere-mediated chromosomal truncation in Arabidopsis. Plant Cell (2011) 1.00

TELOMERASE ACTIVATOR1 induces telomerase activity and potentiates responses to auxin in Arabidopsis. Plant Cell (2004) 0.93

OsKu70 is associated with developmental growth and genome stability in rice. Plant Physiol (2009) 0.92

DNA repair and recombination functions in Arabidopsis telomere maintenance. Chromosome Res (2005) 0.88

Suppression of Ku70/80 or Lig4 leads to decreased stable transformation and enhanced homologous recombination in rice. New Phytol (2012) 0.85

Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding. Nucleic Acids Res (2007) 0.84

Determination of Arabidopsis thaliana telomere length by PCR. Sci Rep (2014) 0.80

Visualization of specific repetitive genomic sequences with fluorescent TALEs in Arabidopsis thaliana. J Exp Bot (2016) 0.78

Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell. Front Plant Sci (2016) 0.77

Arabidopsis DNA polymerase lambda mutant is mildly sensitive to DNA double strand breaks but defective in integration of a transgene. Front Plant Sci (2015) 0.76

Plant hormone signaling and modulation of DNA repair under stressful conditions. Plant Cell Rep (2013) 0.76

Characterization of Brca2-deficient plants excludes the role of NHEJ and SSA in the meiotic chromosomal defect phenotype. PLoS One (2011) 0.76

Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation. DNA Repair (Amst) (2014) 0.75

Protection of Arabidopsis blunt-ended telomeres is mediated by a physical association with the Ku heterodimer. Plant Cell (2017) 0.75

Articles cited by this

T-DNA as an insertional mutagen in Arabidopsis. Plant Cell (1999) 7.72

Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62

An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell (1993) 6.89

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature (1996) 5.80

Control of human telomere length by TRF1 and TRF2. Mol Cell Biol (2000) 4.54

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A (1997) 4.13

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol (1996) 3.57

Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity (1997) 3.35

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep (2000) 3.00

Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol Cell Biol (2000) 2.93

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. J Exp Med (1997) 2.71

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc Natl Acad Sci U S A (1999) 2.58

Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev (2000) 2.38

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nat Genet (1999) 2.22

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat Genet (2001) 2.19

Ku, a DNA repair protein with multiple cellular functions? Mutat Res (1999) 2.16

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proc Natl Acad Sci U S A (1997) 2.12

Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Proc Natl Acad Sci U S A (1999) 1.99

Living with genome instability: plant responses to telomere dysfunction. Science (2001) 1.94

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol (2001) 1.94

Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast. Curr Biol (2001) 1.91

DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A (2001) 1.64

Interaction of human Ku70 with TRF2. FEBS Lett (2000) 1.55

Identification of bacterial homologues of the Ku DNA repair proteins. FEBS Lett (2001) 1.49

Involvement of Arabidopsis thaliana ribosomal protein S27 in mRNA degradation triggered by genotoxic stress. EMBO J (1999) 1.43

RAD50 function is essential for telomere maintenance in Arabidopsis. Proc Natl Acad Sci U S A (2001) 1.32

Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity. Plant J (2001) 1.28

Recombination in telomere-length maintenance. Trends Biochem Sci (2000) 1.27

Recombination: a frank view of exchanges and vice versa. Curr Opin Cell Biol (2000) 1.22

Developmental control of telomere lengths and telomerase activity in plants. Plant Cell (1998) 1.20

Telomeres and double-strand breaks: trying to make ends meet. Trends Cell Biol (1998) 1.08

A plant gene encoding a Myb-like protein that binds telomeric GGTTTAG repeats in vitro. J Biol Chem (2001) 1.01

The repressor which binds the -75 GATA motif of the GPB promoter contains Ku70 as the DNA binding subunit. Nucleic Acids Res (1999) 0.88

Articles by these authors

Rewiring of genetic networks in response to DNA damage. Science (2010) 4.03

The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol (2010) 2.06

Dissection of DNA damage responses using multiconditional genetic interaction maps. Mol Cell (2012) 1.78

Maintenance of embryonic auxin distribution for apical-basal patterning by PIN-FORMED-dependent auxin transport in Arabidopsis. Plant Cell (2005) 1.60

An Arabidopsis hAT-like transposase is essential for plant development. Nature (2005) 1.59

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection. Nature (2012) 1.53

DDB2 promotes chromatin decondensation at UV-induced DNA damage. J Cell Biol (2012) 1.34

The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast. J Cell Sci (2007) 1.28

The chromatin response to DNA breaks: leaving a mark on genome integrity. Annu Rev Biochem (2013) 1.25

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J (2012) 1.24

Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutants. Plant Cell (2002) 1.24

Genome-wide association data reveal a global map of genetic interactions among protein complexes. PLoS Genet (2009) 1.23

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling. J Cell Sci (2012) 1.13

Chromatin and the DNA damage response: the cancer connection. Mol Oncol (2011) 1.12

SWI/SNF complex in disorder: SWItching from malignancies to intellectual disability. Epigenetics (2012) 1.10

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks. EMBO J (2012) 0.99

Insertional mutagenesis in yeasts using T-DNA from Agrobacterium tumefaciens. Yeast (2002) 0.96

Close encounters of the RNF8th kind: when chromatin meets DNA repair. Curr Opin Cell Biol (2012) 0.95

Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation. J Biol Chem (2012) 0.93

Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks. Trends Biochem Sci (2013) 0.91

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining. Cell Cycle (2013) 0.90

Molecular analysis of "de novo" purine biosynthesis in solanaceous species and in Arabidopsis thaliana. Front Biosci (2004) 0.82

Chromatin at the crossroads. Meeting on signalling to chromatin epigenetics. EMBO Rep (2006) 0.82

Improved functional overview of protein complexes using inferred epistatic relationships. BMC Syst Biol (2011) 0.77

Remodeling and spacing factor 1 (RSF1): a rising star in DNA repair. Epigenomics (2014) 0.76

NuRD alert! NuRD regulates the DNA damage response. Epigenomics (2011) 0.76

Yeast (Saccharomyces cerevisiae). Methods Mol Biol (2006) 0.76

Mapping genomic targets of DNA helicases by chromatin immunoprecipitation in Saccharomyces cerevisiae. Methods Mol Biol (2010) 0.75