Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.

PubWeight™: 2.15‹?› | Rank: Top 2%

🔗 View Article (PMC 1472304)

Published in Genes Dev on April 05, 2006

Authors

Dafna Nathan1, Kristin Ingvarsdottir, David E Sterner, Gwendolyn R Bylebyl, Milos Dokmanovic, Jean A Dorsey, Kelly A Whelan, Mihajlo Krsmanovic, William S Lane, Pamela B Meluh, Erica S Johnson, Shelley L Berger

Author Affiliations

1: Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

Articles citing this

Regulation of chromatin by histone modifications. Cell Res (2011) 8.44

Epigenetic regulation of stress responses in plants. Curr Opin Plant Biol (2009) 3.46

ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome. PLoS Comput Biol (2008) 3.46

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev (2007) 2.81

SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77

Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol (2013) 2.71

Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet (2010) 1.76

Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Proc Natl Acad Sci U S A (2009) 1.75

Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol (2014) 1.74

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep (2009) 1.63

Chromatin and transcription in yeast. Genetics (2012) 1.61

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem (2006) 1.50

SUMO: a multifaceted modifier of chromatin structure and function. Dev Cell (2013) 1.50

Emerging roles of the SUMO pathway in mitosis. Cell Div (2008) 1.48

Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. PLoS One (2009) 1.48

A role for SUMO modification in transcriptional repression and activation. Biochem Soc Trans (2007) 1.46

Abscisic acid-mediated epigenetic processes in plant development and stress responses. J Integr Plant Biol (2008) 1.44

Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification. Mol Cell Biol (2007) 1.40

Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32

Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. Biol Direct (2010) 1.26

Protein modifications in transcription elongation. Biochim Biophys Acta (2008) 1.26

SUMO functions in constitutive transcription and during activation of inducible genes in yeast. Genes Dev (2010) 1.20

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5. Mol Cell Biol (2007) 1.19

Genome-wide enhancer prediction from epigenetic signatures using genetic algorithm-optimized support vector machines. Nucleic Acids Res (2012) 1.17

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. Nat Cell Biol (2011) 1.17

SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX. Mol Endocrinol (2008) 1.12

Regulation of the sumoylation system in gene expression. Curr Opin Cell Biol (2008) 1.09

Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation. Genome Res (2013) 1.08

Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates. J Biol Chem (2012) 1.08

Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. Mol Cell Proteomics (2009) 1.05

Identification of a novel post-translational modification in Plasmodium falciparum: protein sumoylation in different cellular compartments. Cell Microbiol (2008) 1.05

Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Mol Cell Biol (2007) 1.04

Ubiquitin proteolytic system: focus on SUMO. Expert Rev Proteomics (2008) 1.02

Protein lysine acetylation by p300/CBP. Chem Rev (2015) 1.02

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. J Cell Biol (2013) 0.98

Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae. Mol Cell Biol (2007) 0.98

Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes. Nucleic Acids Res (2012) 0.98

Chromatin at the intersection of viral infection and DNA damage. Biochim Biophys Acta (2009) 0.97

Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier. J Biol Chem (2008) 0.96

Epigenetics and psychoneuroimmunology: mechanisms and models. Brain Behav Immun (2010) 0.95

Essential role of nuclear localization for yeast Ulp2 SUMO protease function. Mol Biol Cell (2009) 0.95

A cassette of N-terminal amino acids of histone H2B are required for efficient cell survival, DNA repair and Swi/Snf binding in UV irradiated yeast. Nucleic Acids Res (2009) 0.95

Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation. Adv Immunol (2013) 0.94

The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination. Neoplasia (2013) 0.93

Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions. J Biol Chem (2014) 0.92

SUMOylation regulates polo-like kinase 1-interacting checkpoint helicase (PICH) during mitosis. J Biol Chem (2015) 0.92

Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes Dev (2016) 0.91

Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV. Front Microbiol (2012) 0.89

Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae. Nucleic Acids Res (2010) 0.89

Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes. Genome Res (2015) 0.89

The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair. Mol Genet Genomics (2006) 0.87

Chromatin dynamics during lytic infection with herpes simplex virus 1. Viruses (2013) 0.87

Functional Role of G9a Histone Methyltransferase in Cancer. Front Immunol (2015) 0.87

Discovery of histone modification crosstalk networks by stable isotope labeling of amino acids in cell culture mass spectrometry (SILAC MS). Mol Cell Proteomics (2013) 0.86

Histone H3 tails containing dimethylated lysine and adjacent phosphorylated serine modifications adopt a specific conformation during mitosis and meiosis. Mol Cell Biol (2008) 0.86

Micro- and nanofluidic technologies for epigenetic profiling. Biomicrofluidics (2013) 0.85

Generation of nonhydrolyzable ubiquitin-histone mimics. Methods (2014) 0.84

Functional mimicry of the acetylated C-terminal tail of p53 by a SUMO-1 acetylated domain, SAD. J Cell Physiol (2010) 0.84

SUMO-interacting motifs (SIMs) in Polo-like kinase 1-interacting checkpoint helicase (PICH) ensure proper chromosome segregation during mitosis. Cell Cycle (2016) 0.84

Folate and epigenetic mechanisms in neural tube development and defects. Childs Nerv Syst (2013) 0.83

Role of Extrachromosomal Histone H2B on Recognition of DNA Viruses and Cell Damage. Front Genet (2013) 0.83

Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines. Genetics (2010) 0.83

The epigenetics of adult (somatic) stem cells. Crit Rev Eukaryot Gene Expr (2008) 0.83

Strategies to Identify Recognition Signals and Targets of SUMOylation. Biochem Res Int (2012) 0.83

A genetic and molecular toolbox for analyzing histone ubiquitylation and sumoylation in yeast. Methods (2011) 0.82

The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species. Microbiol Mol Biol Rev (2016) 0.82

The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae. Eukaryot Cell (2012) 0.81

SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin. Mol Biol Cell (2016) 0.80

SUMO Wrestles with Recombination. Biomolecules (2012) 0.80

SUMOylation by the E3 ligase TbSIZ1/PIAS1 positively regulates VSG expression in Trypanosoma brucei. PLoS Pathog (2014) 0.79

The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state. PLoS Comput Biol (2013) 0.79

Sumoylation controls the timing of Tup1-mediated transcriptional deactivation. Nat Commun (2015) 0.79

Human factors and pathways essential for mediating epigenetic gene silencing. Epigenetics (2014) 0.79

In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. Chromosome Res (2008) 0.79

Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death. Cell Death Dis (2014) 0.79

For a healthy histone code, a little SUMO in the tail keeps the acetyl away. ACS Chem Biol (2006) 0.78

A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs. Neurotox Res (2014) 0.77

Functions for diverse metabolic activities in heterochromatin. Proc Natl Acad Sci U S A (2016) 0.76

Sumoylation and transcription regulation at nuclear pores. Chromosoma (2014) 0.76

Small ubiquitin-like modifier (SUMO)-mediated repression of the Xenopus Oocyte 5 S rRNA genes. J Biol Chem (2014) 0.76

p53 and the PWWP domain containing effector proteins in chromatin damage repair. Cell Dev Biol (2013) 0.76

Epigenetic dysfunctional diseases and therapy for infection and inflammation. Biochim Biophys Acta (2016) 0.75

A high throughput mutagenic analysis of yeast sumo structure and function. PLoS Genet (2017) 0.75

Effects of Valproic Acid on Radiation-Induced Chromosomal Aberrations in Human Lymphocytes. Genome Integr (2017) 0.75

The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing. Plant Cell (2016) 0.75

SUMOhunt: Combining Spatial Staging between Lysine and SUMO with Random Forests to Predict SUMOylation. ISRN Bioinform (2013) 0.75

Identification of family determining residues in Jumonji-C lysine demethylases: A sequence-based, family wide classification. Proteins (2016) 0.75

Rapid Semisynthesis of Acetylated and Sumoylated Histone Analogs. Methods Enzymol (2016) 0.75

The Histone Modification Code in the Pathogenesis of Autoimmune Diseases. Mediators Inflamm (2017) 0.75

Analysis of Small Ubiquitin-Like Modifier (SUMO) Targets Reflects the Essential Nature of Protein SUMOylation and Provides Insight to Elucidate the Role of SUMO in Plant Development. Plant Physiol (2015) 0.75

Articles cited by this

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J Am Soc Mass Spectrom (1994) 45.51

The language of covalent histone modifications. Nature (2000) 44.92

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63

The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64

Protein modification by SUMO. Annu Rev Biochem (2004) 10.59

SUMO: a history of modification. Mol Cell (2005) 10.40

Structure and ligand of a histone acetyltransferase bromodomain. Nature (1999) 10.08

Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell (1996) 9.86

Histone modifications in transcriptional regulation. Curr Opin Genet Dev (2002) 8.10

The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae. Annu Rev Biochem (2003) 7.22

Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell (2005) 7.20

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell (1991) 7.17

Heterochromatin and epigenetic control of gene expression. Science (2003) 7.12

Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Cell (2003) 6.83

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell (1987) 6.73

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell (1998) 6.62

The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01

Global histone acetylation and deacetylation in yeast. Nature (2000) 5.16

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13

Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci U S A (2004) 4.88

An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell (2001) 4.81

Rad6-dependent ubiquitination of histone H2B in yeast. Science (2000) 4.68

Class II histone deacetylases: versatile regulators. Trends Genet (2003) 4.63

Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning. PLoS Biol (2005) 4.48

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev (1997) 4.27

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature (1995) 4.20

SUMO modification of Huntingtin and Huntington's disease pathology. Science (2004) 3.85

A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A (2005) 3.62

Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53

Histone H2A.Z regulats transcription and is partially redundant with nucleosome remodeling complexes. Cell (2000) 3.50

Regulation of transcriptional activation domain function by ubiquitin. Science (2001) 3.36

Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions. EMBO J (2001) 3.27

Import of proteins into mitochondria. The precursor of cytochrome c1 is processed in two steps, one of them heme-dependent. J Biol Chem (1982) 3.26

Modification with SUMO. A role in transcriptional regulation. EMBO Rep (2003) 3.25

The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol (2000) 3.24

Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci U S A (2003) 3.18

Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A (2003) 3.09

Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins. J Cell Biol (1999) 3.03

SUMO promotes HDAC-mediated transcriptional repression. Mol Cell (2004) 2.97

SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell (2002) 2.93

Molecular model for telomeric heterochromatin in yeast. Curr Opin Cell Biol (1997) 2.73

Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem (2004) 2.60

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J (2002) 2.56

An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J Biol Chem (1995) 2.50

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism. Curr Biol (2002) 2.44

Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo. EMBO J (1992) 2.42

The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast. J Biol Chem (2003) 2.38

A proteome-wide approach identifies sumoylated substrate proteins in yeast. J Biol Chem (2004) 2.31

Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30

Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J Biol Chem (2004) 2.27

A new class of histone H2A mutations in Saccharomyces cerevisiae causes specific transcriptional defects in vivo. Mol Cell Biol (1995) 2.20

Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol Cell Biol (2005) 2.18

The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme. Proc Natl Acad Sci U S A (1998) 2.05

Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev (2004) 2.04

SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J Biol Chem (2002) 1.99

SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol (2004) 1.89

Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics (2001) 1.89

Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity. Curr Opin Genet Dev (2003) 1.70

Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy. Proc Natl Acad Sci U S A (2003) 1.60

Global shifts in protein sumoylation in response to electrophile and oxidative stress. Chem Res Toxicol (2004) 1.57

Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51

Transcription factor Sp3 is regulated by acetylation. Nucleic Acids Res (2001) 1.47

A novel factor required for the SUMO1/Smt3 conjugation of yeast septins. Gene (2001) 1.46

A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties. Mol Cell Biol (2005) 1.40

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1. EMBO Rep (2002) 1.12

Articles by these authors

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25

IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31

HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell (2008) 3.42

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33

HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04

The emerging field of dynamic lysine methylation of non-histone proteins. Curr Opin Genet Dev (2008) 3.01

Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell (2009) 2.99

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97

Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science (2010) 2.78

A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70

G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64

Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem (2004) 2.60

Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev (2008) 2.48

Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48

In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques (2006) 2.46

Ubiquitin-dependent proteolytic control of SUMO conjugates. J Biol Chem (2007) 2.44

SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42

Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41

The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast. J Biol Chem (2003) 2.38

H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell (2007) 2.32

Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem (2005) 2.23

The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13

Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05

Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Dev (2006) 2.05

Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert Opin Investig Drugs (2005) 2.03

System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol (2008) 1.97

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93

Ubc9 sumoylation regulates SUMO target discrimination. Mol Cell (2008) 1.86

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83

H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. Mol Cell Biol (2005) 1.82

Global synthetic-lethality analysis and yeast functional profiling. Trends Genet (2005) 1.82

Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80

Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80

SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell (2002) 1.80

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev (2013) 1.78

An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76

Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem (2005) 1.76

Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75

Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68

The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex. J Biol Chem (2002) 1.68

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67

Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor. Proc Natl Acad Sci U S A (2006) 1.67

Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1. J Virol (2006) 1.65

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64

SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription. Proc Natl Acad Sci U S A (2002) 1.62

Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59

Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56

The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics (2007) 1.53

Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52

Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51

The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol (2003) 1.50

The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1. J Virol (2008) 1.48

Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Mol Cell (2003) 1.47

Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Genome Res (2013) 1.45

LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. Cancer Res (2006) 1.43

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43

Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae. Curr Biol (2005) 1.41

Lysosome-mediated processing of chromatin in senescence. J Cell Biol (2013) 1.38

Misregulation of 2 microm circle copy number in a SUMO pathway mutant. Mol Cell Biol (2005) 1.36

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol (2011) 1.35

Multiple domains in Siz SUMO ligases contribute to substrate selectivity. J Cell Sci (2006) 1.34

Senescent cells harbour features of the cancer epigenome. Nat Cell Biol (2013) 1.34

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A (2009) 1.30

MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J (2011) 1.29

Characterization and cloning of T24, a Taenia solium antigen diagnostic for cysticercosis. Mol Biochem Parasitol (2006) 1.28

Phylogenetic and transcriptomic analysis of chemosensory receptors in a pair of divergent ant species reveals sex-specific signatures of odor coding. PLoS Genet (2012) 1.27

Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem (2009) 1.27