Published in Structure on September 01, 2002
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol (2005) 2.91
A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc Natl Acad Sci U S A (2005) 2.69
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. PLoS Biol (2011) 2.32
A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev (2006) 2.29
Nuclear Receptors, RXR, and the Big Bang. Cell (2014) 2.22
Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Cell Metab (2009) 2.00
Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol (2010) 1.98
Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. Annu Rev Nutr (2011) 1.88
Identification of an endogenous ligand bound to a native orphan nuclear receptor. PLoS One (2009) 1.70
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc Natl Acad Sci U S A (2005) 1.67
Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol (2008) 1.60
Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice. J Biol Chem (2012) 1.42
Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J Biol Chem (2006) 1.41
Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. J Mol Evol (2005) 1.31
Docosahexaenoic acid (DHA) and hepatic gene transcription. Chem Phys Lipids (2008) 1.30
Multidomain integration in the structure of the HNF-4α nuclear receptor complex. Nature (2013) 1.30
Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Mol Cell (2006) 1.23
Dynamic regulation of Drosophila nuclear receptor activity in vivo. Development (2006) 1.21
Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol (2008) 1.21
Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis. Arterioscler Thromb Vasc Biol (2010) 1.20
Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem (2006) 1.16
Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics. PLoS One (2008) 1.15
Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. PLoS Biol (2010) 1.15
HNF4α--role in drug metabolism and potential drug target? Curr Opin Pharmacol (2010) 1.14
Mechanisms of gene regulation by fatty acids. Adv Nutr (2012) 1.11
Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. Mol Cell Biol (2010) 1.10
Nuclear receptors as therapeutic targets in cholestatic liver diseases. Br J Pharmacol (2009) 1.07
Retracted Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Biochem J (2006) 1.03
Pathogenesis of Nonalcoholic Steatohepatitis. Gastroenterology (2016) 1.02
Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patterns. BMC Evol Biol (2009) 1.01
Fatty acid-regulated transcription factors in the liver. Annu Rev Nutr (2013) 1.00
Pathogenesis of alcoholic liver disease: the role of nuclear receptors. Exp Biol Med (Maywood) (2010) 1.00
What are nuclear receptor ligands? Mol Cell Endocrinol (2010) 0.99
Polymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs. PLoS One (2013) 0.98
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists. PLoS One (2012) 0.97
Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes. Proc Natl Acad Sci U S A (2010) 0.97
Orphan nuclear receptors as targets for drug development. Pharm Res (2010) 0.97
Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors. J Biol Chem (2010) 0.96
Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor kappaB pathway. Biochem J (2006) 0.93
Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response. Endocr Relat Cancer (2010) 0.93
Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity. Nucleic Acids Res (2003) 0.92
An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution. BMC Evol Biol (2008) 0.91
A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism. Nat Commun (2015) 0.90
Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. Biochem J (2006) 0.90
The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. PLoS One (2010) 0.90
Structural and functional insights into nuclear receptor signaling. Adv Drug Deliv Rev (2010) 0.89
Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents? Cancer Biol Ther (2010) 0.89
HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol (2012) 0.88
Intra-abdominal adipose tissue is independently associated with sex-hormone binding globulin in premenopausal women. Obesity (Silver Spring) (2012) 0.87
The Caenorhabditis elegans HNF4alpha Homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase. PLoS Genet (2009) 0.85
Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. PLoS Genet (2014) 0.83
Proteomics reveals a physical and functional link between hepatocyte nuclear factor 4alpha and transcription factor IID. J Biol Chem (2009) 0.83
Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism. Expert Opin Drug Metab Toxicol (2009) 0.82
Flavonoids as dietary regulators of nuclear receptor activity. Food Funct (2013) 0.82
Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis. Front Biosci (Landmark Ed) (2009) 0.81
A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3. Nucleic Acids Res (2008) 0.81
Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. J Lipid Res (2013) 0.81
The orphan nuclear receptors at their 25-year reunion. J Mol Endocrinol (2013) 0.80
Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. J Mass Spectrom (2005) 0.80
Characterizing protein domain associations by Small-molecule ligand binding. J Proteome Sci Comput Biol (2012) 0.80
Molecular mechanism by which palmitate inhibits PKR autophosphorylation. Biochemistry (2011) 0.79
Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice. J Lipid Res (2012) 0.78
Effects of multiple genetic loci on the pathogenesis from serum urate to gout. Sci Rep (2017) 0.77
Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action. J Endocrinol (2016) 0.77
Crystallization of hepatocyte nuclear factor 4 alpha (HNF4 alpha) in complex with the HNF1 alpha promoter element. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.77
Network insights into the genes regulated by hepatocyte nuclear factor 4 in response to drug induced perturbations: a review. Curr Drug Discov Technol (2013) 0.77
Thyroid-Stimulating Hormone Increases HNF-4α Phosphorylation via cAMP/PKA Pathway in the Liver. Sci Rep (2015) 0.76
Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism. Int J Mol Sci (2015) 0.75
Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer. Front Endocrinol (Lausanne) (2015) 0.75
TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men. Oncotarget (2017) 0.75
Hepatocyte Nuclear Factor 4α (HNF4α) Is a Transcription Factor of Vertebrate Fatty Acyl Desaturase Gene as Identified in Marine Teleost Siganus canaliculatus. PLoS One (2016) 0.75
Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver. PPAR Res (2011) 0.75
Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct. PLoS One (2016) 0.75
HNF-4 participates in the hibernation-associated transcriptional regulation of the chipmunk hibernation-related protein gene. Sci Rep (2017) 0.75
Genes Related to Fatty Acid β-Oxidation Play a Role in the Functional Decline of the Drosophila Brain with Age. PLoS One (2016) 0.75
The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol (2016) 0.75
The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2. PLoS One (2017) 0.75
Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis. JCI Insight (2017) 0.75
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature (2005) 6.83
ApoE promotes the proteolytic degradation of Abeta. Neuron (2008) 4.75
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
Effectiveness of universal school-based programs to prevent violent and aggressive behavior: a systematic review. Am J Prev Med (2007) 3.98
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A (2006) 3.77
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell (2005) 3.29
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest (2004) 3.23
Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell (2002) 3.13
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature (2002) 3.11
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry (2002) 2.97
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev (2002) 2.95
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol (2002) 2.94
Too many roads not taken. Nature (2011) 2.93
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem (2001) 2.70
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem (2003) 2.28
Open access chemical and clinical probes to support drug discovery. Nat Chem Biol (2009) 2.28
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol (2003) 2.26
Polymer-fullerene bulk-heterojunction solar cells. Adv Mater (2010) 2.12
Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res (2003) 2.01
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem (2002) 2.01
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorg Med Chem Lett (2003) 1.90
The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study. CMAJ (2010) 1.88
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem (2002) 1.85
A public-private partnership to unlock the untargeted kinome. Nat Chem Biol (2013) 1.83
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma. Endocrinology (2003) 1.69
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol (2004) 1.69
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Mol Endocrinol (2002) 1.67
The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem (2004) 1.65
Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. Neurobiol Aging (2010) 1.56
The effectiveness of universal school-based programs for the prevention of violent and aggressive behavior: a report on recommendations of the Task Force on Community Preventive Services. MMWR Recomm Rep (2007) 1.56
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci (2003) 1.56
A study of shingles and the development of postherpetic neuralgia in East London. J Med Virol (2003) 1.55
The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res (2003) 1.53
Vitamin D and cancer: a review of molecular mechanisms. Biochem J (2012) 1.51
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Mol Cell (2004) 1.51
Structural basis for an unexpected mode of SERM-mediated ER antagonism. Mol Cell (2005) 1.50
Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arterioscler Thromb Vasc Biol (2006) 1.50
Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Mol Cell Proteomics (2004) 1.46
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell (2003) 1.44
A public health focus on infertility prevention, detection, and management. Fertil Steril (2008) 1.41
A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor. J Biol Chem (2005) 1.41
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol (2010) 1.41
Chlamydia trachomatis trends in the United States among persons 14 to 39 years of age, 1999-2008. Sex Transm Dis (2012) 1.41
Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis. Cancer Res (2006) 1.40
Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mol Cell (2003) 1.40
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J Lipid Res (2002) 1.39
X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J Biol Chem (2006) 1.37
Genomics versus orphan nuclear receptors--a half-time report. Mol Endocrinol (2002) 1.35
X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. J Biol Chem (2003) 1.33
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Mol Endocrinol (2007) 1.29
The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem (2008) 1.27
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem (2005) 1.27
Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes. Cell Signal (2007) 1.26
Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. J Med Chem (2006) 1.25
Crystallization of protein-ligand complexes. Acta Crystallogr D Biol Crystallogr (2006) 1.23
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis (2007) 1.23
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol (2007) 1.22
The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress. J Lipid Res (2008) 1.21
The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Nucleic Acids Res (2003) 1.20
Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg Med Chem (2006) 1.19
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proc Natl Acad Sci U S A (2008) 1.18
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. Carcinogenesis (2007) 1.18
Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes. J Med Chem (2004) 1.16
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther (2005) 1.16
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. J Biol Chem (2009) 1.14
Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS). Curr Top Med Chem (2014) 1.11
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res (2004) 1.11
A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. Mol Endocrinol (2007) 1.10
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol (2013) 1.09
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines. Toxicology (2007) 1.09
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem (2011) 1.08
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett (2005) 1.08
Measurement of total pulmonary arterial compliance using invasive pressure monitoring and MR flow quantification during MR-guided cardiac catheterization. Am J Physiol Heart Circ Physiol (2005) 1.08
Comparison of psychological and physical function in neuropathic pain and nociceptive pain: implications for cognitive behavioral pain management programs. Eur J Pain (2007) 1.06
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett (2004) 1.06
Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. J Biol Chem (2004) 1.06
Employment related productivity loss associated with herpes zoster and postherpetic neuralgia: a 6-month prospective study. Vaccine (2012) 1.05
Review of an institutional experience of coronary arterial fistulas in childhood set in context of review of the literature. Cardiol Young (2004) 1.05
Burden of post-herpetic neuralgia in a sample of UK residents aged 50 years or older: findings from the Zoster Quality of Life (ZQOL) study. Health Qual Life Outcomes (2014) 1.04
The impact of perceived child physical and sexual abuse history on Native American women's psychological well-being and AIDS risk. J Consult Clin Psychol (2002) 1.03
Effects on violence of laws and policies facilitating the transfer of juveniles from the juvenile justice system to the adult justice system: a systematic review. Am J Prev Med (2007) 1.02
Cardiac magnetic resonance imaging after stage I Norwood operation for hypoplastic left heart syndrome. Circulation (2005) 1.02