Published in EMBO Rep on October 22, 2002
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15
Role of desumoylation in the development of prostate cancer. Neoplasia (2006) 1.90
SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin. Mol Cell Biol (2005) 1.48
Sumoylation induced by the Arf tumor suppressor: a p53-independent function. Proc Natl Acad Sci U S A (2005) 1.34
Human pathogens and the host cell SUMOylation system. J Virol (2011) 1.31
Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol (2010) 1.26
Regulation of the tumor suppressor PTEN by SUMO. Cell Death Dis (2012) 1.02
Transcription and beyond: the role of mammalian class I lysine deacetylases. Chromosoma (2013) 1.01
Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation. PLoS Pathog (2013) 0.98
Arabidopsis thaliana histone deacetylase 1 (AtHD1) is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro. Cell Res (2006) 0.95
Viral manipulation of cellular protein conjugation pathways: The SUMO lesson. World J Virol (2013) 0.92
Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV. Front Microbiol (2012) 0.89
Host cell detection of noncoding stuffer DNA contained in helper-dependent adenovirus vectors leads to epigenetic repression of transgene expression. J Virol (2009) 0.89
Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α. Virology (2012) 0.88
Sumoylation at the host-pathogen interface. Biomolecules (2012) 0.86
BC-box protein domain-related mechanism for VHL protein degradation. Proc Natl Acad Sci U S A (2013) 0.86
Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenoviruses. BMC Bioinformatics (2003) 0.80
Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention. Rev Med Virol (2015) 0.79
The chicken adenovirus Gam1 protein, an inhibitor of the sumoylation pathway, partially complements ICP0-null mutant herpes simplex virus 1. J Virol (2014) 0.76
The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections. Ecancermedicalscience (2015) 0.76
Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease. Cell Death Differ (2017) 0.75
Expression and in vitro functional analyses of recombinant Gam1 protein. Protein Expr Purif (2014) 0.75
A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction. Heliyon (2016) 0.75
Stimulation of the Replication of ICP0-Null Mutant Herpes Simplex Virus 1 and pp71-Deficient Human Cytomegalovirus by Epstein-Barr Virus Tegument Protein BNRF1. J Virol (2016) 0.75
The Epstein-Barr virus miR-BHRF1-1 targets RNF4 during productive infection to promote the accumulation of SUMO conjugates and the release of infectious virus. PLoS Pathog (2017) 0.75
Viral manipulation of the cellular sumoylation machinery. Cell Commun Signal (2017) 0.75
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Histone acetylation and transcriptional regulatory mechanisms. Genes Dev (1998) 10.16
Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev (2000) 9.36
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J Cell Biol (1999) 5.83
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J Biol Chem (2000) 4.96
HSV-1 IE protein Vmw110 causes redistribution of PML. EMBO J (1994) 4.61
Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell (1997) 4.39
Role of SUMO-1-modified PML in nuclear body formation. Blood (2000) 4.05
The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition. J Cell Biol (1996) 3.91
A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A (1998) 3.85
Evolution and function of ubiquitin-like protein-conjugation systems. Nat Cell Biol (2000) 3.76
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. EMBO J (1999) 3.08
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption. J Virol (1999) 2.87
The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells. J Virol (1997) 2.83
Functional significance of histone deacetylase diversity. Curr Opin Genet Dev (2001) 2.79
The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1. Exp Cell Res (1996) 2.69
Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol Cell Biol (2000) 2.59
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J (2002) 2.56
Nucleosomes: regulators of transcription. Trends Genet (1990) 2.44
Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 affect cellular structures and proteins. J Virol (2000) 2.25
Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. J Biol Chem (2001) 2.08
Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies. J Virol (2001) 2.07
Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J (2002) 2.06
SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J Biol Chem (2002) 1.99
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol (2001) 1.70
Protein modification by SUMO. Trends Biochem Sci (2001) 1.54
Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1. J Mol Biol (2001) 1.38
Activation of heat-shock response by an adenovirus is essential for virus replication. Nature (2000) 1.34
Intracellular targeting of proteins by sumoylation. Exp Cell Res (2001) 1.25
Inhibition of histone deacetylation induces constitutive derepression of the beta interferon promoter and confers antiviral activity. J Virol (2001) 1.16
The bovine herpesvirus 1 immediate-early protein (bICP0) associates with histone deacetylase 1 to activate transcription. J Virol (2001) 1.14
Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo. J Virol (2002) 1.02
Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus. J Virol (1997) 0.96
Histone deacetylase 1 inactivation by an adenovirus early gene product. Curr Biol (2002) 0.92
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature (2003) 3.54
Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol (2006) 2.28
Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep (2003) 2.21
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev (2010) 2.14
Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol (2007) 2.07
Dual mode of degradation of Cdc25 A phosphatase. EMBO J (2002) 1.95
A mechanism for inhibiting the SUMO pathway. Mol Cell (2004) 1.93
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol (2003) 1.77
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. J Clin Invest (2015) 1.74
14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. EMBO J (2007) 1.69
Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation. Int J Dev Biol (2009) 1.66
Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis. Oncogene (2004) 1.66
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res (2009) 1.54
EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. Oncogene (2004) 1.54
The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol Cell Biol (2009) 1.42
The biology of HDAC in cancer: the nuclear and epigenetic components. Handb Exp Pharmacol (2011) 1.41
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39
Nuclear ubiquitin ligases, NF-kappaB degradation, and the control of inflammation. Sci Signal (2008) 1.38
Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. Mol Cell Biol (2002) 1.36
Sumoylation induced by the Arf tumor suppressor: a p53-independent function. Proc Natl Acad Sci U S A (2005) 1.34
Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene. Proc Natl Acad Sci U S A (2007) 1.33
Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem (2004) 1.33
Frequent alterations in the expression of serine/threonine kinases in human cancers. Cancer Res (2006) 1.32
Viruses and sumoylation: recent highlights. Curr Opin Microbiol (2006) 1.32
Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation. J Biol Chem (2007) 1.27
Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol (2010) 1.26
Histone H3 phosphorylation - a versatile chromatin modification for different occasions. Biochimie (2012) 1.23
Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res (2010) 1.19
Autoregulation of mouse histone deacetylase 1 expression. Mol Cell Biol (2003) 1.19
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance. Blood (2013) 1.19
Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation. Biochem Biophys Res Commun (2006) 1.17
Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis. Cell Cycle (2011) 1.17
Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells. Mol Biol Cell (2009) 1.12
Gam1-associated alterations of drug responsiveness through activation of apoptosis. Mol Cancer Ther (2007) 1.12
Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation. Cell Cycle (2004) 1.09
TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO J (2002) 1.07
Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol (2005) 1.07
Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. EMBO J (2010) 1.03
A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors. J Biol Chem (2010) 1.02
Transcription and beyond: the role of mammalian class I lysine deacetylases. Chromosoma (2013) 1.01
Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns. Cell Cycle (2008) 0.99
Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification. J Biol Chem (2002) 0.99
The polycomb repressive complex 2 is a potential target of SUMO modifications. PLoS One (2008) 0.99
Epigenetic regulation of a murine retrotransposon by a dual histone modification mark. PLoS Genet (2010) 0.99
Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. EMBO J (2013) 0.98
Tumors and mitochondrial respiration: a neglected connection. Cancer Res (2015) 0.98
In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells. Genes Dev (2012) 0.97
Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities. Mol Cancer Ther (2013) 0.94
Viral manipulation of cellular protein conjugation pathways: The SUMO lesson. World J Virol (2013) 0.92
Histone deacetylase 1 inactivation by an adenovirus early gene product. Curr Biol (2002) 0.92
Dynamic distribution of HDAC1 and HDAC2 during mitosis: association with F-actin. J Cell Physiol (2013) 0.89
Gam1 and the SUMO pathway. Cell Cycle (2005) 0.88
Protein kinase CK2 regulates the dimerization of histone deacetylase 1 (HDAC1) and HDAC2 during mitosis. J Biol Chem (2013) 0.88
A role for paralog-specific sumoylation in histone deacetylase 1 stability. J Mol Cell Biol (2013) 0.87
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery. J Comb Chem (2008) 0.87
Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids. Blood (2009) 0.86
Single inner cell masses yield embryonic stem cell lines differing in lifr expression and their developmental potential. Biochem Biophys Res Commun (2005) 0.86
BC-box protein domain-related mechanism for VHL protein degradation. Proc Natl Acad Sci U S A (2013) 0.86
Sumo paralogs: redundancy and divergencies. Front Biosci (Schol Ed) (2013) 0.84
Expression of class I histone deacetylases during chick and mouse development. Int J Dev Biol (2010) 0.83
A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter. PLoS Genet (2012) 0.83
SUMO Ubc9 enzyme as a viral target. IUBMB Life (2014) 0.82
The human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner. PLoS One (2012) 0.82
Fragment-based identification of Hsp90 inhibitors. ChemMedChem (2009) 0.82
Embryonic stem cells facilitate the isolation of persistent clonal cardiovascular progenitor cell lines and leukemia inhibitor factor maintains their self-renewal and myocardial differentiation potential in vitro. Cells Tissues Organs (2013) 0.79
Inhibition of the SUMO pathway by Gam1. Methods Mol Biol (2009) 0.79
Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. J Med Chem (2010) 0.78
tert-Butylcarbamate-containing histone deacetylase inhibitors: apoptosis induction, cytodifferentiation, and antiproliferative activities in cancer cells. ChemMedChem (2013) 0.78
Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. Oncogene (2003) 0.78
Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors. J Med Chem (2011) 0.77
Histone deacetylase inhibitor Trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. Differentiation (2013) 0.77
Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime. ChemMedChem (2014) 0.76
Listeria monocytogenes: a bacterial pathogen to hit on the SUMO pathway. Cell Res (2010) 0.76
The chicken adenovirus Gam1 protein, an inhibitor of the sumoylation pathway, partially complements ICP0-null mutant herpes simplex virus 1. J Virol (2014) 0.76
Lifting the threshold between life and death: SUMO and HDAC fine-tune HIPK2 to sense redox status. Mol Cell (2012) 0.75
Protein acetylation and the physiological role of HDACs. J Biomed Biotechnol (2011) 0.75
Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors. Eur J Med Chem (2013) 0.75
Spiro[chromane-2,4'-piperidine]-based histone deacetylase inhibitors with improved in vivo activity. ChemMedChem (2012) 0.75
Synthesis and biological characterization of amidopropenyl hydroxamates as HDAC inhibitors. ChemMedChem (2010) 0.75