Published in Mol Cell Biol on December 04, 2006
MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet (2008) 6.00
Translating insights from the cancer genome into clinical practice. Nature (2008) 4.37
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature (2010) 4.36
Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94
End-joining, translocations and cancer. Nat Rev Cancer (2013) 2.13
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell (2007) 1.96
The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev (2007) 1.88
The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J (2010) 1.83
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res (2009) 1.23
Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res (2009) 1.19
Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV. Nucleic Acids Res (2007) 1.15
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? Trends Biochem Sci (2015) 1.13
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res (2011) 1.12
Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ. J Cell Biol (2009) 1.11
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
Telomere shortening and ageing. Z Gerontol Geriatr (2007) 1.10
End joining at Caenorhabditis elegans telomeres. Genetics (2008) 1.01
Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction. Nucleic Acids Res (2012) 1.00
Complex interactions between the DNA-damage response and mammalian telomeres. Nat Struct Mol Biol (2015) 0.97
Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol (2012) 0.87
53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response. J Cell Biol (2012) 0.86
Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett (2010) 0.86
Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Res (2011) 0.86
Genome instability of ageing stem cells--Induction and defence mechanisms. Ageing Res Rev (2015) 0.84
ZNF365 promotes stability of fragile sites and telomeres. Cancer Discov (2013) 0.83
Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe. Eukaryot Cell (2010) 0.83
Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus. Brain Res (2014) 0.82
PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis. Oncogene (2012) 0.81
Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol (2017) 0.80
Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics. Am J Physiol Gastrointest Liver Physiol (2015) 0.78
The landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma. Mol Cancer Res (2014) 0.77
Different DNA-PKcs functions in the repair of radiation-induced and spontaneous DSBs within interstitial telomeric sequences. Chromosoma (2011) 0.76
Effects of Prenatal Testosterone Exposure on Sexually Dimorphic Gene Expression in the Neonatal Mouse Cortex and Hippocampus. J Steroids Horm Sci (2014) 0.75
The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes. PLoS One (2014) 0.75
53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition. PLoS One (2014) 0.75
Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
A severe combined immunodeficiency mutation in the mouse. Nature (1983) 13.99
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13
Origin of concatemeric T7 DNA. Nat New Biol (1972) 9.08
DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08
Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development (1990) 8.37
Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell Biol (1996) 7.33
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol (1973) 7.28
Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23
Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 5.98
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell (2006) 5.33
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet (1993) 4.78
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature (1998) 4.37
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res (1996) 4.37
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat Genet (1999) 4.18
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett (2005) 4.04
DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol (2002) 3.95
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell (2000) 3.82
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity (1998) 3.58
Gut instincts: thoughts on intestinal epithelial stem cells. J Clin Invest (2000) 3.49
Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol Cell Biol (2003) 3.32
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J (1999) 3.29
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev (2003) 3.21
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell (2003) 3.01
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep (2000) 3.00
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc Natl Acad Sci U S A (1999) 2.97
Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci U S A (1999) 2.97
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet (2001) 2.92
The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res (1996) 2.90
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell (2005) 2.89
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol (1985) 2.80
The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72
Telomere position effect in human cells. Science (2001) 2.61
Mechanism of DNA double-strand break repair by non-homologous end joining. DNA Repair (Amst) (2005) 2.53
The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity (1998) 2.43
Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev (2000) 2.38
Ku is associated with the telomere in mammals. Proc Natl Acad Sci U S A (1999) 2.36
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet (2000) 2.34
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev (1996) 2.29
Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res (2004) 2.26
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21
Telomere length homeostasis. Chromosoma (2006) 2.12
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Mol Cell (2001) 1.95
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol (2001) 1.94
Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell (2000) 1.94
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst) (2004) 1.93
Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev (1996) 1.89
Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Biol Cell (2001) 1.85
Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70. EMBO J (2002) 1.84
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J (2002) 1.74
Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. EMBO J (2004) 1.72
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell (2001) 1.68
Ku: a multifunctional protein involved in telomere maintenance. DNA Repair (Amst) (2005) 1.68
DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A (2001) 1.64
Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Proc Natl Acad Sci U S A (1999) 1.61
Interaction of human Ku70 with TRF2. FEBS Lett (2000) 1.55
Ku binds telomeric DNA in vitro. J Biol Chem (1999) 1.55
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A (2004) 1.53
Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment. Mol Cell Biol (2000) 1.48
Long-range silencing and position effects at telomeres and centromeres: parallels and differences. Cell Mol Life Sci (2003) 1.48
Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol (2006) 1.47
The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proc Natl Acad Sci U S A (1996) 1.44
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res (1997) 1.41
Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. Proc Natl Acad Sci U S A (2003) 1.37
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J (2002) 1.32
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. EMBO J (2002) 1.21
Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant. Nucleic Acids Res (2002) 1.19
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep (2004) 1.18
Elongated telomeres in scid mice. Genomics (1999) 1.17
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. J Cell Biol (2004) 1.11
Telomeres and the DNA damage response: why the fox is guarding the henhouse. DNA Repair (Amst) (2004) 1.10
The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation. Oncogene (1996) 1.08
DNA-dependent protein kinase-independent activation of p53 in response to DNA damage. J Biol Chem (1999) 1.06
B and T cell leakiness in the scid mouse mutant. Immunodefic Rev (1992) 1.05
Effects of double-strand break repair proteins on vertebrate telomere structure. Nucleic Acids Res (2002) 1.04
Function of DNA-protein kinase catalytic subunit during the early meiotic prophase without Ku70 and Ku86. Biol Reprod (2003) 0.95
Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts. Exp Cell Res (2002) 0.93
p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice. Carcinogenesis (1996) 0.88
Molecular pathology of severe combined immunodeficiency in mice, horses, and dogs. Vet Pathol (2004) 0.85
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol Cell Biol (2000) 0.83
Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells. Oncogene (1999) 0.82
International network of cancer genome projects. Nature (2010) 20.35
Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med (2008) 14.47
High-throughput oncogene mutation profiling in human cancer. Nat Genet (2007) 12.68
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell (2007) 12.33
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell (2010) 11.20
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (2007) 10.60
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer (2006) 10.05
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature (2006) 9.20
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell (2009) 8.64
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev (2003) 8.27
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A (2008) 8.08
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet (2009) 7.81
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77
Pancreatic cancer biology and genetics. Nat Rev Cancer (2002) 7.36
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature (2009) 7.05
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med (2006) 6.96
Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol Cell (2011) 6.83
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature (2013) 6.53
High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A (2005) 6.52
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature (2002) 6.10
How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol (2007) 5.80
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature (2007) 5.65
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev (2006) 5.53
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res (2007) 5.45
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest (2009) 5.07
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev (2004) 5.00
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature (2008) 5.00
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell (2007) 4.85
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov (2011) 4.80
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res (2006) 4.80
Connecting chromosomes, crisis, and cancer. Science (2002) 4.69
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57
PI3 kinase signals BCR-dependent mature B cell survival. Cell (2009) 4.43
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science (2003) 4.32
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31
Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res (2011) 4.22
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science (2013) 4.20
Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature (2005) 4.16
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci U S A (2009) 4.02
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell (2007) 3.76
High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A (2004) 3.75
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature (2011) 3.69
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell (2011) 3.61
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell (2010) 3.40
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell (2012) 3.39
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell (2009) 3.37
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell (2009) 3.37
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science (2009) 3.34
Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc Natl Acad Sci U S A (2008) 3.30
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov (2013) 3.25
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab (2008) 3.22
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell (2013) 3.13
Passenger deletions generate therapeutic vulnerabilities in cancer. Nature (2012) 3.11
Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell (2002) 3.06
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A (2012) 3.06
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol (2010) 3.05
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev (2004) 2.91
Stromal biology of pancreatic cancer. J Cell Biochem (2007) 2.88
Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87
Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biol Psychiatry (2006) 2.85
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet (2007) 2.84
Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet (2004) 2.83
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature (2009) 2.77
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A (2009) 2.77
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell (2011) 2.77
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity (2002) 2.77
Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet (2012) 2.75
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell (2012) 2.74
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Cancer Res (2005) 2.72
Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas. J Thorac Oncol (2013) 2.68
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell (2010) 2.68
Characterization of the cell of origin for small cell lung cancer. Cell Cycle (2011) 2.62
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis. Nat Med (2002) 2.58
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest (2007) 2.57
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet (2002) 2.53
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells (2011) 2.52
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol (2008) 2.50
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov (2012) 2.47
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest (2009) 2.46