Published in Exp Hematol on May 11, 2011
The long history of iron in the Universe and in health and disease. Biochim Biophys Acta (2011) 1.33
Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Biochim Biophys Acta (2014) 1.12
Cellular and mitochondrial iron homeostasis in vertebrates. Biochim Biophys Acta (2012) 1.05
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest (2014) 0.96
Heme metabolism and erythropoiesis. Curr Opin Hematol (2012) 0.87
Copper import into the mitochondrial matrix in Saccharomyces cerevisiae is mediated by Pic2, a mitochondrial carrier family protein. J Biol Chem (2013) 0.85
Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Dis Model Mech (2014) 0.84
Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron. Leukemia (2014) 0.83
Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria. J Biol Chem (2014) 0.78
Modelling inborn errors of metabolism in zebrafish. J Inherit Metab Dis (2014) 0.77
Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease. Biochim Biophys Acta (2016) 0.77
A Trypanosomatid Iron Transporter that Regulates Mitochondrial Function Is Required for Leishmania amazonensis Virulence. PLoS Pathog (2016) 0.76
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science (2017) 0.76
Mitochondrial transport of protoporphyrinogen IX in erythroid cells. Oncotarget (2015) 0.75
RNA splicing during terminal erythropoiesis. Curr Opin Hematol (2017) 0.75
Studying disorders of vertebrate iron and heme metabolism using zebrafish. Methods Cell Biol (2016) 0.75
Expansion of the eukaryotic proteome by alternative splicing. Nature (2010) 8.84
Nonsense-mediated decay approaches the clinic. Nat Genet (2004) 5.12
SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing. Cell (2008) 4.54
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa. Hum Mol Genet (2002) 2.34
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature (2005) 2.25
The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis. Nat Struct Biol (2001) 1.96
Defective splicing, disease and therapy: searching for master checkpoints in exon definition. Nucleic Acids Res (2006) 1.89
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A (2009) 1.82
Liver transplantation for erythropoietic protoporphyria liver disease. Liver Transpl (2005) 1.76
Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol (2008) 1.71
Heme synthetase deficiency in human protoporphyria. Demonstration of the defect in liver and cultured skin fibroblasts. J Clin Invest (1975) 1.70
C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload. Am J Hum Genet (2008) 1.64
Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood (2005) 1.64
A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism. J Biol Chem (2004) 1.62
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood (2005) 1.59
The penetrance of dominant erythropoietic protoporphyria is modulated by expression of wildtype FECH. Nat Genet (2001) 1.51
Erythropoietic protoporphyria: evidence for multiple sites of excess protoporphyrin formation. J Clin Invest (1971) 1.43
Erythropoietic protoporphyria. Orphanet J Rare Dis (2009) 1.39
Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters. Cell Mol Life Sci (2000) 1.38
Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase. Biochem Biophys Res Commun (1990) 1.35
Structure of the human ferrochelatase gene. Exon/intron gene organization and location of the gene to chromosome 18. Eur J Biochem (1992) 1.34
Pre-mRNA splicing and retinitis pigmentosa. Mol Vis (2006) 1.32
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood (2010) 1.31
Diminished erythroid ferrochelatase activity in protoporphyria. J Lab Clin Med (1975) 1.31
Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery. Blood (2009) 1.30
Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. J Clin Invest (2005) 1.26
Inheritance in erythropoietic protoporphyria: a common wild-type ferrochelatase allelic variant with low expression accounts for clinical manifestation. Blood (1999) 1.21
Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation. Blood (2007) 1.14
NF1 mRNA biogenesis: effect of the genomic milieu in splicing regulation of the NF1 exon 37 region. FEBS Lett (2006) 1.12
Hepatobiliary implications and complications in protoporphyria, a 20-year study. Clin Biochem (1989) 1.05
Hepatic disease in erythropoietic protoporphyria. Am J Med (1975) 1.04
Systematic analysis of molecular defects in the ferrochelatase gene from patients with erythropoietic protoporphyria. Am J Hum Genet (1998) 1.03
Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase. Blood (2002) 1.03
Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. J Clin Invest (1998) 1.02
Vascular changes in erythropoietic protoporphyria: histopathologic and immunohistochemical study. J Am Acad Dermatol (2000) 0.96
Ferrochelatase gene mutations in erythropoietic protoporphyria: focus on liver disease. Cell Mol Biol (Noisy-le-grand) (2002) 0.96
Molecular and cellular mechanisms of porphyrin photosensitization. Photodermatol (1986) 0.95
Early involvement of hepatic parenchymal cells in erythrohepatic protoporphyria? An ultrastructural study of patients with and without overt liver disease and the effect of chenodeoxycholic acid treatment. Hepatology (1990) 0.94
Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria. Gastroenterology (1999) 0.94
The pathological splicing mutation c.6792C>G in NF1 exon 37 causes a change of tenancy between antagonistic splicing factors. FEBS Lett (2008) 0.92
Genotypic determinants of phenotype in North American patients with erythropoietic protoporphyria. Mol Genet Metab (2003) 0.90
Gene dosage analysis identifies large deletions of the FECH gene in 10% of families with erythropoietic protoporphyria. J Invest Dermatol (2007) 0.89
Protoporphyrin-induced cholestasis in the isolated in situ perfused rat liver. J Clin Invest (1981) 0.89
Regulation of the expression of human ferrochelatase by intracellular iron levels. Eur J Biochem (2000) 0.86
Protoporphyrin metabolic balance in human protoporphyria. Gastroenterology (1985) 0.86
Screening for ferrochelatase mutations: molecular heterogeneity of erythropoietic protoporphyria. Biochim Biophys Acta (1994) 0.83
Transport proteins (carriers) of mitochondria. IUBMB Life (2009) 0.81
An ultrastructural study of the liver in erythropoietic protoporphyria. Med Electron Microsc (2000) 0.78
Examination of ferrochelatase mutations that cause erythropoietic protoporphyria. Blood (1998) 0.78
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55
The protein network of HIV budding. Cell (2003) 7.82
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol (2003) 5.73
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature (2013) 5.35
The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci (2006) 4.93
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. N Engl J Med (2012) 4.26
Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci (2007) 3.92
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol (2004) 3.80
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab (2008) 3.78
Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1. Science (2006) 3.46
Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex. Nature (2005) 3.41
A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A (2008) 3.10
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Recommendations for the diagnosis and treatment of the acute porphyrias. Ann Intern Med (2005) 2.95
Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol (2008) 2.92
High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res (2004) 2.75
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood (2005) 2.65
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res (2007) 2.52
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45
Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res (2008) 2.44
A heme export protein is required for red blood cell differentiation and iron homeostasis. Science (2008) 2.36
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood (2012) 2.29
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature (2005) 2.25
Retracted The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab (2008) 2.25
Iron depletion limits intracellular bacterial growth in macrophages. Blood (2008) 2.24
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci (2005) 2.21
A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nat Genet (2009) 2.12
The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A (2005) 2.10
Specific iron chelators determine the route of ferritin degradation. Blood (2009) 2.10
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J Biol Chem (2007) 2.08
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol (2006) 2.06
Ibrutinib in previously treated Waldenström's macroglobulinemia. N Engl J Med (2015) 2.04
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A (2005) 2.03
Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. J Biol Chem (2008) 2.01
Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med (2011) 1.97
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 1.95
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes (2006) 1.91
Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia. Blood (2014) 1.89
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A (2009) 1.82
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev (2010) 1.80
Design and characterization of a spatially distributed multibeam field emission x-ray source for stationary digital breast tomosynthesis. Med Phys (2009) 1.80
The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation. Crit Care Med (2010) 1.78
Liver transplantation for erythropoietic protoporphyria liver disease. Liver Transpl (2005) 1.76
Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis. J Biol Chem (2004) 1.75
A supermatrix analysis of genomic, morphological, and paleontological data from crown Cetacea. BMC Evol Biol (2011) 1.74
The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem (2005) 1.73
Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol (2008) 1.71
Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev Biol (2002) 1.70
Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J (2007) 1.69
Single-stranded DNA aptamers that bind differentiated but not parental cells: subtractive systematic evolution of ligands by exponential enrichment. J Biotechnol (2003) 1.67
Iron acquisition and transcriptional regulation. Chem Rev (2009) 1.66
Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. EMBO J (2006) 1.66
Characterization of embryonic globin genes of the zebrafish. Dev Biol (2003) 1.65
Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest (2010) 1.64
Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem (2003) 1.64
A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism. J Biol Chem (2004) 1.62
Herd behavior in a complex adaptive system. Proc Natl Acad Sci U S A (2011) 1.62
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood (2012) 1.61
The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood (2005) 1.60
Transition metal transport in yeast. Annu Rev Microbiol (2002) 1.59
High resolution stationary digital breast tomosynthesis using distributed carbon nanotube x-ray source array. Med Phys (2012) 1.58
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem (2008) 1.55
Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Cell Stem Cell (2013) 1.55
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab (2013) 1.54
The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis. Plant Cell (2009) 1.53
Mutation mapping and identification by whole-genome sequencing. Genome Res (2012) 1.51
The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood (2009) 1.51
The pu.1 promoter drives myeloid gene expression in zebrafish. Blood (2004) 1.49
Association between physical activity and urinary incontinence in a community-based elderly population aged 70 years and over. Eur Urol (2007) 1.49
Post-transcriptional regulation of the yeast high affinity iron transport system. J Biol Chem (2005) 1.48
Frataxin knockin mouse. FEBS Lett (2002) 1.47
Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast. Mol Cell Biol (2007) 1.46
Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proc Natl Acad Sci U S A (2009) 1.45
[Effects of Rhaponticum uniforum polysaccharide on immune response of mice after antigen stimulation and their possible mechanisms]. Zhongguo Zhong Yao Za Zhi (2007) 1.44
Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells. Proc Natl Acad Sci U S A (2004) 1.39
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 August 2009-30 September 2009. Mol Ecol Resour (2010) 1.39
The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood (2007) 1.38
IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol (2011) 1.37
Tumor cell-secreted caveolin-1 has proangiogenic activities in prostate cancer. Cancer Res (2008) 1.37