Published in J Immunol on September 01, 2002
Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nat Immunol (2009) 1.97
Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. Immunology (2004) 1.96
Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid. Proc Natl Acad Sci U S A (2004) 1.66
Antimicrobial peptides: natural effectors of the innate immune system. Semin Immunopathol (2007) 1.43
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci (2003) 1.39
Innate immune defences in the human endometrium. Reprod Biol Endocrinol (2003) 1.35
The role of antimicrobial peptides at the ocular surface. Ophthalmic Res (2008) 1.32
Antiviral mechanisms of human defensins. J Mol Biol (2013) 1.22
The immunobiology of cholangiocytes. Immunol Cell Biol (2008) 1.18
Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease. Invest Ophthalmol Vis Sci (2003) 1.09
Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection. Infect Immun (2004) 1.07
Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3. Histochem Cell Biol (2008) 1.07
Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res (2007) 1.06
Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice. PLoS Genet (2013) 1.04
Antimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2alpha, HE2beta1 and HE2beta2. Reprod Biol Endocrinol (2004) 1.04
Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf (2004) 1.00
Identification, characterization, and evolution of a primate beta-defensin gene cluster. Genes Immun (2005) 1.00
Peptide-based Antifungal Therapies against Emerging Infections. Drugs Future (2010) 0.97
Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. J Clin Microbiol (2004) 0.92
Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells. Histochem Cell Biol (2010) 0.90
Expressed sequence tag profiling identifies developmental and anatomic partitioning of gene expression in the mouse prostate. Genome Biol (2003) 0.90
Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.87
Inducibility of the endogenous antibiotic peptide beta-defensin 2 is impaired in patients with severe sepsis. Crit Care (2007) 0.87
Expression of CRAMP via PGN-TLR-2 and of alpha-defensin-3 via CpG-ODN-TLR-9 in corneal fibroblasts. Br J Ophthalmol (2006) 0.86
The potential role of increasing the release of mouse β- defensin-14 in the treatment of osteomyelitis in mice: a primary study. PLoS One (2014) 0.86
The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword. Front Immunol (2014) 0.85
Identification, cloning and functional characterization of novel sperm associated antigen 11 (SPAG11) isoforms in the rat. Reprod Biol Endocrinol (2006) 0.84
Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus). Reprod Biol Endocrinol (2006) 0.84
Novel partners of SPAG11B isoform D in the human male reproductive tract. Biol Reprod (2009) 0.81
Genomic organization, molecular diversification, and evolution of antimicrobial peptide myticin-C genes in the mussel (Mytilus galloprovincialis). PLoS One (2011) 0.81
Expression of beta defensins in ocular surface tissue of experimentally developed allergic conjunctivitis mouse model. Jpn J Ophthalmol (2006) 0.80
Sperm-associated antigen 11A is expressed exclusively in the principal cells of the mouse caput epididymis in an androgen-dependent manner. Reprod Biol Endocrinol (2013) 0.80
Modulation of neutrophil apoptosis by antimicrobial peptides. ISRN Microbiol (2012) 0.80
Molecular cloning and characterization of three beta-defensins from canine testes. Infect Immun (2005) 0.80
Novel phenotype of mouse spermatozoa following deletion of nine β-defensin genes. Asian J Androl (2015) 0.79
The role of human beta-defensin-2 in bone. J Anat (2008) 0.78
Evidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the β-defensin-2 gene. Genome Biol Evol (2014) 0.78
Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes. PLoS One (2010) 0.76
Androgenic regulation of beta-defensins in the mouse epididymis. Reprod Biol Endocrinol (2014) 0.76
Effect of Rabbit Epididymal Antimicrobial Peptide, REHbβP, on LPS-Induced Proinflammatory Cytokine Responses in Human Vaginal Cells In Vitro. Int J Pept (2012) 0.75
Expressions of Antimicrobial Peptides LL-37, Human Beta Defensin-2 and -3 in the Lesions of Cutaneous Tuberculosis and Tuberculids. Chin Med J (Engl) (2016) 0.75
Defending sperm function. PLoS Genet (2013) 0.75
Rattusin structure reveals a novel defensin scaffold formed by intermolecular disulfide exchanges. Sci Rep (2017) 0.75
ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat. Biomed Rep (2017) 0.75
Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A (2004) 6.33
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell (2009) 5.19
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature (2002) 2.32
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc Natl Acad Sci U S A (2007) 2.30
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol (2008) 2.24
Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol (2007) 2.22
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol (2008) 2.07
Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo. Circ Res (2002) 1.87
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest (2008) 1.69
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. Am J Physiol Cell Physiol (2007) 1.65
VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. J Cell Sci (2005) 1.61
Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy. PLoS One (2007) 1.60
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell (2005) 1.59
Transcriptional activity of Pax3 is co-activated by TAZ. Biochem Biophys Res Commun (2005) 1.57
Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men. Hypertens Res (2010) 1.57
A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem (2004) 1.56
Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory. Science (2011) 1.53
Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. J Biol Chem (2002) 1.52
Endothelin-1 regulates the dorsoventral branchial arch patterning in mice. Mech Dev (2004) 1.52
Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement. Development (2011) 1.50
Prevalence of metabolic syndrome in the general Japanese population in 2000. J Atheroscler Thromb (2006) 1.50
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene. Circ Res (2002) 1.49
Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. EMBO J (2013) 1.48
Increased plasma interleukin-6 is associated with the pathogenesis of obstructive sleep apnea syndrome. Chest (2004) 1.47
Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn (2008) 1.45
Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells. Cancer Res (2009) 1.45
GPR98/Gpr98 gene is involved in the regulation of human and mouse bone mineral density. J Clin Endocrinol Metab (2012) 1.44
Retracted Effect of nasal continuous positive airway pressure treatment on plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome: roles of nocturnal hypoxia and oxidant stress. Hypertens Res (2007) 1.43
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci (2002) 1.42
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem (2005) 1.40
Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. EMBO Rep (2008) 1.40
Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J Appl Physiol (1985) (2002) 1.38
Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1. Dev Biol (2007) 1.37
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat Med (2002) 1.35
Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells. Mol Biol Cell (2009) 1.33
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest (2004) 1.31
Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest (2010) 1.27
Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res (2005) 1.27
Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses. J Immunol (2005) 1.26
SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. J Atheroscler Thromb (2010) 1.25
Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circ Res (2006) 1.24
Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes. Circ Res (2005) 1.24
The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. Cell Metab (2013) 1.24
Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis. Cancer Res (2012) 1.23
An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A (2008) 1.22
Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth. Cancer Res (2009) 1.20
Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. Eur J Pharmacol (2006) 1.16
Platelet-activating factor receptor. Prostaglandins Other Lipid Mediat (2002) 1.16
TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer. Mol Endocrinol (2012) 1.15
Calpain 6 is involved in microtubule stabilization and cytoskeletal organization. Mol Cell Biol (2007) 1.14
Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin. J Biol Chem (2011) 1.14
Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway. Arterioscler Thromb Vasc Biol (2010) 1.12
Association of polypharmacy with fall risk among geriatric outpatients. Geriatr Gerontol Int (2011) 1.12
Low testosterone level is an independent determinant of endothelial dysfunction in men. Hypertens Res (2007) 1.11
Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer. Int J Cancer (2011) 1.11
Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. Oncogene (2005) 1.10
Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature. Cancer Sci (2008) 1.10
Small intestinal intussusceptions caused by percutaneous endoscopic jejunostomy tube placement. J Am Geriatr Soc (2007) 1.09
Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. Biochem Biophys Res Commun (2009) 1.09
Detection of the archetypal regulatory region of JC virus from the tonsil tissue of patients with tonsillitis and tonsilar hypertrophy. J Neurovirol (2004) 1.07
Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1. Exp Mol Med (2009) 1.07
Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature. Arterioscler Thromb Vasc Biol (2003) 1.07
Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. J Cell Biol (2013) 1.06
Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem (2008) 1.06
Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. J Biol Chem (2004) 1.05
Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. Arterioscler Thromb Vasc Biol (2011) 1.04
Increased C-reactive protein and increased plasma interleukin-6 may synergistically affect the progression of coronary atherosclerosis in obstructive sleep apnea syndrome. Circulation (2003) 1.04
Tumor necrosis factor-alpha enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming growth factor-beta1. Exp Lung Res (2010) 1.03
Serum lipid survey and its recent trend in the general Japanese population in 2000. J Atheroscler Thromb (2005) 1.03
The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus. Biochem Biophys Res Commun (2007) 1.03
Simultaneous stimulation with TGF-β1 and TNF-α induces epithelial mesenchymal transition in bronchial epithelial cells. Int Arch Allergy Immunol (2010) 1.03
Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors. Atherosclerosis (2009) 1.02
Toward the realization of a better aged society: messages from gerontology and geriatrics. Geriatr Gerontol Int (2012) 1.02
Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci U S A (2008) 1.01
Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development (2008) 1.01
The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases. Sci Signal (2014) 1.01
Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK. Evid Based Complement Alternat Med (2012) 1.01
Estrogen-responsive finger protein as a new potential biomarker for breast cancer. Clin Cancer Res (2005) 1.00
Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. Int J Cancer (2010) 1.00
An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by microRNAs in lung cancer cells. PLoS One (2013) 1.00
Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor. Biochem Biophys Res Commun (2006) 0.99
A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2002) 0.99
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem (2013) 0.99
Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice. Am J Respir Crit Care Med (2009) 0.99
Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A. FEBS Lett (2004) 0.99
Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity. J Biol Chem (2010) 0.99
Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J Recept Signal Transduct Res (2003) 0.98
Association of estrogen receptor alpha and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cells. Cancer Res (2009) 0.98