Published in J Cell Biol on April 28, 2008
A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One (2009) 3.83
A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle (2009) 1.58
Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutat Res (2011) 1.56
Human RAP1 inhibits non-homologous end joining at telomeres. EMBO J (2009) 1.49
Conservation of telomere protein complexes: shuffling through evolution. Crit Rev Biochem Mol Biol (2009) 1.29
Distinct functions of POT1 at telomeres. Mol Cell Biol (2008) 1.18
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol Cell Proteomics (2010) 1.12
GNL3L stabilizes the TRF1 complex and promotes mitotic transition. J Cell Biol (2009) 1.09
TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase. J Biol Chem (2011) 1.04
Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita. Blood (2012) 0.99
Androgen receptor interacts with telomeric proteins in prostate cancer cells. J Biol Chem (2010) 0.97
Molecular basis of telomere dysfunction in human genetic diseases. Nat Struct Mol Biol (2015) 0.97
Telomeric armor: the layers of end protection. J Cell Sci (2009) 0.95
Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrity. Cell Res (2014) 0.88
Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment. PLoS Genet (2014) 0.86
Structural and functional association of androgen receptor with telomeres in prostate cancer cells. Aging (Albany NY) (2013) 0.83
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. PLoS Genet (2015) 0.82
Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives. J Cell Mol Med (2011) 0.79
Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis. Mutat Res Rev Mutat Res (2014) 0.78
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell (2016) 0.77
Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors. PLoS One (2011) 0.77
Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression. Aging Cell (2015) 0.76
Telomerase turns telomere dysfunction from bad to worse. Asian J Androl (2012) 0.75
Telomeres and telomerase in prostate cancer development and therapy. Nat Rev Urol (2017) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13
DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08
Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62
Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (1999) 5.89
Telomere states and cell fates. Nature (2000) 5.71
Regulation of telomerase by telomeric proteins. Annu Rev Biochem (2004) 5.69
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol (2005) 5.49
POT1 as a terminal transducer of TRF1 telomere length control. Nature (2003) 5.43
Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 4.96
TIN2, a new regulator of telomere length in human cells. Nat Genet (1999) 4.66
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature (2007) 4.23
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell (2006) 4.13
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell (2006) 4.11
PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol (2004) 3.33
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev (2004) 3.25
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc Natl Acad Sci U S A (1999) 2.97
Different telomere damage signaling pathways in human and mouse cells. EMBO J (2002) 2.87
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76
Telomere analysis by fluorescence in situ hybridization and flow cytometry. Nucleic Acids Res (1998) 2.75
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem (2004) 2.52
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol (2004) 2.45
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem (2004) 2.36
TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev (2003) 2.27
TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J (1999) 2.20
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci U S A (2006) 2.04
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
POT1 and TRF2 cooperate to maintain telomeric integrity. Mol Cell Biol (2005) 1.74
Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol Cell Biol (2002) 1.69
Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res (2004) 1.66
Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol (2005) 1.64
Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc Natl Acad Sci U S A (1993) 1.60
Importance of TRF1 for functional telomere structure. J Biol Chem (2003) 1.37
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol (2003) 1.32
Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene (2001) 1.31
Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol (2004) 1.08
The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep (2003) 1.03
Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts. Hum Mol Genet (2003) 0.90
Inhibition of p53 by lentiviral mediated shRNA abrogates G1 arrest and apoptosis in retinal pigmented epithelial cell line. Cell Cycle (2005) 0.86
Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models. Aging Cell (2005) 0.84
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
Four faces of cellular senescence. J Cell Biol (2011) 6.86
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc (2009) 4.47
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci (2005) 3.96
A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One (2009) 3.83
Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med (2010) 3.79
A dissection of specific and non-specific protein-protein interfaces. J Mol Biol (2004) 3.77
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest (2013) 3.47
Puzzles, promises and a cure for ageing. Nature (2008) 3.23
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med (2012) 3.21
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res (2002) 3.16
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem (2006) 3.00
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A (2009) 2.82
Two faces of p53: aging and tumor suppression. Nucleic Acids Res (2007) 2.78
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell (2009) 2.76
Microbial metalloproteomes are largely uncharacterized. Nature (2010) 2.62
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J (2011) 2.61
TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem (2004) 2.52
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) (2009) 2.49
Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol (2007) 2.42
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One (2010) 2.38
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci (2010) 2.34
Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A (2003) 2.24
Dissecting subunit interfaces in homodimeric proteins. Proteins (2003) 2.24
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle (2011) 2.15
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem (2011) 2.11
Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol (2002) 2.08
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell (2007) 2.00
Ageing: balancing regeneration and cancer. Nature (2006) 1.88
Mechanisms of cellular senescence in human and mouse cells. Biogerontology (2004) 1.76
Telomeres, aging and cancer: in search of a happy ending. Oncogene (2002) 1.69
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Res (2004) 1.66
The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci (2009) 1.64
Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol (2005) 1.64
Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Mol Cancer Ther (2005) 1.59
Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients. Mol Cell Proteomics (2008) 1.58
A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle (2009) 1.58
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep (2005) 1.56
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol (2006) 1.55
Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. J Biol Chem (2002) 1.50
Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells. Cell Cycle (2009) 1.49
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nat Protoc (2013) 1.49
Oncogene-induced senescence pathways weave an intricate tapestry. Cell (2007) 1.47
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell (2010) 1.43
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst) (2002) 1.40
Hierarchical classification of protein folds using a novel ensemble classifier. PLoS One (2013) 1.36
Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. Cancer Res (2002) 1.32
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol (2003) 1.32
Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease. J Biol Chem (2006) 1.31
A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: the t(8;22)(q24.13;q11.21). Am J Hum Genet (2010) 1.30
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem (2002) 1.27
A nanostructure-initiator mass spectrometry-based enzyme activity assay. Proc Natl Acad Sci U S A (2008) 1.27
Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron (2011) 1.26
Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach. Mol Cell Proteomics (2010) 1.26
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol (2013) 1.25
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst) (2005) 1.25
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res (2004) 1.24
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell (2003) 1.23
SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res (2003) 1.22
The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev (2005) 1.22
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Genet (2005) 1.22
The role of inflammation in age-related disease. Aging (Albany NY) (2013) 1.22
A low-concentration hydrothermal synthesis of biocompatible ordered mesoporous carbon nanospheres with tunable and uniform size. Angew Chem Int Ed Engl (2010) 1.21
Quantification of epithelial cells in coculture with fibroblasts by fluorescence image analysis. Cytometry (2002) 1.21
A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus. Immunity (2006) 1.19
p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A (2007) 1.18
Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res (2002) 1.18