Published in J Clin Invest on November 08, 2010
High-resolution transcriptome of human macrophages. PLoS One (2012) 1.42
MDM2-p53 pathway in hepatocellular carcinoma. Cancer Res (2014) 1.09
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget (2015) 1.05
p63 the guardian of human reproduction. Cell Cycle (2012) 0.98
The Many Faces of MDM2 Binding Partners. Genes Cancer (2012) 0.90
Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One (2014) 0.82
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. J Hepatol (2012) 0.79
Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A. PLoS One (2014) 0.78
Dietary lysine imbalance affects muscle proteome in zebrafish (Danio rerio): a comparative 2D-DIGE study. Mar Biotechnol (NY) (2012) 0.77
The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation. BMC Cancer (2017) 0.75
Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. Oncogene (2016) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Surfing the p53 network. Nature (2000) 35.36
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
Regulation of p53 stability by Mdm2. Nature (1997) 18.20
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53
The p53-mdm-2 autoregulatory feedback loop. Genes Dev (1993) 11.19
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18
Modes of p53 regulation. Cell (2009) 9.31
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell (2004) 8.18
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene (1994) 7.24
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem (2000) 6.92
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci U S A (2001) 6.25
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol (2001) 5.82
Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol (1993) 5.31
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J (1998) 4.98
The MDM2 gene amplification database. Nucleic Acids Res (1998) 4.64
The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol (2003) 4.46
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Coping with stress: multiple ways to activate p53. Oncogene (2007) 3.57
The LIM domain: regulation by association. Mech Dev (2000) 3.45
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res (2000) 3.30
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ (2006) 2.95
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene (2000) 2.84
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A (2003) 2.73
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42
Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev (2006) 2.35
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J (2006) 2.21
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J (2006) 2.11
Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol Cell (2006) 2.09
Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing. J Physiol Pharmacol (2002) 2.00
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J Biol Chem (2004) 1.95
Protein-protein interaction of zinc finger LIM domains with protein kinase C. J Biol Chem (1996) 1.90
The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth. Gene (2001) 1.80
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc Natl Acad Sci U S A (1998) 1.79
Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol (2007) 1.77
Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53. Exp Cell Res (2001) 1.73
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2. Nat Cell Biol (2007) 1.70
Phosphorylation of HDM2 by Akt. Oncogene (2002) 1.63
MDM2 and prognosis. Mol Cancer Res (2004) 1.62
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A (2007) 1.56
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56
Identification of brain- and bone-specific breast cancer metastasis genes. Cancer Lett (2008) 1.54
E2F and Ras synergize in transcriptionally activating p14ARF expression. Cell Cycle (2003) 1.54
Altered patterns of MDM2 and TP53 expression in human bladder cancer. J Natl Cancer Inst (1994) 1.52
p53-independent functions of MDM2. Mol Cancer Res (2003) 1.44
E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. Nat Med (2006) 1.40
Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage. FASEB J (2002) 1.34
Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res (2008) 1.27
Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. Hepatology (2006) 1.18
Expression of the serum response factor in hepatocellular carcinoma: implications for epithelial-mesenchymal transition. Int J Oncol (2007) 1.13
The PDZ domain of the LIM protein enigma binds to beta-tropomyosin. Mol Biol Cell (1999) 1.12
LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads. J Biol Chem (2006) 1.11
Specificity of LIM domain interactions with receptor tyrosine kinases. J Biol Chem (1996) 1.11
Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development. Bioessays (2010) 1.10
KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells. Cancer Lett (2006) 1.09
Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells. J Biol Chem (2006) 1.08
HDM2 phosphorylation by MAPKAP kinase 2. Oncogene (2005) 0.98
Mdm2 in growth signaling and cancer. Growth Factors (2005) 0.97
Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Mol Cell Biol (1998) 0.96
A molecular and immunohistochemical study of the MDM2 protein isoforms and p53 gene product in bronchogenic carcinoma. J Pathol (1996) 0.95
Protein expression of MDM2 and its clinicopathological relationships in human hepatocellular carcinoma. Liver (2000) 0.94
Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Am J Physiol (1995) 0.90
Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation. Mol Endocrinol (2006) 0.85
Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway. J Cell Biochem (2008) 0.84
Adenovirus-mediated p53 tumor suppressor gene therapy against subcutaneous HuH7 hepatoma cell line nodule of nude mice. J Korean Med Sci (1999) 0.76
P53-protein accumulation and MDM2-protein overexpression in gastric carcinomas. No apparent correlation with survival. Pathol Res Pract (1999) 0.76
Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma. Hepatology (2012) 2.40
Benefit of systematic segmentectomy of the hepatocellular carcinoma: revisiting the dye injection method for various portal vein branches. Ann Surg (2013) 2.02
Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J Biol Chem (2002) 1.70
E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. Nat Med (2006) 1.40
Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B. Hepatology (2007) 1.33
Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis (2008) 1.24
Clevudine is highly efficacious in hepatitis B e antigen-negative chronic hepatitis B with durable off-therapy viral suppression. Hepatology (2007) 1.21
Epigenetic regulation of microRNA-10b and targeting of oncogenic MAPRE1 in gastric cancer. Epigenetics (2011) 1.19
Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. Hepatology (2006) 1.18
EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma. Int J Cancer (2010) 1.14
Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. Biochem Biophys Res Commun (2010) 1.13
Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin. EMBO J (2012) 1.10
[Four cases of hepatic fascioliasis mimicking cholangiocarcinoma]. Korean J Hepatol (2005) 1.09
Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis. Cancer Res (2005) 1.09
Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma. Hepatology (2004) 1.05
Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice. J Pathol (2009) 1.04
Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells. Exp Mol Med (2009) 1.03
Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival. Genes Chromosomes Cancer (2011) 1.02
Laparoscopic major liver resection in Korea: a multicenter study. J Hepatobiliary Pancreat Sci (2013) 1.01
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Biochem Biophys Res Commun (2006) 1.01
An imported case of cystic echinococcosis in the liver. Korean J Parasitol (2012) 1.00
Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma. BMC Cancer (2011) 1.00
Vitamin D3 upregulated protein 1 suppresses TNF-α-induced NF-κB activation in hepatocarcinogenesis. J Immunol (2010) 0.99
Quantitative analysis of cell-free DNA in the plasma of gastric cancer patients. Oncol Lett (2012) 0.98
Partially cystic thyroid nodules: ultrasound findings of malignancy. Korean J Radiol (2012) 0.98
Carcinosarcoma of the liver: a case report. Korean J Radiol (2007) 0.98
Meta- and gene set analysis of stomach cancer gene expression data. Mol Cells (2007) 0.96
[A case of primary small cell carcinoma in the common bile duct]. Korean J Gastroenterol (2004) 0.95
Cytochrome c oxidase subunit III: a molecular marker for N-(4-hydroxyphenyl)retinamise-induced oxidative stress in hepatoma cells. J Biol Chem (2001) 0.94
Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells. Cancer Res (2005) 0.94
Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression. Cancer Lett (2006) 0.93
Inflammatory pseudotumors mimicking intrahepatic cholangiocarcinoma of the liver; IgG4-positivity and its clinical significance. J Hepatobiliary Pancreat Sci (2012) 0.93
Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancer. Carcinogenesis (2013) 0.93
ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma. Gastroenterology (2009) 0.92
Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer. Biochem Biophys Res Commun (2011) 0.92
Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. Mol Cancer Res (2008) 0.92
The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration. Biochem Biophys Res Commun (2006) 0.92
Frequent silencing of popeye domain-containing genes, BVES and POPDC3, is associated with promoter hypermethylation in gastric cancer. Carcinogenesis (2010) 0.92
The single incision laparoscopic intragastric wedge resection of gastric submucosal tumor. J Gastric Cancer (2011) 0.92
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level. Biochem Biophys Res Commun (2012) 0.91
Pro-oncogenic potential of NM23-H2 in hepatocellular carcinoma. Exp Mol Med (2012) 0.91
Characterization of the adenoassociated virus Rep protein complex formed on the viral origin of DNA replication. Virology (2003) 0.91
SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility. Cancer (2010) 0.91
L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma. Clin Cancer Res (2010) 0.90
Adeno-associated virus-mediated gene transfer of a secreted form of TRAIL inhibits tumor growth and occurrence in an experimental tumor model. J Gene Med (2006) 0.89
NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. Clin Cancer Res (2007) 0.89
Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancer growth via nuclear factor-κB and is associated with poor patient outcome. Cancer Lett (2011) 0.89
Involvement of GADD153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of H9c2 cells. J Biol Chem (2005) 0.89
[Inflammatory pseudotumor of liver--a clinical review of 15 cases]. Korean J Hepatol (2006) 0.89
Oncolytic effects of adenovirus mutant capable of replicating in hypoxic and normoxic regions of solid tumor. Mol Ther (2004) 0.89
L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells. Cancer Lett (2011) 0.89
Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma. Clin Exp Metastasis (2012) 0.89
Genes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling. J Korean Med Sci (2011) 0.89
Cell-cycle regulator Cks1 promotes hepatocellular carcinoma by supporting NF-κB-dependent expression of interleukin-8. Cancer Res (2011) 0.88
LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer. Cancer Res (2008) 0.88
Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway. Hepatology (2013) 0.88
Arginine methylation of Sam68 and SLM proteins negatively regulates their poly(U) RNA binding activity. Arch Biochem Biophys (2007) 0.87
Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis. J Gastrointest Surg (2002) 0.87
Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells. Hepatology (2003) 0.87
Identification of cystatin B as a potential serum marker in hepatocellular carcinoma. Clin Cancer Res (2008) 0.87
The autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinoma. PLoS One (2013) 0.87
Frequent amplification of CENPF, GMNN and CDK13 genes in hepatocellular carcinomas. PLoS One (2012) 0.86
Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem (2011) 0.86
Inhibition of the proliferation and invasion of hepatocellular carcinoma cells by lipocalin 2 through blockade of JNK and PI3K/Akt signaling. Int J Oncol (2010) 0.86
CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers. Carcinogenesis (2008) 0.86
Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis. Hepatology (2013) 0.85
Aberrant upregulation of ASCL2 by promoter demethylation promotes the growth and resistance to 5-fluorouracil of gastric cancer cells. Cancer Sci (2013) 0.85
PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. Biochim Biophys Acta (2008) 0.85
Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway. J Cell Biochem (2008) 0.84
Retrospective analysis of treatment outcomes after postoperative chemoradiotherapy in advanced gastric cancer. Radiat Oncol J (2011) 0.84
Genetic variants A1826H and D2937Y in GAG-beta domain of versican influence susceptibility to intestinal-type gastric cancer. J Cancer Res Clin Oncol (2009) 0.84
Transcriptome analysis of human gastric cancer. Mamm Genome (2005) 0.84
Epigenetic alteration of CCDC67 and its tumor suppressor function in gastric cancer. Carcinogenesis (2012) 0.84
A propensity score-matched case-control comparative study of laparoscopic and open liver resection for hepatocellular carcinoma. J Laparoendosc Adv Surg Tech A (2014) 0.83
Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells. Exp Mol Med (2010) 0.83
A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. Neoplasia (2009) 0.83
A Case of Colonic Adenocarcinoma in a Patient with Wilson's Disease. Gut Liver (2013) 0.82
Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats. BMB Rep (2012) 0.82
Validation of intra- and interobserver reproducibility of shearwave elastography: Phantom study. Ultrasonics (2013) 0.81
Adenovirus-mediated interleukin-18 mutant in vivo gene transfer inhibits tumor growth through the induction of T cell immunity and activation of natural killer cell cytotoxicity. Cancer Gene Ther (2004) 0.81
Hypoxia-responsive element-mediated soluble Tie2 vector exhibits an anti-angiogenic activity in vitro under hypoxic condition. Int J Oncol (2005) 0.81
TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression. Biochem Biophys Res Commun (2008) 0.81
[Risk factors for early recurrence after surgical resection for hepatocellular carcinoma]. Korean J Hepatol (2008) 0.81
Isolation of EpCAM(+)/CD133 (-) hepatic progenitor cells. Mol Cells (2013) 0.81
Polo-box motif targets a centrosome regulator, RanGTPase. Biochem Biophys Res Commun (2004) 0.80
[A case of primary hepatic leiomyosarcoma with intrahepatic and abdominal subcutaneous metastasis in Behcet's disease]. Korean J Hepatol (2005) 0.79
Prognostic significance of preoperative blood transfusion in stomach cancer. J Gastric Cancer (2010) 0.79
Long-term treatment efficacy and safety of clevudine therapy in naïve patients with chronic hepatitis B. Gut Liver (2012) 0.78
Long-term efficacy of entecavir plus adefovir combination therapy versus entecavir monotherapy in adefovir refractory chronic hepatitis B patients with prior lamivudine resistance. Intervirology (2013) 0.78
Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells. Hepatology (2015) 0.78
Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas. APMIS (2014) 0.78
Adenovirus-mediated E2-EPF UCP gene transfer prevents autoamputation in a mouse model of hindlimb ischemia. Mol Ther (2012) 0.77
The NS5A protein of hepatitis C virus represses gene expression of hRPB10alpha, a common subunit of host RNA polymerases, through interferon regulatory factor-1 binding site. Virus Res (2007) 0.77
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice. BMC Cancer (2005) 0.76
Overexpression of epithelial-mesenchymal transition-related markers according to cell dedifferentiation: clinical implications as an independent predictor of poor prognosis in cholangiocarcinoma. Hum Pathol (2012) 0.76
Identification of potential serum biomarkers for gastric cancer by a novel computational method, multiple normal tissues corrected differential analysis. Clin Chim Acta (2011) 0.76
Disinfection of iceberg lettuce by titanium dioxide-UV photocatalytic reaction. J Food Prot (2009) 0.76
Reply to Letter: "Hepatic Vein-oriented Liver Resection Using Fusion Indocyanine Green Fluorescence Imaging". Ann Surg (2015) 0.75
Neuroprotective Activity of Sibjeondaebo-tang on Aβ Peptide-Induced Damages. Evid Based Complement Alternat Med (2012) 0.75