Published in Circulation on December 20, 2004
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature (2012) 3.63
Formation of human myocardium in the rat heart from human embryonic stem cells. Am J Pathol (2005) 2.60
Human embryonic stem cell transplantation to repair the infarcted myocardium. Heart (2007) 1.86
Stem cell therapy is proarrhythmic. Circulation (2009) 1.83
Cardiac conduction through engineered tissue. Am J Pathol (2006) 1.80
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol (2012) 1.74
HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia. J Mol Cell Cardiol (2007) 1.68
Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state. Biochem Biophys Res Commun (2008) 1.59
Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes. Stem Cells Dev (2009) 1.50
Label-free separation of human embryonic stem cells and their cardiac derivatives using Raman spectroscopy. Anal Chem (2009) 1.47
Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model. J Mol Cell Cardiol (2012) 1.45
Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Eng Part A (2009) 1.42
Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol (2013) 1.38
Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells. Regen Med (2011) 1.35
Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression. Am J Physiol Cell Physiol (2009) 1.32
B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. PLoS One (2008) 1.32
Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. Stem Cells (2013) 1.28
Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng (2011) 1.26
Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts. J Mol Cell Cardiol (2007) 1.23
The relevance of non-excitable cells for cardiac pacemaker function. J Physiol (2007) 1.22
Immunogenicity of pluripotent stem cells and their derivatives. Circ Res (2013) 1.19
Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue. Proc Natl Acad Sci U S A (2013) 1.17
Human embryonic stem cells and cardiac repair. Transplant Rev (Orlando) (2008) 1.15
Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes. Stem Cells Dev (2010) 1.13
beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart. Br J Pharmacol (2008) 1.07
Heart repair and stem cells. J Physiol (2006) 1.04
Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther (2014) 1.03
Mobilized bone marrow progenitor cells serve as donors of cytoprotective genes for cardiac repair. J Mol Cell Cardiol (2007) 1.02
Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells. Prog Biophys Mol Biol (2012) 1.00
HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol (2007) 1.00
Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes. Cell Mol Life Sci (2009) 1.00
Regional difference in dynamical property of sinoatrial node pacemaking: role of na+ channel current. Biophys J (2008) 0.99
Biological pacing by gene and cell therapy. Neth Heart J (2007) 0.99
Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model. Biophys J (2005) 0.99
Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2. Circulation (2012) 0.99
Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling. J Mol Cell Cardiol (2010) 0.99
Current status of drug screening and disease modelling in human pluripotent stem cells. Bioessays (2012) 0.98
Ectopic expression of systemic RNA interference defective protein in embryonic stem cells. Biochem Biophys Res Commun (2007) 0.98
Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine. Heart (2012) 0.97
In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. J Physiol (2009) 0.97
Cardiac applications for human pluripotent stem cells. Curr Pharm Des (2009) 0.97
Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes. Cytotherapy (2010) 0.97
Challenges in identifying the best source of stem cells for cardiac regeneration therapy. Stem Cell Res Ther (2015) 0.95
Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation (2007) 0.94
Characterizing functional stem cell-cardiomyocyte interactions. Regen Med (2010) 0.92
Human pluripotent stem cell-based approaches for myocardial repair: from the electrophysiological perspective. Mol Pharm (2011) 0.91
Non-invasive imaging of human embryonic stem cells. Curr Pharm Biotechnol (2010) 0.91
Genetic manipulation of neural progenitors derived from human embryonic stem cells. Tissue Eng Part A (2009) 0.90
Lessons for cardiac regeneration and repair through development. Trends Mol Med (2010) 0.89
Current stem cell delivery methods for myocardial repair. Biomed Res Int (2012) 0.89
Biomaterial based cardiac tissue engineering and its applications. Biomed Mater (2015) 0.88
Calcium signalling of human pluripotent stem cell-derived cardiomyocytes. J Physiol (2013) 0.87
Regenerative medicine for the heart: perspectives on stem-cell therapy. Antioxid Redox Signal (2014) 0.87
Materials science and tissue engineering: repairing the heart. Mayo Clin Proc (2013) 0.87
Cardiac regeneration using pluripotent stem cells--progression to large animal models. Stem Cell Res (2014) 0.86
Stem cell-based biological pacemakers from proof of principle to therapy: a review. Cytotherapy (2014) 0.86
SHOX2 overexpression favors differentiation of embryonic stem cells into cardiac pacemaker cells, improving biological pacing ability. Stem Cell Reports (2014) 0.85
Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. Int J Cardiol (2009) 0.85
Cardiac repair by embryonic stem-derived cells. Handb Exp Pharmacol (2006) 0.85
Endothelial cells regulate cardiomyocyte development from embryonic stem cells. J Cell Biochem (2010) 0.85
Stem cell differentiation: cardiac repair. Cells Tissues Organs (2007) 0.84
Stem cell therapy for ischemic heart disease. Antioxid Redox Signal (2010) 0.84
Regulation of cardiomyocyte differentiation of embryonic stem cells by extracellular signalling. Cell Mol Life Sci (2007) 0.84
Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells. Int J Cardiol (2012) 0.84
High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation. Biochem J (2015) 0.84
Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair. Adv Drug Deliv Rev (2015) 0.83
Human pluripotent stem cell-derived cardiomyocytes: response to TTX and lidocain reveals strong cell to cell variability. PLoS One (2012) 0.83
Optical mapping of cryoinjured rat myocardium grafted with mesenchymal stem cells. Am J Physiol Heart Circ Physiol (2011) 0.83
Decreased intercellular coupling improves the function of cardiac pacemakers derived from mouse embryonic stem cells. J Mol Cell Cardiol (2008) 0.83
Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med (2014) 0.82
Pluripotent stem cell derived cardiomyocytes for cardiac repair. Curr Treat Options Cardiovasc Med (2014) 0.82
Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation. PLoS One (2013) 0.81
A paradigm shift in cardiac pacing therapy? Circulation (2006) 0.81
Marching towards regenerative cardiac therapy with human pluripotent stem cells. Discov Med (2013) 0.80
Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives. Stem Cell Res Ther (2013) 0.80
Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells. Pflugers Arch (2010) 0.79
Genetically engineered excitable cardiac myofibroblasts coupled to cardiomyocytes rescue normal propagation and reduce arrhythmia complexity in heterocellular monolayers. PLoS One (2013) 0.79
Stem cells for cardiac repair: an introduction. J Geriatr Cardiol (2013) 0.79
Translational medicine. Improving cardiac rhythm with a biological pacemaker. Science (2014) 0.78
Adhesion proteins, stem cells, and arrhythmogenesis. Cardiovasc Toxicol (2008) 0.78
Introduction to stem cell therapy. J Cardiovasc Nurs (2009) 0.78
The role of tissue engineering and biomaterials in cardiac regenerative medicine. Can J Cardiol (2014) 0.78
Stem cells in pediatric cardiology. Eur J Pediatr (2013) 0.78
Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned? Gene Ther (2012) 0.78
Regenerative therapies in electrophysiology and pacing: introducing the next steps. J Interv Card Electrophysiol (2010) 0.78
Genetic engineering and stem cells: combinatorial approaches for cardiac cell therapy. IEEE Eng Med Biol Mag (2008) 0.78
Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration. IEEE Rev Biomed Eng (2015) 0.77
Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med (2012) 0.77
Cellular replacement therapy for arrhythmia treatment: early clinical experience. J Interv Card Electrophysiol (2008) 0.76
Methods for assessing the electromechanical integration of human pluripotent stem cell-derived cardiomyocyte grafts. Methods Mol Biol (2014) 0.76
Current protocols in the generation of pluripotent stem cells: theoretical, methodological and clinical considerations. Stem Cells Cloning (2009) 0.76
Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review). Int J Mol Med (2017) 0.76
Cardiac stem cells and progenitors: developmental biology and therapeutic challenges. Trans Am Clin Climatol Assoc (2006) 0.76
Gene and cell therapies for the failing heart to prevent sudden arrhythmic death. Minerva Cardioangiol (2012) 0.75
Incorporation of gold-coated microspheres into embryoid body of human embryonic stem cells for cardiomyogenic differentiation. Tissue Eng Part A (2014) 0.75
Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K(+) Current: A Simulation Study. Biomed Res Int (2016) 0.75
Use of Adeno-Associated Virus to Enrich Cardiomyocytes Derived from Human Stem Cells. Hum Gene Ther Clin Dev (2015) 0.75
Special issue on biopacemaking: clinically attractive, scientifically a challenge. Med Biol Eng Comput (2007) 0.75
Human embryonic stem cells for cardiac repair: the focus is on refined selection and cardiopoietic programming. Heart (2007) 0.75
Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation (2010) 13.28
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 10.24
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (2012) 9.86
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation (2007) 8.62
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation (2007) 5.09
2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation (2013) 5.02
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem (2003) 3.93
2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2013) 3.63
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol (2012) 3.48
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation (2009) 3.45
End-stage renal disease predicts complications in pacemaker and ICD implants. J Cardiovasc Electrophysiol (2011) 3.21
The mitochondrial origin of postischemic arrhythmias. J Clin Invest (2005) 3.08
Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol (2008) 2.99
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One (2009) 2.89
Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85
Biological pacemaker created by gene transfer. Nature (2002) 2.83
Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy. Circulation (2005) 2.80
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest (2002) 2.74
Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy. JACC Cardiovasc Imaging (2008) 2.64
Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging (2012) 2.62
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation (2009) 2.55
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J (2003) 2.52
Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res (2005) 2.44
Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension (2004) 2.41
Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol (2011) 2.38
Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (2008) 2.37
Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res (2010) 2.33
Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. J Am Coll Cardiol (2008) 2.33
Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation (2011) 2.29
Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull (2011) 2.26
Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet (2010) 2.24
The future of fellowship training in clinical cardiac electrophysiology: Program directors' perspective 2008. Heart Rhythm (2009) 2.22
Proteomic analysis of pharmacological preconditioning: novel protein targets converge to mitochondrial metabolism pathways. Circ Res (2006) 2.20
Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery. J Am Coll Cardiol (2009) 2.20
Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ Res (2004) 2.19
Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. J Physiol (2002) 2.18
Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol (2011) 2.15
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol (2013) 2.11
Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells (2010) 2.10
Functional sarcoplasmic reticulum for calcium handling of human embryonic stem cell-derived cardiomyocytes: insights for driven maturation. Stem Cells (2007) 2.10
Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol (2008) 2.09
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation (2009) 2.09
Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. Mol Cell (2004) 2.05
Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond: a presidential advisory from the American Heart Association. Circulation (2011) 2.05
Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med (2013) 2.04
Dual antiplatelet therapy and heparin "bridging" significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantation. J Am Coll Cardiol (2010) 1.97
Gaps in the ablation line as a potential cause of recovery from electrical isolation and their visualization using MRI. Circ Arrhythm Electrophysiol (2011) 1.95
Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol (2007) 1.94
Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res (2010) 1.90
Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One (2010) 1.89
Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res (2003) 1.89
Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium. Heart Rhythm (2010) 1.89
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res (2009) 1.88
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol (2010) 1.88
Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart. Circ Res (2004) 1.87
Beat-to-beat three-dimensional ECG variability predicts ventricular arrhythmia in ICD recipients. Heart Rhythm (2010) 1.85
Endogenous cardiac stem cells. Prog Cardiovasc Dis (2007) 1.79
Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression. J Clin Invest (2003) 1.78
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol (2012) 1.74
QT-interval duration and mortality rate: results from the Third National Health and Nutrition Examination Survey. Arch Intern Med (2011) 1.73
Modulation of Kv4.3 current by accessory subunits. FEBS Lett (2002) 1.72
Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium. Cardiovasc Res (2003) 1.70
Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res (2002) 1.70
Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation (2006) 1.70
A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte. Biophys J (2006) 1.69
Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circ Cardiovasc Genet (2011) 1.68
Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol (2004) 1.67
Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization. Circulation (2008) 1.67
CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc Natl Acad Sci U S A (2008) 1.66
Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation (2012) 1.65
Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells (2010) 1.63
Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy. Circulation (2009) 1.63
Electrocardiographic QT interval and mortality: a meta-analysis. Epidemiology (2011) 1.62
Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ Res (2002) 1.62
Overexpression of HCN-encoded pacemaker current silences bioartificial pacemakers. Heart Rhythm (2008) 1.61
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol (2009) 1.60
Intracardiac J-point elevation before the onset of polymorphic ventricular tachycardia and ventricular fibrillation in patients with an implantable cardioverter-defibrillator. Heart Rhythm (2012) 1.60
Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. Proc Natl Acad Sci U S A (2004) 1.60
Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? Circulation (2002) 1.59
Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state. Biochem Biophys Res Commun (2008) 1.59