Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces.

PubWeight™: 3.45‹?› | Rank: Top 1%

🔗 View Article (PMID 12153987)

Published in FASEB J on August 01, 2002

Authors

Kevin Kit Parker1, Amy Lepre Brock, Cliff Brangwynne, Robert J Mannix, Ning Wang, Emanuele Ostuni, Nicholas A Geisse, Josephine C Adams, George M Whitesides, Donald E Ingber

Author Affiliations

1: Department of Pathology and Surgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

(truncated to the top 100)

Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56

Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci U S A (2010) 4.63

Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06

Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63

Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci U S A (2010) 3.44

A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44

Mechanical control of tissue and organ development. Development (2010) 3.18

The dynamics and mechanics of endothelial cell spreading. Biophys J (2005) 2.76

The SLC4 family of HCO 3 - transporters. Pflugers Arch (2004) 2.73

Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs. Biophys J (2004) 2.46

Directing cell migration with asymmetric micropatterns. Proc Natl Acad Sci U S A (2005) 2.22

Can cancer be reversed by engineering the tumor microenvironment? Semin Cancer Biol (2008) 2.07

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat Commun (2012) 1.96

Tensegrity-based mechanosensing from macro to micro. Prog Biophys Mol Biol (2008) 1.90

A bio-chemo-mechanical model for cell contractility. Proc Natl Acad Sci U S A (2006) 1.82

Biomechanics: cell research and applications for the next decade. Ann Biomed Eng (2009) 1.81

The regulation of traction force in relation to cell shape and focal adhesions. Biomaterials (2010) 1.72

Sarcomere alignment is regulated by myocyte shape. Cell Motil Cytoskeleton (2008) 1.71

Topography, cell response, and nerve regeneration. Annu Rev Biomed Eng (2010) 1.70

Mechanosensation through integrins: cells act locally but think globally. Proc Natl Acad Sci U S A (2003) 1.67

Quantifying cell-generated mechanical forces within living embryonic tissues. Nat Methods (2013) 1.64

Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64

United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction. J Cell Sci (2012) 1.63

Dynamic reciprocity in the wound microenvironment. Wound Repair Regen (2011) 1.62

Physical mechanisms redirecting cell polarity and cell shape in fission yeast. Curr Biol (2008) 1.55

Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem (2010) 1.53

Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch (2011) 1.52

Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. Am J Pathol (2004) 1.51

Dynamics of membranes driven by actin polymerization. Biophys J (2005) 1.50

Cytoskeleton dynamics: fluctuations within the network. Biochem Biophys Res Commun (2007) 1.50

Myofibrillar architecture in engineered cardiac myocytes. Circ Res (2008) 1.48

Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis. Mol Biol Cell (2007) 1.45

Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. EMBO J (2003) 1.45

Physical model of the dynamic instability in an expanding cell culture. Biophys J (2010) 1.45

Filamentous network mechanics and active contractility determine cell and tissue shape. Biophys J (2008) 1.44

Biology on a chip: microfabrication for studying the behavior of cultured cells. Crit Rev Biomed Eng (2003) 1.42

Self-organization of muscle cell structure and function. PLoS Comput Biol (2011) 1.39

Nuclear morphology and deformation in engineered cardiac myocytes and tissues. Biomaterials (2010) 1.33

Nucleation geometry governs ordered actin networks structures. Nat Mater (2010) 1.31

Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals. Mol Biol Cell (2007) 1.25

Cellular and multicellular form and function. Adv Drug Deliv Rev (2007) 1.24

Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci (2007) 1.24

Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Biophys J (2010) 1.20

Geometry regulates traction stresses in adherent cells. Biophys J (2014) 1.19

Rheological characterization of polysaccharide-poly(ethylene glycol) star copolymer hydrogels. Biomacromolecules (2005) 1.14

Effects of physiological electric fields on migration of human dermal fibroblasts. J Invest Dermatol (2010) 1.13

Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. Proc Natl Acad Sci U S A (2012) 1.13

The simulation of stress fibre and focal adhesion development in cells on patterned substrates. J R Soc Interface (2008) 1.11

Mapping the cytoskeletal prestress. Am J Physiol Cell Physiol (2010) 1.08

Subcellular curvature at the perimeter of micropatterned cells influences lamellipodial distribution and cell polarity. Cell Motil Cytoskeleton (2008) 1.08

A micropatterning and image processing approach to simplify measurement of cellular traction forces. Acta Biomater (2011) 1.07

Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS One (2011) 1.06

Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces. Integr Biol (Camb) (2011) 1.03

Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02

The contribution of cellular mechanotransduction to cardiomyocyte form and function. Biomech Model Mechanobiol (2012) 1.02

Short peptides enhance single cell adhesion and viability on microarrays. Langmuir (2007) 0.99

Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling. PLoS One (2013) 0.98

Geometric control of tissue morphogenesis. Biochim Biophys Acta (2009) 0.96

From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009. Ann Biomed Eng (2010) 0.96

Extracellular matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis. PLoS One (2014) 0.95

A predictive model of cell traction forces based on cell geometry. Biophys J (2010) 0.95

Steering cell migration using microarray amplification of natural directional persistence. Langmuir (2011) 0.95

Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes. Biomaterials (2014) 0.93

Fabrication of skeletal muscle constructs by topographic activation of cell alignment. Biotechnol Bioeng (2009) 0.93

Cell spreading analysis with directed edge profile-guided level set active contours. Med Image Comput Comput Assist Interv (2008) 0.89

The role of mechanics in actin stress fiber kinetics. Exp Cell Res (2013) 0.89

Protrusion fluctuations direct cell motion. Biophys J (2014) 0.88

A mathematical model of the coupled mechanisms of cell adhesion, contraction and spreading. J Math Biol (2013) 0.87

Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression. J Cell Sci (2014) 0.87

Energetics and dynamics of constrained actin filament bundling. Biophys J (2006) 0.87

Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury. Sci Rep (2015) 0.86

Particle-induced indentation of the alveolar epithelium caused by surface tension forces. J Appl Physiol (1985) (2010) 0.85

Effect of fiber diameter on the spreading, proliferation and differentiation of chondrocytes on electrospun chitosan matrices. Cells Tissues Organs (2011) 0.84

A potential role for integrin signaling in mechanoelectrical feedback. Prog Biophys Mol Biol (2012) 0.84

Geometric control of cell migration. Sci Rep (2013) 0.84

E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics. Cell Adh Migr (2013) 0.84

A novel method for measuring tension generated in stress fibers by applying external forces. Biophys J (2011) 0.84

The effects of proteoglycan surface patterning on neuronal pathfinding. Materwiss Werksttech (2007) 0.83

Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering. Adv Healthc Mater (2014) 0.83

A Novel Technique for Micro-patterning Proteins and Cells on Polyacrylamide Gels. Soft Matter (2012) 0.83

Let's push things forward: disruptive technologies and the mechanics of tissue assembly. Integr Biol (Camb) (2013) 0.83

Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering. Trends Cell Biol (2010) 0.83

Fabrication of interdigitated micropatterns of self-assembled polymer nanofilms containing cell-adhesive materials. Langmuir (2006) 0.82

Geometric control of vimentin intermediate filaments. Biomaterials (2013) 0.82

Adhesion, spreading and osteogenic differentiation of mesenchymal stem cells cultured on micropatterned amorphous diamond, titanium, tantalum and chromium coatings on silicon. J Mater Sci Mater Med (2009) 0.82

The influence of sub-micron inhibitory clusters on growth cone substratum attachments and CD44 expression. Biomaterials (2008) 0.82

Polarizing pathways: balancing endothelial polarity, permeability, and lumen formation. Exp Cell Res (2013) 0.82

Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin. Sci Rep (2016) 0.82

Paxillin controls directional cell motility in response to physical cues. Cell Adh Migr (2012) 0.81

Short-term molecular polarization of cells on symmetric and asymmetric micropatterns. Soft Matter (2010) 0.81

Biophysical basis for airway hyperresponsiveness. Can J Physiol Pharmacol (2007) 0.81

Experimental and numerical determination of cellular traction force on polymeric hydrogels. Interface Focus (2011) 0.80

Initial stem cell adhesion on porous silicon surface: molecular architecture of actin cytoskeleton and filopodial growth. Nanoscale Res Lett (2014) 0.80

Mesenchymal Stem Cells Sense Three Dimensional Type I Collagen through Discoidin Domain Receptor 1. Open Stem Cell J (2009) 0.80

LIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis. Mol Biol Cell (2014) 0.79

A toolbox to explore the mechanics of living embryonic tissues. Semin Cell Dev Biol (2016) 0.79

Signaling in cell differentiation and morphogenesis. Cold Spring Harb Perspect Biol (2012) 0.78

α-Catenin localization and sarcomere self-organization on N-cadherin adhesive patterns are myocyte contractility driven. PLoS One (2012) 0.78

Adult Stem Cell Responses to Nanostimuli. J Funct Biomater (2015) 0.78

A strain-cue hypothesis for biological network formation. J R Soc Interface (2010) 0.78

Articles by these authors

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33

Self-assembled monolayers of thiolates on metals as a form of nanotechnology. Chem Rev (2005) 10.41

Chaotic mixer for microchannels. Science (2002) 8.22

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60

Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Acc Chem Res (2002) 7.35

Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis (2003) 6.40

Reconstituting organ-level lung functions on a chip. Science (2010) 5.75

Patterned paper as a platform for inexpensive, low-volume, portable bioassays. Angew Chem Int Ed Engl (2007) 5.58

Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Anal Chem (2003) 5.51

Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest (2006) 5.48

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol (2009) 5.41

Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat Biotechnol (2002) 5.37

Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal Chem (2010) 4.88

Soft lithography for micro- and nanoscale patterning. Nat Protoc (2010) 4.82

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81

Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis. Anal Chem (2008) 4.59

New approaches to nanofabrication: molding, printing, and other techniques. Chem Rev (2005) 4.33

Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. Lancet Oncol (2012) 4.21

Three-dimensional microfluidic devices fabricated in layered paper and tape. Proc Natl Acad Sci U S A (2008) 4.12

Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06

Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett (2005) 3.90

Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63

Multigait soft robot. Proc Natl Acad Sci U S A (2011) 3.57

Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun (2009) 3.49

Microfabrication meets microbiology. Nat Rev Microbiol (2007) 3.45

A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44

Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science (2012) 3.33

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation (2008) 3.33

Cancer survival in China, 2003-2005: a population-based study. Int J Cancer (2014) 3.32

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater (2009) 3.30

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature (2013) 3.27

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol (2010) 3.25

Muscular thin films for building actuators and powering devices. Science (2007) 3.21

Mechanical control of tissue and organ development. Development (2010) 3.18

Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up. Lab Chip (2006) 3.17

Heterosexual transmission of HIV in China: a systematic review of behavioral studies in the past two decades. Sex Transm Dis (2005) 3.10

Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci U S A (2008) 3.04

Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci (2006) 2.98

Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics (2003) 2.92

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J (2005) 2.91

Swimming in circles: motion of bacteria near solid boundaries. Biophys J (2005) 2.86

From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83

HIV prevalence in China: integration of surveillance data and a systematic review. Lancet Infect Dis (2013) 2.82

FLASH: a rapid method for prototyping paper-based microfluidic devices. Lab Chip (2008) 2.78

Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun (2003) 2.71

Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol (2006) 2.62

Gradients of substrate-bound laminin orient axonal specification of neurons. Proc Natl Acad Sci U S A (2002) 2.62

The HIV epidemic in Yunnan Province, China, 1989-2007. J Acquir Immune Defic Syndr (2010) 2.61

The effect of highly active antiretroviral therapy on mortality among HIV-infected former plasma donors in China. Clin Infect Dis (2008) 2.56

Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc Res (2009) 2.54

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med (2012) 2.52

Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia. Nat Genet (2011) 2.48

Hepatitis C virus infection in former commercial plasma/blood donors in rural Shanxi Province, China: the China Integrated Programs for Research on AIDS. J Infect Dis (2005) 2.47

Micropatterning tractional forces in living cells. Cell Motil Cytoskeleton (2002) 2.45

An integrated approach to a portable and low-cost immunoassay for resource-poor settings. Angew Chem Int Ed Engl (2004) 2.45

High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol (2005) 2.44

Understanding wax printing: a simple micropatterning process for paper-based microfluidics. Anal Chem (2009) 2.43

Cell tension, matrix mechanics, and cancer development. Cancer Cell (2005) 2.42

Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol (2005) 2.39

Escherichia coli swim on the right-hand side. Nature (2005) 2.37

MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway. Circulation (2012) 2.36

Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE (2002) 2.36

Co-infection with HIV and hepatitis C virus in former plasma/blood donors: challenge for patient care in rural China. AIDS (2006) 2.36

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip (2012) 2.36

Syphilis among female sex workers in southwestern China: potential for HIV transmission. Sex Transm Dis (2006) 2.34

FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis. Cell Res (2008) 2.33

Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. Angew Chem Int Ed Engl (2005) 2.30

The 2007 Estimates for People at Risk for and Living With HIV in China: Progress and Challenges. J Acquir Immune Defic Syndr (2009) 2.27

A microfabricated array of clamps for immobilizing and imaging C. elegans. Lab Chip (2007) 2.27

Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem Rev (2008) 2.27

HIV and syphilis prevalence among men who have sex with men: a cross-sectional survey of 61 cities in China. Clin Infect Dis (2013) 2.24

Directing cell migration with asymmetric micropatterns. Proc Natl Acad Sci U S A (2005) 2.22

Nanomagnetic actuation of receptor-mediated signal transduction. Nat Nanotechnol (2007) 2.22

Microengineered physiological biomimicry: organs-on-chips. Lab Chip (2012) 2.21

Stretchable, transparent, ionic conductors. Science (2013) 2.18

Men who have sex with men and human immunodeficiency virus/sexually transmitted disease control in China. Sex Transm Dis (2006) 2.18

Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater (2012) 2.15

Soft robotics for chemists. Angew Chem Int Ed Engl (2011) 2.14

Retracted MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem (2007) 2.14

Robotic tentacles with three-dimensional mobility based on flexible elastomers. Adv Mater (2012) 2.13

Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn (2005) 2.13

Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol (2008) 2.12

Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals. BMC Bioinformatics (2003) 2.10

Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am J Physiol Cell Physiol (2003) 2.09

Physiological integration in an introduced, invasive plant increases its spread into experimental communities and modifies their structure. Am J Bot (2009) 2.07

MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation. Circulation (2010) 2.07

Electrochemical sensing in paper-based microfluidic devices. Lab Chip (2009) 2.06

Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology (2013) 2.06

Prevalence and predictors of HIV infection among female sex workers in Kaiyuan City, Yunnan Province, China. Int J Infect Dis (2008) 2.05

A paper-based multiplexed transaminase test for low-cost, point-of-care liver function testing. Sci Transl Med (2012) 2.05

Collaborative non-self recognition system in S-RNase-based self-incompatibility. Science (2010) 2.04

Components for integrated poly(dimethylsiloxane) microfluidic systems. Electrophoresis (2002) 2.01

Dependence of effective molarity on linker length for an intramolecular protein-ligand system. J Am Chem Soc (2007) 1.98