Published in Brain Pathol on July 01, 2002
Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15
Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res (2006) 1.91
Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun (2009) 1.86
Macrophages promote axon regeneration with concurrent neurotoxicity. J Neurosci (2009) 1.80
Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (Lond) (2011) 1.73
Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus peptidoglycan but not intact bacteria by microglia. Glia (2005) 1.46
Glial toll-like receptor signaling in central nervous system infection and autoimmunity. Brain Behav Immun (2007) 1.40
Immunopathogenesis of brain abscess. J Neuroinflammation (2004) 1.32
Flow cytometry and in vitro analysis of human glioma-associated macrophages. Laboratory investigation. J Neurosurg (2009) 1.32
Peroxisome proliferator-activated receptor-alpha agonist fenofibrate regulates IL-12 family cytokine expression in the CNS: relevance to multiple sclerosis. J Neurochem (2007) 1.19
Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application. Mediators Inflamm (2010) 1.11
Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. Immunol Invest (2011) 1.04
Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis. J Neuroinflammation (2008) 0.98
Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production. Glia (2009) 0.97
Toll-like receptors are key players in neurodegeneration. Int Immunopharmacol (2011) 0.95
Role of toll-like receptors in multiple sclerosis. Am J Clin Exp Immunol (2013) 0.94
Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis. Clin Exp Immunol (2009) 0.93
Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury. J Neurotrauma (2011) 0.93
Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2. Infect Immun (2006) 0.91
Mycobacteria-induced suppression of autoimmunity in the central nervous system. J Neuroimmune Pharmacol (2010) 0.90
Toll-like receptors in multiple sclerosis. Curr Top Microbiol Immunol (2009) 0.90
15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. J Clin Immunol (2008) 0.89
Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proc Natl Acad Sci U S A (2006) 0.86
Overview of toll-like receptors in the CNS. Curr Top Microbiol Immunol (2009) 0.83
hsp70-dependent antiviral immunity against cytopathic neuronal infection by vesicular stomatitis virus. J Virol (2013) 0.78
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron (2006) 6.38
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med (2009) 4.87
Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med (2003) 3.87
Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest. Crit Care Med (2009) 3.56
Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci (2002) 2.97
Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med (2006) 2.74
Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci (2003) 2.52
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A (2013) 2.45
Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci (2007) 2.28
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination. Ann Neurol (2012) 2.25
Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci (2004) 2.21
Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology (2009) 2.11
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci (2008) 2.11
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00
Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem (2007) 1.92
MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem (2008) 1.86
Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain (2009) 1.84
Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. J Immunol (2007) 1.65
Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J Neurochem (2007) 1.61
Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci (2007) 1.57
How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51
Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain (2011) 1.50
Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci (2006) 1.49
Bone-marrow-derived microglia: myth or reality? Curr Opin Pharmacol (2008) 1.48
Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. J Neurosci (2002) 1.46
Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis. J Infect Dis (2007) 1.43
Glucocorticoids play a fundamental role in protecting the brain during innate immune response. J Neurosci (2003) 1.37
An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. J Neurosci (2003) 1.34
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol Dis (2004) 1.34
Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. J Neurosci (2011) 1.31
Taking advantage of the systemic immune system to cure brain diseases. Neuron (2009) 1.31
Innate immunity in the CNS: redefining the relationship between the CNS and Its environment. Neuron (2013) 1.30
Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis. J Neuroimmunol (2005) 1.29
Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria. Eur J Immunol (2003) 1.29
Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology (2008) 1.28
Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci (2006) 1.28
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J Neurosci (2011) 1.27
CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Neurosci (2011) 1.27
A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease. J Mol Cell Biol (2013) 1.25
MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. J Cell Biol (2007) 1.24
Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. J Neurosci (2009) 1.22
Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system. Brain Behav Immun (2007) 1.22
Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J (2006) 1.22
A novel fluorescent probe that is brain permeable and selectively binds to myelin. J Histochem Cytochem (2006) 1.19
The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1. ASN Neuro (2011) 1.19
Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes. J Biol Chem (2002) 1.18
Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. J Immunol (2002) 1.18
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J (2005) 1.18
A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1. Immunity (2009) 1.14
Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment. Mol Pharmacol (2006) 1.14
Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain. Eur J Neurosci (2002) 1.13
Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep (2013) 1.13
P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis. J Neuroinflammation (2008) 1.12
Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol Aging (2006) 1.11
Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties. J Neurochem (2005) 1.10
Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection. Infect Immun (2008) 1.08
Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice. J Infect Dis (2007) 1.06
Neuroprotective effects of resident microglia following acute brain injury. J Comp Neurol (2007) 1.05
The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes. J Neuroinflammation (2011) 1.05
The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. J Neurochem (2006) 1.04
Glucocorticoids: protectors of the brain during innate immune responses. Neuroscientist (2004) 1.04
Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain. Cell Transplant (2011) 1.04
Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients. J Leukoc Biol (2003) 1.04
Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production. J Neuroinflammation (2004) 1.03
Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain. J Immunol (2005) 1.03
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli. J Neurochem (2005) 1.03
The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's disease. Neurobiol Aging (2011) 1.03
Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. J Neurosci (2013) 1.02
mTOR kinase, a key player in the regulation of glial functions: relevance for the therapy of multiple sclerosis. Glia (2012) 1.02
Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain. J Immunol (2004) 1.02
Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol (2013) 1.01
Characterization of the early neuroinflammation after spinal cord injury in mice. J Neuropathol Exp Neurol (2007) 1.01
Genes involved in the balance between neuronal survival and death during inflammation. PLoS One (2007) 1.00
Effect of pioglitazone treatment in a patient with secondary multiple sclerosis. J Neuroinflammation (2004) 1.00
Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice. Neurobiol Aging (2012) 1.00
Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. Eur J Immunol (2005) 0.99
A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. J Biol Chem (2004) 0.99
A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res (2009) 0.99
Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta. J Neurochem (2007) 0.98
Immunotherapy for neurological diseases. Clin Immunol (2008) 0.97
Molecular and cellular immune mediators of neuroprotection. Mol Neurobiol (2006) 0.96
Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Mol Med (2012) 0.96
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur J Neurosci (2012) 0.95
Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infect Immun (2002) 0.95
Effect of pioglitazone treatment on behavioral symptoms in autistic children. J Neuroinflammation (2007) 0.95
Norepinephrine protects cortical neurons against microglial-induced cell death. J Neurosci Res (2005) 0.94
Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits. J Comp Neurol (2009) 0.94
Increasing CNS noradrenaline reduces EAE severity. J Neuroimmune Pharmacol (2009) 0.93
Do pathogen exposure and innate immunity cause brain diseases? Neurol Res (2005) 0.93
The role of the glia limitans in ADP-induced pial arteriolar relaxation in intact and ovariectomized female rats. Am J Physiol Heart Circ Physiol (2004) 0.92
Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain. Neurochem Res (2004) 0.92
Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system. J Cell Biol (2003) 0.92
A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis. J Neuroimmunol (2009) 0.91
Epinephrine induces rapid deterioration in pulmonary oxygen exchange in intact, anesthetized rats: a flow and pulmonary capillary pressure-dependent phenomenon. Anesthesiology (2012) 0.91
Modulation of inducible nitric oxide synthase expression by sumoylation. J Neuroinflammation (2009) 0.91
Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression. J Neurochem (2003) 0.90
Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis. J Neuroimmunol (2005) 0.89
Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis. J Infect Dis (2008) 0.89
Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors. Endocr Rev (2012) 0.89