Published in Proc Natl Acad Sci U S A on August 21, 2002
The sodium phosphate cotransporter family SLC34. Pflugers Arch (2003) 2.13
A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc. Am J Physiol Renal Physiol (2008) 1.81
Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. J Clin Invest (2007) 1.57
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands. Mol Cell Biol (2007) 1.52
Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis. J Biol Chem (2012) 1.52
Regulation of phosphate transport in proximal tubules. Pflugers Arch (2008) 1.33
NHERF1/EBP50 is a new marker in colorectal cancer. Neoplasia (2010) 1.22
The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner. J Cell Biol (2010) 1.19
A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization. Mol Biol Cell (2010) 1.15
NaPi-IIa and interacting partners. J Physiol (2005) 1.11
Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. Am J Physiol Renal Physiol (2008) 1.10
The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. J Physiol (2005) 1.08
Expression and regulation of the renal Na/phosphate cotransporter NaPi-IIa in a mouse model deficient for the PDZ protein PDZK1. Pflugers Arch (2004) 1.08
Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. J Biol Chem (2010) 1.01
Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters. J Biol Chem (2011) 1.00
Regulation of organic cation transport. Pflugers Arch (2004) 0.98
PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. Am J Physiol Renal Physiol (2009) 0.97
The SLC34 family of sodium-dependent phosphate transporters. Pflugers Arch (2013) 0.96
A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation. J Biol Chem (2009) 0.96
NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. Neoplasia (2014) 0.95
Increased renal dopamine and acute renal adaptation to a high-phosphate diet. Am J Physiol Renal Physiol (2011) 0.94
Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells. J Biol Chem (2010) 0.93
Protein/protein interactions (PDZ) in proximal tubules. J Membr Biol (2005) 0.91
Na+-H+ exchanger regulatory factor 1 is a PDZ scaffold for the astroglial glutamate transporter GLAST. Glia (2007) 0.91
Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. J Biol Chem (2011) 0.90
Beyond the brush border: NHERF4 blazes new NHERF turf. J Physiol (2005) 0.90
Structural basis for NHERF1 PDZ domain binding. Biochemistry (2012) 0.90
Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. Am J Physiol Renal Physiol (2010) 0.87
Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3. Cell Physiol Biochem (2003) 0.87
The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells. Mol Endocrinol (2009) 0.87
Shank2 redistributes with NaPilla during regulated endocytosis. Am J Physiol Cell Physiol (2010) 0.86
Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics (2010) 0.85
Shank2 contributes to the apical retention and intracellular redistribution of NaPiIIa in OK cells. Am J Physiol Cell Physiol (2013) 0.85
Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters. Pflugers Arch (2010) 0.85
Secretory carrier membrane protein 2 regulates exocytic insertion of NKCC2 into the cell membrane. J Biol Chem (2011) 0.83
A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism. PLoS One (2012) 0.83
Liver X receptor-activating ligands modulate renal and intestinal sodium-phosphate transporters. Kidney Int (2011) 0.82
Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP. Pflugers Arch (2010) 0.81
Phosphaturia as a promising predictor of recurrent stone formation in patients with urolithiasis. Korean J Urol (2010) 0.81
GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes. Am J Physiol Renal Physiol (2009) 0.80
Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate. Biochem J (2004) 0.78
PTH-mediated inhibition of the renal transport of phosphate. Exp Cell Res (2012) 0.77
NaPi-IIa interacting proteins and regulation of renal reabsorption of phosphate. Urol Res (2010) 0.77
Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter. Am J Physiol Renal Physiol (2015) 0.77
The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation. Mol Biol Cell (2015) 0.75
Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport. J Biol Chem (2016) 0.75
A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium. Nat Genet (1995) 4.61
Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J Cell Biol (1997) 4.32
A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature (1999) 3.95
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A (1998) 3.24
cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proc Natl Acad Sci U S A (1997) 3.19
Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells. J Cell Biol (1983) 3.03
PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J Clin Invest (1999) 2.67
Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. J Clin Invest (1995) 2.65
Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol Rev (2000) 2.17
Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell (2000) 2.15
Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am J Physiol (1994) 1.83
Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem (2000) 1.73
A PDZ-interacting domain in CFTR is an apical membrane polarization signal. J Clin Invest (1999) 1.73
X-linked hypophosphataemia: a homologous disorder in humans and mice. Nephrol Dial Transplant (1999) 1.53
Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. Lab Invest (1998) 1.52
Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I. Proc Natl Acad Sci U S A (2000) 1.47
Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions. J Biol Chem (2000) 1.41
The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. J Biol Chem (2000) 1.39
NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry (2000) 1.37
The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membrane. J Biol Chem (2000) 1.36
PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest (1999) 1.32
Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. Am J Physiol Cell Physiol (2001) 1.32
Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors. J Am Soc Nephrol (1999) 1.27
Luminal and contraluminal action of 1-34 and 3-34 PTH peptides on renal type IIa Na-P(i) cotransporter. Am J Physiol Renal Physiol (2000) 1.18
Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. Am J Physiol Renal Physiol (2000) 1.15
Identification of a new gene product (diphor-1) regulated by dietary phosphate. Am J Physiol (1997) 1.14
Parathyroid hormone-dependent degradation of type II Na+/Pi cotransporters. J Biol Chem (1997) 1.10
Studies on the topology of the renal type II NaPi-cotransporter. Pflugers Arch (1999) 1.05
Molecular determinants for apical expression of the renal type IIa Na+/Pi-cotransporter. Pflugers Arch (2001) 1.04
Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. Am J Physiol Renal Physiol (2001) 1.00
Cellular mechanisms involved in the acute adaptation of OK cell Na/Pi-cotransport to high- or low-Pi medium. Pflugers Arch (1998) 0.97
The cell biology of ion pumps: sorting and regulation. Eur J Cell Biol (2000) 0.90
Asymmetrical targeting of type II Na-P(i) cotransporters in renal and intestinal epithelial cell lines. Am J Physiol Renal Physiol (2000) 0.89
Regulation of the renal type IIa Na/Pi cotransporter by cGMP. Pflugers Arch (2001) 0.88
Effects of phosphate intake on distribution of type II Na/Pi cotransporter mRNA in rat kidney. Kidney Int (1999) 0.88
Regulation of expression of type II sodium-phosphate cotransporters by protein kinases A and C. Am J Physiol (1998) 0.86
The sodium phosphate cotransporter family SLC34. Pflugers Arch (2003) 2.13
The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am J Physiol Renal Physiol (2008) 2.12
Regulation of ion transport by the NHERF family of PDZ proteins. Physiology (Bethesda) (2004) 1.74
PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int (2003) 1.64
Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol (2003) 1.64
Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J Biol Chem (2003) 1.60
Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. J Biol Chem (2007) 1.59
The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Mol Biol Cell (2007) 1.53
Phosphate transporters: a tale of two solute carrier families. Am J Physiol Renal Physiol (2007) 1.50
Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int (2011) 1.40
Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+/H+ exchanger regulatory factor-1 complexes. Am J Physiol Cell Physiol (2005) 1.36
Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. Am J Physiol Cell Physiol (2003) 1.35
PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int (2003) 1.35
Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements. Am J Physiol Cell Physiol (2007) 1.33
The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch (2003) 1.30
Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest (2009) 1.30
Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC). Proc Natl Acad Sci U S A (2006) 1.30
Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. J Biol Chem (2004) 1.29
Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2005) 1.25
Forging the link between structure and function of electrogenic cotransporters: the renal type IIa Na+/Pi cotransporter as a case study. Prog Biophys Mol Biol (2002) 1.23
Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter. Proc Natl Acad Sci U S A (2005) 1.23
Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. Am J Physiol Renal Physiol (2006) 1.18
Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system. Mol Cell Proteomics (2008) 1.18
Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. Am J Physiol Renal Physiol (2005) 1.18
Regulation of Na/Pi transporter in the proximal tubule. Annu Rev Physiol (2002) 1.17
Isolation of renal proximal tubular brush-border membranes. Nat Protoc (2007) 1.17
The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. J Am Soc Nephrol (2002) 1.14
Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Res (2008) 1.14
Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. J Biol Chem (2007) 1.11
Activation of dopamine D1-like receptors induces acute internalization of the renal Na+/phosphate cotransporter NaPi-IIa in mouse kidney and OK cells. Am J Physiol Renal Physiol (2004) 1.11
Substrate interactions in the human type IIa sodium-phosphate cotransporter (NaPi-IIa). Am J Physiol Renal Physiol (2004) 1.11
Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. Am J Physiol Renal Physiol (2008) 1.10
Expression and regulation of the renal Na/phosphate cotransporter NaPi-IIa in a mouse model deficient for the PDZ protein PDZK1. Pflugers Arch (2004) 1.08
Intestinal phosphate absorption and the effect of vitamin D: a comparison of rats with mice. Exp Physiol (2006) 1.07
ClC-5: role in endocytosis in the proximal tubule. Am J Physiol Renal Physiol (2005) 1.07
Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter. Am J Physiol Renal Physiol (2002) 1.06
Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice. Pflugers Arch (2007) 1.06
Intestinal and renal adaptation to a low-Pi diet of type II NaPi cotransporters in vitamin D receptor- and 1alphaOHase-deficient mice. Am J Physiol Cell Physiol (2005) 1.05
Voltage clamp fluorometric measurements on a type II Na+-coupled Pi cotransporter: shedding light on substrate binding order. J Gen Physiol (2006) 1.05
Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med (2013) 1.05
Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. Am J Physiol Cell Physiol (2006) 1.01
Acute regulation of Na/H exchanger NHE3 by adenosine A(1) receptors is mediated by calcineurin homologous protein. J Biol Chem (2003) 1.00
Acute and chronic changes in cholesterol modulate Na-Pi cotransport activity in OK cells. Am J Physiol Renal Physiol (2005) 1.00
Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J Am Soc Nephrol (2007) 0.98
Novel aspects in regulated expression of the renal type IIa Na/Pi-cotransporter. Kidney Int Suppl (2004) 0.98
Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Am J Physiol Renal Physiol (2002) 0.98
Involvement of the MAPK-kinase pathway in the PTH-mediated regulation of the proximal tubule type IIa Na+/Pi cotransporter in mouse kidney. Pflugers Arch (2003) 0.98
Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate. Cell Physiol Biochem (2007) 0.98
NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem (2010) 0.98
Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). J Am Soc Nephrol (2004) 0.98
Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption. Pflugers Arch (2008) 0.97
Lithium interactions with Na+-coupled inorganic phosphate cotransporters: insights into the mechanism of sequential cation binding. Am J Physiol Cell Physiol (2011) 0.97
Functional characterization of two naturally occurring mutations in the human sodium-phosphate cotransporter type IIa. J Bone Miner Res (2003) 0.96
Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells. J Am Soc Nephrol (2005) 0.96
Nerve growth factor-regulated emergence of functional delta-opioid receptors. J Neurosci (2010) 0.96
Mapping conformational changes of a type IIb Na+/Pi cotransporter by voltage clamp fluorometry. J Biol Chem (2006) 0.96
Integrated compensatory network is activated in the absence of NCC phosphorylation. J Clin Invest (2015) 0.96
The SLC34 family of sodium-dependent phosphate transporters. Pflugers Arch (2013) 0.96
Transport function of the renal type IIa Na+/P(i) cotransporter is codetermined by residues in two opposing linker regions. J Gen Physiol (2002) 0.95
Na+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions. Am J Physiol Cell Physiol (2003) 0.95
PDZ interactions and proximal tubular phosphate reabsorption. Am J Physiol Renal Physiol (2004) 0.95
Structure-function relations of the first and fourth predicted extracellular linkers of the type IIa Na+/Pi cotransporter: I. Cysteine scanning mutagenesis. J Gen Physiol (2004) 0.94
kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. J Biol Chem (2004) 0.94
Substrate interactions of the electroneutral Na+-coupled inorganic phosphate cotransporter (NaPi-IIc). J Physiol (2009) 0.93