Published in Am J Hum Genet on November 01, 1983
Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage. Am J Hum Genet (1988) 4.86
Estimating the power of a proposed linkage study for a complex genetic trait. Am J Hum Genet (1989) 4.42
Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data. Am J Hum Genet (1986) 3.16
Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet (2004) 2.58
Joint linkage of multiple loci for a complex disorder. Am J Hum Genet (1993) 2.20
Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. Am J Hum Genet (1992) 1.91
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev (2008) 1.66
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. Am J Hum Genet (1992) 1.63
HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity. Am J Hum Genet (2002) 1.51
Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2. Am J Hum Genet (2004) 1.51
A new test for linkage in the presence of locus heterogeneity. Am J Hum Genet (1992) 1.44
Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. Am J Hum Genet (1995) 1.42
Cutaneous malignant melanoma and familial dysplastic nevi: evidence for autosomal dominance and pleiotropy. Am J Hum Genet (1986) 1.39
Use of molecular haplotypes specific for the human pro alpha 2(I) collagen gene in linkage analysis of the mild autosomal dominant forms of osteogenesis imperfecta. Am J Hum Genet (1986) 1.29
A new statistical test for linkage heterogeneity. Am J Hum Genet (1988) 1.26
KELVIN: a software package for rigorous measurement of statistical evidence in human genetics. Hum Hered (2011) 1.23
Multipoint gene mapping using seriation. II. Analysis of simulated and empirical data. Am J Hum Genet (1987) 1.21
High-resolution mapping of the X-linked hypohidrotic ectodermal dysplasia (EDA) locus. Am J Hum Genet (1992) 1.07
Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q. Proc Natl Acad Sci U S A (2003) 1.01
Chromosome 14 and late-onset familial Alzheimer disease (FAD). Am J Hum Genet (1993) 0.98
'Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease. J Clin Endocrinol Metab (2008) 0.97
Genetic heterogeneity among kindreds with Alport syndrome. Am J Hum Genet (1986) 0.95
TDT-HET: a new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data. BMC Bioinformatics (2012) 0.92
Genetic heterogeneity of insulin-dependent (type I) diabetes mellitus: evidence from a study of extended haplotypes. Am J Hum Genet (1984) 0.89
Detection of linkage for heterogeneous disorders by using multipoint linkage analysis. Am J Hum Genet (1991) 0.89
Empirical power of three preliminary methods for ordering loci. Am J Hum Genet (1988) 0.87
DSLINK: a computer program for gene-centromere linkage analysis in families with a trisomic offspring. Am J Hum Genet (1987) 0.85
Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases. J Med Genet (2006) 0.83
A genome-wide search replicates evidence of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE) unlinked to the ACE gene. BMC Med Genomics (2008) 0.82
A novel analytical framework for dissecting the genetic architecture of behavioral symptoms in neuropsychiatric disorders. PLoS One (2010) 0.79
A linkage search for joint panic disorder/bipolar genes. Am J Med Genet B Neuropsychiatr Genet (2009) 0.77
A combined test of linkage heterogeneity. Am J Hum Genet (1994) 0.76
Distribution of model-based multipoint heterogeneity lod scores. Genet Epidemiol (2010) 0.76
A combined segregation and linkage analysis of insulin-dependent diabetes mellitus. Am J Hum Genet (1987) 0.75
A latent class model for testing for linkage and classifying families when the sample may contain segregating and non-segregating families. Hum Hered (2010) 0.75
Detection of genetic heterogeneity between families of insulin-dependent diabetes mellitus patients using linkage analysis. Am J Hum Genet (1985) 0.75
Sequential tests for the detection of linkage. Am J Hum Genet (1955) 43.74
Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet (1974) 23.66
The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Am J Hum Genet (1956) 8.34
TESTING FOR HETEROGENEITY OF RECOMBINATION FRACTION VALUES IN HUMAN GENETICS. Ann Hum Genet (1963) 6.17
HL-A, immune-response genes, and disease. Lancet (1974) 5.67
Counting methods (EM algorithm) in human pedigree analysis: linkage and segregation analysis. Ann Hum Genet (1977) 4.54
Bias of the estimated recombination fraction and lod score due to an association between a disease gene and a marker gene. Ann Hum Genet (1982) 3.12
A simple scheme for the analysis of HLA linkages in pedigrees. Ann Hum Genet (1978) 3.01
A two locus model for juvenile diabetes. Ann Hum Genet (1980) 2.63
Gene dosage and suceptibility to insulin-dependent diabetes. Ann Hum Genet (1980) 2.29
Variability of human linkage data. Am J Hum Genet (1978) 1.97
Insulin-dependent diabetes mellitus: the initial lesion. N Engl J Med (1981) 1.93
Some epistatic two-locus models of disease. II. The confounding of linkage and association. Am J Hum Genet (1981) 1.73
X-linkage and genetic heterogeneity in bipolar-related major affective illness: reanalysis of linkage data. Ann Hum Genet (1982) 1.71
A three-allele model for heterogeneity of juvenile onset insulin-dependent diabetes. Ann Hum Genet (1980) 1.70
Studies of the HLA system and insulin-dependent diabetes mellitus. Diabetes Care (1980) 1.63
IgG heavy-chain (Gm) allotypes and immune response to insulin in insulin-requiring diabetes mellitus. N Engl J Med (1981) 1.57
The modes of inheritance of insulin-dependent diabetes mellitus or the genetics of IDDM, no longer a nightmare but still a headache. Am J Hum Genet (1981) 1.47
BF types and the mode of inheritance of insulin-dependent diabetes mellitus (IDDM). Immunogenetics (1981) 1.42
Heterogeneity in diabetes mellitus--update, 1978. Evidence for further genetic heterogeneity within juvenile-onset insulin-dependent diabetes mellitus. Diabetes (1978) 1.38
Genetic marker for insulin-dependent diabetes mellitus. Lancet (1979) 1.36
A simple method for testing two-locus models of inheritance. Am J Hum Genet (1981) 1.33
Genetics of Type I diabetes mellitus: a single, recessive predisposition gene mapping between HLA-B and GLO. With an appendix on the estimation of selection bias. Am J Hum Genet (1981) 1.30
Close genetic linkage between diabetes mellitus and kidd blood group. Lancet (1981) 1.30
Report of the committee on the genetic constitution of chromosome 1. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping. Cytogenet Cell Genet (1982) 1.16
The 1981 catalogue of assigned human genetic markers and report of the nomenclature committee. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping. Cytogenet Cell Genet (1982) 1.15
Juvenile insulin-dependent diabetes: a possible susceptibility gene in interaction with HLA. Ann Hum Genet (1981) 1.15
Genetic studies of insulin-dependent diabetes mellitus: segregation and linkage analyses. Tissue Antigens (1982) 1.06
Heterogeneity of insulin-dependent diabetes-new evidence. Clin Genet (1982) 1.05
The search for heterogeneity in insulin-dependent diabetes mellitus: evidence for familial and nonfamilial forms. Am J Med Genet (1983) 0.98
A search for heterogeneity in insulin dependent diabetes mellitus (IDDM): HLA and autoimmune studies in simplex, multiplex and multigenerational families. Metabolism (1983) 0.95
Genetic susceptibility to diabetes mellitus: the distribution of properdin factor B (Bf) and glyoxalase (GLO) phenotypes. Diabetes (1979) 0.92
No evidence for linkage between diabetes and the Kidd marker. Diabetes (1982) 0.91
Linkage disequilibrium between insulin-dependent diabetes and the Kidd blood group Jkb allele. J Clin Endocrinol Metab (1982) 0.89
Current concepts of diabetic complications with emphasis on hereditary factors: a brief review. Prog Clin Biol Res (1979) 0.86
The increased frequency of the Lewis negative blood group in a diabetic population. Diabetologia (1978) 0.86
Analysis of linkage relationships of Co, Jk and K with each other and with chromosome 2 loci ACP1 and Km. Ann Hum Genet (1982) 0.83
The HLAB*18,BF*F1 in haplotype in type 1 diabetes. Am J Med Genet (1982) 0.83
Genetic polymorphisms in juvenile-onset diabetes. Hum Hered (1978) 0.82
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell (1993) 5.37
Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. Science (1981) 5.28
Loss of information due to ambiguous haplotyping of SNPs. Nat Genet (1999) 4.90
Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs. Am J Hum Genet (1981) 4.49
Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D. Science (1983) 4.43
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet (2000) 4.42
Beta glucuronidase deficiency: report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis. J Pediatr (1973) 3.44
The information contained in multiple sibling pairs. Genet Epidemiol (1984) 3.10
Mental retardation associated with "balanced" chromosome rearrangements. Am J Hum Genet (1977) 3.06
Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat Genet (1995) 2.93
Genetic and clinical heterogeneity in the oral-facial-digital syndromes. J Pediatr (1967) 2.92
Adequacy of single-locus approximations for linkage analyses of oligogenic traits. Genet Epidemiol (1992) 2.89
Patient with 13 chromosome deletion: evidence that the retinoblastoma gene is a recessive cancer gene. Science (1983) 2.78
The power to detect linkage in complex disease by means of simple LOD-score analyses. Am J Hum Genet (1998) 2.74
Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14. Science (1980) 2.72
A simple method to detect linkage for rare recessive diseases: an application to juvenile diabetes. Clin Genet (1979) 2.70
Pachydermoperiostosis: an update. Clin Genet (2005) 2.65
Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. Ann Intern Med (1979) 2.61
Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Nat Genet (1995) 2.55
Cellulose acetate electrophoresis of human glucose-6-phosphate dehydrogenase. J Lab Clin Med (1969) 2.49
The human retinal degeneration slow (RDS) gene: chromosome assignment and structure of the mRNA. Genomics (1991) 2.39
Direct evidence for a bone marrow origin of the alveolar macrophage in man. Science (1976) 2.23
Regional assignment of the steroid sulfatase-X-linked ichthyosis locus: implications for a noninactivated region on the short arm of human X chromosome. Proc Natl Acad Sci U S A (1979) 2.13
Linkage analysis of neurofibromatosis (von Recklinghausen disease). J Med Genet (1983) 2.13
The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J Biol Chem (1987) 2.13
A robust method for the detection of linkage in familial disease. Am J Hum Genet (1978) 2.10
Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. Genomics (1989) 2.10
The G deletion syndromes. J Pediatr (1970) 2.09
Metaphyseal chondrodysplasia, Schmid type. Clinical and radiographic delineation with a review of the literature. Pediatr Radiol (1988) 2.06
The probability of obtaining compatible blood from related directed donors. Arch Pathol Lab Med (1990) 2.01
Expression of an X-linked gene from an inactive human X chromosome in mouse-human hybrid cells: further evidence for the noninactivation of the steroid sulfatase locus in man. Proc Natl Acad Sci U S A (1980) 2.00
Inherent intractability of the ascertainment problem for pedigree data: a general likelihood framework. Am J Hum Genet (1995) 1.92
Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. Am J Hum Genet (1992) 1.91
Affecteds-only linkage methods are not a panacea. Am J Hum Genet (1996) 1.90
Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis. Medicine (Baltimore) (1991) 1.89
Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. Am J Hum Genet (1999) 1.87
Camurati-Engelmann disease. Genetics and clinical manifestations with a review of the literature. J Med Genet (1972) 1.83
Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6. Am J Med Genet (1988) 1.82
Multiple vertebral segmentation defects: analysis of 26 new patients and review of the literature. Am J Med Genet (1996) 1.81
Identification by fluorescent microscopy of the abnormal chromosomes associated with the G-deletion syndromes. Am J Hum Genet (1973) 1.77
Linkage analysis under "random" and "genetic" reduced penetrance. Genet Epidemiol (1989) 1.77
Some epistatic two-locus models of disease. II. The confounding of linkage and association. Am J Hum Genet (1981) 1.73
Osteogenesis imperfecta type II delineation of the phenotype with reference to genetic heterogeneity. Am J Med Genet (1984) 1.72
A three-allele model for heterogeneity of juvenile onset insulin-dependent diabetes. Ann Hum Genet (1980) 1.70
Familial retinoblastoma and chromosome 13 deletion transmitted via an insertional translocation. Science (1981) 1.70
Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3. Science (1988) 1.69
Adequacy of single-locus approximations for linkage analyses of oligogenic traits: extension to multigenerational pedigree structures. Hum Hered (1994) 1.69
The lacrimo-auriculo-dento-digital syndrome. J Pediatr (1973) 1.67
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet (1999) 1.67
Tandem duplication within a type II collagen gene (COL2A1) exon in an individual with spondyloepiphyseal dysplasia. Proc Natl Acad Sci U S A (1990) 1.66
Genetic aspects of clinical endocrinology. Recent Prog Horm Res (1968) 1.64
Logistic regression model for analyzing extended haplotype data. Genet Epidemiol (1998) 1.61
Duodenal-ulcer disease associated with elevated serum pepsinogen I: an inherited autosomal dominant disorder. N Engl J Med (1979) 1.61
Spondylo-meta-epiphyseal dysplasia (SMED), short limb-hand type: a congenital familial skeletal dysplasia with distinctive features and histopathology. Am J Med Genet (1993) 1.60
Anal atresia, eye anomalies, and an additional small abnormal acrocentric chromosome (47,XX,mar+): report of a case. J Pediatr (1970) 1.58
Geleophysic dysplasia: a storage disorder affecting the skin, bone, liver, heart, and trachea. J Pediatr (1990) 1.58
Absent thumbs with a ring D2 chromosome: a new deletion syndrome. Am J Hum Genet (1967) 1.55
Evidence for recessive and against dominant inheritance at the HLA-"linked" locus in coeliac disease. Am J Hum Genet (1982) 1.54
Acute septic arthritis complicating chronic rheumatoid arthritis. JAMA (1966) 1.54
Bone marrow origin of hepatic macrophages (Kupffer cells) in humans. Science (1978) 1.53
Growth-hormone deficiency in man: an isolated, recessively inherited defect. Science (1966) 1.51
Pericentric inversion of a number 15 chromosome in nine members of one family. Cytogenetics (1970) 1.51
De novo interstitial deletion in the long arm of chromosome 9: a new chromosome syndrome. J Med Genet (1982) 1.48
Linkage of an autosomal dominant clefting syndrome (Van der Woude) to loci on chromosome Iq. Am J Hum Genet (1990) 1.48
Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hünermann syndrome. Nat Genet (1999) 1.47
HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees. Am J Hum Genet (1980) 1.46
Huntington disease: linkage analysis with age-of-onset corrections. Am J Med Genet (1980) 1.46
HLA genotypic study of insulin-dependent diabetes the excess of DR3/DR4 heterozygotes allows rejection of the recessive hypothesis. Diabetes (1983) 1.45
The efficacy of indium-111-polyclonal IgG for the detection of infection and inflammation. J Nucl Med (1994) 1.44
Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene. Nat Genet (1996) 1.44
Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32. Circulation (1997) 1.43
Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue. N Engl J Med (1968) 1.43
The chondrodystrophies. Adv Hum Genet (1975) 1.42
Peptic ulcer disease--a heterogeneous group of disorders? Gastroenterology (1977) 1.42
D2 dopamine receptor gene and cigarette smoking: a reward gene? Med Hypotheses (1994) 1.42
Genetic homogeneity of cartilage-hair hypoplasia. Hum Genet (1995) 1.39
Fetal varicella syndrome. J Pediatr (1987) 1.39
Heterogeneity in diabetes mellitus--update, 1978. Evidence for further genetic heterogeneity within juvenile-onset insulin-dependent diabetes mellitus. Diabetes (1978) 1.38
Ring 10 chromosome: 46,XX,r10(p15q26). Hum Genet (1978) 1.37
Classification of osteogenesis imperfect. Lancet (1978) 1.37
Event excess in the MiniBooNE search for ¯νμ→¯νe oscillations. Phys Rev Lett (2010) 1.37
The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution. Cell (1988) 1.36
Confirmation of linkage between juvenile myoclonic epilepsy locus and the HLA region of chromosome 6. Am J Med Genet (1991) 1.36
Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A synthase and the chromosomal localization of the human gene. J Biol Chem (1986) 1.36
Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics (1993) 1.35
Spondylocostal dysplasia. A dominantly inherited form of short-trunked dwarfism. Am J Med (1968) 1.35
Origin of human bone marrow fibroblasts. Br J Haematol (1980) 1.34
A familial syndrome of deafness, alopecia, and hypogonadism. J Pediatr (1973) 1.34
Possible heterogeneity in the segregation pattern of breast cancer in families with bilateral breast cancer. Genet Epidemiol (1988) 1.33
A new variant of Ehlers-Danlos syndrome: an autosomal dominant disorder of fragile skin, abnormal scarring, and generalized periodontitis. Birth Defects Orig Artic Ser (1977) 1.33
Assignment of the human and mouse prion protein genes to homologous chromosomes. Proc Natl Acad Sci U S A (1986) 1.33
Probable trisomy 22 identified by fluorescent and trypsin-giemsa banding. Ann Genet (1973) 1.33
Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum. Am J Hum Genet (1998) 1.33
Standard growth curves for achondroplasia. J Pediatr (1978) 1.32
BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. Eur Respir J (2002) 1.31
Human X-autosome translocations: differential inactivation of the X chromosome in a kindred with an X-9 translocation. Am J Hum Genet (1975) 1.31
D2 dopamine receptor gene and obesity. Int J Eat Disord (1994) 1.30
Close genetic linkage between diabetes mellitus and kidd blood group. Lancet (1981) 1.30