Published in Cell Microbiol on July 01, 2005
Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. J Virol (2006) 1.62
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Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response. Cell Microbiol (2012) 1.00
A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage. PLoS One (2008) 1.00
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Cholesterol depletion reduces entry of Campylobacter jejuni cytolethal distending toxin and attenuates intoxication of host cells. Infect Immun (2011) 0.91
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Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins. PLoS One (2015) 0.78
Dynamic Duo-The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin. Toxins (Basel) (2016) 0.76
Crystallization of Escherichia coli CdtB, the biologically active subunit of cytolethal distending toxin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.76
Cytolethal Distending Toxin From Campylobacter jejuni Requires the Cytoskeleton for Toxic Activity. Jundishapur J Microbiol (2016) 0.75
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Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury. PLoS Pathog (2017) 0.75
Molecular Mechanisms and Potential Clinical Applications of Campylobacter jejuni Cytolethal Distending Toxin. Front Cell Infect Microbiol (2016) 0.75
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections. Front Cell Infect Microbiol (2017) 0.75
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97
The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell (2004) 8.89
A membrane protein required for dislocation of misfolded proteins from the ER. Nature (2004) 5.39
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature (2008) 5.15
Haploid genetic screens in human cells identify host factors used by pathogens. Science (2009) 4.91
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature (2002) 3.93
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell (2007) 3.49
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43
Sortagging: a versatile method for protein labeling. Nat Chem Biol (2007) 3.39
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 3.01
A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol (2006) 2.94
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci (2012) 2.90
The known unknowns of antigen processing and presentation. Nat Rev Immunol (2008) 2.85
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem (2004) 2.75
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure (2006) 2.56
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54
Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med (2002) 2.53
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity (2011) 2.50
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Mol Cell (2005) 2.43
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. J Infect Dis (2008) 2.40
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2008) 2.38
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol (2011) 2.23
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem (2003) 2.22
Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell (2003) 2.22
A role for N-glycanase in the cytosolic turnover of glycoproteins. EMBO J (2003) 2.18
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol (2006) 2.13
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. J Am Chem Soc (2007) 2.10
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A (2004) 2.09
Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. J Invest Dermatol (2006) 2.05
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol (2008) 2.03
Membrane ruffling and macropinocytosis in A431 cells require cholesterol. J Cell Sci (2002) 2.02
Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol (2012) 2.00
Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol (2007) 1.90
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol (2005) 1.85
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The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Adv Immunol (2006) 1.78
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods (2005) 1.78
Caveolae: anchored, multifunctional platforms in the lipid ocean. Trends Cell Biol (2003) 1.75
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell (2007) 1.75
Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science (2010) 1.74
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature (2006) 1.73
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J (2009) 1.72
Identification of proteins associated with murine cytomegalovirus virions. J Virol (2004) 1.72
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J Neurochem (2005) 1.71
Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection. Cell Host Microbe (2009) 1.69
Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol (2011) 1.68
Structural basis for the activation of cholera toxin by human ARF6-GTP. Science (2005) 1.66
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J Exp Med (2002) 1.64
Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity. J Am Chem Soc (2009) 1.63
Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. J Virol (2006) 1.62
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A (2004) 1.59
Making and breaking peptide bonds: protein engineering using sortase. Angew Chem Int Ed Engl (2011) 1.58
Screen for ISG15-crossreactive deubiquitinases. PLoS One (2007) 1.57
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J (2007) 1.56
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One (2008) 1.55
Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding. J Biol Chem (2002) 1.54
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J (2004) 1.53
Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9. Eur J Immunol (2011) 1.52
High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. J Virol (2006) 1.52
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proc Natl Acad Sci U S A (2008) 1.51
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol (2005) 1.50
Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J Immunol (2002) 1.50
Structural characterization of the SARS-coronavirus spike S fusion protein core. J Biol Chem (2004) 1.48
Identification of host cell factors required for intoxication through use of modified cholera toxin. J Cell Biol (2011) 1.47
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem (2003) 1.46
Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell (2004) 1.44
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A (2008) 1.43
Site-specific protein labeling via sortase-mediated transpeptidation. Curr Protoc Protein Sci (2009) 1.43
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunol Rev (2005) 1.43
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chem Biol (2004) 1.42
Quality and quantity control at the endoplasmic reticulum. Curr Opin Cell Biol (2010) 1.42
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. Cancer Res (2005) 1.39
Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J (2002) 1.39
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem (2005) 1.39
Preparation of unnatural N-to-N and C-to-C protein fusions. Proc Natl Acad Sci U S A (2012) 1.38
Granulin is a soluble cofactor for toll-like receptor 9 signaling. Immunity (2011) 1.36
Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments. J Virol (2002) 1.36
Preferred in vivo ubiquitination sites. Bioinformatics (2004) 1.36
Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim Biophys Acta (2013) 1.35
The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens. J Virol (2008) 1.35
Lipid modification of proteins through sortase-catalyzed transpeptidation. J Am Chem Soc (2008) 1.34
Enzymatic blockade of the ubiquitin-proteasome pathway. PLoS Biol (2011) 1.33
A closer look at proteolysis and MHC-class-II-restricted antigen presentation. Curr Opin Immunol (2002) 1.32
A straight path to circular proteins. J Biol Chem (2009) 1.31
The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA. Cell Microbiol (2003) 1.31
Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Mol Microbiol (2006) 1.30
Revised nomenclature of Clostridium difficile toxins and associated genes. J Med Microbiol (2005) 1.28
The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. J Virol (2002) 1.28
Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proc Natl Acad Sci U S A (2011) 1.28