MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMC 2140021)

Published in J Cell Biol on December 17, 2007

Authors

Jihong Kang1, Serge Rivest

Author Affiliations

1: Laboratory of Molecular Endocrinology, Centre hospitalier de l'Université Laval Research Center and Department of Anatomy and Physiology, Laval University, Québec G1V 4G2, Canada.

Articles citing this

Mechanisms underlying inflammation in neurodegeneration. Cell (2010) 7.66

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol (2009) 5.65

Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury. Glia (2010) 1.54

Systemic inflammatory cells fight off neurodegenerative disease. Nat Rev Neurol (2010) 1.52

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A (2009) 1.33

Inflammation in ALS and SMA: sorting out the good from the evil. Neurobiol Dis (2009) 1.29

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis. J Neuroimmune Pharmacol (2013) 1.23

Inflammation in the early stages of neurodegenerative pathology. J Neuroimmunol (2011) 1.21

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation. Front Cell Neurosci (2013) 1.20

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus. EMBO J (2013) 1.16

Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application. Mediators Inflamm (2010) 1.11

The brain's best friend: microglial neurotoxicity revisited. Front Cell Neurosci (2013) 1.09

Glial cells in amyotrophic lateral sclerosis. Neurol Res Int (2011) 1.08

How to get from here to there: macrophage recruitment in Alzheimer's disease. Curr Alzheimer Res (2011) 1.02

Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS. PLoS One (2011) 1.00

Inflammatory responses are not sufficient to cause delayed neuronal death in ATP-induced acute brain injury. PLoS One (2010) 1.00

A clear and present danger: endogenous ligands of Toll-like receptors. Neuromolecular Med (2009) 0.99

Stem cell transplantation for motor neuron disease: current approaches and future perspectives. Neurotherapeutics (2011) 0.92

Innate immunity and neuroinflammation. Mediators Inflamm (2013) 0.90

Neuroinflammation in motor neuron disease. Nagoya J Med Sci (2015) 0.89

Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide. J Assoc Res Otolaryngol (2014) 0.88

MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease. Mol Neurodegener (2011) 0.87

Inhibition of microglia activation as a phenotypic assay in early drug discovery. J Biomol Screen (2013) 0.86

Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology. J Immunol (2013) 0.86

The role of microglia in human disease: therapeutic tool or target? Acta Neuropathol (2014) 0.85

The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration. J Neuroinflammation (2011) 0.84

Development of ALS-like disease in SOD-1 mice deficient of B lymphocytes. J Neurol (2009) 0.83

Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy. Neurosci Lett (2010) 0.81

Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis? Int J Mol Sci (2015) 0.79

ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad. Front Cell Neurosci (2015) 0.77

Cell-Based Neurorestorotherapy in Amyotrophic Lateral Sclerosis - Scientific Truth should Rely on Facts, but Not Conjecture. Front Integr Neurosci (2011) 0.75

Brain-borne IL-1 adjusts glucoregulation and provides fuel support to astrocytes and neurons in an autocrine/paracrine manner. Mol Psychiatry (2015) 0.75

Articles cited by this

Pathogen recognition and innate immunity. Cell (2006) 44.14

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature (1993) 21.65

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science (1994) 18.08

Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron (2006) 6.38

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol (2004) 6.26

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2006) 4.52

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci (2005) 3.69

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2000) 3.11

Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci (2002) 2.97

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment. J Neurosci (2001) 2.43

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration. J Neurosci (2000) 2.27

Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci (2004) 2.21

Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded. Cell (2001) 1.71

An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. J Neurosci (1999) 1.55

Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues. Brain (2004) 1.52

Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J Neurosci (2007) 1.52

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis. J Neurosci (2005) 1.51

Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS. J Neurochem (2001) 1.41

Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis. Glia (2006) 1.30

Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci (2006) 1.28

Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations. J Neurosci (2006) 1.15

Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. Ann Neurol (2001) 1.08

Defective axonal transport of neurofilament proteins in neurons overexpressing peripherin. J Neurochem (2006) 0.88

Modulation of the innate immune response by NMDA receptors has neuropathological consequences. J Neurosci (2003) 0.86

Articles by these authors

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron (2006) 6.38

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med (2009) 4.87

Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci (2002) 2.97

Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci (2003) 2.52

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A (2013) 2.45

Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci (2007) 2.28

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination. Ann Neurol (2012) 2.25

Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci (2004) 2.21

Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci (2008) 2.11

Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00

Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem (2007) 1.92

MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem (2008) 1.86

Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain (2009) 1.84

Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. J Immunol (2007) 1.65

Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci (2007) 1.57

How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51

Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci (2006) 1.49

Bone-marrow-derived microglia: myth or reality? Curr Opin Pharmacol (2008) 1.48

Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis. J Infect Dis (2007) 1.43

Glucocorticoids play a fundamental role in protecting the brain during innate immune response. J Neurosci (2003) 1.37

An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. J Neurosci (2003) 1.34

Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol Dis (2004) 1.34

Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. J Neurosci (2011) 1.31

Taking advantage of the systemic immune system to cure brain diseases. Neuron (2009) 1.31

Innate immunity in the CNS: redefining the relationship between the CNS and Its environment. Neuron (2013) 1.30

Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria. Eur J Immunol (2003) 1.29

Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci (2006) 1.28

Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J Neurosci (2011) 1.27

CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Neurosci (2011) 1.27

A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease. J Mol Cell Biol (2013) 1.25

Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system. Brain Behav Immun (2007) 1.22

Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J (2006) 1.22

Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. J Immunol (2002) 1.18

An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J (2005) 1.18

A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1. Immunity (2009) 1.14

Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep (2013) 1.13

Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain. Eur J Neurosci (2002) 1.13

The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol (2002) 1.10

Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection. Infect Immun (2008) 1.08

Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice. J Infect Dis (2007) 1.06

Neuroprotective effects of resident microglia following acute brain injury. J Comp Neurol (2007) 1.05

Glucocorticoids: protectors of the brain during innate immune responses. Neuroscientist (2004) 1.04

Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain. Cell Transplant (2011) 1.04

Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain. J Immunol (2005) 1.03

Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli. J Neurochem (2005) 1.03

Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. J Neurosci (2013) 1.02

Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain. J Immunol (2004) 1.02

Characterization of the early neuroinflammation after spinal cord injury in mice. J Neuropathol Exp Neurol (2007) 1.01

Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol (2013) 1.01

Genes involved in the balance between neuronal survival and death during inflammation. PLoS One (2007) 1.00

Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice. Neurobiol Aging (2012) 1.00

Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. Eur J Immunol (2005) 0.99

A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. J Biol Chem (2004) 0.99

Immunotherapy for neurological diseases. Clin Immunol (2008) 0.97

Molecular and cellular immune mediators of neuroprotection. Mol Neurobiol (2006) 0.96

Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Mol Med (2012) 0.96

The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur J Neurosci (2012) 0.95

Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infect Immun (2002) 0.95

Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits. J Comp Neurol (2009) 0.94

Do pathogen exposure and innate immunity cause brain diseases? Neurol Res (2005) 0.93

Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system. J Cell Biol (2003) 0.92

Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells. Stem Cells (2007) 0.89

Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis. J Infect Dis (2008) 0.89

Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors. Endocr Rev (2012) 0.89

Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis. J Neuroimmunol (2005) 0.89

Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems. Exp Biol Med (Maywood) (2004) 0.88

Estrogen receptor transrepresses brain inflammation. Cell (2011) 0.88

The neuroendocrine control of the innate immune system in health and brain diseases. Immunol Rev (2012) 0.88

Microglia. Curr Biol (2008) 0.88

Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain. J Innate Immun (2009) 0.88

MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease. Mol Neurodegener (2011) 0.87

Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice. Front Cell Neurosci (2012) 0.87

Immune receptors involved in Streptococcus suis recognition by dendritic cells. PLoS One (2012) 0.87

Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease. Physiol Behav (2011) 0.86

Modulation of the innate immune response by NMDA receptors has neuropathological consequences. J Neurosci (2003) 0.86

Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis. J Neuroimmunol (2011) 0.85

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity. Brain Struct Funct (2014) 0.84

Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. J Gen Virol (2012) 0.84

Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology (2011) 0.84

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease. Front Physiol (2013) 0.83

Role of inflammation in the neurobiology of stem cells. Neuroreport (2004) 0.82

IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults. Front Cell Neurosci (2013) 0.82

Interactions between microglia and T cells in multiple sclerosis pathobiology. J Interferon Cytokine Res (2014) 0.81

Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury. J Neurosci (2013) 0.81

Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly? Endocrinology (2002) 0.81

A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600. J Biol Chem (2013) 0.80

Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis. Behav Brain Res (2011) 0.80

Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease. Stem Cell Rev (2012) 0.79

In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain. Endocrinology (2002) 0.79

Is survival possible without arachidonate metabolites in the brain during systemic infection? News Physiol Sci (2003) 0.79

Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis. Neurotherapeutics (2011) 0.78

Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites. Brain Behav Immun (2010) 0.78

[Bone marrow stem cells to the rescue of Alzheimer's disease]. Med Sci (Paris) (2006) 0.77

Targeting the hematopoietic system for the treatment of Alzheimer's disease. Brain Behav Immun (2010) 0.77

[The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease]. Med Sci (Paris) (2009) 0.76

[Role of the innate immune response in the brain]. Med Sci (Paris) (2003) 0.76

Are glucocorticoids good or bad for brain development and plasticity? Endocrinology (2002) 0.75

Perspective: how to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems. Endocrinology (2002) 0.75