Maintaining genome stability at the replication fork.

The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13

DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57

Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site. Nature (2011) 2.69

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature (2014) 2.67

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65

Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell (2011) 2.50

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol (2010) 2.40

ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37

Chromatin replication and epigenome maintenance. Nat Rev Mol Cell Biol (2012) 2.25

Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18

Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol (2013) 2.17

SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. Mol Cell (2011) 2.13

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs. Mol Oncol (2011) 2.07

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. Mol Cell (2013) 1.97

Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall. Mol Cell (2014) 1.90

Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science (2013) 1.90

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods (2013) 1.88

Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. Mol Cell (2012) 1.79

Chromatin and the genome integrity network. Nat Rev Genet (2013) 1.72

ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev (2013) 1.70

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet (2014) 1.68

More forks on the road to replication stress recovery. J Mol Cell Biol (2011) 1.64

dNTP pools determine fork progression and origin usage under replication stress. EMBO J (2012) 1.58

Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle (2010) 1.58

DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat Struct Mol Biol (2012) 1.51

Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell (2012) 1.51

The ATR barrier to replication-born DNA damage. DNA Repair (Amst) (2010) 1.50

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J (2011) 1.49

Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol (2012) 1.48

Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen. PLoS Genet (2012) 1.47

Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47

Coordination of cell cycle, DNA repair and muscle gene expression in myoblasts exposed to genotoxic stress. Cell Cycle (2011) 1.47

Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress. Cell (2013) 1.46

Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. Mol Cell Biol (2012) 1.45

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA. Nucleic Acids Res (2011) 1.45

The arabidopsis DNA polymerase δ has a role in the deposition of transcriptionally active epigenetic marks, development and flowering. PLoS Genet (2015) 1.42

Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res (2012) 1.40

Substrate-selective repair and restart of replication forks by DNA translocases. Cell Rep (2013) 1.39

Repriming of DNA synthesis at stalled replication forks by human PrimPol. Nat Struct Mol Biol (2013) 1.39

Rescuing stalled or damaged replication forks. Cold Spring Harb Perspect Biol (2013) 1.34

DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis. J Cell Biol (2013) 1.30

Exploiting replicative stress to treat cancer. Nat Rev Drug Discov (2015) 1.27

Network calisthenics: control of E2F dynamics in cell cycle entry. Cell Cycle (2011) 1.25

Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev (2010) 1.24

Genomic instability in cancer. Cold Spring Harb Perspect Biol (2013) 1.23

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Nat Commun (2013) 1.21

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure. J Cell Biol (2013) 1.21

Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switch. PLoS Genet (2010) 1.19

High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events. Genetics (2012) 1.19

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Science (2015) 1.18

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity. Nucleic Acids Res (2011) 1.17

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. Genes Dev (2013) 1.17

Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem (2012) 1.16

New histone supply regulates replication fork speed and PCNA unloading. J Cell Biol (2013) 1.16

Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia. Proc Natl Acad Sci U S A (2012) 1.15

Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res (2010) 1.14

High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IV. PLoS Genet (2013) 1.12

Signaling pathways that regulate cell division. Cold Spring Harb Perspect Biol (2012) 1.12

Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem (2013) 1.11

Chromosome Duplication in Saccharomyces cerevisiae. Genetics (2016) 1.11

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med (2016) 1.10

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability. Mol Cell (2015) 1.10

The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress. Plant Cell (2011) 1.10

DNA interstrand cross-link repair requires replication-fork convergence. Nat Struct Mol Biol (2015) 1.09

An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet (2013) 1.09

Human telomeres replicate using chromosome-specific, rather than universal, replication programs. J Cell Biol (2012) 1.08

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks. Oncotarget (2010) 1.06

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Cell Death Differ (2013) 1.06

Recovery of arrested replication forks by homologous recombination is error-prone. PLoS Genet (2012) 1.05

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Res (2014) 1.05

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer. Mol Cancer (2011) 1.05

Visualization of recombination-mediated damage bypass by template switching. Nat Struct Mol Biol (2014) 1.05

The meiotic checkpoint network: step-by-step through meiotic prophase. Cold Spring Harb Perspect Biol (2014) 1.04

HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal. Mol Cell (2015) 1.04

ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency. Cancer Res (2014) 1.03

Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila. PLoS Genet (2011) 1.03

Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the Polα/Primase/Ctf4 Complex. Mol Cell (2015) 1.03

Structure of monoubiquitinated PCNA: implications for DNA polymerase switching and Okazaki fragment maturation. Cell Cycle (2012) 1.03

DNA polymerase delta in DNA replication and genome maintenance. Environ Mol Mutagen (2012) 1.02

RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer. Carcinogenesis (2010) 1.02

Impediments to replication fork movement: stabilisation, reactivation and genome instability. Chromosoma (2013) 1.02

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation. Cell Stem Cell (2015) 1.02

Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major. J Nucleic Acids (2010) 1.01

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier. Nucleic Acids Res (2011) 1.01

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication. Genes Dev (2014) 1.01

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity. EMBO J (2014) 1.00

ATR maintains select progenitors during nervous system development. EMBO J (2012) 1.00

DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS One (2011) 1.00

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress. Proc Natl Acad Sci U S A (2013) 0.98

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest (2013) 0.98

Nonallelic homologous recombination between retrotransposable elements is a driver of de novo unbalanced translocations. Genome Res (2012) 0.98

Preventing replication fork collapse to maintain genome integrity. DNA Repair (Amst) (2015) 0.98

Thresholds of replication stress signaling in cancer development and treatment. Nat Struct Mol Biol (2012) 0.97

Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the MultiBac system. PLoS One (2012) 0.97

Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity. PLoS Genet (2013) 0.96

Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells. Stem Cells Dev (2014) 0.96

DNA methylation, its mediators and genome integrity. Int J Biol Sci (2015) 0.96

Instability and decay of the primary structure of DNA. Nature (1993) 25.58

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63

DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem (2001) 12.53

Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol (2002) 11.79

Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol (2007) 11.48

A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell (2007) 9.81

DNA topoisomerases. Annu Rev Biochem (1996) 9.48

Trinucleotide repeat disorders. Annu Rev Neurosci (2007) 9.45

The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature (2003) 8.68

Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell (1997) 8.23

Replication dynamics of the yeast genome. Science (2001) 7.56

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science (2002) 7.46

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat Rev Genet (2007) 7.29

The DNA replication checkpoint response stabilizes stalled replication forks. Nature (2001) 7.04

DNA rearrangements associated with a transposable element in yeast. Cell (1980) 7.03

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature (2003) 6.43

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature (2003) 6.31

Uninterrupted MCM2-7 function required for DNA replication fork progression. Science (2000) 6.27

Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell (2004) 6.12

Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science (2001) 6.06

DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol (2007) 5.78

Genome instability: a mechanistic view of its causes and consequences. Nat Rev Genet (2008) 5.41

Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol (2008) 5.10

The organization of replication and transcription. Science (1999) 5.08

Maintenance of genome stability in Saccharomyces cerevisiae. Science (2002) 5.08

Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol (2001) 5.05

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet (2006) 4.98

Chromosome fragile sites. Annu Rev Genet (2007) 4.95

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature (2005) 4.88

The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85

Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nat Rev Mol Cell Biol (2006) 4.79

ATR regulates fragile site stability. Cell (2002) 4.74

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science (2002) 4.72

Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium. Science (1977) 4.59

Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53

Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell (2006) 4.44

Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell (2007) 4.28

S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27

Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet (2004) 4.18

Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell (2005) 4.02

Stable DNA replication: interplay between DNA replication, homologous recombination, and transcription. Microbiol Mol Biol Rev (1997) 3.90

A model for replication repair in mammalian cells. J Mol Biol (1976) 3.78

Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. Cell (2005) 3.74

The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. Mol Cell (2003) 3.72

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc Natl Acad Sci U S A (2002) 3.70

A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A (2005) 3.62

Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) (2006) 3.61

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell (2006) 3.60

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev (2003) 3.59

Replication fork stalling at natural impediments. Microbiol Mol Biol Rev (2007) 3.47

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell (2005) 3.44

ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44

The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol Cell (2004) 3.44

DNA replication fork pause sites dependent on transcription. Science (1996) 3.43

Replication fork reactivation downstream of a blocked nascent leading strand. Nature (2006) 3.40

Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations. Mol Gen Genet (1981) 3.31

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci U S A (2008) 3.29

Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27

How telomeres are replicated. Nat Rev Mol Cell Biol (2007) 3.27

Mapping of early firing origins on a replication profile of budding yeast. Genes Cells (2002) 3.23

Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication. Nat Cell Biol (2006) 3.22

Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science (1994) 3.16

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J (2003) 3.15

Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. Mol Cell Biol (1992) 3.12

Repeat instability as the basis for human diseases and as a potential target for therapy. Nat Rev Mol Cell Biol (2010) 3.09

The Mcm2-7 complex has in vitro helicase activity. Mol Cell (2008) 3.08

CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature (2003) 3.07

Gross chromosomal rearrangements and elevated recombination at an inducible site-specific replication fork barrier. Cell (2005) 2.99

The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell (2000) 2.99

Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91

RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Genetics (1997) 2.84

Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli. Nature (1991) 2.83

Antitumour drugs impede DNA uncoiling by topoisomerase I. Nature (2007) 2.77

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell (2005) 2.75

The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell (2008) 2.68

Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae. Mol Cell (2009) 2.65

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol (2009) 2.60

Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev (2002) 2.59

Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell (1993) 2.52

Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae. Mol Cell Biol (2004) 2.49

Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell (2005) 2.47

Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae. Mol Cell Biol (2002) 2.37

Impairment of replication fork progression mediates RNA polII transcription-associated recombination. EMBO J (2005) 2.32

Double-strand breaks associated with repetitive DNA can reshape the genome. Proc Natl Acad Sci U S A (2008) 2.28

DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses. Chembiochem (2005) 2.28

The checkpoint response to replication stress. DNA Repair (Amst) (2009) 2.27

Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins. Proc Natl Acad Sci U S A (2008) 2.23

Positive torsional strain causes the formation of a four-way junction at replication forks. J Biol Chem (2000) 2.22

Remodeling of DNA replication structures by the branch point translocase FANCM. Proc Natl Acad Sci U S A (2008) 2.20

The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Mol Cell (2008) 2.19

SUMOylation regulates Rad18-mediated template switch. Nature (2008) 2.14

Topological challenges to DNA replication: conformations at the fork. Proc Natl Acad Sci U S A (2001) 2.11

The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination. Proc Natl Acad Sci U S A (2005) 2.08

The replisome uses mRNA as a primer after colliding with RNA polymerase. Nature (2008) 2.08

Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res (2005) 2.05

DNA structures, repeat expansions and human hereditary disorders. Curr Opin Struct Biol (2006) 2.04

Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae. Genetics (2001) 2.03

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science (2002) 7.46

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature (2004) 6.94

Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45

Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol (2008) 5.10

Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell (2006) 4.44

Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol Cell (2002) 3.76

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell (2006) 3.60

Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65

Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell (2005) 2.47

The DNA damage response during DNA replication. Curr Opin Cell Biol (2005) 2.44

The checkpoint response to replication stress. DNA Repair (Amst) (2009) 2.27

SUMOylation regulates Rad18-mediated template switch. Nature (2008) 2.14

Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing. Oncogene (2004) 1.89

Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair (Amst) (2007) 1.84

Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms. Mol Cell (2003) 1.83

Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78

G-quadruplex-induced instability during leading-strand replication. EMBO J (2011) 1.77

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation. Genes Dev (2007) 1.75

Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements. Mol Cell (2010) 1.74

Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69

Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. Mol Cell (2012) 1.59

The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res (2006) 1.52

Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes. Cell (2012) 1.51

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J (2011) 1.49

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell (2009) 1.48

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol Biol Cell (2009) 1.44

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair. EMBO J (2009) 1.29

Yeast Rad52 and Rad51 recombination proteins define a second pathway of DNA damage assessment in response to a single double-strand break. Mol Cell Biol (2003) 1.24

RecQ helicases queuing with Srs2 to disrupt Rad51 filaments and suppress recombination. Genes Dev (2007) 1.24

Template switching: from replication fork repair to genome rearrangements. Cell (2007) 1.10

Methods to study replication fork collapse in budding yeast. Methods Enzymol (2006) 1.10

Signal transduction: how rad53 kinase is activated. Curr Biol (2005) 1.09

The DNA polymerase alpha-primase complex: multiple functions and interactions. ScientificWorldJournal (2003) 0.99

Characterization of the BUD31 gene of Saccharomyces cerevisiae. Biochem Biophys Res Commun (2004) 0.98

Preserving the genome by regulating chromatin association with the nuclear envelope. Trends Cell Biol (2012) 0.95

Acetylation: a novel link between double-strand break repair and autophagy. Cancer Res (2012) 0.93

A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A (2002) 0.89

Leaping forks at inverted repeats. Genes Dev (2010) 0.88

Mechanisms controlling the integrity of replicating chromosomes in budding yeast. Cell Cycle (2003) 0.85

Molecular pathways: old drugs define new pathways: non-histone acetylation at the crossroads of the DNA damage response and autophagy. Clin Cancer Res (2012) 0.83

ChIP-on-chip analysis of DNA topoisomerases. Methods Mol Biol (2009) 0.83

Dna2 offers support for stalled forks. Cell (2012) 0.81

A lethal combination for cancer cells: synthetic lethality screenings for drug discovery. Eur J Cancer (2010) 0.78

Initiation of DNA replication: a new hint from archaea. Cell (2004) 0.78

The double life of Holliday junctions. Cell Res (2010) 0.77

ATM and ATR signaling at a glance. J Cell Sci (2016) 0.77

Molecular biology: Disruptive influence. Nature (2003) 0.77

Cohesion by topology: sister chromatids interlocked by DNA. Genes Dev (2008) 0.77

Recombination at collapsed replication forks: the payoff for survival. Mol Cell (2005) 0.76

Sometimes size does matter. Eur J Cancer (2003) 0.75