Published in Brain Res on August 23, 2002
Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J Neurochem (2008) 1.88
Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis. Hepatology (2006) 1.83
Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts. Hepatology (2007) 1.81
Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients. J Mol Med (Berl) (2007) 1.49
Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver Int (2009) 1.48
Value of the critical flicker frequency in patients with minimal hepatic encephalopathy. Hepatology (2007) 1.41
Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. Gastroenterology (2010) 1.21
Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death. J Neurochem (2005) 1.11
IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy. J Clin Gastroenterol (2009) 1.07
Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase, and cGMP-degrading phosphodiesterase. J Neurosci (2002) 1.04
Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts. Hepatology (2005) 1.03
Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. Neurochem Int (2003) 1.01
Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity. J Neurosci Res (2009) 0.98
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. Neurochem Int (2005) 0.97
Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex. Gastroenterology (2008) 0.95
Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying. Am J Physiol Gastrointest Liver Physiol (2002) 0.95
p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts. Gut (2011) 0.95
Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. Metab Brain Dis (2008) 0.95
Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance. J Proteome Res (2010) 0.94
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology (2010) 0.93
[Normality tables in the Spanish population for psychometric tests used in the diagnosis of minimal hepatic encephalopathy]. Med Clin (Barc) (2006) 0.92
Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function. Cerebellum (2005) 0.91
Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function. Cerebellum (2005) 0.90
Chronic liver failure in rats impairs glutamatergic synaptic transmission and long-term potentiation in hippocampus and learning ability. Eur J Neurosci (2007) 0.88
Sources of oxygen radicals in brain in acute ammonia intoxication in vivo. Brain Res (2003) 0.88
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metab Brain Dis (2005) 0.87
Molecular mechanism of acute ammonia toxicity: role of NMDA receptors. Neurochem Int (2002) 0.87
Brain cholinergic impairment in liver failure. Brain (2008) 0.87
Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain. Brain Res (2005) 0.87
Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved. Neurochem Int (2010) 0.86
Encapsulation of glutamine synthetase in mouse erythrocytes: a new procedure for ammonia detoxification. Biochem Cell Biol (2008) 0.86
Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy. Neuroimage (2012) 0.86
Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation. Hepatology (2006) 0.86
Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium-calmodulin kinase II. J Neurochem (2008) 0.85
Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients. Hepatology (2002) 0.85
3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis. Am J Gastroenterol (2011) 0.85
Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra. J Hepatol (2006) 0.85
Molecular mechanisms of the alterations in NMDA receptor-dependent long-term potentiation in hyperammonemia. Metab Brain Dis (2005) 0.85
Modulation of NMDA receptors by AKT kinase. Neurochem Int (2006) 0.84
Proteome analysis of primary neurons and astrocytes from rat cerebellum. J Proteome Res (2005) 0.84
Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task. J Neurosci Res (2009) 0.83
Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease. J Biol Chem (2013) 0.83
Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment. Alcohol Clin Exp Res (2007) 0.83
Effects of hyperammonemia and liver failure on glutamatergic neurotransmission. Metab Brain Dis (2002) 0.83
Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture. J Neurochem (2005) 0.82
Hyperammonemia alters the modulation by different neurosteroids of the glutamate-nitric oxide-cyclic GMP pathway through NMDA- GABAA - or sigma receptors in cerebellum in vivo. J Neurochem (2013) 0.82
Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants. J Pharmacol Exp Ther (2002) 0.82
Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications. Metab Brain Dis (2010) 0.82
Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: therapeutical implications. Neurochem Int (2009) 0.82
NMDA receptors in hyperammonemia and hepatic encephalopathy. Metab Brain Dis (2007) 0.82
Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity. Bioorg Med Chem (2004) 0.82
Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons. Eur J Neurosci (2007) 0.82
Blocking NMDA receptors delays death in rats with acute liver failure by dual protective mechanisms in kidney and brain. Neuromolecular Med (2013) 0.81
Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats. ACS Chem Neurosci (2013) 0.81
Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo. Neurobiol Dis (2003) 0.81
Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain. Am J Physiol Gastrointest Liver Physiol (2008) 0.81
A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J Pharmacol Exp Ther (2002) 0.81
Pharmacological manipulation of cyclic GMP levels in brain restores learning ability in animal models of hepatic encephalopathy: therapeutic implications. Neuropsychiatr Dis Treat (2006) 0.81
Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis. Liver Int (2005) 0.81
Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications. Neurochem Int (2009) 0.81
The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats. Learn Mem (2007) 0.81
Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats. Eur J Neurosci (2008) 0.80
An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain. J Pharmacol Exp Ther (2012) 0.80
Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats. J Neurosci Res (2010) 0.80
Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum. J Neurochem (2009) 0.80
Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations. Metab Brain Dis (2012) 0.80
Sequential activation of soluble guanylate cyclase, protein kinase G and cGMP-degrading phosphodiesterase is necessary for proper induction of long-term potentiation in CA1 of hippocampus. Alterations in hyperammonemia. Neurochem Int (2004) 0.80
Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats. Eur J Neurosci (2007) 0.79
Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy. Liver Int (2013) 0.79
Brain regional alterations in the modulation of the glutamate-nitric oxide-cGMP pathway in liver cirrhosis. Role of hyperammonemia and cell types involved. Neurochem Int (2006) 0.79
Acute ammonia intoxication induces an NMDA receptor-mediated increase in poly(ADP-ribose) polymerase level and NAD metabolism in nuclei of rat brain cells. J Neurochem (2004) 0.79
Role of extracellular cGMP and of hyperammonemia in the impairment of learning in rats with chronic hepatic failure. Therapeutic implications. Neurochem Int (2006) 0.79
Is cognitive impairment in cirrhotic patients due to increased peroxynitrite and oxidative stress? Antioxid Redox Signal (2015) 0.79
Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices. Neurotoxicology (2007) 0.79
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition. Metab Brain Dis (2013) 0.79
Control of brain glutamine synthesis by NMDA receptors. Front Biosci (2007) 0.79
Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls. J Proteomics (2012) 0.78
Amyloid-β impairs, and ibuprofen restores, the cGMP pathway, synaptic expression of AMPA receptors and long-term potentiation in the hippocampus. J Alzheimers Dis (2010) 0.78
Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture. J Neurochem (2004) 0.78
Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis. World J Gastroenterol (2006) 0.78
Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G. Neurobiol Dis (2004) 0.78
Gender differential effects of developmental exposure to methyl-mercury, polychlorinated biphenyls 126 or 153, or its combinations on motor activity and coordination. Toxicology (2012) 0.78
Animal models in the study of episodic hepatic encephalopathy in cirrhosis. Metab Brain Dis (2005) 0.78
Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase, alterations in hyperammonemia. BMC Pharmacol (2005) 0.77
Reduced white matter microstructural integrity correlates with cognitive deficits in minimal hepatic encephalopathy. Gut (2013) 0.77
Increased protein kinase A regulatory subunit content and cGMP binding in erythrocyte membranes in liver cirrhosis. J Hepatol (2004) 0.77
Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure. J Neurochem (2007) 0.77
Altered modulation of soluble guanylate cyclase in lymphocytes from patients with liver disease. J Mol Med (Berl) (2001) 0.77
Trialkylglycines: a new family of compounds with in vivo neuroprotective activity. CNS Drug Rev (2003) 0.77
Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Chem Res Toxicol (2010) 0.77
Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors. J Neurochem (2007) 0.77
Metabotropic glutamate receptor 5 modulates the nitric oxide-cGMP pathway in cerebellum in vivo through activation of AMPA receptors. Neurochem Int (2011) 0.77
Cerebellum proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138. Toxicol Sci (2011) 0.77
Hyperammonaemia alters the mechanisms by which metabotropic glutamate receptors in nucleus accumbens modulate motor function. J Neurochem (2007) 0.77
Altered modulation of motor activity by group I metabotropic glutamate receptors in the nucleus accumbens in hyperammonemic rats. Metab Brain Dis (2005) 0.77
Lymphocyte cytochrome c oxidase, cyclic GMP and cholinergic muscarinic receptors as peripheral indicators of carbon monoxide neurotoxicity after acute and repeated exposure in the rat. Life Sci (2005) 0.77
The effects of hyperammonemia in learning and brain metabolic activity. Metab Brain Dis (2014) 0.77
A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A. Am J Physiol Gastrointest Liver Physiol (2007) 0.76
In vivo exposure to carbon monoxide causes delayed impairment of activation of soluble guanylate cyclase by nitric oxide in rat brain cortex and cerebellum. J Neurochem (2004) 0.76
Acute ammonia neurotoxicity in vivo involves increase in cytoplasmic protein P53 without alterations in other markers of apoptosis. J Neurosci Res (2007) 0.76