Published in J Neurosci on January 01, 2002
Allele-specific silencing of dominant disease genes. Proc Natl Acad Sci U S A (2003) 3.00
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol (2007) 2.09
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol (2006) 1.68
Autophagic dysfunction in mucolipidosis type IV patients. Hum Mol Genet (2008) 1.66
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A (2002) 1.66
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A (2006) 1.44
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest (2008) 1.37
Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice. Am J Pathol (2007) 1.26
Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. EMBO J (2007) 1.22
Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. Am J Pathol (2008) 1.21
Knock-out and transgenic mouse models of tauopathies. Neurobiol Aging (2007) 1.14
Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism? Biochim Biophys Acta (2007) 1.13
Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol (2004) 1.11
RNAi: a potential new class of therapeutic for human genetic disease. Hum Genet (2011) 1.10
Macroautophagy is defective in mucolipin-1-deficient mouse neurons. Neurobiol Dis (2010) 1.07
Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol (2005) 1.05
Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases. Hum Mol Genet (2010) 1.03
Recent rodent models for Alzheimer's disease: clinical implications and basic research. J Neural Transm (Vienna) (2011) 0.99
Fragmentation of the Golgi apparatus induced by the overexpression of wild-type and mutant human tau forms in neurons. Am J Pathol (2005) 0.96
Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation. Genes Brain Behav (2008) 0.95
An update of animal models of Alzheimer disease with a reevaluation of plaque depositions. Exp Neurobiol (2013) 0.95
HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proc Natl Acad Sci U S A (2013) 0.92
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. PLoS One (2012) 0.91
Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol (2006) 0.91
Physiological and pathological phosphorylation of tau by Cdk5. Front Mol Neurosci (2014) 0.91
Neurogenesis in Alzheimer's disease. J Anat (2011) 0.90
The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy. PLoS One (2015) 0.89
Tau alternative splicing and frontotemporal dementia. Alzheimer Dis Assoc Disord (2005) 0.88
Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. Curr Pharm Des (2012) 0.88
Genetic rodent models of amyotrophic lateral sclerosis. J Biomed Biotechnol (2011) 0.87
Gene-environment interaction research and transgenic mouse models of Alzheimer's disease. Int J Alzheimers Dis (2010) 0.85
Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1. Am J Pathol (2006) 0.84
Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PLoS One (2013) 0.83
Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model. Hum Mol Genet (2015) 0.83
Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss. Sci Rep (2016) 0.81
Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies? Oxid Med Cell Longev (2015) 0.80
Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration. Cell Mol Life Sci (2014) 0.80
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nat Commun (2015) 0.79
Neurogenesis in Alzheimer´s disease: a realistic alternative to neuronal degeneration? Curr Signal Transduct Ther (2011) 0.78
Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Mol Neurobiol (2011) 0.78
Electroacupuncture Analgesia Is Improved by Adenoviral Gene Transfer of Dopamine Beta-hydroxylase into the Hypothalamus of Rats. Korean J Physiol Pharmacol (2013) 0.78
Neurodegenerative tauopathy in the worm. Proc Natl Acad Sci U S A (2003) 0.77
Direct interaction between selenoprotein P and tubulin. Int J Mol Sci (2014) 0.76
Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model. PLoS One (2014) 0.76
Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage. Front Aging Neurosci (2017) 0.75
Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A (2004) 6.33
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell (2003) 3.96
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron (2013) 3.27
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nat Neurosci (2007) 2.90
Digital atlasing and standardization in the mouse brain. PLoS Comput Biol (2011) 2.53
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell (2002) 2.53
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Aluminum induces tau aggregation in vitro but not in vivo. J Alzheimers Dis (2007) 2.10
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons. J Neurosci (2005) 1.86
Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron (2002) 1.82
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice. Hum Mol Genet (2002) 1.73
Granular tau oligomers as intermediates of tau filaments. Biochemistry (2007) 1.67
In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem (2005) 1.66
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A (2002) 1.66
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem (2003) 1.64
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J Neurosci (2004) 1.63
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci (2007) 1.58
Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. J Immunol (2002) 1.53
Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory. Science (2011) 1.53
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem (2003) 1.52
Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2002) 1.51
Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neurosci Res (2006) 1.49
A seed for Alzheimer amyloid in the brain. J Neurosci (2004) 1.45
Comparative analysis of layer-specific genes in Mammalian neocortex. Cereb Cortex (2006) 1.41
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem (2006) 1.37
Assembly of two distinct dimers and higher-order oligomers from full-length tau. Eur J Neurosci (2007) 1.31
Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. J Biol Chem (2003) 1.26
GABA(A) receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin. PLoS One (2008) 1.26
Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J Cell Sci (2006) 1.25
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiol Dis (2006) 1.23
Surface structure of amyloid-beta fibrils contributes to cytotoxicity. Biochemistry (2007) 1.23
Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells. J Biol Chem (2002) 1.23
Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. EMBO J (2007) 1.22
Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res (2010) 1.21
Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. Hum Mol Genet (2006) 1.20
Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy. J Biol Chem (2002) 1.19
Electrical stimulation modulates fate determination of differentiating embryonic stem cells. Stem Cells (2006) 1.18
Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner. J Neurochem (2004) 1.18
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition. J Neurosci (2007) 1.17
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun (2004) 1.16
Mechanism of ER stress-induced brain damage by IP(3) receptor. Neuron (2010) 1.16
Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2. J Neurosci (2002) 1.16
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Res (2005) 1.16
Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. J Neurosci (2002) 1.15
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci (2008) 1.15
Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Hum Mol Genet (2003) 1.14
Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation. J Biol Chem (2003) 1.13
From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc Natl Acad Sci U S A (2006) 1.13
Cytoarchitectonic and chemoarchitectonic subdivisions of the perirhinal and parahippocampal cortices in macaque monkeys. J Comp Neurol (2007) 1.12
Pore-forming proteins share structural and functional homology with amyloid oligomers. Neuromolecular Med (2007) 1.12
Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. J Neurosci (2011) 1.11
GSK-3beta is required for memory reconsolidation in adult brain. PLoS One (2008) 1.11
Amyloid oligomer conformation in a group of natively folded proteins. PLoS One (2008) 1.10
Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond B Biol Sci (2013) 1.10
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem (2002) 1.09
Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains. Biochem Biophys Res Commun (2003) 1.09
Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Cereb Cortex (2008) 1.08
Detection of the archetypal regulatory region of JC virus from the tonsil tissue of patients with tonsillitis and tonsilar hypertrophy. J Neurovirol (2004) 1.07
Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis (2009) 1.06
Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem (2012) 1.05
Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss. J Biol Chem (2010) 1.04
Retinol-binding protein gene is highly expressed in higher-order association areas of the primate neocortex. Cereb Cortex (2004) 1.04
Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase. Nat Struct Mol Biol (2010) 1.03
U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J Neurochem (2004) 1.03
Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation. Acta Neuropathol (2004) 1.02
Neuron-specific distribution of P2X7 purinergic receptors in the monkey retina. J Comp Neurol (2003) 1.02
Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2. Mol Cell Neurosci (2003) 1.01
Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization. J Biol Chem (2003) 1.00
Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol Dis (2005) 1.00
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. EMBO Rep (2008) 1.00