Published in Nat Med on November 01, 2002
miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci U S A (2010) 3.99
Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest (2006) 3.76
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity (2009) 2.99
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol (2005) 2.91
Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc Natl Acad Sci U S A (2004) 2.79
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sci Transl Med (2016) 2.69
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest (2006) 2.55
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem (2006) 2.20
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest (2005) 2.03
Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol (2006) 1.90
Regulation of macrophage function in inflammation and atherosclerosis. J Lipid Res (2008) 1.32
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J Biol Chem (2009) 1.22
Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol (2010) 1.13
Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo. J Clin Biochem Nutr (2012) 1.11
Androgen deprivation by activating the liver X receptor. Endocrinology (2008) 1.10
MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation. Mol Endocrinol (2011) 1.05
Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster. Mol Cell Biol (2009) 1.02
Overexpression of mitochondrial cholesterol delivery protein, StAR, decreases intracellular lipids and inflammatory factors secretion in macrophages. Atherosclerosis (2008) 1.01
PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1. Nucl Recept Signal (2010) 0.98
The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation. Exp Biol Med (Maywood) (2008) 0.97
Spatial distribution of the pathways of cholesterol homeostasis in human retina. PLoS One (2012) 0.95
Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacol (2009) 0.93
Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. Mol Med (2012) 0.92
Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model. J Lipid Res (2009) 0.92
Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem (2011) 0.91
Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity. J Lipid Res (2010) 0.90
Parameter adaptations during phenotype transitions in progressive diseases. BMC Syst Biol (2011) 0.90
Targets for current pharmacologic therapy in cholesterol gallstone disease. Gastroenterol Clin North Am (2010) 0.90
Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies. Nutr Metab (Lond) (2012) 0.90
Therapy of gallstone disease: What it was, what it is, what it will be. World J Gastrointest Pharmacol Ther (2012) 0.90
Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury. J Biol Chem (2009) 0.90
Lifestyle changes for the treatment of nonalcoholic fatty liver disease: a review of observational studies and intervention trials. Therap Adv Gastroenterol (2016) 0.90
Combination therapy in cholesterol reduction: focus on ezetimibe and statins. Vasc Health Risk Manag (2008) 0.89
Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging (2008) 0.89
Macrophage immunoregulatory pathways in tuberculosis. Semin Immunol (2014) 0.88
Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice. J Lipid Res (2009) 0.88
Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome. J Diabetes Metab Disord (2014) 0.88
Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology (2014) 0.87
Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus. Brain Res (2010) 0.86
A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. PLoS One (2011) 0.86
Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands. Biochem J (2005) 0.86
Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis. Adv Healthc Mater (2014) 0.84
Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRα. Am J Pathol (2011) 0.83
Myelin-derived lipids modulate macrophage activity by liver X receptor activation. PLoS One (2012) 0.83
Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice. Hepatology (2011) 0.83
Modulation of endosomal cholesteryl ester metabolism by membrane cholesterol. J Biol Chem (2005) 0.83
Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? Mol Neurodegener (2010) 0.81
Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug Conjugate. Bioconjug Chem (2015) 0.81
LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity. J Clin Invest (2013) 0.81
Current views on genetics and epigenetics of cholesterol gallstone disease. Cholesterol (2013) 0.80
Parameter trajectory analysis to identify treatment effects of pharmacological interventions. PLoS Comput Biol (2013) 0.80
Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis. J Biol Chem (2010) 0.80
Association of ApoE and LRP mRNA levels with dementia and AD neuropathology. Neurobiol Aging (2011) 0.80
Overexpression of the steroidogenic acute regulatory protein increases the expression of ATP-binding cassette transporters in microvascular endothelial cells (bEnd.3). J Zhejiang Univ Sci B (2010) 0.79
Activation of human stearoyl-coenzyme A desaturase 1 contributes to the lipogenic effect of PXR in HepG2 cells. PLoS One (2013) 0.78
Two- and three-dimensional quantitative structure-activity relationships studies on a series of liver x receptor ligands. Open Med Chem J (2008) 0.78
The combination of L-4F and simvastatin stimulate cholesterol efflux and related proteins expressions to reduce atherosclerotic lesions in apoE knockout mice. Lipids Health Dis (2013) 0.78
Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRα. Drug Metab Dispos (2014) 0.77
Hepatic glucose sensing: does flux matter? J Clin Invest (2008) 0.77
Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS One (2015) 0.77
Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.77
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. PLoS One (2012) 0.77
Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells. Toxicol Appl Pharmacol (2013) 0.77
Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation. Int J Mol Sci (2016) 0.76
Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α. Int J Biol Sci (2016) 0.76
Transcriptomic profiles of skeletal muscle tissue following an euglycemic-hyperinsulinemic clamp in insulin-resistant obese subjects. Genes Nutr (2012) 0.76
Blood cellular mutant LXR-α protein stability governs initiation of coronary heart disease. World J Cardiol (2013) 0.76
Protein mediators of sterol transport across intestinal brush border membrane. Subcell Biochem (2010) 0.76
Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages. Sci Rep (2016) 0.75
Phosphatidylcholine: Greasing the Cholesterol Transport Machinery. Lipid Insights (2016) 0.75
Ligands of Therapeutic Utility for the Liver X Receptors. Molecules (2017) 0.75
Hormone and receptor interplay in the regulation of mosquito lipid metabolism. Proc Natl Acad Sci U S A (2017) 0.75
Liver X receptor alpha (LXRalpha) as a therapeutic target in chronic lymphocytic leukemia (CLL). J Leukoc Biol (2009) 0.75
Activation of Liver X Receptor Attenuates Oleic Acid-Induced Acute Respiratory Distress Syndrome. Am J Pathol (2016) 0.75
GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway. Sci Rep (2016) 0.75
Emerging role of liver X receptors in cardiac pathophysiology and heart failure. Basic Res Cardiol (2015) 0.75
Design and synthesis of boron containing potential pan-RAR inverse agonists. Tetrahedron Lett (2012) 0.75
Re-adopting classical nuclear receptors by cholesterol metabolites. J Steroid Biochem Mol Biol (2015) 0.75
Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss. Mol Oral Microbiol (2015) 0.75
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 9.62
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med (2003) 6.21
Nuclear receptor expression links the circadian clock to metabolism. Cell (2006) 5.43
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell (2006) 4.64
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A (2009) 3.99
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell (2006) 3.82
Vitamin D receptor as an intestinal bile acid sensor. Science (2002) 3.64
Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol (2003) 3.59
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem (2002) 3.52
Structural determinants of allosteric ligand activation in RXR heterodimers. Cell (2004) 3.36
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med (2004) 3.17
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (2011) 3.16
Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal (2003) 3.14
Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med (2005) 3.12
LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol (2006) 3.11
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell (2012) 3.07
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev (2012) 2.91
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci U S A (2004) 2.89
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab (2008) 2.76
LXRs regulate the balance between fat storage and oxidation. Cell Metab (2005) 2.75
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol (2010) 2.67
Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab (2007) 2.51
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A (2007) 2.50
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab (2005) 2.42
High-throughput real-time quantitative reverse transcription PCR. Curr Protoc Mol Biol (2006) 2.41
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc Natl Acad Sci U S A (2012) 2.38
Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr (2009) 2.35
βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab (2012) 2.27
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol (2003) 2.26
International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev (2006) 2.22
FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 2.20
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med (2007) 2.18
A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol (2005) 2.13
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev Cell (2006) 2.11
A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol (2005) 2.06
International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev (2006) 2.04
Identification of a hormonal basis for gallbladder filling. Nat Med (2006) 2.03
A natural product that lowers cholesterol as an antagonist ligand for FXR. Science (2002) 1.99
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. Cell Metab (2011) 1.97
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem (2003) 1.92
FGF21 contributes to neuroendocrine control of female reproduction. Nat Med (2013) 1.89
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem (2003) 1.89
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Mol Endocrinol (2008) 1.85
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol (2007) 1.75
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem (2006) 1.72
MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol (2009) 1.71
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife (2012) 1.69
Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science (2009) 1.69
Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J Biol Chem (2004) 1.57
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol (2009) 1.49
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem (2002) 1.48
Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol (2008) 1.47
The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. J Biol Chem (2003) 1.46
Liver X receptors regulate adrenal cholesterol balance. J Clin Invest (2006) 1.45
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell (2003) 1.44
Regulation of bile acid synthesis by fat-soluble vitamins A and D. J Biol Chem (2010) 1.40
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol Endocrinol (2011) 1.39
Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest (2012) 1.38
Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Cardiovasc Res (2007) 1.32
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. J Lipid Res (2007) 1.31
Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol Cell Endocrinol (2003) 1.28
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A (2002) 1.28
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc Natl Acad Sci U S A (2009) 1.26
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. Diabetes (2008) 1.21
Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology (2007) 1.20
Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer. PLoS Med (2010) 1.19
Expression profiling of nuclear receptors in human and mouse embryonic stem cells. Mol Endocrinol (2009) 1.16
Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions. Mol Endocrinol (2010) 1.15
Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo. J Biol Chem (2012) 1.13
Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem (2006) 1.13
Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol (2012) 1.12
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev (2011) 1.10
The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J Atheroscler Thromb (2002) 1.08
LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J Clin Invest (2010) 1.06
Nuclear receptor regulation of stemness and stem cell differentiation. Exp Mol Med (2009) 1.03
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell (2011) 1.03
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. Mol Endocrinol (2007) 1.03
Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol (2012) 1.01
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. J Med Chem (2007) 0.99
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol Endocrinol (2004) 0.97
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol (2009) 0.96
Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells. J Biol Chem (2002) 0.92
Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology (2002) 0.92
Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. Clin Gastroenterol Hepatol (2009) 0.92
Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Mol Endocrinol (2003) 0.91
AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. J Biol Chem (2010) 0.91
Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J Invest Dermatol (2002) 0.91
Nuclear receptors of the enteric tract: guarding the frontier. Nutr Rev (2008) 0.88
Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development. Anat Rec A Discov Mol Cell Evol Biol (2005) 0.87
Bile Acids as Hormones: The FXR-FGF15/19 Pathway. Dig Dis (2015) 0.86
Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis. Chem Biol (2003) 0.85
Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes. J Biol Chem (2011) 0.85
Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Mol Endocrinol (2004) 0.85
Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. Mol Endocrinol (2014) 0.83