Published in Nat Cell Biol on November 01, 2002
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell (2008) 4.33
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J (2003) 2.14
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature (2010) 2.11
Regulation of ubiquitin chain initiation to control the timing of substrate degradation. Mol Cell (2011) 2.01
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol (2010) 1.50
Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol (2009) 1.49
The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell (2012) 1.47
APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Nat Cell Biol (2011) 1.39
The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. Oncogene (2009) 1.35
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell (2007) 1.27
Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol (2015) 1.25
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. EMBO Rep (2005) 1.21
Specificity of the anaphase-promoting complex: a single-molecule study. Science (2015) 1.18
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. J Cell Sci (2010) 1.18
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27. Mol Cell Biol (2004) 1.10
Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nat Struct Mol Biol (2013) 1.09
Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol (2005) 1.09
Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control. J Cell Sci (2012) 1.06
Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol (2014) 1.03
State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol (2011) 1.02
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. EMBO J (2013) 1.01
Cullin 4-ring finger-ligase plays a key role in the control of endoreplication cycles in Arabidopsis trichomes. Proc Natl Acad Sci U S A (2010) 1.00
A Wee1 checkpoint inhibits anaphase onset. J Cell Biol (2013) 0.98
Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol (2009) 0.96
Processive ubiquitin chain formation by the anaphase-promoting complex. Semin Cell Dev Biol (2011) 0.95
Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr Biol (2014) 0.94
Global control of histone modification by the anaphase-promoting complex. Mol Cell Biol (2003) 0.93
Regulation of APC/C-Cdh1 and its function in neuronal survival. Mol Neurobiol (2012) 0.91
Spindle assembly requires complete disassembly of spindle remnants from the previous cell cycle. Mol Biol Cell (2011) 0.86
A minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei. PLoS One (2013) 0.85
Control the host cell cycle: viral regulation of the anaphase-promoting complex. J Virol (2013) 0.84
Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II. Mol Biol Cell (2010) 0.82
Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis. J Cell Sci (2014) 0.81
Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2. J Biol Chem (2014) 0.80
Structural biology: a new look for the APC. Nature (2011) 0.79
The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells. Eukaryot Cell (2006) 0.79
Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex. Mol Cell (2016) 0.78
APC/C-mediated degradation of dsRNA-binding protein 4 (DRB4) involved in RNA silencing. PLoS One (2012) 0.78
Quantitative framework for ordered degradation of APC/C substrates. BMC Biol (2015) 0.78
Cdc20, an activator at last. Mol Cell (2008) 0.78
A role for the anaphase promoting complex in hormone regulation. Planta (2011) 0.76
Understanding the structural basis for controlling chromosome division. Philos Trans A Math Phys Eng Sci (2015) 0.75
An E2 Accessory Domain Increases Affinity for the Anaphase-promoting Complex and Ensures E2 Competition. J Biol Chem (2015) 0.75
Targets of the cyclin-dependent kinase Cdk1. Nature (2003) 8.05
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science (2009) 5.37
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature (2005) 4.08
Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol (2007) 3.32
Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell (2007) 3.26
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med (2007) 2.65
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A (2008) 2.53
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
Positive feedback sharpens the anaphase switch. Nature (2008) 2.07
Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol (2006) 1.96
Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell (2008) 1.93
The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol (2005) 1.90
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature (2011) 1.86
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell (2007) 1.48
The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell (2012) 1.47
Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell (2011) 1.42
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell (2010) 1.36
Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell (2007) 1.27
Enzymology of the anaphase-promoting complex. Methods Enzymol (2005) 1.25
Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem (2011) 1.16
Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell (2011) 1.11
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc (2002) 1.06
Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol (2013) 1.01
Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell (2009) 1.00
A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem (2007) 0.99
Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol (2009) 0.96
The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell (2008) 0.96
Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol (2008) 0.95
Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell (2012) 0.88
Oscillation sensation. Nature (2002) 0.87
Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci (2014) 0.80
Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc (2013) 0.80
The role of self-association in Fin1 function on the mitotic spindle. J Biol Chem (2007) 0.78
Cell division: Mitotic regulation comes into focus. Nature (2016) 0.75