Published in Science on July 26, 2002
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 4.97
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40
Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev (2004) 4.19
Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99
Cell cycle regulation of DNA replication. Annu Rev Genet (2007) 3.80
Chromosome and replisome dynamics in E. coli: loss of sister cohesion triggers global chromosome movement and mediates chromosome segregation. Cell (2005) 3.54
Replication fork stalling at natural impediments. Microbiol Mol Biol Rev (2007) 3.47
Comparative genomics and molecular dynamics of DNA repeats in eukaryotes. Microbiol Mol Biol Rev (2008) 3.35
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol (2003) 3.29
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J (2003) 3.15
Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal. Cell Cycle (2011) 3.11
Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev (2005) 3.07
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site. Nature (2011) 2.69
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68
Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae. Mol Cell (2009) 2.65
Impairment of replication fork progression mediates RNA polII transcription-associated recombination. EMBO J (2005) 2.32
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J (2006) 2.25
Eucaryotic genome evolution through the spontaneous duplication of large chromosomal segments. EMBO J (2003) 2.21
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol (2003) 2.19
Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev (2005) 2.17
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol (2005) 2.13
Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase. Mol Cell Biol (2006) 2.05
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J (2003) 2.03
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A (2005) 2.03
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1. Mol Cell Biol (2004) 1.94
Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast. Genes Dev (2005) 1.89
The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. Genes Dev (2006) 1.87
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol (2010) 1.87
Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences. Nat Rev Genet (2010) 1.82
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
Replication fork barriers: pausing for a break or stalling for time? EMBO Rep (2007) 1.78
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78
DNA replication timing: random thoughts about origin firing. Nat Cell Biol (2006) 1.75
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J (2004) 1.75
The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication. EMBO J (2003) 1.74
Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements. Mol Cell (2010) 1.74
ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress. Cell (2014) 1.73
Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell (2012) 1.70
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance. Mol Cell (2015) 1.62
ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet (2008) 1.61
Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell (2005) 1.60
Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents. Cancer Discov (2012) 1.59
Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cells. Cell Cycle (2009) 1.59
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease. Hum Mutat (2011) 1.53
An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae. Mol Cell (2007) 1.51
Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol (2003) 1.50
Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis. Proc Natl Acad Sci U S A (2008) 1.47
Genome-wide amplifications caused by chromosomal rearrangements play a major role in the adaptive evolution of natural yeast. Genetics (2003) 1.47
A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics (2005) 1.46
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol Cell Biol (2004) 1.45
ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet (2009) 1.43
Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast. EMBO J (2006) 1.40
Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1. PLoS One (2015) 1.39
Spatial organization of the budding yeast genome in the cell nucleus and identification of specific chromatin interactions from multi-chromosome constrained chromatin model. PLoS Comput Biol (2017) 1.39
Roles of Chk1 in cell biology and cancer therapy. Int J Cancer (2013) 1.37
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J (2004) 1.36
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae. Genetics (2006) 1.33
Fragile genomic sites are associated with origins of replication. Genome Biol Evol (2009) 1.32
The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. EMBO J (2009) 1.26
Viral transport of DNA damage that mimics a stalled replication fork. J Virol (2005) 1.24
Diminished S-phase cyclin-dependent kinase function elicits vital Rad53-dependent checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.23
Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) (2008) 1.23
Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae. DNA Repair (Amst) (2009) 1.22
Single molecule measurement of the "speed limit" of DNA polymerase. Proc Natl Acad Sci U S A (2009) 1.21
Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2014) 1.21
Formation, maintenance and consequences of the imprint at the mating-type locus in fission yeast. EMBO J (2004) 1.20
Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinase. EMBO J (2009) 1.20
Replication stress-induced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formation. G3 (Bethesda) (2011) 1.19
Dynamic large-scale chromosomal rearrangements fuel rapid adaptation in yeast populations. PLoS Genet (2013) 1.18
ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase. J Cell Biol (2010) 1.17
ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis. Genes Dev (2005) 1.16
Replicative stress, stem cells and aging. Mech Ageing Dev (2008) 1.14
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci (2007) 1.14
Fbh1 limits Rad51-dependent recombination at blocked replication forks. Mol Cell Biol (2009) 1.13
Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM. Chromosome Res (2007) 1.12
Transcription regulatory elements are punctuation marks for DNA replication. Proc Natl Acad Sci U S A (2006) 1.12
Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. PLoS Genet (2010) 1.11
Checking that replication breakdown is not terminal. Science (2002) 1.11
Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks. Mol Biol Cell (2005) 1.10
The recombinases DMC1 and RAD51 are functionally and spatially separated during meiosis in Arabidopsis. Plant Cell (2012) 1.09
A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae. Genetics (2008) 1.09
Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery. PLoS Genet (2013) 1.09
Activation of a LTR-retrotransposon by telomere erosion. Proc Natl Acad Sci U S A (2003) 1.09
Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells. Nucleic Acids Res (2013) 1.08
Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle (2007) 1.07
Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe. EMBO J (2008) 1.07
Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. Proc Natl Acad Sci U S A (2010) 1.05
Proteomic analysis of the Kaposi's sarcoma-associated herpesvirus terminal repeat element binding proteins. J Virol (2006) 1.04
DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences. Nucleic Acids Res (2007) 1.01
Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics (2006) 1.00
Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol Biol Cell (2007) 1.00
High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains. Genetics (2008) 1.00
Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae. Genetics (2013) 0.98
Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants. Proc Natl Acad Sci U S A (2009) 0.98
Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes. Proc Natl Acad Sci U S A (2003) 0.98
Capturing chromosome conformation. Science (2002) 23.93
Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell (2004) 6.54
Chromosome and replisome dynamics in E. coli: loss of sister cohesion triggers global chromosome movement and mediates chromosome segregation. Cell (2005) 3.54
Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation. Cell (2002) 3.26
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell (2002) 2.85
The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell (2003) 2.07
Double Holliday junctions are intermediates of DNA break repair. Nature (2010) 2.02
Four-dimensional imaging of E. coli nucleoid organization and dynamics in living cells. Cell (2013) 1.89
Sister cohesion and structural axis components mediate homolog bias of meiotic recombination. Cell (2010) 1.76
Meiotic double-strand breaks at the interface of chromosome movement, chromosome remodeling, and reductional division. Genes Dev (2003) 1.67
Recombination proteins mediate meiotic spatial chromosome organization and pairing. Cell (2010) 1.60
Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition. Proc Natl Acad Sci U S A (2003) 1.60
Escherichia coli sister chromosome separation includes an abrupt global transition with concomitant release of late-splitting intersister snaps. Proc Natl Acad Sci U S A (2011) 1.49
Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis. Proc Natl Acad Sci U S A (2008) 1.47
Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis. PLoS Genet (2008) 1.43
The Escherichia coli baby cell column: a novel cell synchronization method provides new insight into the bacterial cell cycle. Mol Microbiol (2005) 1.37
PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis. Proc Natl Acad Sci U S A (2010) 1.30
Dynamic chromosome movements during meiosis: a way to eliminate unwanted connections? Trends Cell Biol (2009) 1.28
Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling. Proc Natl Acad Sci U S A (2005) 1.27
The structure of DNA overstretched from the 5'5' ends differs from the structure of DNA overstretched from the 3'3' ends. Proc Natl Acad Sci U S A (2009) 1.26
Coupling meiotic chromosome axis integrity to recombination. Genes Dev (2008) 1.23
Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Proc Natl Acad Sci U S A (2007) 1.18
The logic and mechanism of homologous recombination partner choice. Mol Cell (2013) 1.07
Examination of interchromosomal interactions in vegetatively growing diploid Schizosaccharomyces pombe cells by Cre/loxP site-specific recombination. Genetics (2008) 0.97
Intra-G1 arrest in response to UV irradiation in fission yeast. Proc Natl Acad Sci U S A (2003) 0.97
Tsr-GFP accumulates linearly with time at cell poles, and can be used to differentiate 'old' versus 'new' poles, in Escherichia coli. Mol Microbiol (2008) 0.95
Single-molecule studies of the stringency factors and rates governing the polymerization of RecA on double-stranded DNA. Nucleic Acids Res (2011) 0.94
The differential extension in dsDNA bound to Rad51 filaments may play important roles in homology recognition and strand exchange. Nucleic Acids Res (2013) 0.88
Meiotic crossover patterns: obligatory crossover, interference and homeostasis in a single process. Cell Cycle (2015) 0.87
Changes in the tension in dsDNA alter the conformation of RecA bound to dsDNA-RecA filaments. Nucleic Acids Res (2011) 0.81
Dynamic trans interactions in yeast chromosomes. PLoS One (2013) 0.78
Assaying chromosome pairing by FISH analysis of spread Saccharomyces cerevisiae nuclei. Methods Mol Biol (2009) 0.75