Published in Science on May 17, 2002
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Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev (2010) 1.07
The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel beta(1) subunit is a lithocholate sensor. FEBS Lett (2008) 1.06
The yin and yang of vitamin D receptor (VDR) signaling in neoplastic progression: operational networks and tissue-specific growth control. Biochem Pharmacol (2009) 1.06
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Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proc Natl Acad Sci U S A (2003) 1.01
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Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2. Ann Pharmacother (2010) 0.88
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Nuclear receptors of the enteric tract: guarding the frontier. Nutr Rev (2008) 0.88
MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor. J Biol Chem (2015) 0.88
Regulation of the cytosolic sulfotransferases by nuclear receptors. Drug Metab Rev (2013) 0.87
Ligand unbinding pathways from the vitamin D receptor studied by molecular dynamics simulations. Eur Biophys J (2008) 0.87
Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice. J Lipid Res (2013) 0.87
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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 9.62
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
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Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell (2003) 6.53
AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med (2003) 6.21
Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol (2004) 5.66
Nuclear receptor expression links the circadian clock to metabolism. Cell (2006) 5.43
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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
A role for adult TLX-positive neural stem cells in learning and behaviour. Nature (2008) 4.14
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A (2009) 3.99
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature (2008) 3.98
Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science (2003) 3.97
Muscle-specific Pparg deletion causes insulin resistance. Nat Med (2003) 3.93
Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology (2003) 3.83
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PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2006) 3.29
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (2006) 3.26
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Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med (2004) 3.17
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FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (2011) 3.16
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature (2016) 3.13
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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05
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Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature (2002) 2.78
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NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75
LXRs regulate the balance between fat storage and oxidation. Cell Metab (2005) 2.75
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69
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Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med (2004) 2.61
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Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab (2007) 2.51
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A (2007) 2.50
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A (2003) 2.46
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology (2007) 2.43
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab (2005) 2.42
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PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A (2009) 2.38
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc Natl Acad Sci U S A (2012) 2.38
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Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature (2011) 2.34
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Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol (2005) 2.28
βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab (2012) 2.27
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol (2003) 2.26
Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. Sci Transl Med (2009) 2.25
The liver X receptor gene team: potential new players in atherosclerosis. Nat Med (2002) 2.24
International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev (2006) 2.22
Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am J Hum Genet (2008) 2.21
FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 2.20
The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A (2002) 2.20
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem (2006) 2.20
PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci U S A (2007) 2.19
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med (2007) 2.18
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab (2007) 2.14
A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol (2005) 2.13
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev Cell (2006) 2.11
PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A (2003) 2.10
Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics (2007) 2.08
1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol (2005) 2.08
A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol (2005) 2.06