Published in Curr Opin Pharmacol on May 16, 2008
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat Med (2010) 4.24
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Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci (2007) 2.28
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination. Ann Neurol (2012) 2.25
Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci (2004) 2.21
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci (2008) 2.11
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00
Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem (2007) 1.92
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Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain (2009) 1.84
Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. J Immunol (2007) 1.65
Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci (2007) 1.57
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Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci (2006) 1.49
Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis. J Infect Dis (2007) 1.43
Glucocorticoids play a fundamental role in protecting the brain during innate immune response. J Neurosci (2003) 1.37
An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. J Neurosci (2003) 1.34
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol Dis (2004) 1.34
Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. J Neurosci (2011) 1.31
Taking advantage of the systemic immune system to cure brain diseases. Neuron (2009) 1.31
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Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci (2006) 1.28
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J Neurosci (2011) 1.27
CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Neurosci (2011) 1.27
A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease. J Mol Cell Biol (2013) 1.25
MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. J Cell Biol (2007) 1.24
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Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J (2006) 1.22
Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. J Immunol (2002) 1.18
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J (2005) 1.18
A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1. Immunity (2009) 1.14
Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain. Eur J Neurosci (2002) 1.13
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The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol (2002) 1.10
Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection. Infect Immun (2008) 1.08
Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice. J Infect Dis (2007) 1.06
Neuroprotective effects of resident microglia following acute brain injury. J Comp Neurol (2007) 1.05
Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain. Cell Transplant (2011) 1.04
Glucocorticoids: protectors of the brain during innate immune responses. Neuroscientist (2004) 1.04
Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain. J Immunol (2005) 1.03
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli. J Neurochem (2005) 1.03
Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. J Neurosci (2013) 1.02
Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain. J Immunol (2004) 1.02
Characterization of the early neuroinflammation after spinal cord injury in mice. J Neuropathol Exp Neurol (2007) 1.01
Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol (2013) 1.01
Genes involved in the balance between neuronal survival and death during inflammation. PLoS One (2007) 1.00
Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice. Neurobiol Aging (2012) 1.00
A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. J Biol Chem (2004) 0.99
Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. Eur J Immunol (2005) 0.99
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Molecular and cellular immune mediators of neuroprotection. Mol Neurobiol (2006) 0.96
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The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur J Neurosci (2012) 0.95
Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infect Immun (2002) 0.95
Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits. J Comp Neurol (2009) 0.94
Do pathogen exposure and innate immunity cause brain diseases? Neurol Res (2005) 0.93
Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system. J Cell Biol (2003) 0.92
Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells. Stem Cells (2007) 0.89
Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis. J Infect Dis (2008) 0.89
Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors. Endocr Rev (2012) 0.89
Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis. J Neuroimmunol (2005) 0.89
Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems. Exp Biol Med (Maywood) (2004) 0.88
Estrogen receptor transrepresses brain inflammation. Cell (2011) 0.88
The neuroendocrine control of the innate immune system in health and brain diseases. Immunol Rev (2012) 0.88
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MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease. Mol Neurodegener (2011) 0.87
Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice. Front Cell Neurosci (2012) 0.87
Immune receptors involved in Streptococcus suis recognition by dendritic cells. PLoS One (2012) 0.87
Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease. Physiol Behav (2011) 0.86
Modulation of the innate immune response by NMDA receptors has neuropathological consequences. J Neurosci (2003) 0.86
Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis. J Neuroimmunol (2011) 0.85
Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity. Brain Struct Funct (2014) 0.84
Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. J Gen Virol (2012) 0.84
Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology (2011) 0.84
The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease. Front Physiol (2013) 0.83
Role of inflammation in the neurobiology of stem cells. Neuroreport (2004) 0.82
IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults. Front Cell Neurosci (2013) 0.82
Interactions between microglia and T cells in multiple sclerosis pathobiology. J Interferon Cytokine Res (2014) 0.81
Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury. J Neurosci (2013) 0.81
Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly? Endocrinology (2002) 0.81
A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600. J Biol Chem (2013) 0.80
Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis. Behav Brain Res (2011) 0.80
Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease. Stem Cell Rev (2012) 0.79
In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain. Endocrinology (2002) 0.79
Is survival possible without arachidonate metabolites in the brain during systemic infection? News Physiol Sci (2003) 0.79
Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis. Neurotherapeutics (2011) 0.78
Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites. Brain Behav Immun (2010) 0.78
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Targeting the hematopoietic system for the treatment of Alzheimer's disease. Brain Behav Immun (2010) 0.77
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Perspective: how to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems. Endocrinology (2002) 0.75