Published in DNA Repair (Amst) on August 26, 2005
Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One (2007) 1.11
A model system for analyzing somatic mutations in Drosophila melanogaster. Nat Methods (2007) 1.02
Genome dynamics and transcriptional deregulation in aging. Neuroscience (2006) 1.01
Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells. FASEB J (2008) 0.91
Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. Histochem Cell Biol (2016) 0.89
Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells. PLoS One (2008) 0.86
TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts. DNA Repair (Amst) (2015) 0.80
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
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Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc (2009) 4.47
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci (2005) 3.96
A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One (2009) 3.83
Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med (2010) 3.79
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
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Puzzles, promises and a cure for ageing. Nature (2008) 3.23
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med (2012) 3.21
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res (2002) 3.16
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem (2006) 3.00
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A (2009) 2.82
Two faces of p53: aging and tumor suppression. Nucleic Acids Res (2007) 2.78
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J (2011) 2.61
TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem (2004) 2.52
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) (2009) 2.49
DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44
Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol (2007) 2.42
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One (2010) 2.38
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci (2010) 2.34
Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A (2003) 2.24
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle (2011) 2.15
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem (2011) 2.11
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell (2004) 2.11
Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol (2002) 2.08
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
Ageing: balancing regeneration and cancer. Nature (2006) 1.88
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med (2010) 1.86
Mechanisms of cellular senescence in human and mouse cells. Biogerontology (2004) 1.76
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants. Mutat Res (2011) 1.75
Telomeres, aging and cancer: in search of a happy ending. Oncogene (2002) 1.69
Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol (2005) 1.64
A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle (2009) 1.58
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Large genome rearrangements as a primary cause of aging. Mech Ageing Dev (2002) 1.56
Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res (2011) 1.56
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A (2002) 1.54
Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. J Biol Chem (2002) 1.50
Oncogene-induced senescence pathways weave an intricate tapestry. Cell (2007) 1.47
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum Mutat (2002) 1.44
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res (2006) 1.43
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell (2010) 1.43
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
SNP discovery in associating genetic variation with human disease phenotypes. Mutat Res (2005) 1.42
Genome instability, cancer and aging. Biochim Biophys Acta (2009) 1.40
Aging and genome maintenance. Ann N Y Acad Sci (2005) 1.39
Mortality in low- and very low-risk patients undergoing cardiac surgery: Evaluation according to the EuroSCORE II as a new standard. Cardiol J (2015) 1.39
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) (2005) 1.38
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol (2003) 1.32
Mitochondrial DNA mutations and aging: devils in the details? Trends Genet (2008) 1.30
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem (2002) 1.27
Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron (2011) 1.26
Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach. Mol Cell Proteomics (2010) 1.26
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol (2013) 1.25
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res (2004) 1.24
Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech Ageing Dev (2008) 1.24
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell (2003) 1.23
Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol (2008) 1.23
SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res (2003) 1.22
The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev (2005) 1.22
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. Antimicrob Agents Chemother (2005) 1.22
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Genet (2005) 1.22
The role of inflammation in age-related disease. Aging (Albany NY) (2013) 1.22
Quantification of epithelial cells in coculture with fibroblasts by fluorescence image analysis. Cytometry (2002) 1.21
Genome dynamics in aging mice. Genome Res (2002) 1.20
Aging alters the apoptotic response to genotoxic stress. Nat Med (2002) 1.18
p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A (2007) 1.18
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech Ageing Dev (2003) 1.18
Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res (2002) 1.18
Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci (2005) 1.17
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis (2011) 1.17
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. Antioxid Redox Signal (2006) 1.16
Does damage to DNA and other macromolecules play a role in aging? If so, how? J Gerontol A Biol Sci Med Sci (2009) 1.16
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res (2008) 1.15
ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle (2004) 1.15
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol (2008) 1.14
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Mol Cell Biol (2006) 1.13
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res (2005) 1.12
Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One (2007) 1.11