Published in Nucleic Acids Res on July 15, 2003
Deciphering the nuclear bile acid receptor FXR paradigm. Nucl Recept Signal (2010) 1.53
Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics (2007) 1.52
Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. Mol Endocrinol (2005) 1.33
Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. Curr Drug Metab (2006) 1.32
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics (2008) 1.27
Functional evolution of the vitamin D and pregnane X receptors. BMC Evol Biol (2007) 1.17
Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nucl Recept (2005) 1.17
Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex. BMC Genomics (2009) 1.09
Ligand specificity and evolution of liver X receptors. J Steroid Biochem Mol Biol (2008) 1.06
Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patterns. BMC Evol Biol (2009) 1.01
What are nuclear receptor ligands? Mol Cell Endocrinol (2010) 0.99
Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Mol Cell Endocrinol (2010) 0.97
Functional evolution of the pregnane X receptor. Expert Opin Drug Metab Toxicol (2006) 0.96
Expression and regulation of the vitamin D receptor in the zebrafish, Danio rerio. J Bone Miner Res (2008) 0.94
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nucl Recept (2004) 0.93
Dietary exposure of largemouth bass to OCPs changes expression of genes important for reproduction. Aquat Toxicol (2006) 0.92
Intrinsic disorder in nuclear hormone receptors. J Proteome Res (2008) 0.92
Paralogous vitamin D receptors in teleosts: transition of nuclear receptor function. Endocrinology (2008) 0.92
Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes. PLoS One (2014) 0.89
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. BMC Biochem (2011) 0.89
C-type lectin-like domains in Fugu rubripes. BMC Genomics (2004) 0.87
The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicol Appl Pharmacol (2013) 0.86
Cholesterol efflux is LXRα isoform-dependent in human macrophages. BMC Cardiovasc Disord (2014) 0.85
The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia species. Gen Comp Endocrinol (2014) 0.82
A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). Mol Genet Genomics (2007) 0.81
Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquat Toxicol (2010) 0.81
Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective. Sci Rep (2015) 0.79
Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons. Hum Genomics (2005) 0.79
Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels. Aquat Toxicol (2015) 0.78
Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates. PLoS One (2015) 0.77
Functional diversification of vitamin D receptor paralogs in teleost fish after a whole genome duplication event. Endocrinology (2014) 0.77
Tissue expression of PPAR-α isoforms in Scophthalmus maximus and transcriptional response of target genes in the heart after exposure to WY-14643. Fish Physiol Biochem (2012) 0.76
Regulation of FADS2 transcription by SREBP-1 and PPAR-α influences LC-PUFA biosynthesis in fish. Sci Rep (2017) 0.75
LXRα and LXRβ nuclear receptors evolved in the common ancestor of gnathostomes. Genome Biol Evol (2017) 0.75
Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus. Nucl Receptor Res (2017) 0.75
Acyl-coenzyme A oxidases 1 and 3 in brown trout (Salmo trutta f. fario): Can peroxisomal fatty acid β-oxidation be regulated by estrogen signaling? Fish Physiol Biochem (2015) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The sequence of the human genome. Science (2001) 101.55
T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88
Profile hidden Markov models. Bioinformatics (1998) 56.04
The Pfam protein families database. Nucleic Acids Res (2002) 51.34
Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science (2002) 20.59
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell (1998) 5.97
The PPARs: from orphan receptors to drug discovery. J Med Chem (2000) 5.29
Vitamin D receptor as an intestinal bile acid sensor. Science (2002) 3.64
Removing near-neighbour redundancy from large protein sequence collections. Bioinformatics (1998) 3.47
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (2001) 3.27
Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu Rev Biochem (2001) 3.17
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol (2000) 2.74
Peroxisome proliferator-activated receptors: from genes to physiology. Recent Prog Horm Res (2001) 2.46
Orphan nuclear receptors: shifting endocrinology into reverse. Science (1999) 2.32
BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J Lipid Res (2002) 2.26
PXR, CAR and drug metabolism. Nat Rev Drug Discov (2002) 2.06
Minireview: nuclear receptor coactivators--an update. Endocrinology (2002) 2.04
Orphan nuclear receptors--new ligands and new possibilities. Genes Dev (1998) 1.98
Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem (2001) 1.94
The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. Genome Res (1999) 1.92
Nuclear hormone receptor coregulators in action: diversity for shared tasks. Mol Endocrinol (2000) 1.72
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Mol Endocrinol (2002) 1.67
Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Genome Biol (2001) 1.57
Nuclear receptors in nematodes: themes and variations. Trends Genet (2001) 1.46
PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci (2002) 1.40
Genomics versus orphan nuclear receptors--a half-time report. Mol Endocrinol (2002) 1.35
How many nuclear hormone receptors are there in the human genome? Trends Genet (2001) 1.34
Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. J Biol Chem (2001) 1.27
Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol (2003) 1.25
Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism. Med Res Rev (2001) 1.14
Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. J Biol Chem (2002) 1.11
BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes Dev (1998) 1.10
Revisiting recent challenges to the ancient fish-specific genome duplication hypothesis. Curr Biol (2001) 0.98
Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Mol Endocrinol (2002) 0.96
Comparing nuclear receptors in worms, flies and humans. Trends Pharmacol Sci (2001) 0.89
Identification of cDNAs encoding two subtypes of vitamin D receptor in flounder, Paralichthys olivaceus. Biochem Biophys Res Commun (2000) 0.88
Molecular cloning and functional characterization of a novel nuclear receptor similar to an embryonic benzoate receptor BXR. Biochem Biophys Res Commun (2000) 0.81
Multiple variants of the peroxisome proliferator-activated receptor (PPAR) gamma are expressed in the liver of atlantic salmon (Salmo salar). Gene (2000) 0.79
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature (2005) 6.83
A critical assessment of docking programs and scoring functions. J Med Chem (2006) 5.78
ApoE promotes the proteolytic degradation of Abeta. Neuron (2008) 4.75
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A (2006) 3.77
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell (2005) 3.29
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest (2004) 3.23
Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell (2002) 3.13
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature (2002) 3.11
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry (2002) 2.97
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev (2002) 2.95
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol (2002) 2.94
Too many roads not taken. Nature (2011) 2.93
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem (2001) 2.70
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem (2003) 2.28
Open access chemical and clinical probes to support drug discovery. Nat Chem Biol (2009) 2.28
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol (2003) 2.26
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure (2002) 2.10
Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res (2003) 2.01
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem (2002) 2.01
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. Comb Chem High Throughput Screen (2005) 1.99
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorg Med Chem Lett (2003) 1.90
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem (2002) 1.85
A public-private partnership to unlock the untargeted kinome. Nat Chem Biol (2013) 1.83
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma. Endocrinology (2003) 1.69
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol (2004) 1.69
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Mol Endocrinol (2002) 1.67
The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem (2004) 1.65
Activation of nuclear receptors: a perspective from structural genomics. Structure (2003) 1.59
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci (2003) 1.56
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol (2005) 1.55
The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res (2003) 1.53
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Mol Cell (2004) 1.51
Structural basis for an unexpected mode of SERM-mediated ER antagonism. Mol Cell (2005) 1.50
Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arterioscler Thromb Vasc Biol (2006) 1.50
Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Mol Cell Proteomics (2004) 1.46
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell (2003) 1.44
A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor. J Biol Chem (2005) 1.41
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol (2010) 1.41
Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis. Cancer Res (2006) 1.40
Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mol Cell (2003) 1.40
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J Lipid Res (2002) 1.39
X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J Biol Chem (2006) 1.37
Genomics versus orphan nuclear receptors--a half-time report. Mol Endocrinol (2002) 1.35
X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. J Biol Chem (2003) 1.33
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Mol Endocrinol (2007) 1.29
The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem (2008) 1.27
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem (2005) 1.27
Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes. Cell Signal (2007) 1.26
Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. J Med Chem (2006) 1.25
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis (2007) 1.23
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol (2007) 1.22
The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress. J Lipid Res (2008) 1.21
Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg Med Chem (2006) 1.19
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol (2004) 1.19
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. Carcinogenesis (2007) 1.18
Shedding of membrane proteins by ADAM family proteases. Essays Biochem (2002) 1.18
Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes. J Med Chem (2004) 1.16
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther (2005) 1.16
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. J Biol Chem (2009) 1.14
Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS). Curr Top Med Chem (2014) 1.11
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res (2004) 1.11
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol (2013) 1.09
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines. Toxicology (2007) 1.09
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem (2011) 1.08
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett (2005) 1.08
Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorg Med Chem Lett (2010) 0.99
Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. J Biol Chem (2002) 0.99
Sweet dreams for LXR. Cell Metab (2007) 0.98
Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction. Nat Struct Mol Biol (2010) 0.97
Interactions that determine the assembly of a retinoid X receptor/corepressor complex. Proc Natl Acad Sci U S A (2002) 0.97
Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J Biol Chem (2007) 0.97
PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism. Dig Dis Sci (2007) 0.96
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem (2008) 0.96
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. J Med Chem (2004) 0.95
Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells. Biochem Biophys Res Commun (2002) 0.94
Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth. J Immunol (2008) 0.94
Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms. J Biol Chem (2003) 0.93