Randall K Holmes

Author PubWeight™ 43.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell 2003 2.22
2 Structural basis for the activation of cholera toxin by human ARF6-GTP. Science 2005 1.66
3 Structural characterization of the SARS-coronavirus spike S fusion protein core. J Biol Chem 2004 1.48
4 Cellular internalization of cytolethal distending toxin: a new end to a known pathway. Cell Microbiol 2005 1.32
5 An allelic exchange system for compliant genetic manipulation of the select agents Burkholderia pseudomallei and Burkholderia mallei. Gene 2008 1.26
6 Identification of a DtxR-regulated operon that is essential for siderophore-dependent iron uptake in Corynebacterium diphtheriae. J Bacteriol 2002 1.25
7 Conformational instability of the cholera toxin A1 polypeptide. J Mol Biol 2007 1.22
8 Transfer of the cholera toxin A1 polypeptide from the endoplasmic reticulum to the cytosol is a rapid process facilitated by the endoplasmic reticulum-associated degradation pathway. Infect Immun 2002 1.21
9 Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules. Infect Immun 2008 1.20
10 Molecular characterization of Rab11-FIP3 binding to ARF GTPases. Eur J Cell Biol 2007 1.14
11 Construction and characterization of transposon insertion mutations in Corynebacterium diphtheriae that affect expression of the diphtheria toxin repressor (DtxR). J Bacteriol 2002 1.12
12 Structural and functional studies on the interaction of GspC and GspD in the type II secretion system. PLoS Pathog 2011 1.12
13 Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. J Biol Chem 2004 1.10
14 Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism. Biochemistry 2004 1.09
15 Inhibition of endoplasmic reticulum-associated degradation in CHO cells resistant to cholera toxin, Pseudomonas aeruginosa exotoxin A, and ricin. Infect Immun 2002 1.04
16 The cholera toxin A1(3) subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosol. Infect Immun 2006 1.02
17 Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions. J Mol Biol 2004 1.01
18 Functional studies of the Mycobacterium tuberculosis iron-dependent regulator. J Biol Chem 2004 1.01
19 Bacteriophage-based vectors for site-specific insertion of DNA in the chromosome of Corynebacteria. Gene 2006 1.01
20 A class of mutant CHO cells resistant to cholera toxin rapidly degrades the catalytic polypeptide of cholera toxin and exhibits increased endoplasmic reticulum-associated degradation. Traffic 2003 1.00
21 Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clin Vaccine Immunol 2012 0.98
22 Analysis of genes that encode DtxR-like transcriptional regulators in pathogenic and saprophytic corynebacterial species. Infect Immun 2004 0.97
23 Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis. Infect Immun 2004 0.96
24 Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry 2007 0.95
25 Contribution of subdomain structure to the thermal stability of the cholera toxin A1 subunit. Biochemistry 2010 0.93
26 Transcription of the contiguous sigB, dtxR, and galE genes in Corynebacterium diphtheriae: evidence for multiple transcripts and regulation by environmental factors. J Bacteriol 2006 0.92
27 Vesicular transport is not required for the cytoplasmic pool of cholera toxin to interact with the stimulatory alpha subunit of the heterotrimeric g protein. Infect Immun 2004 0.90
28 A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway. MBio 2012 0.89
29 Mutational analysis of ganglioside GM(1)-binding ability, pentamer formation, and epitopes of cholera toxin B (CTB) subunits and CTB/heat-labile enterotoxin B subunit chimeras. Infect Immun 2002 0.87
30 Cholera holotoxin assembly requires a hydrophobic domain at the A-B5 interface: mutational analysis and development of an in vitro assembly system. Infect Immun 2003 0.87
31 Characterization of fluorescent chimeras of cholera toxin and Escherichia coli heat-labile enterotoxins produced by use of the twin arginine translocation system. Infect Immun 2005 0.85
32 Type II heat-labile enterotoxins from 50 diverse Escherichia coli isolates belong almost exclusively to the LT-IIc family and may be prophage encoded. PLoS One 2012 0.85
33 ADP-ribosylation factor 6 acts as an allosteric activator for the folded but not disordered cholera toxin A1 polypeptide. Mol Microbiol 2014 0.84
34 Characterization of OxyR as a negative transcriptional regulator that represses catalase production in Corynebacterium diphtheriae. PLoS One 2012 0.83
35 Evaluation of TcpF-A2-CTB chimera and evidence of additive protective efficacy of immunizing with TcpF and CTB in the suckling mouse model of cholera. PLoS One 2012 0.81
36 Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker. PLoS One 2011 0.80
37 Immunization with cholera toxin B subunit induces high-level protection in the suckling mouse model of cholera. PLoS One 2013 0.78
38 Analysis of truncated variants of the iron dependent transcriptional regulators from Corynebacterium diphtheriae and Mycobacterium tuberculosis. FEMS Microbiol Lett 2005 0.77
39 Dissection of the fusion machine of SARS-coronavirus. Adv Exp Med Biol 2006 0.77
40 Evaluation of heat-labile enterotoxins type IIa and type IIb in the pathogenicity of enterotoxigenic Escherichia coli for neonatal pigs. Vet Microbiol 2012 0.77
41 Purification and structural characterization of siderophore (corynebactin) from Corynebacterium diphtheriae. PLoS One 2012 0.76
42 Development and use of a selectable, broad-host-range reporter transposon for identifying environmentally regulated promoters in bacteria. FEMS Microbiol Lett 2009 0.75
43 Heat-Labile Enterotoxins. Ecosal Plus 2006 0.75