Published in Cancer Cell on September 01, 2005
The Hippo pathway: regulators and regulations. Genes Dev (2013) 4.55
Biomechanics and biophysics of cancer cells. Acta Biomater (2007) 4.35
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
Mechanotransduction gone awry. Nat Rev Mol Cell Biol (2009) 4.00
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Three-dimensional context regulation of metastasis. Clin Exp Metastasis (2008) 2.49
Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates. Proc Natl Acad Sci U S A (2007) 2.47
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med (2014) 2.47
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Sci Transl Med (2011) 2.35
Can cancer be reversed by engineering the tumor microenvironment? Semin Cancer Biol (2008) 2.07
Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol (2009) 2.05
Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One (2010) 1.70
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A (2008) 1.60
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
The effect of actin disrupting agents on contact guidance of human embryonic stem cells. Biomaterials (2007) 1.45
Acoustomotive optical coherence elastography for measuring material mechanical properties. Opt Lett (2009) 1.45
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40
Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models. Semin Cancer Biol (2008) 1.29
Mechanical homeostasis is altered in uterine leiomyoma. Am J Obstet Gynecol (2008) 1.22
A photo-modulatable material for probing cellular responses to substrate rigidity. Soft Matter (2009) 1.22
Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis. Cancer Metastasis Rev (2012) 1.17
Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II. Biomaterials (2015) 1.15
ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation. Mol Biol Cell (2012) 1.14
AFM stiffness nanotomography of normal, metaplastic and dysplastic human esophageal cells. Phys Biol (2011) 1.14
The mechanical cell. Curr Biol (2009) 1.13
Crosslinking of cell-derived 3D scaffolds up-regulates the stretching and unfolding of new extracellular matrix assembled by reseeded cells. Integr Biol (Camb) (2009) 1.08
Fibroblast cytoskeletal remodeling contributes to connective tissue tension. J Cell Physiol (2011) 1.07
Constitutive modeling of mouse carotid arteries using experimentally measured microstructural parameters. Biophys J (2012) 1.07
Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment. Biochem J (2011) 1.05
Glioma-induced remodeling of the neurovascular unit. Brain Res (2009) 1.04
Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis. PLoS One (2012) 0.99
Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation. BMC Syst Biol (2009) 0.99
Soft substrate up-regulates the interaction of STIM1 with store-operated Ca2+ channels that lead to normal epithelial cell apoptosis. Mol Biol Cell (2008) 0.99
Evaluating the viscoelastic properties of tissue from laser speckle fluctuations. Sci Rep (2012) 0.99
Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging. Mol Pharm (2010) 0.98
Mechanotransduction and fibrosis. J Biomech (2014) 0.97
Boundary stiffness regulates fibroblast behavior in collagen gels. Ann Biomed Eng (2009) 0.96
Multiscale mechanical simulations of cell compacted collagen gels. J Biomech Eng (2013) 0.95
Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties. Front Oncol (2013) 0.94
From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterials. J Mech Behav Biomed Mater (2014) 0.93
A mechanically coupled reaction-diffusion model for predicting the response of breast tumors to neoadjuvant chemotherapy. Phys Med Biol (2013) 0.91
An historical perspective on cell mechanics. Pflugers Arch (2007) 0.91
Neural regulation of cancer: from mechanobiology to inflammation. Clin Transl Immunology (2016) 0.90
Probing the mechanical contributions of the pectin matrix: insights for cell growth. Plant Signal Behav (2012) 0.89
A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?". Hear Res (2013) 0.89
Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation. Tissue Eng Part A (2014) 0.87
Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK. Cell Mol Bioeng (2013) 0.87
Stromal biomarkers in breast cancer development and progression. Clin Exp Metastasis (2012) 0.86
Soft matrix is a natural stimulator for cellular invasiveness. Mol Biol Cell (2013) 0.86
Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Lett (2013) 0.86
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. Am J Pathol (2013) 0.85
Contribution of bone tissue modulus to breast cancer metastasis to bone. Cancer Microenviron (2011) 0.85
Fluorescence-based force/tension sensors: a novel tool to visualize mechanical forces in structural proteins in live cells. Antioxid Redox Signal (2014) 0.85
Worms under Pressure: Bulk Mechanical Properties of C. elegans Are Independent of the Cuticle. Biophys J (2015) 0.84
Biomechanics of fibrous proteins of the extracellular matrix studied by Brillouin scattering. J R Soc Interface (2014) 0.84
JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4. J Biol Chem (2008) 0.84
Mechanomics: an emerging field between biology and biomechanics. Protein Cell (2014) 0.83
A mechanically-induced colon cancer cell population shows increased metastatic potential. Mol Cancer (2014) 0.83
A unifying mechanism for cancer cell death through ion channel activation by HAMLET. PLoS One (2013) 0.81
The antagonistic roles of PDGF and integrin αvβ3 in regulating ROS production at focal adhesions. Biomaterials (2013) 0.80
Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel. Med Devices (Auckl) (2010) 0.79
NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin. J Cell Biol (2015) 0.79
Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells. Commun Integr Biol (2013) 0.79
Bioprinting the Cancer Microenvironment. ACS Biomater Sci Eng (2016) 0.79
Mechanical Genomics Identifies Diverse Modulators of Bacterial Cell Stiffness. Cell Syst (2016) 0.78
Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway. PLoS One (2015) 0.78
Ultra-soft PDMS-based magnetoactive elastomers as dynamic cell culture substrata. PLoS One (2013) 0.78
The extracellular matrix microtopography drives critical changes in cellular motility and Rho A activity in colon cancer cells. Cancer Cell Int (2010) 0.78
Periodontal Biological Events Associated with Orthodontic Tooth Movement: The Biomechanics of the Cytoskeleton and the Extracellular Matrix. ScientificWorldJournal (2015) 0.78
Biocompatible Optically Transparent MEMS for Micromechanical Stimulation and Multimodal Imaging of Living Cells. Ann Biomed Eng (2014) 0.77
Nano- and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein J Nanotechnol (2016) 0.77
Daily application of low magnitude mechanical stimulus inhibits the growth of MDA-MB-231 breast cancer cells in vitro. Cancer Cell Int (2014) 0.77
Assessing the accuracy and reproducibility of modality independent elastography in a murine model of breast cancer. J Med Imaging (Bellingham) (2015) 0.76
Evolving models of tumor origin and progression. Tumour Biol (2012) 0.76
Changes in cellular mechanical properties during onset or progression of colorectal cancer. World J Gastroenterol (2016) 0.76
Validation of Ultrasound Elastography Imaging for Nondestructive Characterization of Stiffer Biomaterials. Ann Biomed Eng (2015) 0.76
Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Sci Rep (2015) 0.75
MR Imaging Biomarkers in Oncology Clinical Trials. Magn Reson Imaging Clin N Am (2016) 0.75
Identification of biomechanical force as a novel inducer of epithelial-mesenchymal transition features in mechanical stretched skin. Am J Transl Res (2015) 0.75
Quantified ultrasound elastography in the assessment of cutaneous carcinoma. Br J Radiol (2015) 0.75
Nano-mechanical Phenotype as a Promising Biomarker to Evaluate Cancer Development, Progression, and Anti-cancer Drug Efficacy. J Cancer Prev (2016) 0.75
Mechanical models for the self-organization of tubular patterns. Biomatter (2013) 0.75
AFM study shows prominent physical changes in elasticity and pericellular layer in human acute leukemic cells due to inadequate cell-cell communication. Nanotechnology (2016) 0.75
Build to understand: synthetic approaches to biology. Integr Biol (Camb) (2015) 0.75
Intermediate filament reorganization dynamically influences cancer cell alignment and migration. Sci Rep (2017) 0.75
A gene expression-based comparison of cell adhesion to extracellular matrix and RGD-terminated monolayers. Biomaterials (2015) 0.75
Biomechanical regulation of drug sensitivity in an engineered model of human tumor. Biomaterials (2017) 0.75
A potential role for genome structure in the translation of mechanical force during immune cell development. Nucleus (2016) 0.75
Spatiotemporal variation of endogenous cell-generated stresses within 3D multicellular spheroids. Sci Rep (2017) 0.75
Tumor Microenvironment on a Chip: The Progress and Future Perspective. Bioengineering (Basel) (2017) 0.75
Nucleus deformation of SaOs-2 cells on rhombic µ-pillars. J Mater Sci Mater Med (2015) 0.75
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60
Reconstituting organ-level lung functions on a chip. Science (2010) 5.75
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol (2009) 5.41
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J (2006) 4.06
Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett (2005) 3.90
Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J (2002) 3.45
A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44
Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science (2012) 3.33
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation (2008) 3.33
Mechanical control of tissue and organ development. Development (2010) 3.18
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci (2006) 2.98
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics (2003) 2.92
From 3D cell culture to organs-on-chips. Trends Cell Biol (2011) 2.83
Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun (2003) 2.71
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol (2006) 2.62
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med (2012) 2.52
Micropatterning tractional forces in living cells. Cell Motil Cytoskeleton (2002) 2.45
High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol (2005) 2.44
Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE (2002) 2.36
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip (2012) 2.36
Nanomagnetic actuation of receptor-mediated signal transduction. Nat Nanotechnol (2007) 2.22
Microengineered physiological biomimicry: organs-on-chips. Lab Chip (2012) 2.21
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn (2005) 2.13
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am J Physiol Cell Physiol (2003) 2.09
Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology (2013) 2.06
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem (2004) 1.98
Combined microfluidic-micromagnetic separation of living cells in continuous flow. Biomed Microdevices (2006) 1.96
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol (2006) 1.95
Self-assembly of three-dimensional prestressed tensegrity structures from DNA. Nat Nanotechnol (2010) 1.95
Micromagnetic-microfluidic blood cleansing device. Lab Chip (2009) 1.95
Geometric determinants of directional cell motility revealed using microcontact printing. Langmuir (2003) 1.85
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res (2009) 1.84
Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell (2011) 1.82
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem (2007) 1.81
Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci (2012) 1.76
Selective chemical treatment of cellular microdomains using multiple laminar streams. Chem Biol (2003) 1.74
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74
Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. J Cell Sci (2006) 1.72
Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB J (2008) 1.71
Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress. Am J Physiol Cell Physiol (2004) 1.68
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A (2008) 1.60
Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A (2009) 1.60
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol (2005) 1.59
Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem (2006) 1.58
Multistable and multistep dynamics in neutrophil differentiation. BMC Cell Biol (2006) 1.56
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr Biol (Camb) (2013) 1.54
Noise-driven stem cell and progenitor population dynamics. PLoS One (2008) 1.52
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb) (2013) 1.52
Forty-year journey of angiogenesis translational research. Sci Transl Med (2011) 1.51
Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci (2007) 1.51
A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. Breast Dis (2007) 1.49
Mechanobiology and developmental control. Annu Rev Cell Dev Biol (2013) 1.48
Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol (2009) 1.45
Microfabrication of human organs-on-chips. Nat Protoc (2013) 1.44
Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med (2010) 1.43
Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res (2004) 1.43
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. EMBO J (2002) 1.42
Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mech Chem Biosyst (2005) 1.40
Micromechanical control of cell and tissue development: implications for tissue engineering. Adv Drug Deliv Rev (2007) 1.36
A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip (2012) 1.35
ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem (2008) 1.34
Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun (2004) 1.29
Rheological behavior of living cells is timescale-dependent. Biophys J (2007) 1.29
Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A (2005) 1.28
Carbon metabolism-mediated myogenic differentiation. Nat Chem Biol (2010) 1.25
Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci (2007) 1.24
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) (2010) 1.23
Towards a holistic, yet gene-centered analysis of gene expression profiles: a case study of human lung cancers. J Biomed Biotechnol (2006) 1.22
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol (2005) 1.17
Rho signaling and mechanical control of vascular development. Curr Opin Hematol (2008) 1.17
Engineered in vitro disease models. Annu Rev Pathol (2015) 1.16
Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering. Tissue Eng (2006) 1.13
Investigating complexity of protein-protein interactions in focal adhesions. Biochem Biophys Res Commun (2008) 1.11
Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PLoS One (2008) 1.10
Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility. Angiogenesis (2003) 1.10
A computational tensegrity model predicts dynamic rheological behaviors in living cells. Ann Biomed Eng (2004) 1.09
A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis. Sci Signal (2012) 1.09
Multizone paper platform for 3D cell cultures. PLoS One (2011) 1.09
A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent. Exp Cell Res (2002) 1.08
Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A (2013) 1.08
Tensegrity, cellular biophysics, and the mechanics of living systems. Rep Prog Phys (2014) 1.06
Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J (2009) 1.06
Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc (2009) 1.06
Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS One (2011) 1.06
Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation. Biochem Biophys Res Commun (2002) 1.05
Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation (2008) 1.05
Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching. J Cell Biochem (2006) 1.04
Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta Biomater (2005) 1.04
A multi-modular tensegrity model of an actin stress fiber. J Biomech (2008) 1.03
Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice. Sci Transl Med (2014) 1.03
Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol (2005) 1.03
Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02
Nogo-A is a negative regulator of CNS angiogenesis. Proc Natl Acad Sci U S A (2013) 1.02
A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP). Biophys Chem (2005) 1.01
Tools to study cell mechanics and mechanotransduction. Methods Cell Biol (2007) 1.01
Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions. J Cell Biochem (2006) 1.00
Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. J Surg Res (2002) 1.00
Synaptic reorganization in scaled networks of controlled size. J Neurosci (2007) 0.97