Published in Am J Respir Crit Care Med on August 28, 2002
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am J Respir Crit Care Med (2005) 3.69
Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive Care Med (2014) 2.51
Management of renal replacement therapy in acute kidney injury: a survey of practitioner prescribing practices. Clin J Am Soc Nephrol (2007) 1.82
Design of the VA/NIH Acute Renal Failure Trial Network (ATN) Study: intensive versus conventional renal support in acute renal failure. Clin Trials (2005) 1.75
Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome. Ann Thorac Surg (2006) 1.59
Meta-analysis of tidal volumes in ARDS. Am J Respir Crit Care Med (2003) 1.41
Choosing a control intervention for a randomised clinical trial. BMC Med Res Methodol (2003) 1.41
Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome. Crit Care (2006) 1.23
Bench-to-bedside review: Permissive hypercapnia. Crit Care (2004) 1.22
Effects of a clinical trial on mechanical ventilation practices in patients with acute lung injury. Am J Respir Crit Care Med (2008) 1.21
Biomechanics of liquid-epithelium interactions in pulmonary airways. Respir Physiol Neurobiol (2008) 1.20
Usual care as the control group in clinical trials of nonpharmacologic interventions. Proc Am Thorac Soc (2007) 1.16
Meta-analysis of acute lung injury and acute respiratory distress syndrome trials. Am J Respir Crit Care Med (2002) 1.15
Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis. PLoS One (2008) 1.08
Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysis. PLoS One (2011) 1.02
Bench-to-bedside review: the evaluation of complex interventions in critical care. Crit Care (2008) 1.00
Low Tidal Volume Ventilation in Patients without Acute Respiratory Distress Syndrome: A Paradigm Shift in Mechanical Ventilation. Crit Care Res Pract (2012) 0.99
The Japanese guidelines for the management of sepsis. J Intensive Care (2014) 0.99
Severe novel influenza A (H1N1) infection in cancer patients. Ann Oncol (2010) 0.98
Ventilator-induced lung injury. Similarity and differences between children and adults. Am J Respir Crit Care Med (2014) 0.97
Effects of surfactant depletion on regional pulmonary metabolic activity during mechanical ventilation. J Appl Physiol (1985) (2011) 0.97
Cecal ligation puncture procedure. J Vis Exp (2011) 0.95
Considering usual medical care in clinical trial design. PLoS Med (2009) 0.91
Matching positive end-expiratory pressure to intra-abdominal pressure improves oxygenation in a porcine sick lung model of intra-abdominal hypertension. Crit Care (2012) 0.89
Mechanical ventilation of acute respiratory distress syndrome. J Intensive Care (2015) 0.87
Very low tidal volume ventilation with associated hypercapnia--effects on lung injury in a model for acute respiratory distress syndrome. PLoS One (2011) 0.87
Is the current management of severe sepsis and septic shock really evidence based? PLoS Med (2006) 0.86
The role of a journal in a scientific controversy. Am J Respir Crit Care Med (2003) 0.85
Tidal volumes in ARDS and meta-analysis. Am J Respir Crit Care Med (2003) 0.84
Tidal volumes in ARDS and meta-analysis. Am J Respir Crit Care Med (2003) 0.83
Feasibility study on full closed-loop control ventilation (IntelliVent-ASV™) in ICU patients with acute respiratory failure: a prospective observational comparative study. Crit Care (2013) 0.82
Controversial choice of a control intervention in a trial of ventilator therapy in ARDS: standard of care arguments in a randomised controlled trial. J Med Ethics (2005) 0.82
Low tidal volume, high respiratory rate and auto-PEEP: the importance of the basics. Crit Care (2003) 0.82
Metaanalysis of tidal volume in ARDS. Am J Respir Crit Care Med (2003) 0.81
Role of airway recruitment and derecruitment in lung injury. Crit Rev Biomed Eng (2011) 0.81
Estimating the Causal Effect of Low Tidal Volume Ventilation on Survival in Patients with Acute Lung Injury. J R Stat Soc Ser C Appl Stat (2011) 0.80
Adult respiratory distress syndrome. Ann R Coll Surg Engl (2016) 0.80
Dynamic preload indicators decrease when the abdomen is opened. BMC Anesthesiol (2014) 0.79
Sepsis syndrome in Croatian intensive care units: piloting a national comparative clinical database. Croat Med J (2006) 0.79
Controversies around lung protective mechanical ventilation. Am J Respir Crit Care Med (2002) 0.79
Airway pressure and transpulmonary pressure during high-frequency oscillation for acute respiratory distress syndrome. Can Respir J (2013) 0.78
Questions about ARDSNetwork trial of low tidal volume. Am J Respir Crit Care Med (2003) 0.77
Mechanisms of ventilator-induced lung injury: the clinician's perspective. Crit Care (2003) 0.77
Where are the institutional review boards? Am J Respir Crit Care Med (2002) 0.76
Lost in translation? The pursuit of lung-protective ventilation. Crit Care (2008) 0.75
Tidal volumes in ARDS and meta-analysis. Am J Respir Crit Care Med (2003) 0.75
The 32nd Annual Congress of the Society of Critical Care Medicine, 28 January - 2 February 2003, San Antonio, USA. Crit Care (2003) 0.75
End-inspiratory pause prolongation in acute respiratory distress syndrome patients: effects on gas exchange and mechanics. Ann Intensive Care (2016) 0.75
SARS in the Intensive Care Unit. Curr Infect Dis Rep (2004) 0.75
Impact of thrombosis on pulmonary endothelial injury and repair following sepsis. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Tidal volumes in ARDS and meta-analysis. Am J Respir Crit Care Med (2003) 0.75
[Activated protein C. Inevitable in sepsis?]. Anaesthesist (2003) 0.75
Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med (2008) 19.93
Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA (2008) 8.60
Changes in the use of postmenopausal hormone therapy after the publication of clinical trial results. Ann Intern Med (2004) 6.42
Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med (2004) 5.23
Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion (2011) 3.94
Potential savings from substituting generic drugs for brand-name drugs: medical expenditure panel survey, 1997-2000. Ann Intern Med (2005) 3.55
Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis. Am J Respir Crit Care Med (2002) 2.95
Excess deaths associated with tigecycline after approval based on noninferiority trials. Clin Infect Dis (2012) 2.90
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest (2005) 2.75
Bundled care for septic shock: an analysis of clinical trials. Crit Care Med (2010) 2.57
Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly. N Engl J Med (2006) 2.32
Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood (2012) 2.22
Defining normal adrenal function testing in the intensive care unit setting: a canine study. Crit Care Med (2010) 2.10
An overview of anthrax infection including the recently identified form of disease in injection drug users. Intensive Care Med (2012) 2.10
Separating practice guidelines from pharmaceutical marketing. Crit Care Med (2007) 2.03
Increasing evidence that the risks of rhAPC may outweigh its benefits. Intensive Care Med (2007) 1.97
Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.97
Practice misalignments in randomized controlled trials: Identification, impact, and potential solutions. Anesth Analg (2010) 1.96
Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols. Crit Care Med (2007) 1.88
Mechanical ventilation in ARDS: One size does not fit all. Crit Care Med (2005) 1.80
Novel therapies for sepsis: a review. J Trauma (2005) 1.74
Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood (2013) 1.66
Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model. Crit Care Med (2007) 1.63
Ethyl pyruvate decreased early nuclear factor-kappaB levels but worsened survival in lipopolysaccharide-challenged mice. Crit Care Med (2008) 1.62
The importance of usual care control groups for safety monitoring and validity during critical care research. Intensive Care Med (2008) 1.62
Effective dosing of lipid A analogue E5564 in rats depends on the timing of treatment and the route of Escherichia coli infection. J Infect Dis (2006) 1.61
Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats. Crit Care Med (2009) 1.60
The NERI Hypogonadism Screener: psychometric validation in male patients and controls. Clin Endocrinol (Oxf) (2011) 1.53
Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis. J Infect Dis (2004) 1.51
Tidal volume and plateau pressure use for acute lung injury from 2000 to present: a systematic literature review. Crit Care Med (2014) 1.46
The effect of heparin administration in animal models of sepsis: a prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies. Crit Care Med (2011) 1.46
Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials. Crit Care Med (2003) 1.44
Effects of intra-aortic balloon counterpulsation in a model of septic shock. Crit Care Med (2009) 1.44
Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis. Crit Care Med (2013) 1.42
Anthrax infection. Am J Respir Crit Care Med (2011) 1.39
Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies. Expert Opin Drug Metab Toxicol (2011) 1.36
Utility of the Time-Line Follow-Back to assess substance use among homeless adults. J Nerv Ment Dis (2003) 1.31
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog (2009) 1.30
Patterns and prevalence of arrest in a statewide cohort of mental health care consumers. Psychiatr Serv (2006) 1.19
Anthrax lethal and edema toxins produce different patterns of cardiovascular and renal dysfunction and synergistically decrease survival in canines. J Infect Dis (2010) 1.19
A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med (2007) 1.19
A canine model of septic shock: balancing animal welfare and scientific relevance. Am J Physiol Heart Circ Physiol (2007) 1.17
More on the Age of Transfused Red Cells. N Engl J Med (2015) 1.14
Recombinant human activated protein C, package labeling, and hemorrhage risks. Crit Care Med (2009) 1.12
Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy. Am J Respir Crit Care Med (2006) 1.08
The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin Investig Drugs (2011) 1.07
Arrests of adolescent clients of a public mental health system during adolescence and young adulthood. Psychiatr Serv (2007) 1.07
Once is not enough: clinical trials in sepsis. Intensive Care Med (2008) 1.04
Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis. Intensive Care Med (2007) 1.02
Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model. Am J Physiol Heart Circ Physiol (2011) 0.98
Does prolonged storage of red blood cells cause harm? Br J Haematol (2014) 0.97
Red blood cell transfusion. Ann Intern Med (2012) 0.97
Nonstandard shift schedules and the risk of job-related injuries. Scand J Work Environ Health (2006) 0.95
Reassessing recombinant human activated protein C for sepsis: time for a new randomized controlled trial. Crit Care Med (2005) 0.95
Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion (2014) 0.95
Examining the challenges of recruiting women into a cardiac rehabilitation clinical trial. J Cardiopulm Rehabil Prev (2009) 0.94
Protective antigen antibody augments hemodynamic support in anthrax lethal toxin shock in canines. J Infect Dis (2012) 0.92
Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model. J Appl Physiol (1985) (2004) 0.92
Activated protein C in sepsis: emerging insights regarding its mechanism of action and clinical effectiveness. Curr Opin Infect Dis (2004) 0.91
Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis. Am J Physiol Heart Circ Physiol (2008) 0.91
Drug-related arrests in a cohort of public mental health service recipients. Psychiatr Serv (2007) 0.91
Neutrophil stimulation with granulocyte colony-stimulating factor worsens ventilator-induced lung injury and mortality in rats. Anesthesiology (2005) 0.90
New insights into the pathogenesis and treatment of anthrax toxin-induced shock. Expert Opin Biol Ther (2007) 0.90
Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model. J Infect Dis (2013) 0.90
Antithrombotic therapies for sepsis: a need for more studies. Crit Care Med (2006) 0.89
Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low-quality reviews overwhelms the results of well-performed meta-analyses. Intensive Care Med (2012) 0.89
Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats. Anesthesiology (2003) 0.88
The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock. Toxins (Basel) (2011) 0.88
B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model. Am J Physiol Heart Circ Physiol (2013) 0.88