Published in Cytometry on October 01, 2002
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci (2005) 3.96
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One (2010) 2.38
Active mask segmentation of fluorescence microscope images. IEEE Trans Image Process (2009) 1.81
Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression. J Pathol (2013) 1.07
Cellular Senescence - its role in cancer and the response to ionizing radiation. Genome Integr (2011) 0.98
A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res (2008) 0.91
Multiresolution Multiscale Active Mask Segmentation of Fluorescence Microscope Images. Proc SPIE Int Soc Opt Eng (2009) 0.75
Ionizing radiation abrogates the pro-tumorigenic capacity of cancer-associated fibroblasts co-implanted in xenografts. Sci Rep (2017) 0.75
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74
Automatic and quantitative measurement of protein-protein colocalization in live cells. Biophys J (2004) 7.62
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
Four faces of cellular senescence. J Cell Biol (2011) 6.86
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc (2009) 4.47
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci (2005) 3.96
A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One (2009) 3.83
Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med (2010) 3.79
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest (2013) 3.47
Puzzles, promises and a cure for ageing. Nature (2008) 3.23
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med (2012) 3.21
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res (2002) 3.16
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem (2006) 3.00
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A (2009) 2.82
Two faces of p53: aging and tumor suppression. Nucleic Acids Res (2007) 2.78
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res (2008) 2.63
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J (2011) 2.61
TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem (2004) 2.52
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) (2009) 2.49
Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol (2007) 2.42
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One (2010) 2.38
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci (2010) 2.34
Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A (2003) 2.24
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle (2011) 2.15
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem (2011) 2.11
Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol (2002) 2.08
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
Ageing: balancing regeneration and cancer. Nature (2006) 1.88
High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis. Proc Natl Acad Sci U S A (2009) 1.76
Mechanisms of cellular senescence in human and mouse cells. Biogerontology (2004) 1.76
Telomeres, aging and cancer: in search of a happy ending. Oncogene (2002) 1.69
Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol (2005) 1.64
A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle (2009) 1.58
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. J Biol Chem (2002) 1.50
Oncogene-induced senescence pathways weave an intricate tapestry. Cell (2007) 1.47
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell (2010) 1.43
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide. J Biol Chem (2005) 1.39
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol (2003) 1.32
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem (2002) 1.27
Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron (2011) 1.26
Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach. Mol Cell Proteomics (2010) 1.26
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol (2013) 1.25
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res (2004) 1.24
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell (2003) 1.23
SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res (2003) 1.22
The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev (2005) 1.22
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Genet (2005) 1.22
Role of murine leukemia virus nucleocapsid protein in virus assembly. J Virol (2004) 1.22
The role of inflammation in age-related disease. Aging (Albany NY) (2013) 1.22
Whole cell segmentation in solid tissue sections. Cytometry A (2005) 1.21
Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol (2003) 1.21
Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor. J Immunol (2004) 1.20
Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction. Toxicol Appl Pharmacol (2010) 1.20
p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A (2007) 1.18
RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. Mol Cell (2006) 1.18
Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res (2002) 1.18
Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci (2005) 1.17
High-throughput analysis of multispectral images of breast cancer tissue. IEEE Trans Image Process (2006) 1.17
Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. Mol Cell Biol (2005) 1.17
ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle (2004) 1.15
Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts. J Cell Physiol (2007) 1.14
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol (2008) 1.14
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Mol Cell Biol (2006) 1.13
Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission. Proc Natl Acad Sci U S A (2010) 1.09
The demographic and biomedical case for late-life interventions in aging. Sci Transl Med (2010) 1.08
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell (2012) 1.08
Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol (2004) 1.08
Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. PLoS Genet (2010) 1.06
Sphingomyelinase restricts the lateral diffusion of CD4 and inhibits human immunodeficiency virus fusion. J Virol (2007) 1.06
CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2. FASEB J (2005) 1.06
Between Scylla and Charybdis: p53 links tumor suppression and aging. Mech Ageing Dev (2002) 1.05
Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors. J Immunol (2006) 1.04
The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep (2003) 1.03
Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells (2014) 1.01
Aging: past, present and future. Aging (Albany NY) (2009) 1.01
Senescent cells and their secretory phenotype as targets for cancer therapy. Interdiscip Top Gerontol (2013) 1.00
In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transfer. J Biol Chem (2004) 1.00
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics (2012) 0.99
p53: Pro-aging or pro-longevity? Aging (Albany NY) (2010) 0.98
Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair (Amst) (2005) 0.98
mTORC1 and p53: clash of the gods? Cell Cycle (2013) 0.98
Fragile fugue: p53 in aging, cancer and IGF signaling. Nat Med (2004) 0.93
Hypoxia-inducible factor-1 and neuroglobin expression. Neurosci Lett (2012) 0.93
Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand. J Immunol (2007) 0.92
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal (2012) 0.92
Cancer and aging: more puzzles, more promises? Cell Cycle (2008) 0.92
GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. Differentiation (2011) 0.92
A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res (2008) 0.91
Genomic instability, aging, and cellular senescence. Ann N Y Acad Sci (2004) 0.91
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res (2008) 0.90