Published in Proc Natl Acad Sci U S A on June 04, 2002
Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol (2004) 6.67
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J (2002) 6.65
Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res (2004) 5.14
RNA editing of a miRNA precursor. RNA (2004) 4.43
RNA editing of human microRNAs. Genome Biol (2006) 4.16
A survey of RNA editing in human brain. Genome Res (2004) 4.14
A-to-I RNA editing and human disease. RNA Biol (2006) 3.32
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science (2003) 2.34
ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells. J Biol Chem (2004) 2.15
RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. EMBO J (2002) 2.14
How does RNA editing affect dsRNA-mediated gene silencing? Cold Spring Harb Symp Quant Biol (2006) 2.12
Evolutionarily conserved human targets of adenosine to inosine RNA editing. Nucleic Acids Res (2005) 1.96
Non-coding RNAs in the nervous system. J Physiol (2006) 1.87
A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes. Genome Res (2013) 1.81
ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. J Cell Biol (2005) 1.78
RNA-editing-mediated exon evolution. Genome Biol (2007) 1.77
RNA editing level in the mouse is determined by the genomic repeat repertoire. RNA (2006) 1.75
Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci U S A (2003) 1.73
C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes. RNA (2008) 1.70
RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. RNA (2003) 1.70
High levels of RNA-editing site conservation amongst 15 laboratory mouse strains. Genome Biol (2012) 1.68
Effects of length and location on the cellular response to double-stranded RNA. Microbiol Mol Biol Rev (2004) 1.57
The APOBEC3 family of retroelement restriction factors. Curr Top Microbiol Immunol (2013) 1.46
RNA editing in Drosophila melanogaster: New targets and functional consequences. RNA (2006) 1.43
Altered RNA editing in mice lacking ADAR2 autoregulation. Mol Cell Biol (2006) 1.36
Intronic Alus influence alternative splicing. PLoS Genet (2008) 1.35
Inosine-containing dsRNA binds a stress-granule-like complex and downregulates gene expression in trans. Mol Cell (2007) 1.35
Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA binding. RNA (2004) 1.31
A starvation-induced noncoding RNA modulates expression of Dicer-regulated genes. Proc Natl Acad Sci U S A (2008) 1.27
Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene. Nucleic Acids Res (2004) 1.26
ADAR2 A-->I editing: site selectivity and editing efficiency are separate events. Nucleic Acids Res (2003) 1.25
Letter from the editor: Adenosine-to-inosine RNA editing in Alu repeats in the human genome. EMBO Rep (2005) 1.20
Double-stranded RNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis. Nat Struct Mol Biol (2010) 1.19
Identification of widespread ultra-edited human RNAs. PLoS Genet (2011) 1.16
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One (2009) 1.16
Screening of human SNP database identifies recoding sites of A-to-I RNA editing. RNA (2008) 1.16
A distant cis acting intronic element induces site-selective RNA editing. Nucleic Acids Res (2012) 1.14
Identification of RNA editing sites in the SNP database. Nucleic Acids Res (2005) 1.14
Retrotransposons as regulators of gene expression. Science (2016) 1.09
Elevated activity of the large form of ADAR1 in vivo: very efficient RNA editing occurs in the cytoplasm. RNA (2003) 1.08
The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc Natl Acad Sci U S A (2008) 1.05
Tudor-SN and ADAR1 are components of cytoplasmic stress granules. RNA (2012) 1.04
Biochemical analysis and scanning force microscopy reveal productive and nonproductive ADAR2 binding to RNA substrates. RNA (2003) 1.04
A genome-wide map of hyper-edited RNA reveals numerous new sites. Nat Commun (2014) 1.04
RNA editing and alternative splicing of the insect nAChR subunit alpha6 transcript: evolutionary conservation, divergence and regulation. BMC Evol Biol (2007) 1.02
A method to find tissue-specific novel sites of selective adenosine deamination. Nucleic Acids Res (2005) 1.00
TRANSAT-- method for detecting the conserved helices of functional RNA structures, including transient, pseudo-knotted and alternative structures. PLoS Comput Biol (2010) 0.99
RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. J Biol Chem (2012) 0.98
RNA aptamers binding the double-stranded RNA-binding domain. RNA (2006) 0.98
Alu elements shape the primate transcriptome by cis-regulation of RNA editing. Genome Biol (2014) 0.97
The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing. Elife (2015) 0.95
Modulation of ADAR1 editing activity by Z-RNA in vitro. Nucleic Acids Res (2005) 0.95
Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats. BMC Genomics (2010) 0.95
Large-scale overexpression and purification of ADARs from Saccharomyces cerevisiae for biophysical and biochemical studies. Methods Enzymol (2007) 0.95
An accurate fluorescent assay for quantifying the extent of RNA editing. RNA (2006) 0.93
A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans. Dev Cell (2014) 0.93
A novel RNA pentaloop fold involved in targeting ADAR2. RNA (2005) 0.93
Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNA. BMC Genomics (2013) 0.93
Adenosine-to-inosine RNA editing. Wiley Interdiscip Rev Syst Biol Med (2010) 0.92
Genome-wide analysis of Alu editability. Nucleic Acids Res (2014) 0.92
Profiling the RNA editomes of wild-type C. elegans and ADAR mutants. Genome Res (2014) 0.91
A transition state analogue for an RNA-editing reaction. J Am Chem Soc (2004) 0.91
The difficult calls in RNA editing. Interviewed by H Craig Mak. Nat Biotechnol (2012) 0.91
ADBP-1 regulates an ADAR RNA-editing enzyme to antagonize RNA-interference-mediated gene silencing in Caenorhabditis elegans. Genetics (2008) 0.90
Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules. Nucleic Acids Res (2013) 0.88
Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage. RNA (2012) 0.87
The RNA binding domain within the nucleoporin Nup153 associates preferentially with single-stranded RNA. RNA (2004) 0.84
ADAR enzyme and miRNA story: a nucleotide that can make the difference. Int J Mol Sci (2013) 0.84
The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome. Cell Rep (2014) 0.84
Extra double-stranded RNA binding domain (dsRBD) in a squid RNA editing enzyme confers resistance to high salt environment. J Biol Chem (2012) 0.83
Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains. RNA (2013) 0.83
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system. Front Neurosci (2013) 0.83
RNA surveillance-an emerging role for RNA regulatory networks in aging. Ageing Res Rev (2010) 0.81
Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration. Front Genet (2013) 0.80
Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes. Immunology (2008) 0.79
Genome-wide profiling of the C. elegans dsRNAome. RNA (2015) 0.79
Identification of human RNA editing sites: A historical perspective. Methods (2016) 0.78
Alu mobile elements: from junk DNA to genomic gems. Scientifica (Cairo) (2012) 0.78
Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs. Nucleic Acids Res (2015) 0.78
Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript. RNA Biol (2015) 0.77
TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO J (2014) 0.77
The dynamic epitranscriptome: A to I editing modulates genetic information. Chromosoma (2015) 0.77
Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. RNA Biol (2015) 0.76
Identification and characterization of two novel RNA editing sites in grin1b transcripts of embryonic Danio rerio. Neural Plast (2012) 0.76
Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development. PLoS One (2014) 0.76
Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis. Exp Hematol (2016) 0.75
A nuclear RNA is cut out for translation. Cell (2005) 0.75
ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer. Int J Mol Sci (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol (1999) 41.48
Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06
Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature (1997) 7.92
Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature (2000) 6.67
RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell (1993) 5.62
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science (1994) 5.21
Regulation of alternative splicing by RNA editing. Nature (1999) 5.00
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (1998) 4.95
The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs. Cell (2001) 4.72
Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. Proc Natl Acad Sci U S A (2000) 4.54
Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Science (2000) 4.19
RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase. Nature (1996) 4.04
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell (2000) 3.86
Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA. EMBO J (1998) 3.23
The rest is silence. RNA (2001) 3.07
Imprinting in Prader-Willi and Angelman syndromes. Trends Genet (1998) 2.85
The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin. Mol Biol Cell (1998) 2.70
pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos. Cell (1995) 2.61
Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA. J Virol (1995) 2.54
RNA editing and hypermutation by adenosine deamination. Trends Biochem Sci (1997) 2.51
Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA. Proc Natl Acad Sci U S A (1999) 2.08
Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts. Curr Opin Cell Biol (1995) 2.06
HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project. Nucleic Acids Res (2002) 1.98
Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proc Natl Acad Sci U S A (1996) 1.92
The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing. Neuron (2000) 1.82
Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the Prader-Willi deletion region, which Is highly expressed in brain. Am J Hum Genet (2000) 1.80
A transposon-based strategy for sequencing repetitive DNA in eukaryotic genomes. Genome Res (1997) 1.78
Detection of inosine in messenger RNA by inosine-specific cleavage. Biochemistry (1997) 1.62
Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Biochem Biophys Res Commun (1998) 1.52
A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15. Hum Mol Genet (2001) 1.44
Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms. J Biol Chem (2000) 1.26
Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression. J Biol Chem (1995) 1.24
Positioning of longitudinal nerves in C. elegans by nidogen. Science (2000) 1.23
Towards a molecular understanding of Prader-Willi and Angelman syndromes. Hum Mol Genet (1999) 1.22
Identification of a novel paternally expressed transcript adjacent to snRPN in the Prader-Willi syndrome critical region. Genome Res (1996) 1.13
cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. Biochem Biophys Res Commun (1998) 1.08
Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. Biochim Biophys Acta (1994) 0.99
Alternative splicing of human NrCAM in neural and nonneural tissues. Mol Cell Neurosci (1998) 0.93
Identification of novel exons 3' to the human SNRPN gene. Genomics (1997) 0.87
MER53, a non-autonomous DNA transposon associated with a variety of functionally related defense genes in the human genome. DNA Seq (1998) 0.84
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science (2005) 2.94
The role of RNA editing by ADARs in RNAi. Mol Cell (2002) 2.35
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science (2003) 2.34
RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. EMBO J (2002) 2.14
Predicting sites of ADAR editing in double-stranded RNA. Nat Commun (2011) 1.74
C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes. RNA (2008) 1.70
ADAR editing in double-stranded UTRs and other noncoding RNA sequences. Trends Biochem Sci (2010) 1.63
Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. RNA (2007) 1.51
Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode. Mol Cell (2011) 1.49
RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA. RNA (2006) 1.40
dsRNA binding properties of RDE-4 and TRBP reflect their distinct roles in RNAi. J Mol Biol (2008) 1.39
Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA binding. RNA (2004) 1.31
A starvation-induced noncoding RNA modulates expression of Dicer-regulated genes. Proc Natl Acad Sci U S A (2008) 1.27
Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs. RNA (2010) 1.26
Improved annotation of C. elegans microRNAs by deep sequencing reveals structures associated with processing by Drosha and Dicer. RNA (2011) 1.05
miRNA editing--we should have inosine this coming. Mol Cell (2007) 1.03
Mechanistic insights into editing-site specificity of ADARs. Proc Natl Acad Sci U S A (2012) 1.03
Effects of ADARs on small RNA processing pathways in C. elegans. Genome Res (2012) 0.97
Large-scale overexpression and purification of ADARs from Saccharomyces cerevisiae for biophysical and biochemical studies. Methods Enzymol (2007) 0.95
In C. elegans, high levels of dsRNA allow RNAi in the absence of RDE-4. PLoS One (2008) 0.93
Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation. Mol Cell Biol (2009) 0.92
A transition state analogue for an RNA-editing reaction. J Am Chem Soc (2004) 0.91
Dynamic linear model for the identification of miRNAs in next-generation sequencing data. Biometrics (2011) 0.80
Small DNA pieces in C. elegans are intermediates of DNA fragmentation during apoptosis. PLoS One (2010) 0.79