Published in Annu Rev Microbiol on January 30, 2002
Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med (2004) 2.90
Response to iron deprivation in Saccharomyces cerevisiae. Eukaryot Cell (2007) 2.35
Untapped potential: exploiting fungi in bioremediation of hazardous chemicals. Nat Rev Microbiol (2011) 2.29
The yeast lysosome-like vacuole: endpoint and crossroads. Biochim Biophys Acta (2008) 2.22
Specific iron chelators determine the route of ferritin degradation. Blood (2009) 2.10
Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. J Biol Chem (2008) 2.01
Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells. Eukaryot Cell (2004) 1.90
Cryptococcus neoformans gene expression during murine macrophage infection. Eukaryot Cell (2005) 1.89
Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae. Genome Biol (2005) 1.70
Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J (2007) 1.69
Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Proc Natl Acad Sci U S A (2003) 1.63
Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast. Mol Cell Biol (2007) 1.46
Characterizing the role of rice NRAMP5 in Manganese, Iron and Cadmium Transport. Sci Rep (2012) 1.45
The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans. Eukaryot Cell (2006) 1.41
The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins. Mol Cell Biol (2004) 1.41
Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans. J Clin Invest (2007) 1.32
A genomic screen for yeast vacuolar membrane ATPase mutants. Genetics (2005) 1.22
Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res (2003) 1.18
Iron-mediated control of the basic helix-loop-helix protein FER, a regulator of iron uptake in tomato. Plant Physiol (2005) 1.04
The ins and outs of algal metal transport. Biochim Biophys Acta (2012) 1.00
Alr0397 is an outer membrane transporter for the siderophore schizokinen in Anabaena sp. strain PCC 7120. J Bacteriol (2008) 0.97
Application of genome-wide expression analysis to identify molecular markers useful in monitoring industrial fermentations. Appl Environ Microbiol (2003) 0.96
Phenotypic switching in Candida glabrata accompanied by changes in expression of genes with deduced functions in copper detoxification and stress. Eukaryot Cell (2005) 0.96
Role of CTR4 in the Virulence of Cryptococcus neoformans. MBio (2012) 0.96
The homeostasis of iron, copper, and zinc in paracoccidioides brasiliensis, cryptococcus neoformans var. Grubii, and cryptococcus gattii: a comparative analysis. Front Microbiol (2011) 0.91
OsNRAMP5, a major player for constitutive iron and manganese uptake in rice. Plant Signal Behav (2012) 0.88
Sphingolipid signaling mediates iron toxicity. Cell Metab (2012) 0.86
The lack of synchronization between iron uptake and cell growth leads to iron overload in Saccharomyces cerevisiae during post-exponential growth modes. Biochemistry (2013) 0.84
Probing the role of copper in the biosynthesis of the molybdenum cofactor in Escherichia coli and Rhodobacter sphaeroides. J Biol Inorg Chem (2007) 0.80
The first external loop of the metal ion transporter DCT1 is involved in metal ion binding and specificity. Proc Natl Acad Sci U S A (2003) 0.80
High-spin ferric ions in Saccharomyces cerevisiae vacuoles are reduced to the ferrous state during adenine-precursor detoxification. Biochemistry (2014) 0.78
Pun1p is a metal ion-inducible, calcineurin/Crz1p-regulated plasma membrane protein required for cell wall integrity. Biochim Biophys Acta (2011) 0.78
Signal transduction triggered by iron to induce the nuclear importation of a Myb3 transcription factor in the parasitic protozoan Trichomonas vaginalis. J Biol Chem (2014) 0.77
Identification of the molecular mechanisms underlying the cytotoxic action of a potent platinum metallointercalator. J Chem Biol (2011) 0.77
Genome-wide analysis of copper, iron and zinc transporters in the arbuscular mycorrhizal fungus Rhizophagus irregularis. Front Plant Sci (2014) 0.77
The Phosphoinositide 3-Kinase Regulates Retrograde Trafficking of the Iron Permease CgFtr1 and Iron Homeostasis in Candida glabrata. J Biol Chem (2016) 0.76
Interaction of the heterotrimeric G protein alpha subunit SSG-1 of Sporothrix schenckii with proteins related to stress response and fungal pathogenicity using a yeast two-hybrid assay. BMC Microbiol (2010) 0.76
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
The protein network of HIV budding. Cell (2003) 7.82
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab (2008) 3.78
Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1. Science (2006) 3.46
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol (2008) 2.92
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45
A heme export protein is required for red blood cell differentiation and iron homeostasis. Science (2008) 2.36
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature (2005) 2.25
Retracted The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab (2008) 2.25
Iron depletion limits intracellular bacterial growth in macrophages. Blood (2008) 2.24
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
Chediak-Higashi syndrome. Curr Opin Hematol (2008) 2.23
The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A (2005) 2.10
Specific iron chelators determine the route of ferritin degradation. Blood (2009) 2.10
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol (2006) 2.06
Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. J Biol Chem (2008) 2.01
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A (2009) 1.82
Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis. J Biol Chem (2004) 1.75
The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem (2005) 1.73
Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol (2008) 1.71
Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J (2007) 1.69
Iron acquisition and transcriptional regulation. Chem Rev (2009) 1.66
Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. EMBO J (2006) 1.66
Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest (2010) 1.64
Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem (2003) 1.64
A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism. J Biol Chem (2004) 1.62
The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood (2005) 1.60
The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis. Plant Cell (2009) 1.53
The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood (2009) 1.51
Post-transcriptional regulation of the yeast high affinity iron transport system. J Biol Chem (2005) 1.48
Frataxin knockin mouse. FEBS Lett (2002) 1.47
Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast. Mol Cell Biol (2007) 1.46
Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proc Natl Acad Sci U S A (2009) 1.45
Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells. Proc Natl Acad Sci U S A (2004) 1.39
The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood (2007) 1.38
Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis. Proc Natl Acad Sci U S A (2002) 1.33
Inhibition of heme biosynthesis prevents transcription of iron uptake genes in yeast. J Biol Chem (2003) 1.31
Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta (2012) 1.27
Hepcidin regulation: ironing out the details. J Clin Invest (2007) 1.26
Chediak-Higashi syndrome: a clinical and molecular view of a rare lysosomal storage disorder. Curr Mol Med (2002) 1.24
Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica (2006) 1.23
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. Nat Genet (2007) 1.23
Chediak-Higashi Syndrome: a rare disorder of lysosomes and lysosome related organelles. Pigment Cell Res (2002) 1.22
Evidence for the multimeric structure of ferroportin. Blood (2006) 1.22
Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification. J Biol Chem (2003) 1.16
The enlarged lysosomes in beige j cells result from decreased lysosome fission and not increased lysosome fusion. Traffic (2011) 1.14
Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations. Blood (2007) 1.13
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature (2012) 1.09
Genetic and biochemical analysis of high iron toxicity in yeast: iron toxicity is due to the accumulation of cytosolic iron and occurs under both aerobic and anaerobic conditions. J Biol Chem (2010) 1.07
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Iron overload due to mutations in ferroportin. Haematologica (2006) 1.03
YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae. J Biol Chem (2006) 1.03
A dominant allele of PDR1 alters transition metal resistance in yeast. J Biol Chem (2002) 1.02
Recruitment of Tup1p and Cti6p regulates heme-deficient expression of Aft1p target genes. EMBO J (2006) 1.02
Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux. Blood (2010) 1.02
Use of expression constructs to dissect the functional domains of the CHS/beige protein: identification of multiple phenotypes. Traffic (2003) 1.02
Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Exp Hematol (2011) 1.01
Genetic dissection of a mitochondria-vacuole signaling pathway in yeast reveals a link between chronic oxidative stress and vacuolar iron transport. J Biol Chem (2010) 0.99
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol (2011) 0.97
A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast. J Biol Chem (2012) 0.96
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest (2014) 0.96
Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood (2011) 0.96
Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi. Blood (2009) 0.96
Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity. J Biol Chem (2011) 0.95
Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. PLoS Pathog (2008) 0.94
Retracted The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin. Cell Metab (2011) 0.94
PKR1 encodes an assembly factor for the yeast V-type ATPase. J Biol Chem (2006) 0.93
Clinical, pathological, and molecular correlates in ferroportin disease: a study of two novel mutations. J Hepatol (2008) 0.92
Genetic analysis of iron citrate toxicity in yeast: implications for mammalian iron homeostasis. Proc Natl Acad Sci U S A (2002) 0.92
Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity. Biochem J (2009) 0.91
Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins. Antimicrob Agents Chemother (2011) 0.91
A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity. J Biol Chem (2008) 0.91
Hepcidin and ferroportin: the new players in iron metabolism. Semin Liver Dis (2011) 0.88
Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation. Blood (2010) 0.87
Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting. Traffic (2004) 0.86