Published in Mol Cell on August 30, 2012
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore. Nat Rev Mol Cell Biol (2013) 3.01
Microtubule-dependent regulation of mitotic protein degradation. Mol Cell (2014) 2.24
Enhanced protein degradation by branched ubiquitin chains. Cell (2014) 2.02
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
Kinetic framework of spindle assembly checkpoint signalling. Nat Cell Biol (2013) 1.47
Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests. PLoS Genet (2016) 1.43
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. Chromosoma (2013) 1.39
Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol (2015) 1.25
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators. Dev Cell (2015) 1.23
The composition, functions, and regulation of the budding yeast kinetochore. Genetics (2013) 1.15
Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein. J Biol Chem (2014) 1.14
Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol (2014) 1.03
Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms. Genetics (2014) 0.97
The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. J Biol Chem (2014) 0.96
Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature (2016) 0.96
Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase. Chromosoma (2014) 0.95
The current view for the silencing of the spindle assembly checkpoint. Cell Cycle (2014) 0.95
Molecular mechanisms creating bistable switches at cell cycle transitions. Open Biol (2013) 0.92
Cdc20: a potential novel therapeutic target for cancer treatment. Curr Pharm Des (2013) 0.90
The spindle-assembly checkpoint and the beauty of self-destruction. Nat Struct Mol Biol (2012) 0.89
Cohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrest. PLoS One (2012) 0.89
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol Cell (2016) 0.88
Bub3 promotes Cdc20-dependent activation of the APC/C in S. cerevisiae. J Cell Biol (2015) 0.85
The biochemistry of mitosis. Cold Spring Harb Perspect Biol (2015) 0.82
The end of mitosis from a phosphatase perspective. Cell Cycle (2013) 0.82
How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models. Mol Cells (2014) 0.81
Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly. Proc Natl Acad Sci U S A (2013) 0.81
Spatial rule-based modeling: a method and its application to the human mitotic kinetochore. Cells (2013) 0.80
EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole. J Biol Chem (2015) 0.80
Quantitative framework for ordered degradation of APC/C substrates. BMC Biol (2015) 0.78
Regulation of mitotic progression by the spindle assembly checkpoint. Mol Cell Oncol (2015) 0.78
Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C. Biol Open (2016) 0.76
WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity. Proc Natl Acad Sci U S A (2016) 0.76
Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling. MAbs (2016) 0.75
An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast. Cell Cycle (2013) 0.75
Bub3 activation and inhibition of the APC/C. Cell Cycle (2016) 0.75
Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest. Curr Biol (2017) 0.75
Understanding the structural basis for controlling chromosome division. Philos Trans A Math Phys Eng Sci (2015) 0.75
Transcriptional and post-transcriptional regulation of Cdc20 during the spindle assembly checkpoint in S. cerevisiae. Cell Signal (2017) 0.75
Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast. Cell Div (2013) 0.75
An E2 Accessory Domain Increases Affinity for the Anaphase-promoting Complex and Ensures E2 Competition. J Biol Chem (2015) 0.75
The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae. Mol Biol Cell (2015) 0.75
Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast. Cell Rep (2017) 0.75
The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS Mol Sci (2016) 0.75
Dynamic ubiquitin signaling in cell cycle regulation. J Cell Biol (2017) 0.75
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol (2001) 6.80
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev (1998) 5.96
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev Cell (2001) 5.82
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature (2007) 4.31
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol (2008) 4.08
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol (2005) 3.77
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol (2004) 3.65
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol Biol Cell (2002) 3.65
Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell (2009) 3.36
MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p. J Cell Biol (2000) 3.31
Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell (2007) 3.26
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol (2001) 2.98
Structure of the mitotic checkpoint complex. Nature (2012) 2.72
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Dev Cell (2009) 2.69
Identification of a physiological E2 module for the human anaphase-promoting complex. Proc Natl Acad Sci U S A (2009) 2.65
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol (2010) 2.50
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol (2000) 2.49
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45
The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis. Curr Biol (1998) 2.43
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev (2007) 2.32
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. Nat Cell Biol (2009) 2.29
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J (2003) 2.14
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature (2010) 2.11
Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev (2004) 2.11
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell (2010) 2.08
Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. PLoS One (2007) 2.08
Identification of a MAD2-binding protein, CMT2, and its role in mitosis. EMBO J (2002) 1.96
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle (2009) 1.94
The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol (2005) 1.90
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J (2006) 1.89
The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol (2002) 1.84
Structural basis for the subunit assembly of the anaphase-promoting complex. Nature (2011) 1.80
Homeostatic control of mitotic arrest. Mol Cell (2011) 1.76
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint. Proc Natl Acad Sci U S A (2007) 1.74
Requirement for proteolysis in spindle assembly checkpoint silencing. Cell Cycle (2010) 1.74
Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation. Nat Cell Biol (2011) 1.69
p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit. J Cell Sci (2011) 1.68
Structure, function and mechanism of the anaphase promoting complex (APC/C). Q Rev Biophys (2010) 1.58
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process. Proc Natl Acad Sci U S A (2011) 1.55
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nat Struct Mol Biol (2010) 1.50
BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. J Cell Sci (2011) 1.49
How APC/C-Cdc20 changes its substrate specificity in mitosis. Nat Cell Biol (2011) 1.48
The influence of catalysis on mad2 activation dynamics. PLoS Biol (2009) 1.40
APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Nat Cell Biol (2011) 1.39
Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.35
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint. Proc Natl Acad Sci U S A (2010) 1.33
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Cell (2005) 1.28
Enzymology of the anaphase-promoting complex. Methods Enzymol (2005) 1.25
Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. J Biol Chem (2003) 1.24
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint. EMBO J (2011) 1.19
Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. Cell (2005) 1.18
BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex. J Biol Chem (2011) 1.17
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet). Mol Biol Cell (2011) 1.15
p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Mol Biol Cell (2011) 1.12
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol (2012) 1.08
Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression. J Biol Chem (2011) 1.04
Regulated degradation of the APC coactivator Cdc20. Cell Div (2010) 0.90
Targets of the cyclin-dependent kinase Cdk1. Nature (2003) 8.05
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science (2009) 5.37
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature (2005) 4.08
Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol (2007) 3.32
Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell (2007) 3.26
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med (2007) 2.65
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A (2008) 2.53
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell (2009) 2.45
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
Positive feedback sharpens the anaphase switch. Nature (2008) 2.07
Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol (2006) 1.96
Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell (2008) 1.93
The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol (2005) 1.90
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature (2011) 1.86
The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol (2002) 1.84
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell (2007) 1.48
Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell (2011) 1.42
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell (2010) 1.36
Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell (2007) 1.27
Enzymology of the anaphase-promoting complex. Methods Enzymol (2005) 1.25
Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem (2011) 1.16
Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell (2011) 1.11
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol (2011) 1.10
Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc (2002) 1.06
Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol (2013) 1.01
Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell (2009) 1.00
A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem (2007) 0.99
Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol (2009) 0.96
The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell (2008) 0.96
Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol (2008) 0.95
Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell (2012) 0.88
Oscillation sensation. Nature (2002) 0.87
Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci (2014) 0.80
Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc (2013) 0.80
The role of self-association in Fin1 function on the mitotic spindle. J Biol Chem (2007) 0.78
Cell division: Mitotic regulation comes into focus. Nature (2016) 0.75