Published in Mol Cell on October 01, 2002
Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol (2004) 6.67
Functions and regulation of RNA editing by ADAR deaminases. Annu Rev Biochem (2010) 5.99
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
Editor meets silencer: crosstalk between RNA editing and RNA interference. Nat Rev Mol Cell Biol (2006) 3.31
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science (2005) 2.94
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science (2003) 2.34
Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev (2005) 2.16
ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells. J Biol Chem (2004) 2.15
RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. EMBO J (2002) 2.14
How does RNA editing affect dsRNA-mediated gene silencing? Cold Spring Harb Symp Quant Biol (2006) 2.12
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
Predicting sites of ADAR editing in double-stranded RNA. Nat Commun (2011) 1.74
ADAR editing in double-stranded UTRs and other noncoding RNA sequences. Trends Biochem Sci (2010) 1.63
Effects of length and location on the cellular response to double-stranded RNA. Microbiol Mol Biol Rev (2004) 1.57
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature (2008) 1.51
Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes. Genome Biol (2004) 1.41
An ADAR that edits transcripts encoding ion channel subunits functions as a dimer. EMBO J (2003) 1.40
A starvation-induced noncoding RNA modulates expression of Dicer-regulated genes. Proc Natl Acad Sci U S A (2008) 1.27
RNAi effector diversity in nematodes. PLoS Negl Trop Dis (2011) 1.24
Pronounced instability of tandem IU base pairs in RNA. Nucleic Acids Res (2004) 1.23
Competition between ADAR and RNAi pathways for an extensive class of RNA targets. Nat Struct Mol Biol (2011) 1.22
Letter from the editor: Adenosine-to-inosine RNA editing in Alu repeats in the human genome. EMBO Rep (2005) 1.20
Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites. Nucleic Acids Res (2005) 1.20
Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells. Oncogene (2006) 1.18
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One (2009) 1.16
Alu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing. PLoS One (2010) 1.15
Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. Genes Dev (2003) 1.12
Mathematical models of RNA silencing: unidirectional amplification limits accidental self-directed reactions. Proc Natl Acad Sci U S A (2003) 1.08
RNA editing regulates transposon-mediated heterochromatic gene silencing. Nat Commun (2013) 1.07
Widespread cleavage of A-to-I hyperediting substrates. RNA (2009) 1.06
High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse. Biochem J (2005) 1.06
The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc Natl Acad Sci U S A (2008) 1.05
Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification. Nucleic Acids Res (2006) 1.04
Anti-viral RNA silencing: do we look like plants? Retrovirology (2006) 1.03
MicroRNAs as Haematopoiesis Regulators. Adv Hematol (2013) 1.03
miRNA editing--we should have inosine this coming. Mol Cell (2007) 1.03
A-to-I RNA editing alters less-conserved residues of highly conserved coding regions: implications for dual functions in evolution. RNA (2008) 1.01
A-to-I editing sites are a genomically encoded G: implications for the evolutionary significance and identification of novel editing sites. RNA (2007) 1.00
Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants. Genetics (2011) 0.98
dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells. Nucleic Acids Res (2011) 0.97
Effects of ADARs on small RNA processing pathways in C. elegans. Genome Res (2012) 0.97
Large-scale overexpression and purification of ADARs from Saccharomyces cerevisiae for biophysical and biochemical studies. Methods Enzymol (2007) 0.95
Ageing and the small, non-coding RNA world. Ageing Res Rev (2012) 0.93
In C. elegans, high levels of dsRNA allow RNAi in the absence of RDE-4. PLoS One (2008) 0.93
Evolution of hepatitis delta virus RNA genome following long-term replication in cell culture. J Virol (2005) 0.92
A structural determinant required for RNA editing. Nucleic Acids Res (2011) 0.90
ADBP-1 regulates an ADAR RNA-editing enzyme to antagonize RNA-interference-mediated gene silencing in Caenorhabditis elegans. Genetics (2008) 0.90
Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs. Nucleic Acids Res (2008) 0.88
Development of resistance to RNAi in mammalian cells. Ann N Y Acad Sci (2005) 0.87
HIV-l and the microRNA-guided silencing pathway: an intricate and multifaceted encounter. Virus Res (2006) 0.87
Emergence of a complex relationship between HIV-1 and the microRNA pathway. Methods Mol Biol (2009) 0.86
Expression of microRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials. Mol Reprod Dev (2009) 0.83
The emerging role of RNA editing in plasticity. J Exp Biol (2015) 0.83
Substrate recognition and specificity of double-stranded RNA binding proteins. Biochemistry (2014) 0.81
Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev (2013) 0.81
p150 ADAR1 isoform involved in maintenance of HeLa cell proliferation. BMC Cancer (2006) 0.80
Alu mobile elements: from junk DNA to genomic gems. Scientifica (Cairo) (2012) 0.78
RNAi pathway integration in Caenorhabditis elegans development. Funct Integr Genomics (2011) 0.78
TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO J (2014) 0.77
Manipulating and enhancing the RNAi response. J RNAi Gene Silencing (2006) 0.75
Tissue homogeneity requires inhibition of unequal gene silencing during development. J Cell Biol (2016) 0.75
A-to-I RNA editing promotes developmental-stage-specific gene and lncRNA expression. Genome Res (2016) 0.75
RNA Editing, ADAR1, and the Innate Immune Response. Genes (Basel) (2017) 0.75
RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA. Proc Natl Acad Sci U S A (2002) 3.41
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science (2005) 2.94
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science (2003) 2.34
RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. EMBO J (2002) 2.14
Predicting sites of ADAR editing in double-stranded RNA. Nat Commun (2011) 1.74
C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes. RNA (2008) 1.70
ADAR editing in double-stranded UTRs and other noncoding RNA sequences. Trends Biochem Sci (2010) 1.63
Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. RNA (2007) 1.51
Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode. Mol Cell (2011) 1.49
RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA. RNA (2006) 1.40
dsRNA binding properties of RDE-4 and TRBP reflect their distinct roles in RNAi. J Mol Biol (2008) 1.39
Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA binding. RNA (2004) 1.31
A starvation-induced noncoding RNA modulates expression of Dicer-regulated genes. Proc Natl Acad Sci U S A (2008) 1.27
Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs. RNA (2010) 1.26
Improved annotation of C. elegans microRNAs by deep sequencing reveals structures associated with processing by Drosha and Dicer. RNA (2011) 1.05
miRNA editing--we should have inosine this coming. Mol Cell (2007) 1.03
Mechanistic insights into editing-site specificity of ADARs. Proc Natl Acad Sci U S A (2012) 1.03
Effects of ADARs on small RNA processing pathways in C. elegans. Genome Res (2012) 0.97
Large-scale overexpression and purification of ADARs from Saccharomyces cerevisiae for biophysical and biochemical studies. Methods Enzymol (2007) 0.95
In C. elegans, high levels of dsRNA allow RNAi in the absence of RDE-4. PLoS One (2008) 0.93
Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation. Mol Cell Biol (2009) 0.92
A transition state analogue for an RNA-editing reaction. J Am Chem Soc (2004) 0.91
Dynamic linear model for the identification of miRNAs in next-generation sequencing data. Biometrics (2011) 0.80
Small DNA pieces in C. elegans are intermediates of DNA fragmentation during apoptosis. PLoS One (2010) 0.79