Published in Eur Respir J on September 01, 2002
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest (2008) 2.71
Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest (2012) 2.59
Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest (2008) 2.49
Genetics and genomics of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 2.31
High frequency of BMPR2 exonic deletions/duplications in familial pulmonary arterial hypertension. Am J Respir Crit Care Med (2006) 1.81
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. J Med Genet (2003) 1.76
BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis. Lancet Respir Med (2016) 1.51
Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension. Am J Respir Cell Mol Biol (2005) 1.28
Pulmonary arterial hypertension. Orphanet J Rare Dis (2013) 1.18
A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. Am J Physiol Lung Cell Mol Physiol (2012) 1.18
The genetic basis of pulmonary arterial hypertension. Hum Genet (2014) 1.14
Pulmonary hypertension: therapeutic targets within the serotonin system. Br J Pharmacol (2008) 1.11
BMPs and their clinical potentials. BMB Rep (2011) 1.11
Genetics of pulmonary arterial hypertension. Semin Respir Crit Care Med (2009) 1.07
Genetics and mediators in pulmonary arterial hypertension. Clin Chest Med (2007) 1.06
Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. Antioxid Redox Signal (2009) 1.02
Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. J Heart Lung Transplant (2009) 1.01
The genetics of pulmonary arterial hypertension. Circ Res (2014) 0.95
Signal transduction in the development of pulmonary arterial hypertension. Pulm Circ (2013) 0.95
A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet? Pulm Circ (2013) 0.94
Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovasc Res (2013) 0.90
Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals. BMC Med (2008) 0.87
Eisenmenger syndrome and atrial septal defect: nature or nurture? Can J Cardiol (2006) 0.86
Genetics of pulmonary arterial hypertension: do the molecular findings have translational value? F1000 Biol Rep (2010) 0.83
Novel promoter and exon mutations of the BMPR2 gene in Chinese patients with pulmonary arterial hypertension. Eur J Hum Genet (2009) 0.82
Heritable forms of pulmonary arterial hypertension. Semin Respir Crit Care Med (2013) 0.81
BMPR2 germline mutation in chronic thromboembolic pulmonary hypertension. Lung (2014) 0.77
Programmatic change: lung disease research in the era of induced pluripotency. Am J Physiol Lung Cell Mol Physiol (2011) 0.77
Metabolic Dysfunction in Pulmonary Arterial Hypertension. Curr Hypertens Rep (2015) 0.76
Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension. Thorax (2007) 0.76
Waiting in anticipation: the genetics of pulmonary arterial hypertension. Am J Respir Crit Care Med (2012) 0.76
The role of genetics in pulmonary arterial hypertension. J Pathol (2016) 0.75
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med (1991) 13.21
Establishing functional speech in echolalic children. Behav Res Ther (1967) 11.82
Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group. N Engl J Med (1996) 11.76
Identification and expression cloning of a leptin receptor, OB-R. Cell (1995) 9.74
X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A (1984) 8.35
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell (1996) 7.45
A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. Prévention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group. N Engl J Med (1998) 7.08
Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med (1995) 6.97
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet (2001) 6.88
Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J (2009) 6.64
Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet (2008) 5.01
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell (1993) 5.00
A pilot basic education program for school dropouts incorporating a token reinforcement system. Behav Res Ther (1968) 4.94
Loss of information due to ambiguous haplotyping of SNPs. Nat Genet (1999) 4.90
DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. Am J Pathol (1998) 4.61
Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs. Am J Hum Genet (1981) 4.49
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet (2000) 4.42
Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. The Tasman Study Group. N Engl J Med (1996) 4.10
Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Ann Intern Med (2000) 4.07
Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk. J Natl Cancer Inst (2000) 4.03
Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet (1997) 3.85
Inbreeding avoidance in animals. Trends Ecol Evol (1996) 3.79
Approaches to sudden death from coronary heart disease. Circulation (1971) 3.58
Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. N Engl J Med (2001) 3.29
Application of operant conditioning procedures to the behavior problems of an autistic child: a follow-up and extension. Behav Res Ther (1967) 3.23
The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity. Am J Hum Genet (1983) 3.23
Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis. J Exp Med (1976) 3.22
Anchored reference loci for comparative genome mapping in mammals. Nat Genet (1993) 3.19
The information contained in multiple sibling pairs. Genet Epidemiol (1984) 3.10
Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nat Genet (1994) 2.97
Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension. Eur Respir J (2010) 2.90
Adequacy of single-locus approximations for linkage analyses of oligogenic traits. Genet Epidemiol (1992) 2.89
Survival with first-line bosentan in patients with primary pulmonary hypertension. Eur Respir J (2005) 2.83
Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med (1995) 2.76
The power to detect linkage in complex disease by means of simple LOD-score analyses. Am J Hum Genet (1998) 2.74
DNA copy number losses in human neoplasms. Am J Pathol (1999) 2.73
A simple method to detect linkage for rare recessive diseases: an application to juvenile diabetes. Clin Genet (1979) 2.70
Natural genetic exchanges between vaccine and wild poliovirus strains in humans. J Virol (2000) 2.62
Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J Clin Invest (2001) 2.59
Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56
Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat Genet (1996) 2.53
Bat flight generates complex aerodynamic tracks. Science (2007) 2.50
Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome. Eur Respir J (2009) 2.41
Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil. Eur Respir J (2006) 2.39
MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8. Oncogene (2010) 2.37
Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost (1992) 2.31
Systematic lung scans reveal a high frequency of silent pulmonary embolism in patients with proximal deep venous thrombosis. Arch Intern Med (2000) 2.25
Leading-edge vortex improves lift in slow-flying bats. Science (2008) 2.24
Diagnosis of familial Mediterranean fever by a molecular genetics method. Ann Intern Med (1998) 2.21
Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension. Eur Respir J (1998) 2.14
A robust method for the detection of linkage in familial disease. Am J Hum Genet (1978) 2.10
Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry (2010) 2.05
Artifactual pulse-oximetry estimation in neonates. Lancet (1994) 2.04
Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell (1996) 2.04
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry (2009) 2.03
Splenectomy and chronic thromboembolic pulmonary hypertension. Thorax (2005) 2.03
Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension. Primary Pulmonary Hypertension Study Group. Circulation (1997) 2.03
Primary pulmonary hypertension and fenfluramine use. Br Heart J (1993) 2.02
The probability of obtaining compatible blood from related directed donors. Arch Pathol Lab Med (1990) 2.01
Terahertz spin current pulses controlled by magnetic heterostructures. Nat Nanotechnol (2013) 2.01
First observation of PeV-energy neutrinos with IceCube. Phys Rev Lett (2013) 2.00
Inherent intractability of the ascertainment problem for pedigree data: a general likelihood framework. Am J Hum Genet (1995) 1.92
Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. Am J Hum Genet (1992) 1.91
Affecteds-only linkage methods are not a panacea. Am J Hum Genet (1996) 1.90
Studies on the ultrastructure of Bordetella pertussis. I. Morphology, origin, and biological activity of structures present in the extracellular fluid of liquid cultures of Bordetella pertussis. J Exp Med (1970) 1.90
Sites of production of primate serum proteins associated with complement system. Proc Soc Exp Biol Med (1967) 1.88
Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. Am J Hum Genet (1999) 1.87
Increased plasma serotonin in primary pulmonary hypertension. Am J Med (1995) 1.86
Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension. Eur Respir J (2009) 1.85
Comparative analysis of brain structure, metabolism, and cognition in myotonic dystrophy 1 and 2. Neurology (2010) 1.84
Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (1999) 1.84
Site-specific degradation of Streptomyces lividans DNA during electrophoresis in buffers contaminated with ferrous iron. Nucleic Acids Res (1988) 1.83
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters. Nature (1985) 1.83
Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging. Med Phys (2001) 1.81
Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension. Eur Respir J (2006) 1.78
Linkage analysis under "random" and "genetic" reduced penetrance. Genet Epidemiol (1989) 1.77
[Guidelines for the diagnosis and treatment of pulmonary hypertension]. Rev Mal Respir (2010) 1.74
Chronic thromboembolic pulmonary hypertension. Eur Respir J (2004) 1.74
Filgrastim in patients with chemotherapy-induced febrile neutropenia. A double-blind, placebo-controlled trial. Ann Intern Med (1994) 1.73