Published in J Biol Chem on March 16, 2010
Pleiotropic roles of bile acids in metabolism. Cell Metab (2013) 2.25
Vitamin D may not improve lipid levels: a serial clinical laboratory data study. Circulation (2012) 1.85
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol (2010) 1.69
Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model. Nat Commun (2015) 1.68
Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev (2014) 1.58
EpiphaNet: An Interactive Tool to Support Biomedical Discoveries. J Biomed Discov Collab (2010) 1.24
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab (2013) 1.03
Nuclear receptors in bile acid metabolism. Drug Metab Rev (2013) 1.02
Expression of the vitamin D receptor in skeletal muscle: are we there yet? Endocrinology (2014) 1.01
The bile acid membrane receptor TGR5: a valuable metabolic target. Dig Dis (2011) 0.99
Involvement of SIK3 in glucose and lipid homeostasis in mice. PLoS One (2012) 0.99
Vitamin D receptor signaling inhibits atherosclerosis in mice. Mol Endocrinol (2012) 0.97
Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J Lipid Res (2011) 0.96
Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism. Am J Physiol Renal Physiol (2011) 0.92
Low vitamin D status is associated with nonalcoholic Fatty liver disease independent of visceral obesity in Korean adults. PLoS One (2013) 0.92
AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. J Biol Chem (2010) 0.91
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat Rev Drug Discov (2015) 0.90
Vitamin D deficiency in chronic liver disease. World J Hepatol (2014) 0.89
Characterizing Factors Associated With Differences in FGF19 Blood Levels and Synthesis in Patients With Primary Bile Acid Diarrhea. Am J Gastroenterol (2016) 0.87
Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry. Cell Metab (2015) 0.86
Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer. Adv Pharmacol (2015) 0.85
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Liver Int (2014) 0.85
Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype. Endocrinology (2014) 0.85
Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules. Pharmacol Res (2015) 0.84
Nuclear receptors in renal disease. Biochim Biophys Acta (2011) 0.84
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Front Immunol (2016) 0.82
All-trans retinoic acid regulates hepatic bile acid homeostasis. Biochem Pharmacol (2014) 0.82
Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model. Am J Physiol Gastrointest Liver Physiol (2014) 0.81
Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice. Hepatology (2013) 0.81
Metabolic syndrome: A review of the role of vitamin D in mediating susceptibility and outcome. World J Diabetes (2015) 0.78
Sources of vitamin A in the diets of pre-school children in the Avon Longitudinal Study of Parents and Children (ALSPAC). Nutrients (2013) 0.78
Regulation of bile acid homeostasis by the intestinal Diet1-FGF15/19 axis. Curr Opin Lipidol (2014) 0.77
Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure. Mol Pharmacol (2013) 0.76
Vitamin D modulates biliary fibrosis in ABCB4-deficient mice. Hepatol Int (2014) 0.76
Vitamin D receptor regulates intestinal proteins involved in cell proliferation, migration and stress response. Lipids Health Dis (2014) 0.76
ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis. PLoS One (2017) 0.75
Effects of bile acids on neurological function and disease. FASEB J (2016) 0.75
Modulation of Hepatic Protein Kinase Cβ Expression in Metabolic Adaptation to a Lithogenic Diet. Cell Mol Gastroenterol Hepatol (2015) 0.75
PKCβ: Expanding role in hepatic adaptation of cholesterol homeostasis to dietary fat/cholesterol. Am J Physiol Gastrointest Liver Physiol (2017) 0.75
Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep (2017) 0.75
Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations. Cancer Prev Res (Phila) (2016) 0.75
Recycling rate of bile acids in the enterohepatic recirculation as a major determinant of whole body 75SeHCAT retention. Eur J Nucl Med Mol Imaging (2013) 0.75
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
Identification of a nuclear receptor for bile acids. Science (1999) 7.81
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell (2000) 7.18
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell (2000) 6.48
The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem (2003) 6.35
Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr (2004) 5.88
Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol (2008) 5.37
LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev (1995) 4.93
Bile acids: regulation of synthesis. J Lipid Res (2009) 4.31
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res (2007) 3.84
Vitamin D receptor as an intestinal bile acid sensor. Science (2002) 3.64
Structural determinants of allosteric ligand activation in RXR heterodimers. Cell (2004) 3.36
Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal (2003) 3.14
How fibroblast growth factor 23 works. J Am Soc Nephrol (2007) 2.92
Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci (2004) 2.90
Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer (2003) 2.82
Vitamin D for cancer prevention: global perspective. Ann Epidemiol (2009) 2.61
Bile acid transporters. J Lipid Res (2009) 2.31
A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. Clin Gastroenterol Hepatol (2009) 2.25
Function of retinoic acid receptors during embryonic development. Nucl Recept Signal (2009) 2.06
The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol (2000) 2.04
CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc Natl Acad Sci U S A (1999) 1.86
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Mol Endocrinol (2008) 1.85
Bile Acids: The Good, the Bad, and the Ugly. News Physiol Sci (1999) 1.81
Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther (2009) 1.76
Role of bile acids in colorectal carcinogenesis. Eur J Cancer (1995) 1.66
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors. J Lipid Res (1998) 1.60
The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol (1997) 1.53
The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells. Hepatology (2003) 1.34
Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. J Cell Biochem (2005) 1.17
Vitamin A and embryonic development: an overview. J Nutr (1998) 1.14
The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol. Pharmacol Ther (2007) 1.05
Overview of retinoid metabolism. J Nutr (1993) 1.01
Lithocholic acid can carry out in vivo functions of vitamin D. Proc Natl Acad Sci U S A (2007) 0.97
Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. Clin Gastroenterol Hepatol (2009) 0.92
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 9.62
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med (2003) 6.21
Nuclear receptor expression links the circadian clock to metabolism. Cell (2006) 5.43
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell (2006) 4.64
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem (2007) 4.42
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A (2009) 3.99
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res (2007) 3.84
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell (2006) 3.82
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev (2003) 3.74
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol (2007) 3.73
Vitamin D receptor as an intestinal bile acid sensor. Science (2002) 3.64
Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol (2003) 3.59
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem (2002) 3.52
Structural determinants of allosteric ligand activation in RXR heterodimers. Cell (2004) 3.36
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med (2004) 3.17
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (2011) 3.16
Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal (2003) 3.14
Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med (2005) 3.12
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature (2002) 3.11
LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol (2006) 3.11
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell (2012) 3.07
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol (2002) 2.94
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev (2012) 2.91
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci U S A (2004) 2.89
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab (2008) 2.76
LXRs regulate the balance between fat storage and oxidation. Cell Metab (2005) 2.75
Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. Mol Cell (2005) 2.69
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol (2010) 2.67
Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest (2003) 2.51
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab (2007) 2.51
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A (2007) 2.50
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab (2005) 2.42
High-throughput real-time quantitative reverse transcription PCR. Curr Protoc Mol Biol (2006) 2.41
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc Natl Acad Sci U S A (2012) 2.38
Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr (2009) 2.35
Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol Cell Biol (2005) 2.32
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem (2003) 2.28
βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab (2012) 2.27
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol (2003) 2.26
The liver X receptor gene team: potential new players in atherosclerosis. Nat Med (2002) 2.24
International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev (2006) 2.22
FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 2.20
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med (2007) 2.18
A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol (2005) 2.13
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev Cell (2006) 2.11
A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol (2005) 2.06
PXR, CAR and drug metabolism. Nat Rev Drug Discov (2002) 2.06
International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev (2006) 2.04
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem (2003) 2.04
Identification of a hormonal basis for gallbladder filling. Nat Med (2006) 2.03
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem (2002) 2.01
A natural product that lowers cholesterol as an antagonist ligand for FXR. Science (2002) 1.99
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. Cell Metab (2011) 1.97
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem (2003) 1.92
FGF21 contributes to neuroendocrine control of female reproduction. Nat Med (2013) 1.89
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem (2003) 1.89
Regulation of cyp3a gene transcription by the pregnane x receptor. Annu Rev Pharmacol Toxicol (2002) 1.87
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Mol Endocrinol (2008) 1.85
Brain SIRT1: anatomical distribution and regulation by energy availability. J Neurosci (2008) 1.75
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol (2007) 1.75
Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes (2002) 1.73
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem (2006) 1.72
MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol (2009) 1.71
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife (2012) 1.69