Published in EMBO J on June 03, 2002
The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev (2007) 4.50
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96
Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1. Proc Natl Acad Sci U S A (2004) 3.86
Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29
Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron (2008) 2.88
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J (2003) 2.81
Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci U S A (2011) 2.80
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell (2008) 2.71
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation (2012) 2.54
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J (2008) 2.44
Epigenetics and assisted reproductive technology: a call for investigation. Am J Hum Genet (2004) 2.41
mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev (2005) 2.37
Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol (2006) 2.28
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A (2009) 2.27
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2010) 2.25
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev (2010) 2.14
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell (2007) 2.07
Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol (2007) 2.07
Arabidopsis histone deacetylase HDA6 is required for maintenance of transcriptional gene silencing and determines nuclear organization of rDNA repeats. Plant Cell (2004) 2.03
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
The clinical development of histone deacetylase inhibitors as targeted anticancer drugs. Expert Opin Investig Drugs (2010) 1.79
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol (2003) 1.77
Regulating histone acetyltransferases and deacetylases. EMBO Rep (2003) 1.76
Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function. Blood (2013) 1.74
Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development. Int J Biochem Cell Biol (2008) 1.71
Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J Mol Cell Cardiol (2013) 1.70
Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. Nat Neurosci (2010) 1.68
HDAC4 promotes growth of colon cancer cells via repression of p21. Mol Biol Cell (2008) 1.67
Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors. Clin Epigenetics (2012) 1.61
The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest (2010) 1.61
Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells. J Exp Med (2005) 1.56
Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev (2009) 1.55
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol (2009) 1.53
The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol Cell Biol (2005) 1.51
Histone deacetylase: a potential therapeutic target for fibrotic disorders. J Pharmacol Exp Ther (2010) 1.51
Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. Dev Biol (2008) 1.48
Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem (2008) 1.48
Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBO J (2010) 1.47
Genetic dissection of histone deacetylase requirement in tumor cells. Proc Natl Acad Sci U S A (2009) 1.46
Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol (2008) 1.46
Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther (2010) 1.45
mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes Dev (2003) 1.44
Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors. J Clin Oncol (2008) 1.42
The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol Cell Biol (2009) 1.42
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39
Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. Oncogene (2011) 1.38
Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biologics (2013) 1.38
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res (2012) 1.37
Ketone bodies as signaling metabolites. Trends Endocrinol Metab (2013) 1.37
Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. Mol Cell Biol (2002) 1.36
Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci (2013) 1.35
A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol (2008) 1.35
Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochim Biophys Acta (2010) 1.35
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med (2011) 1.34
Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs. Clin Immunol (2010) 1.30
Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat. PLoS One (2010) 1.29
Arabidopsis HDA6 regulates locus-directed heterochromatin silencing in cooperation with MET1. PLoS Genet (2011) 1.27
Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol (2010) 1.26
Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis. Arthritis Res Ther (2010) 1.24
Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol (2004) 1.19
Autoregulation of mouse histone deacetylase 1 expression. Mol Cell Biol (2003) 1.19
Chromatin remodeling during mouse and human embryonic stem cell differentiation. Dev Dyn (2008) 1.18
Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res (2012) 1.17
Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis. Cell Cycle (2011) 1.17
Histone deacetylases in skeletal development and bone mass maintenance. Gene (2010) 1.16
Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease. PLoS One (2009) 1.15
Histone deacetylase (HDAC) activity is critical for embryonic kidney gene expression, growth, and differentiation. J Biol Chem (2011) 1.14
Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. J Biol Chem (2010) 1.14
Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy. J Biomed Biotechnol (2010) 1.14
Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proc Natl Acad Sci U S A (2012) 1.12
Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell (2013) 1.12
Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition. Arterioscler Thromb Vasc Biol (2011) 1.12
Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow. Proc Natl Acad Sci U S A (2012) 1.11
Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol (2009) 1.11
Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biol (2010) 1.10
Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling. PLoS One (2008) 1.10
Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cells. PLoS One (2011) 1.09
The emerging role of epigenetic mechanisms in the etiology of neural tube defects. Epigenetics (2011) 1.08
Active repression by unliganded retinoid receptors in development: less is sometimes more. J Cell Biol (2003) 1.08
Expression levels of histone deacetylases determine the cell fate of hematopoietic progenitors. J Biol Chem (2009) 1.07
TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO J (2002) 1.07
Specific activity of class II histone deacetylases in human breast cancer cells. Mol Cancer Res (2008) 1.07
Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice. Blood (2013) 1.06
Trans-regulation of histone deacetylase activities through acetylation. J Biol Chem (2009) 1.06
Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer. Immunol Cell Biol (2011) 1.05
Pluripotency-related, valproic acid (VPA)-induced genome-wide histone H3 lysine 9 (H3K9) acetylation patterns in embryonic stem cells. J Biol Chem (2011) 1.05
Expression profile and cellular localization of maize Rpd3-type histone deacetylases during plant development. Plant Physiol (2003) 1.05
Targeting histone deacetyalses in the treatment of B- and T-cell malignancies. Invest New Drugs (2010) 1.05
Organ-specific requirements for Hdac1 in liver and pancreas formation. Dev Biol (2008) 1.04
Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors. J Biomed Biotechnol (2010) 1.03
Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. EMBO J (2010) 1.03
A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2. J Biol Chem (2009) 1.02
Role of HDAC1 in senescence, aging, and cancer. Exp Gerontol (2009) 1.02
HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J Clin Invest (2013) 1.02
Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse. PLoS Genet (2013) 1.02
Translating the histone code. Science (2001) 56.77
The language of covalent histone modifications. Nature (2000) 44.92
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science (2001) 13.55
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell (2001) 11.39
Histone acetylation and an epigenetic code. Bioessays (2000) 8.84
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A (1999) 6.50
The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol Cell (1998) 5.79
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell (2000) 5.79
Expression of a Delta homologue in prospective neurons in the chick. Nature (1995) 5.73
Signaling to chromatin through histone modifications. Cell (2000) 5.36
Expression pattern of the mouse T gene and its role in mesoderm formation. Nature (1990) 4.97
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A (1996) 4.61
The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol (1993) 4.18
Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem (1997) 4.16
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol Cell (2000) 4.05
A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A (1998) 3.85
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J (2001) 3.36
Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J (2000) 3.35
RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol (1991) 3.22
Histone deacetylases, transcriptional control, and cancer. J Cell Physiol (2000) 3.18
Re-SET-ting heterochromatin by histone methyltransferases. Trends Cell Biol (2001) 3.16
NuRD and SIN3 histone deacetylase complexes in development. Trends Genet (2000) 3.14
Histone deacetylases: silencers for hire. Trends Biochem Sci (2000) 3.02
The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development (1998) 2.90
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem (2000) 2.89
The human histone deacetylase family. Exp Cell Res (2001) 2.86
Functional significance of histone deacetylase diversity. Curr Opin Genet Dev (2001) 2.79
p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci U S A (1998) 2.65
Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol (1999) 2.61
Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts. J Biol Chem (1999) 2.24
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem Biophys Res Commun (1997) 2.22
Embryoid bodies: an in vitro model of mouse embryogenesis. Exp Physiol (2000) 2.02
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem (2001) 1.97
Histone deacetylase as a therapeutic target. Trends Endocrinol Metab (2001) 1.83
Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Mol Cell Biol (1997) 1.62
Emerging connections between DNA methylation and histone acetylation. Cell Mol Life Sci (2001) 1.57
Gene expression in antigen-specific CD8+ T cells during viral infection. J Immunol (2001) 1.50
Molecular cloning and expression of mouse placental lactogen I complementary deoxyribonucleic acid. Mol Endocrinol (1987) 1.31
Butyrate-induced G1 arrest results from p21-independent disruption of retinoblastoma protein-mediated signals. Cell Growth Differ (1998) 1.28
Rb-mediated chromatin structure regulation and transcriptional repression. Oncogene (2001) 1.26
Histone H4 acetylation during interleukin-2 stimulation of mouse T cells. FEBS Lett (1998) 1.10
Essential role of Drosophila Hdac1 in homeotic gene silencing. Proc Natl Acad Sci U S A (2001) 1.10
A comparative study of histone deacetylases of plant, fungal and vertebrate cells. Biochim Biophys Acta (1996) 1.04
Molecular cloning and characterization of the mouse histone deacetylase 1 gene: integration of a retrovirus in 129SV mice. Biochim Biophys Acta (1999) 1.04
Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. J Biol Chem (2000) 1.02
Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen. J Virol (1999) 0.91
Leukemia inhibitory factor modulates cardiogenesis in embryoid bodies in opposite fashions. Circ Res (2000) 0.88
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30
The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
Blimp1 is a critical determinant of the germ cell lineage in mice. Nature (2005) 5.49
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet (2006) 5.36
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51
Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med (2007) 4.48
An epigenetic road map for histone lysine methylation. J Cell Sci (2003) 4.43
Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila. Cell (2011) 4.29
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23
Maternal microRNAs are essential for mouse zygotic development. Genes Dev (2007) 4.16
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res (2008) 3.09
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91
In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet (2012) 2.70
Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol Cell (2007) 2.69
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27. EMBO J (2006) 2.68
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A (2010) 2.67
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66
G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64
The miR-144/451 locus is required for erythroid homeostasis. J Exp Med (2010) 2.54
Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution. Cell (2007) 2.36
Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol (2006) 2.28
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22
A transcription factor-based mechanism for mouse heterochromatin formation. Nat Struct Mol Biol (2012) 2.15
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev (2010) 2.14
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14
Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol (2004) 2.09
Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol (2007) 2.07
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
Histone modification patterns associated with the human X chromosome. EMBO Rep (2006) 1.99
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res (2007) 1.96
MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science (2013) 1.95
EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells. J Biol Chem (2005) 1.93
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
220-plex microRNA expression profile of a single cell. Nat Protoc (2006) 1.88
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Mol Cell Biol (2002) 1.85
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol (2003) 1.77
The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature (2011) 1.77
Arabidopsis REF6 is a histone H3 lysine 27 demethylase. Nat Genet (2011) 1.74
14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. EMBO J (2007) 1.69
The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem (2006) 1.67
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67
Receptor clustering is involved in Reelin signaling. Mol Cell Biol (2004) 1.66
Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation. Int J Dev Biol (2009) 1.66
Quantitative functions of Argonaute proteins in mammalian development. Genes Dev (2012) 1.64
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet (2009) 1.62
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. Cancer Cell (2010) 1.53
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO J (2004) 1.49
A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber. Proc Natl Acad Sci U S A (2011) 1.45
Formation of facultative heterochromatin in the absence of HP1. EMBO J (2003) 1.45
The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol Cell Biol (2009) 1.42
The biology of HDAC in cancer: the nuclear and epigenetic components. Handb Exp Pharmacol (2011) 1.41
Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation. EMBO Rep (2013) 1.39
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39
RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions. Nat Protoc (2006) 1.37
Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. Mol Cell Biol (2002) 1.36
Essential role for Argonaute2 protein in mouse oogenesis. Epigenetics Chromatin (2009) 1.36
Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation. Curr Biol (2002) 1.36
Blimp1 regulates the transition of neonatal to adult intestinal epithelium. Nat Commun (2011) 1.36