Published in Science on February 08, 2008
Ribosomopathies: human disorders of ribosome dysfunction. Blood (2010) 4.43
Forging a field: the golden age of iron biology. Blood (2008) 3.83
Regulation of cellular iron metabolism. Biochem J (2011) 3.03
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest (2010) 2.18
β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood (2011) 1.81
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. Biochemistry (2010) 1.72
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. Am J Hum Genet (2010) 1.72
C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload. Am J Hum Genet (2008) 1.64
Mechanisms of mammalian iron homeostasis. Biochemistry (2012) 1.51
Trafficking of heme and porphyrins in metazoa. Chem Rev (2009) 1.48
Control of intracellular heme levels: heme transporters and heme oxygenases. Biochim Biophys Acta (2011) 1.48
One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans. Biochim Biophys Acta (2012) 1.46
Bacterial heme-transport proteins and their heme-coordination modes. Arch Biochem Biophys (2008) 1.36
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest (2012) 1.36
Iron and porphyrin trafficking in heme biogenesis. J Biol Chem (2010) 1.34
Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica (2010) 1.34
The long history of iron in the Universe and in health and disease. Biochim Biophys Acta (2011) 1.33
Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis. Haematologica (2009) 1.32
Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta (2012) 1.27
Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J Neurochem (2009) 1.23
Diamond Blackfan anemia 2008-2009: broadening the scope of ribosome biogenesis disorders. Curr Opin Pediatr (2010) 1.22
Iron homeostasis: recently identified proteins provide insight into novel control mechanisms. J Biol Chem (2008) 1.22
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes. Front Pharmacol (2014) 1.20
Iron overload in sickle cell disease. Adv Hematol (2010) 1.15
Heme on innate immunity and inflammation. Front Pharmacol (2014) 1.15
Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. J Biol Chem (2010) 1.15
Coupling heme and iron metabolism via ferritin H chain. Antioxid Redox Signal (2013) 1.08
Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiae. PLoS Pathog (2010) 1.06
ABCG2 transports and transfers heme to albumin through its large extracellular loop. J Biol Chem (2010) 1.06
A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst (2009) 1.02
Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450. Gastroenterology (2014) 1.01
An intercellular heme-trafficking protein delivers maternal heme to the embryo during development in C. elegans. Cell (2011) 1.00
Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism. Front Pharmacol (2014) 0.99
The physiological functions of iron regulatory proteins in iron homeostasis - an update. Front Pharmacol (2014) 0.99
Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. PLoS Genet (2010) 0.99
Topologically conserved residues direct heme transport in HRG-1-related proteins. J Biol Chem (2011) 0.98
Crosstalk between Iron Metabolism and Erythropoiesis. Adv Hematol (2010) 0.98
Regulation of iron absorption in hemoglobinopathies. Curr Mol Med (2008) 0.97
Haemopexin affects iron distribution and ferritin expression in mouse brain. J Cell Mol Med (2009) 0.95
Concise review: stem cell-derived erythrocytes as upcoming players in blood transfusion. Stem Cells (2012) 0.94
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front Pharmacol (2012) 0.94
Heme transport and erythropoiesis. Curr Opin Chem Biol (2013) 0.94
The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica (2015) 0.92
The Fowler syndrome-associated protein FLVCR2 is an importer of heme. Mol Cell Biol (2010) 0.92
Identification of a feline leukemia virus variant that can use THTR1, FLVCR1, and FLVCR2 for infection. J Virol (2009) 0.91
Diamond Blackfan anemia treatment: past, present, and future. Semin Hematol (2011) 0.90
The GATA factor revolution in hematology. Blood (2017) 0.90
Mutations in FLVCR2 are associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome). Am J Hum Genet (2010) 0.90
Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab (2014) 0.90
Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources. J Nutr (2011) 0.90
Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1. Neurogenetics (2011) 0.90
Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by heme-responsive gene-2. J Biol Chem (2012) 0.89
Iron Homeostasis in Health and Disease. Int J Mol Sci (2016) 0.89
Macrophages and iron trafficking at the birth and death of red cells. Blood (2015) 0.89
Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake. PLoS One (2013) 0.89
Animal models of Diamond Blackfan anemia. Semin Hematol (2011) 0.88
Heme metabolism and erythropoiesis. Curr Opin Hematol (2012) 0.87
Diamond Blackfan Anemia at the Crossroad between Ribosome Biogenesis and Heme Metabolism. Adv Hematol (2010) 0.86
Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med (2013) 0.86
Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors. Proc Natl Acad Sci U S A (2016) 0.86
Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents. J Nutr (2011) 0.85
Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods. Cell Mol Life Sci (2012) 0.84
Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. PLoS One (2011) 0.84
Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death. Front Pharmacol (2014) 0.83
Mitochondrial heme: an exit strategy at last. J Clin Invest (2012) 0.83
Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation. EMBO Rep (2015) 0.82
Iron transport machinery of human cells: players and their interactions. Curr Top Membr (2012) 0.82
Heme and erythropoieis: more than a structural role. Haematologica (2014) 0.82
Role of heme in cardiovascular physiology and disease. J Am Heart Assoc (2015) 0.82
Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats. J Nutr (2014) 0.82
An all-feline retroviral packaging system for transduction of human cells. Hum Gene Ther (2010) 0.82
Heme Oxygenase-1 and Carbon Monoxide in the Heart: The Balancing Act Between Danger Signaling and Pro-Survival. Circ Res (2016) 0.82
Coordinate expression of heme and globin is essential for effective erythropoiesis. J Clin Invest (2015) 0.81
Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury. J Am Heart Assoc (2015) 0.81
Heme exporter FLVCR is required for T cell development and peripheral survival. J Immunol (2015) 0.81
Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome. Sci Transl Med (2016) 0.81
Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis. Exp Hematol (2011) 0.80
FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood (2013) 0.80
ATP Binding Cassette Transporter Mediates Both Heme and Pesticide Detoxification in Tick Midgut Cells. PLoS One (2015) 0.80
Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status. Reproduction (2014) 0.80
Iron transport proteins: Gateways of cellular and systemic iron homeostasis. J Biol Chem (2017) 0.80
Gene expression profiling in Entamoeba histolytica identifies key components in iron uptake and metabolism. PLoS One (2014) 0.79
A systems biology approach to iron metabolism. Adv Exp Med Biol (2014) 0.78
Manufacturing blood ex vivo: a futuristic approach to deal with the supply and safety concerns. Front Cell Dev Biol (2014) 0.78
Erythropoiesis in the absence of adult hemoglobin. Mol Cell Biol (2013) 0.78
Carbon monoxide induced erythroid differentiation of K562 cells mimics the central macrophage milieu in erythroblastic islands. PLoS One (2012) 0.77
Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function. J Mol Med (Berl) (2013) 0.76
Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res (2016) 0.76
Biology of Heme in Mammalian Erythroid Cells and Related Disorders. Biomed Res Int (2015) 0.76
Regulation of intracellular heme trafficking revealed by subcellular reporters. Proc Natl Acad Sci U S A (2016) 0.76
Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection. Front Cell Infect Microbiol (2017) 0.75
The Heme Connection: Linking Erythrocytes and Macrophage Biology. Front Immunol (2017) 0.75
Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans. FASEB J (2016) 0.75
Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception. PLoS Genet (2016) 0.75
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development. Development (2017) 0.75
The ins and outs of erythroid heme transport. Haematologica (2015) 0.75
"Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels. Pflugers Arch (2017) 0.75
TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages. J Immunol Res (2016) 0.75
Hemin augments growth and hemoglobinization of erythroid precursors from patients with diamond-blackfan anemia. Anemia (2012) 0.75
Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis. PLoS One (2016) 0.75
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
Major causes of death among men and women in China. N Engl J Med (2005) 11.80
The protein network of HIV budding. Cell (2003) 7.82
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal (2009) 5.57
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51
Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database. Am J Kidney Dis (2007) 5.06
Prevalence of the metabolic syndrome and overweight among adults in China. Lancet (2005) 5.05
Mortality attributable to smoking in China. N Engl J Med (2009) 4.75
Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int (2011) 4.74
Community cyberinfrastructure for Advanced Microbial Ecology Research and Analysis: the CAMERA resource. Nucleic Acids Res (2010) 4.39
Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature (2004) 4.20
A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Res (2004) 4.19
Prevalence, awareness, treatment, and control of hypertension in china. Hypertension (2002) 4.18
The genomic sequence of the accidental pathogen Legionella pneumophila. Science (2004) 4.08
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
The contribution of health literacy to disparities in self-rated health status and preventive health behaviors in older adults. Ann Fam Med (2009) 3.84
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab (2008) 3.78
High-throughput SNP genotyping on universal bead arrays. Mutat Res (2005) 3.78
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1. Science (2006) 3.46
Body weight and mortality among men and women in China. JAMA (2006) 3.41
Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc (2009) 3.31
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med (2010) 3.26
Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays. Am J Pathol (2004) 3.04
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
The prevalence of nontraditional risk factors for coronary heart disease in patients with chronic kidney disease. Ann Intern Med (2004) 2.94
Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol (2008) 2.92
Illumina universal bead arrays. Methods Enzymol (2006) 2.88
Effect of soybean protein on blood pressure: a randomized, controlled trial. Ann Intern Med (2005) 2.79
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75
Identification of a human heme exporter that is essential for erythropoiesis. Cell (2004) 2.66
Premature deaths attributable to blood pressure in China: a prospective cohort study. Lancet (2009) 2.62
Resiniferatoxin for treatment of lifelong premature ejaculation: a preliminary study. Int J Urol (2014) 2.61
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell (2011) 2.61
The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci (2010) 2.61
Genome-wide genetic changes during modern breeding of maize. Nat Genet (2012) 2.60
MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr Biol (2010) 2.57
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell (2007) 2.56
Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence. Stem Cells (2008) 2.52
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat Cell Biol (2005) 2.50
Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res (2007) 2.49
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet (2012) 2.47
Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46
Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nat Biotechnol (2012) 2.45
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45
Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2012) 2.42
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39
Body mass index and risk of stroke among Chinese men and women. Ann Neurol (2010) 2.33
All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood (2007) 2.31
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature (2005) 2.25
Retracted The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab (2008) 2.25
Iron depletion limits intracellular bacterial growth in macrophages. Blood (2008) 2.24
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
Chediak-Higashi syndrome. Curr Opin Hematol (2008) 2.23
Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci (2006) 2.22
miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res (2011) 2.22
Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology (2007) 2.20
Risk factors and prevention of inguinal hernia after radical prostatectomy: a systematic review and meta-analysis. J Urol (2012) 2.17
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature (2003) 2.16
The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo. Blood (2005) 2.14
Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis. Blood (2004) 2.13
The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A (2005) 2.10
MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS One (2011) 2.10
Specific iron chelators determine the route of ferritin degradation. Blood (2009) 2.10
Associations between kidney function and subclinical cardiac abnormalities in CKD. J Am Soc Nephrol (2012) 2.10
Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis (2013) 2.09
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol (2006) 2.06
Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study. J Hypertens (2009) 2.06
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
"Maturational" globin switching in primary primitive erythroid cells. Blood (2005) 2.04
MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation (2010) 2.03
Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. J Biol Chem (2008) 2.01
Factors associated with hypertension control in the general population of the United States. Arch Intern Med (2002) 2.01
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol (2007) 2.00
Long term measurements of indoor radon equilibrium factor. Health Phys (2012) 1.99
FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol (2008) 1.97
Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure. Blood (2003) 1.96
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol (2003) 1.92
Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood (2010) 1.91
Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion. Nat Cell Biol (2004) 1.91
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A (2007) 1.88
Myxobacteria gliding motility requires cytoskeleton rotation powered by proton motive force. Proc Natl Acad Sci U S A (2011) 1.86
A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc Natl Acad Sci U S A (2010) 1.85
Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma. PLoS One (2010) 1.82