Published in J Biol Chem on July 31, 2002
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood (2005) 3.22
Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation. PLoS One (2015) 1.41
Independent component analysis: mining microarray data for fundamental human gene expression modules. J Biomed Inform (2010) 1.39
A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res (2010) 1.18
BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells. FASEB J (2010) 1.14
The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic Biol Med (2008) 1.10
Sesquiterpenoids lactones: benefits to plants and people. Int J Mol Sci (2013) 1.03
The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. Mol Cancer Ther (2007) 1.03
Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis. Parasitol Res (2008) 0.96
Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors. Oxid Med Cell Longev (2011) 0.95
Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation. PLoS One (2011) 0.93
Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro. J Exp Clin Cancer Res (2010) 0.92
Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism. J Inflamm (Lond) (2014) 0.92
A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. Int J Cancer (2011) 0.91
Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres. Cancer Biol Ther (2012) 0.89
Anti-cancer activity of carbamate derivatives of melampomagnolide B. Bioorg Med Chem Lett (2014) 0.88
Apoptosis Effect of Girinimbine Isolated from Murraya koenigii on Lung Cancer Cells In Vitro. Evid Based Complement Alternat Med (2013) 0.87
Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor kappaB transcriptional activation in neuroblastoma SH-SY5Y cells. Biochem J (2007) 0.87
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. J Cell Mol Med (2009) 0.87
Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury. Exp Mol Med (2009) 0.87
Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization. ACS Chem Biol (2013) 0.86
Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells. J Med Chem (2015) 0.86
The role of oxidative stress in anticancer activity of sesquiterpene lactones. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.85
Targeting radioresistant osteosarcoma cells with parthenolide. J Cell Biochem (2012) 0.84
Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa. BMC Complement Altern Med (2014) 0.84
Involvement of Akt/NF-κB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. BMC Cancer (2012) 0.84
Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells. Exp Mol Med (2010) 0.83
Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model. Exp Mol Med (2012) 0.83
Selective induction of tumor cell apoptosis by a novel P450-mediated reactive oxygen species (ROS) inducer methyl 3-(4-nitrophenyl) propiolate. J Biol Chem (2013) 0.83
Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. PLoS One (2009) 0.83
Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells. Br J Pharmacol (2010) 0.83
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-Mhigh melanoma cell populations. Oncotarget (2016) 0.81
Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. J Biol Chem (2016) 0.81
Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res (2014) 0.80
Radio-sensitization of the murine osteosarcoma cell line LM8 with parthenolide, a natural inhibitor of NF-κB. Oncol Lett (2011) 0.80
Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. Eur J Med Chem (2014) 0.79
Naringin Reverses Hepatocyte Apoptosis and Oxidative Stress Associated with HIV-1 Nucleotide Reverse Transcriptase Inhibitors-Induced Metabolic Complications. Nutrients (2015) 0.79
The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition. Thromb Res (2011) 0.79
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorg Med Chem (2015) 0.78
Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation. Bioorg Med Chem Lett (2014) 0.78
Parthenolide induces apoptosis in colitis-associated colon cancer, inhibiting NF-κB signaling. Oncol Lett (2015) 0.77
Parthenolide inhibits proliferation of fibroblast-like synoviocytes in vitro. Inflammation (2008) 0.77
Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity. Leukemia (2014) 0.77
Sir2 plays a key role in cell fate determination upon SAPK activation. Aging (Albany NY) (2011) 0.76
Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines. Mol Biol Rep (2012) 0.76
Malondialdehyde-Acetaldehyde-Adducted Surfactant Protein Alters Macrophage Functions Through Scavenger Receptor A. Alcohol Clin Exp Res (2016) 0.76
Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-κB Signaling in HCT116 Human Colorectal Cancer Cells. Intest Res (2015) 0.76
RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation. Acta Pharmacol Sin (2014) 0.76
Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis. Onco Targets Ther (2017) 0.75
Nanodelivery of Parthenolide Using Functionalized Nanographene Enhances its Anticancer Activity. RSC Adv (2015) 0.75
Parthenolide Induces Apoptosis in Committed Progenitor AML Cell line U937 via Reduction in Osteopontin. Rep Biochem Mol Biol (2016) 0.75
Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. Intest Res (2017) 0.75
Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death. Onco Targets Ther (2015) 0.75
Aspartame and Soft Drink-Mediated Neurotoxicity in Rats: Implication of Oxidative Stress, Apoptotic Signaling Pathways, Electrolytes and Hormonal Levels. Metab Brain Dis (2017) 0.75
Succinamide derivatives of melampomagnolide B and their anti-cancer activities. Bioorg Med Chem (2017) 0.75
Oxidative Stress Associated with Chilling Injury in Immature Fruit: Postharvest Technological and Biotechnological Solutions. Int J Mol Sci (2017) 0.75
Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma. Hepatology (2012) 2.40
Discovery-based science education: functional genomic dissection in Drosophila by undergraduate researchers. PLoS Biol (2005) 2.33
Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. Genetics (2007) 1.44
Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B. Hepatology (2007) 1.33
Clevudine is highly efficacious in hepatitis B e antigen-negative chronic hepatitis B with durable off-therapy viral suppression. Hepatology (2007) 1.21
EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma. Int J Cancer (2010) 1.14
Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. Biochem Biophys Res Commun (2010) 1.13
Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis. Cancer Res (2005) 1.09
Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma. Hepatology (2004) 1.05
Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice. J Pathol (2009) 1.04
Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells. Exp Mol Med (2009) 1.03
Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin. FASEB J (2002) 1.02
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Biochem Biophys Res Commun (2006) 1.01
Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma. BMC Cancer (2011) 1.00
Vitamin D3 upregulated protein 1 suppresses TNF-α-induced NF-κB activation in hepatocarcinogenesis. J Immunol (2010) 0.99
Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma. Eur J Immunol (2007) 0.99
Cytochrome c oxidase subunit III: a molecular marker for N-(4-hydroxyphenyl)retinamise-induced oxidative stress in hepatoma cells. J Biol Chem (2001) 0.94
Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells. Cancer Res (2005) 0.94
ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma. Gastroenterology (2009) 0.92
Pro-oncogenic potential of NM23-H2 in hepatocellular carcinoma. Exp Mol Med (2012) 0.91
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. J Clin Invest (2010) 0.91
L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma. Clin Cancer Res (2010) 0.90
NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. Clin Cancer Res (2007) 0.89
Involvement of GADD153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of H9c2 cells. J Biol Chem (2005) 0.89
Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma. Clin Exp Metastasis (2012) 0.89
L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells. Cancer Lett (2011) 0.89
GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells. J Biol Chem (2002) 0.88
Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway. Hepatology (2013) 0.88
Cell-cycle regulator Cks1 promotes hepatocellular carcinoma by supporting NF-κB-dependent expression of interleukin-8. Cancer Res (2011) 0.88
Identification of cystatin B as a potential serum marker in hepatocellular carcinoma. Clin Cancer Res (2008) 0.87
Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells. Hepatology (2003) 0.87
Frequent amplification of CENPF, GMNN and CDK13 genes in hepatocellular carcinomas. PLoS One (2012) 0.86
Inhibition of the proliferation and invasion of hepatocellular carcinoma cells by lipocalin 2 through blockade of JNK and PI3K/Akt signaling. Int J Oncol (2010) 0.86
Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem (2011) 0.86
Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis. Hepatology (2013) 0.85
Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells. Exp Mol Med (2010) 0.83
Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats. BMB Rep (2012) 0.82
A Case of Colonic Adenocarcinoma in a Patient with Wilson's Disease. Gut Liver (2013) 0.82
Role of SIRT1 in heat stress- and lipopolysaccharide-induced immune and defense gene expression in human dental pulp cells. J Endod (2011) 0.82
Isolation of EpCAM(+)/CD133 (-) hepatic progenitor cells. Mol Cells (2013) 0.81
TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression. Biochem Biophys Res Commun (2008) 0.81
Molecular regulation of kidney development. Anat Cell Biol (2013) 0.81
TIP60 represses transcriptional activity of p73beta via an MDM2-bridged ternary complex. J Biol Chem (2008) 0.79
CD30 supports lung inflammation. Int Immunol (2007) 0.78
Long-term treatment efficacy and safety of clevudine therapy in naïve patients with chronic hepatitis B. Gut Liver (2012) 0.78
Long-term efficacy of entecavir plus adefovir combination therapy versus entecavir monotherapy in adefovir refractory chronic hepatitis B patients with prior lamivudine resistance. Intervirology (2013) 0.78
Melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis. J Pineal Res (2014) 0.77
Stimulation of Odontogenesis and Angiogenesis via Bioactive Nanocomposite Calcium Phosphate Cements Through Integrin and VEGF Signaling Pathways. J Biomed Nanotechnol (2016) 0.76
Overexpression of epithelial-mesenchymal transition-related markers according to cell dedifferentiation: clinical implications as an independent predictor of poor prognosis in cholangiocarcinoma. Hum Pathol (2012) 0.76
[Relation of apolipoprotein E polymorphism to clinically diagnosed fatty liver disease]. Taehan Kan Hakhoe Chi (2002) 0.75
Robust and multifunctional nanosheath for chemical and biological nanodevices. Nano Lett (2012) 0.75
Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation. Int Arch Allergy Immunol (2016) 0.75
Functional cross-talk between p73beta and NF-kappaB mediated by p300. Biochem Biophys Res Commun (2006) 0.75
IgG immune complex induces the recruitment of inflammatory cells into the airway and TNF-mediated late airway hyperresponsiveness via NF-κB activation in mice. J Asthma (2011) 0.75