Published in FEBS Lett on September 25, 2002
Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol (2008) 2.09
Na Channel β Subunits: Overachievers of the Ion Channel Family. Front Pharmacol (2011) 1.69
Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol (2006) 1.64
Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons. J Physiol (2008) 1.64
Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol (2005) 1.63
Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation. J Mol Cell Cardiol (2009) 1.58
Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB J (2008) 1.54
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol (2007) 1.46
Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. J Physiol (2004) 1.44
A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents. Heart Rhythm (2011) 1.43
Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. J Physiol (2005) 1.43
KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders. Heart Rhythm (2009) 1.43
DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein. Front Mol Neurosci (2008) 1.31
Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert Opin Ther Targets (2008) 1.30
KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity. Proc Natl Acad Sci U S A (2011) 1.27
Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP. J Membr Biol (2003) 1.16
Regulation of Kv4.3 voltage-dependent gating kinetics by KChIP2 isoforms. J Physiol (2004) 1.11
The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels. J Neurosci (2012) 1.10
Chronic heart failure and the substrate for atrial fibrillation. Cardiovasc Res (2009) 1.05
Modification of K+ channel-drug interactions by ancillary subunits. J Physiol (2007) 1.04
Hormonal regulation of cardiac KCNE2 gene expression. Mol Cell Endocrinol (2008) 0.98
Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle. J Mol Cell Cardiol (2009) 0.96
Sodium channel β subunits: emerging targets in channelopathies. Annu Rev Physiol (2015) 0.96
More than a pore: ion channel signaling complexes. J Neurosci (2014) 0.94
Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating. J Biol Chem (2008) 0.94
Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2. Br J Pharmacol (2010) 0.94
Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels. Br J Pharmacol (2008) 0.94
Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One (2012) 0.92
Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo. J Biol Chem (2011) 0.91
KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene (2015) 0.89
Modulatory mechanisms and multiple functions of somatodendritic A-type K (+) channel auxiliary subunits. Front Cell Neurosci (2014) 0.84
Dual roles of voltage-gated sodium channels in development and cancer. Int J Dev Biol (2015) 0.84
Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proc Natl Acad Sci U S A (2012) 0.84
The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.84
Development of heart failure is independent of K+ channel-interacting protein 2 expression. J Physiol (2013) 0.82
Transient outward potassium channel: a heart failure mediator. Heart Fail Rev (2015) 0.80
The potential role of Kv4.3 K+ channel in heart hypertrophy. Channels (Austin) (2014) 0.80
Inhibitory effects of polyunsaturated fatty acids on Kv4/KChIP potassium channels. Am J Physiol Cell Physiol (2009) 0.80
Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function. Int J Mol Med (2015) 0.79
K(V)4.3 N-terminal deletion mutant Δ2-39: effects on inactivation and recovery characteristics in both the absence and presence of KChIP2b. Channels (Austin) (2011) 0.78
KCNQ and KCNE potassium channel subunit expression in bovine retinal pigment epithelium. Exp Eye Res (2013) 0.78
Kvβ1.1 senses pyridine nucleotide changes in the mouse heart and modulates cardiac electrical activity. Am J Physiol Heart Circ Physiol (2016) 0.77
Increased transient Na(+) conductance and action potential output in layer 2/3 prefrontal cortex neurons of the fmr1-/y mouse. J Physiol (2017) 0.77
β Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants. Front Physiol (2017) 0.75
Transmural gradients in ion channel and auxiliary subunit expression. Prog Biophys Mol Biol (2016) 0.75
Voltage-gated ion channel accessory subunits: sodium, potassium, or both? Epilepsy Curr (2013) 0.75
Potassium channels in the heart: structure, function and regulation. J Physiol (2016) 0.75
Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex. J Biol Chem (2015) 0.75
Myriad roles of voltage-activated potassium channel subunit Kvβ1.1 in the heart. Am J Physiol Heart Circ Physiol (2017) 0.75
Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit. Sci Rep (2017) 0.75
β Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation. Front Physiol (2017) 0.75
Effect of verapamil on tachycardia-induced early cellular electrical remodeling in rabbit atrium. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.75
Heteromeric complexes of aldo-keto reductase auxiliary KVβ subunits (AKR6A) regulate sarcolemmal localization of KV1.5 in coronary arterial myocytes. Chem Biol Interact (2017) 0.75
Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation (2010) 13.28
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 10.24
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation (2007) 5.09
2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation (2013) 5.02
2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 3.63
End-stage renal disease predicts complications in pacemaker and ICD implants. J Cardiovasc Electrophysiol (2011) 3.21
The mitochondrial origin of postischemic arrhythmias. J Clin Invest (2005) 3.08
Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol (2008) 2.99
Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy. Circulation (2005) 2.80
Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy. JACC Cardiovasc Imaging (2008) 2.64
Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging (2012) 2.62
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation (2009) 2.55
Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol (2011) 2.38
The future of fellowship training in clinical cardiac electrophysiology: Program directors' perspective 2008. Heart Rhythm (2009) 2.22
Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ Res (2004) 2.19
Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol (2008) 2.09
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation (2009) 2.09
Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond: a presidential advisory from the American Heart Association. Circulation (2011) 2.05
Dual antiplatelet therapy and heparin "bridging" significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantation. J Am Coll Cardiol (2010) 1.97
Gaps in the ablation line as a potential cause of recovery from electrical isolation and their visualization using MRI. Circ Arrhythm Electrophysiol (2011) 1.95
Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol (2007) 1.94
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res (2009) 1.88
Beat-to-beat three-dimensional ECG variability predicts ventricular arrhythmia in ICD recipients. Heart Rhythm (2010) 1.85
QT-interval duration and mortality rate: results from the Third National Health and Nutrition Examination Survey. Arch Intern Med (2011) 1.73
Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation (2006) 1.70
Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circ Cardiovasc Genet (2011) 1.68
Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization. Circulation (2008) 1.67
Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation (2012) 1.65
Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy. Circulation (2009) 1.63
Electrocardiographic QT interval and mortality: a meta-analysis. Epidemiology (2011) 1.62
Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ Res (2002) 1.62
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol (2009) 1.60
Intracardiac J-point elevation before the onset of polymorphic ventricular tachycardia and ventricular fibrillation in patients with an implantable cardioverter-defibrillator. Heart Rhythm (2012) 1.60
Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? Circulation (2002) 1.59
ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol (2008) 1.55
Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure. J Mol Cell Cardiol (2005) 1.54
Electrical remodeling in the failing heart. Curr Opin Cardiol (2010) 1.51
Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level. Circ Cardiovasc Genet (2009) 1.51
Regional alterations in protein expression in the dyssynchronous failing heart. Circulation (2003) 1.49
Evidence for electrical remodeling of the native conduction system with cardiac resynchronization therapy. Pacing Clin Electrophysiol (2007) 1.47
Molecular basis of arrhythmias. Circulation (2005) 1.46
Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res (2012) 1.44
Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease. J Cardiovasc Electrophysiol (2009) 1.43
Ultrastructure and regulation of lateralized connexin43 in the failing heart. Circ Res (2010) 1.40
Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort. Heart Rhythm (2013) 1.40
Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. Am J Physiol Heart Circ Physiol (2005) 1.39
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet (2011) 1.38
Pathophysiological basis and clinical application of T-wave alternans. J Am Coll Cardiol (2002) 1.37
Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res (2003) 1.35
Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts. Circ Cardiovasc Genet (2009) 1.32
Prospective observational study of implantable cardioverter-defibrillators in primary prevention of sudden cardiac death: study design and cohort description. J Am Heart Assoc (2013) 1.30
Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res (2005) 1.28
Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovasc Res (2005) 1.26
ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am J Gastroenterol (2010) 1.24
Mechanisms of disease: ion channel remodeling in the failing ventricle. Nat Clin Pract Cardiovasc Med (2008) 1.24
Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. Am J Physiol Heart Circ Physiol (2003) 1.22
Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes. Genomics (2004) 1.22
Transmural heterogeneity of Na+-Ca2+ exchange: evidence for differential expression in normal and failing hearts. Circ Res (2005) 1.16
Hospital certification for optimizing cardiovascular disease and stroke quality of care and outcomes. Circulation (2010) 1.15
Risk stratification for sudden cardiac death: a plan for the future. Circulation (2014) 1.14
Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. PLoS One (2010) 1.09
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med (2011) 1.08
A new electrocardiogram marker to identify patients at low risk for ventricular tachyarrhythmias: sum magnitude of the absolute QRST integral. J Electrocardiol (2010) 1.07
Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation? J Gen Physiol (2003) 1.07
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol (2006) 1.05
Predictors of high defibrillation threshold in the modern era. Pacing Clin Electrophysiol (2012) 1.05
Ventricular arrhythmia is predicted by sum absolute QRST integralbut not by QRS width. J Electrocardiol (2010) 1.02
Calmodulin regulation of Nav1.4 current: role of binding to the carboxyl terminus. J Gen Physiol (2008) 1.00
Calcium-mediated dual-mode regulation of cardiac sodium channel gating. Circ Res (2009) 1.00
Mechanisms of gap junction traffic in health and disease. J Cardiovasc Pharmacol (2009) 1.00
A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia. Traffic (2014) 0.99
Myocardial structural associations with local electrograms: a study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping. Circ Arrhythm Electrophysiol (2012) 0.98
Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels. J Biol Chem (2002) 0.98
Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences. Trends Cardiovasc Med (2005) 0.97
Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure. Am J Physiol Heart Circ Physiol (2005) 0.96
Two-photon laser scanning microscopy of the transverse-axial tubule system in ventricular cardiomyocytes from failing and non-failing human hearts. Cardiol Res Pract (2010) 0.95
Tissue sodium concentration in myocardial infarction in humans: a quantitative 23Na MR imaging study. Radiology (2008) 0.94
Complex assessment of the temporal lability of repolarization. Int J Cardiol (2012) 0.93
Altered gating and local anesthetic block mediated by residues in the I-S6 and II-S6 transmembrane segments of voltage-dependent Na+ channels. Mol Pharmacol (2003) 0.93
Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third National Health and Nutrition Examination Survey. PLoS One (2011) 0.92
A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation. J Physiol (2006) 0.91
Desmin modifications associate with amyloid-like oligomers deposition in heart failure. Cardiovasc Res (2014) 0.90
Continuation of warfarin during pacemaker or implantable cardioverter-defibrillator implantation: a randomized clinical trial. Heart Rhythm (2010) 0.89
ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2012) 0.89
Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling. Physiol Genomics (2008) 0.89
Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Lett (2002) 0.89
Ion channels as novel therapeutic targets in heart failure. Ann Med (2005) 0.88
Impact of nonischemic scar features on local ventricular electrograms and scar-related ventricular tachycardia circuits in patients with nonischemic cardiomyopathy. Circ Arrhythm Electrophysiol (2013) 0.87
A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor. Mol Pharmacol (2005) 0.87
Cardiac metabolism and arrhythmias. Circ Arrhythm Electrophysiol (2009) 0.87
Reciprocal regulation of metabolic and signaling pathways. BMC Genomics (2010) 0.87
Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imaging. Heart Rhythm (2012) 0.86
The American Heart Association and the Million Hearts Initiative: a presidential advisory from the American Heart Association. Circulation (2011) 0.86